Biological Models
51 Results were found on Technologies
Sub Category Name
Noncoding RNA-Based Strategy for Diagnosis and Monitoring of Pancreatic Cancer
Pancreatic Ductal Adenocarcinoma (PDAC) is one of the deadliest forms of cancer, with a five-year survival rate of less than 10%. A major contributor to this high mortality is the lack of effective tools for early detection — the disease is typically diagnosed at an advanced, often inoperable stage. Current diagnostic approaches, including imaging and […] Read More >
Bio-Inspired Liquid Compartments for Efficient Encapsulation and Controlled Release of Payloads
Tunable peptide-RNA microcompartments inspired by viral structures that have high encapsulation efficiency of small organic molecules and large macromolecules that their release is triggered by light. UNMET NEED Current drug delivery or microreactor systems are lipid-based nanoparticles (NPs) that has shown a wide range of applications as drug delivery vehicles and are used for various […] Read More >
Diagnostic Tool for Assessing Breast Cancer Aggressiveness via Neutrophil-Tumor Cell Interactions
A novel diagnostic approach based on the discovery that neutrophils physically interact with tumor cells in breast cancer, creating a unique signaling niche that enhances cancer aggressiveness. This interaction can be used to assess the aggressiveness of breast cancer, offering a new way to predict patient outcomes and guide treatment strategies. Unmet Need Current diagnostic […] Read More >
Therapeutic Targeting of CD45: A Novel Approach to Overcome Immunotherapy Resistance
Revolutionizing Cancer Immunotherapy While immune checkpoint inhibitors have transformed cancer treatment, only 50% of patients fail to respond, with resistance being a major challenge, particularly in aggressive cancers such as triple-negative breast cancer (TNBC). TNBC accounts for 15–20% of breast cancer cases and is often diagnosed at advanced stages, with current therapies offering limited efficacy. […] Read More >
Next Generation of the mRNA Therapy: Targeting Cancer Cells Via Boolean Circuits Based on mRNA Molecules
Currently most cancer treatment target proteins that are modified or activated in cancer cells; usually this is done by producing a relevant antibody. The process of finding a new therapy that targets a protein is long and tedious and in addition, in many cancer types there is no therapy at all. Specifically, today there are […] Read More >
Enhancing Plasmid Conjugation Efficiency for Transformative Biotechnological Applications
This technology enhances plasmid-based gene transfer by utilizing a leading region enriched with anti-defense genes. It enables more efficient overcoming of bacterial immune systems, improving applications in biotechnology and microbial engineering. ABSTRACT Our groundbreaking technology dramatically improves plasmid-based gene transfer by utilizing a strategically designed leading region enriched with anti-defense genes. We revealed that the […] Read More >
Development Of Improved Immunosuppressant Targeting Calcineurin-NFAT Protein-Protein Interaction Via Novel Peptides
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
Anti-Influenza A Virus Drug Discovery
Influenza A virus infection is one of the most common respiratory tract diseases in humans. It is the cause of typical seasonal flu as well as major human pandemics worldwide. According to the World Health Organization (WHO) in October 2023, around 3 to 5 million severe influenza cases were recorded, leading to 290,000 to 650,000 […] Read More >
Evaluation of Single Strand DNA Damage in Sperm Using a novel Damage Detection Technique
The Damage Detection technique is an innovative approach to assessing Single Strand DNA (ssDNA) damage by utilizing DNA repair enzymes to identify DNA adducts and single-strand breaks. Spermatozoa are characterized by high levels of DNA fragmentation, despite their condensed nuclear DNA packaging. Sublethal DNA damage, such as single strand breaks and adducts, can occur and […] Read More >
3D Printing of 3-Layered Retina and Choroid Tissue
We present a sequential fabrication of a three-layer retina-like structure. This innovative approach aims to address the challenges associated with age-related macular degeneration (AMD) and other retinal degenerative diseases by creating a bioengineered retinal implant that mimics the natural structure and function of the human retina. Unmet Need: Age-related macular degeneration is the leading cause […] Read More >
