Animal Models

 

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Prof. Barak Segev

Dr. Barak’s research focuses on the psychobiology and neurobiology of alcoholism and drug addiction. In particular, he is interested in the molecular and neuronal mechanisms that underlie learning and memory processes in alcohol addiction.  In addition, Dr. Barak is interested in the  pathophysiology  of schizophrenia, with focus on cognitive impairments in this disorder. See lab […] Read More >

Prof. Ben-Baruch Adit

Breast cancer is a leading cause of death for women in the Western world. The battle against breast cancer has been challenged by the fact that, generally, each component is studied meticulously, but singly. Too little attention is paid to the interactions between the tumor cells and their intimate microenvironment, consisting of various cells and […] Read More >

Prof. Fishelson Zvi

Research Molecular Analysis of Cancer Immunoresistance The long-term goal of our research is to develop a novel treatment for immune resistant cancers. Our research includes characterization of the mechanism of complement-dependent cytotoxicity and of the basis for elevated resistance of cancer cells to cell death, and design of novel reagents that sensitize cancer cells to […] Read More >

Prof. Frenkel Dan

Research topic: The research in our laboratory is focused on the investigation of glial cell and to clarify their role in neurological diseases. We suggest that targeting glia activation in different pathological scenarios may allow us to define common pathways to further understand the role of glia in neuroprotection . We are using three models: 1) […] Read More >

Prof. Gabet Yankel

Genetics: Our laboratory focuses on the genetic and hormonal regulation of bone remodeling, microarchitecture and strength. These traits have a high degree of heritability, and one aspect of our research is to characterize new genetic determinants of bone remodeling as well as elucidate the mechanism of action of selected genes. Our GWAS confirmed the role of […] Read More >

Dr. Gil-Ad Irit

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Prof. Joel Daphna

Prof. Joel studied the involvement of basal ganglia-thalamocortical circuits in normal and abnormal behavior, using mainly animal models of psychopathology. More recently Prof. Joel has expanded her work to research questions related to brain, sex and gender. Ongoing studies attempt to characterize the relations between sex and brain structure and function. Other studies focus on […] Read More >

Dr. Leikin-Frenkel Alicia

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Prof. Jonathan Leor

Professor Leor received an M.D. degree from Tel-Aviv University, continued training in cardiovascular medicine at the Sheba Medical Center, and completed his post doctorate training at the University of Southern California, Los Angeles, under Robert A. Kloner, M.D., Ph.D. Today, his laboratory’s research focuses on infarct repair and the heart’s lack of intrinsic regenerative ability. […] Read More >

Prof. Michaelson Daniel

The research in the Michaelson laboratory is directed at unraveling the basic cellular and molecular mechanisms underlying neurodegenration in Alzheimer’s disease and at the development of novel therapeutic approaches to counteract them. The research focuses on apolipoprotein  E4 (apoE4), the most prevalent genetic risk factor of the disease ,and on it’s interaction with other risk […] Read More >

Leading Researchers:

The Myers Neuro-Behavioral Core Facility

Unit description:The Myers Neuro-Behavioral Core Facility provides researchers with state-of-the-art technology for performing neuro-behavioral tests in mice. Services: The Core Facility provides expertise in design, implementation, and analysis of behavioral experiments. The Core Facility includes five behavior rooms, which can operate simultaneously, and two animal maintenance rooms with IVC cages operating on a reversed light […] Read More >

Leading Researchers:
12-2014-771

Animal models of Addiction and Psychopathologies

Our main focus is on the psychological and neurobiological mechanisms that underlie psychiatric disorders, and in particular addiction We are using rodent models of addiction, anxiety, learning and memory. We focus on behavioral models relevant to different stages of addiction (craving, drug reward, intoxication, sensitization, tolerance, excessive alcohol consumption, withdrawal symptoms, relapse). We are looking […] Read More >

Leading Researchers:
12-2013-717

MULTI SENSOR – Multi Modal Recording System for Behavioral Tracking

It is clear today that brain activity of a restrained (or sedated) animal is completely different from that of a freely behaving animal.That is why neuroscientists are seeking to find ways to study animals freely behaving on their natural grounds.TAU’s interdisciplinary research has led to the development of the MULTI SENSOR – Multi Modal Recording […] Read More >

Leading Researchers:
12-2013-676

analysis of mineralized tissues using microCT

The general purpose of my research is to describe the genetic and endocrine regulation of bone metabolism. To this end, we developed expertise in most aspects of bone research, from in vivo models, imaging of bone microarchitecture, in vitro cell cultures and molecular biology. Main Research Topics Regulation of bone metabolism by sex steroids Role […] Read More >

Leading Researchers:
12-2013-434

The Cohen Rosenthal Diabetic Hypertensive Rat (CRDH) model

The construction of the Cohen Rosenthal Diabetic Hypertensive Rat (CRDH) model was initiated nearly a decade ago by cross-breeding between the Cohen Diabetic rat (CDR) and the SHR. The CDR is a rodent model that expresses the following phenotypes: when fed regular diet, it is non-diabetic; when fed a diabetogenic diet, it invariably develops diabetes […] Read More >

Leading Researchers:
12-2013-415

Laboratory of Immunological and Inflammatory Modules in Malignancy

Research focusProf. Ben-Baruch is an immunologist who investigates the roles of immune and inflammatory elements in physiological and pathological conditions, with major emphasis on malignancy. The studies in her laboratory determine the complex regulatory networks established between chemokines and cytokines of the tumor microenvironment, intrinsic oncogenic modifications in tumor cells, and stroma cells. The research […] Read More >

Leading Researchers:
12-2016-972

Lab of Cancer Angiogenesis and Nanomedicine

Selective therapy remains a key issue for successful treatment in cancer therapy. Prolonged administration of effective concentrations of chemotherapeutic or anti-angiogenic agents is usually not possible because of dose-limiting systemic toxicities involving non-malignant tissues. Therefore, a constant effort has been the development of new drug delivery systems that mediate drug release selectively at the tumor […] Read More >

Leading Researchers:
12-2011-205

Lipid Solutions and Animal Model

SERVICES“ Lipid Solutions” Prof. Alicia Leikin-Frenkel “Lipid Solutions” covering:1. Expert support for questions on: lipid metabolism, isolation, identification and quantitation of lipids in different species and different matrixes.2. Guidance to discover the pathway to physiological and biochemical implications following overexpressed or suppressed gene linked to lipids.3. Counseling to analyze lipids in:• Simple molecules: fatty acids: Saturated, Monounsaturated n7, n9, Polyunsaturated: […] Read More >

Leading Researchers:
12-2011-204

Drug Screening Animal Model for Anti-compulsive Activity

We have developed the signal attenuation rat model of obsessive-compulsive disorder (OCD). This model is based on the theoretical proposition that compulsive behaviors result from a deficit in the feedback, which is associated with the performance of normal goal-directed responses.  In our model, the goal-directed behavior is lever-pressing for food. The feedback associated with making […] Read More >

Leading Researchers:
12-2011-203

Cardiovascular and Physiological Assessment in Animal Models

Neufeld Cardiac Research Institute at Sheba Medical Center, Tel-Aviv University comprises a fully equipped laboratory to conduct cardiovascular and physiological experiments in small (mice, rat) and large animals (swine, sheep, calf) including heart function studies with special echocardiography system designed for small animals (Vevo660 ultrasound biomicroscope; VisualSonics), molecular imaging, pressure‐volume loop machine (Millar/Power Lab) and […] Read More >

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