Life Sciences &
Biotechnology

 




Leading Researchers:

Novel Anti Bacterial Drug

Technology Two non-toxic short peptides were conjugated to form a novel drug candidate. One of the peptides is a polymyxin-B or polymyxin-E analog (PMBN or PMEN, respectively) while the other is an immune cell chemotactic peptide (fMLF). The resulta Read More >

Leading Researchers:

Improved Calcitonin-based Therapeutics

TechnologyThe aggregation site on human calcitonin has been identified, paving the way for development of specific inhibitors of calcitonin amyloid fibril formation. Such inhibitors will enable development of improved calcitonin therapeutics as well Read More >

Leading Researchers:

Novel markers for the identification and isolation of stem and progenitor cells

TechnologyA series of novel markers: (1) chromatin remodeling protein factor termed (CHD9/CReMM), (2) A cell adhesion protein termed (SVEP1), (3) A kinesin protein termed (MS-KIF18A), (4) RNA processing factor (SRRF/hNRNP-L) have been developed as no Read More >

Leading Researchers:

BBS (? secretase Blocking Site) Ab -A novel target for Alzheimer's and ALS immunotherapy

THE TECHNOLOGYBBS is a monoclonal antibody that binds specifically and blocks beta-secretase (BACE1) cleavage site on its substrate, APP.  BBS inhibits Ab production, a hall-mark of AD and other neurodegenerative diseases such as ALS.The mechani Read More >

Leading Researchers:

Cell Therapy for Diabetes: Expansion and re-differentiation of adult human pancreatic islet cells for transplantation

The Technology Prof. Efrat has developed a protocol for re-differentiating human beta cells after expansion; this can be explained by the open chromatin structure around beta-cell-specific genes that is retained in these cells.  Thus, the cells Read More >

Leading Researchers:

Novel oral formulation of Insulin

The TechnologyGagomers are novel particles (neither liposomes nor microspheres/ nanospheres) composed of hyaluronan shell which is crossed linked to phospholipids and can be generated either as micro or nano particles. The research team at Tel Aviv U Read More >

Leading Researchers:

Novel Derivatives of Valproic Acid and Acyclovir as Selective Anti-Cancer Agents

TechnologyHistone deacetylase inhibitors (HDACis) have emerged as a powerful new class of anticancer agents acting through the regulation of histone and other proteins acetylation. However, the current FDAapproved HDACis SAHA and FK228 used for treat Read More >

Leading Researchers:

Targeting the voltage sensor of Kv7.2 and TRPV1 cation channels: Novel treatment for neuropathic pain

TechnologyWe designed unique ligands targeting the voltage sensor domain (VSD) of two voltage-gated cation channels (VGCC), Kv7.2 and TRPV1 channels. These drugs simultaneously function as openers of Kv7.2 and blockers of TRPV1. They act in vitro and Read More >

Leading Researchers:

GSK-3 Peptide Inhibitors for the Treatment of CNS Related Disorders

Technology Novel Glycogen synthase kinase 3 (GSK-3) inhibitors were developed. These inhibitors are substrate competitors that interact specifically with the GSK-3 substrate binding site. The strategy is based on exploiting the unique GSK-3-substrat Read More >

Leading Researchers:

IAPP Oligomers as a Target for Type 2 Diabetes Novel Immunotherapy

TechnologyStabilized human IAPP (hIAPP) oligomers were used for the development of active immunization of type 2 diabetes. This promising novel approach for the treatment of type 2 diabetes is doable due to the establishment of a new protocol for the Read More >