Cancer

 

22 Results were found on Technologies

Leading Researchers:
2022-0176

Restoring Immunity Against GI Cancers

BACKGROUND GI cancers cause over 3.5 million deaths per year globally, accounting for 35% of all cancer-related deaths. Colorectal carcinoma (CRC) is the world’s second leading cause of cancer death. Current immunotherapy treatments for CRC are hamstrung by low response rate, acquired resistance, relapse and severe side effects. ImmuNovation presents a disruptive nanomodular technology utilizing […] Read More >

Leading Researchers:
2-2020-1440

Novel Anti-Tumor Response treatment targeting ErbB receptors and Nucleolin interactions

ErbBs subfamily receptors are mediators of cell growth signals. They have long been associated with a wide variety of lung, ovarian, colon, breast, prostate, and other carcinomas. Nucleolin is a major nucleolar protein of growing eukaryotic cells and is present on the cell surface of a range of cancers. Recently, a robust oncogenic interaction between […] Read More >

Leading Researchers:
2-2017-1108

Early Detection of Ovarian Cancer

We developed a novel proteomic diagnostic assay for detection of epithelial ovarian cancer, offering: • High sensitivity for early stage disease to increase the likelihood of cure. • High specificity for potential delay of risk-reducing surgical procedure. • Early ovarian cancer diagnosis for all age-groups and risk-groups (i.e., BRCA carriers). THE NEED Over 240,000 new […] Read More >

Leading Researchers:
10-2015-950

Mirna for the Treatment of Metastatic Breast Cancer

Metastasis is the primary cause for mortality in breast cancer. We showed that breast cancer metastasis can be prevented by miR-96 or miR-182 treatment. We found that miR-96/miR-182 downregulates Palladin protein levels, thereby reducing breast cancer cell migration and invasion. A hydrogel-embedded, gold-nanoparticle-based delivery vehicle provides efficient local, selective, and sustained release of miR-96/miR-182, markedly […] Read More >

Leading Researchers:
10-2019-1313

Novel Human Anti-Met Monoclonal Antibodies for Cancer Immunotherapy

MET is clinically validated target in several cancer types. MET operates just downstream to the famous P53. Addiction of cancers like breast and lung to MET as well as its absence from healthy adult tissues makes it a highly desirable target. Existing anti-MET marketed drugs (crizotinib & cabozantinib) are non-specific kinase inhibitors, having high toxicity […] Read More >

Leading Researchers:
10-2012-314

Repurposing of Antibiotics for treating APC (Adenomatous Polyposis Coli) Related Colorectal Cancer

Restoration of Adenomatous Polyposis Coli (APC) gene expression by means of antibiotic erythromycin for the treatment of Familial Adenomatous Polyposis. The Technology: Treatment for APC by   conventional antibiotics to regulate adenoma growth and delay the need for preventive surgery in Familial Adenomatous Polyposis (FAP) patients. The Need:  FAP is a high penetrance devastating syndrome manifested […] Read More >

Leading Researchers:
10-2007-109

Macrolid Induced Correction of Premature Stop Codons: A novel Treatment for Colorectal Cancer

Restoration of premature termination codons (PTCs) caused by nonsense mutations for the treatment   of Familial Adenomatous Polyposis. The Need Familial Adenomatous Polyposis (FAP) is a high penetrance devastating syndrome manifested by dozens to thousands of colonic adenomas. FAP patients require tight supervision and eventually undergo surgery, to prevent inevitable development of colorectal cancer (CRC) by […] Read More >

Leading Researchers:
2-2019-1243

Therapeutic Vaccine for the Treatment of Cancer

An active cancer vaccine strategy targeting tumor-associated carbohydrate antigens expressed on tumor cells using biomimetic glyconanoparticles generated from unique red blood cells. The resulting sustained immune response inhibits tumor growth. THE NEED While envisioned already in 1891, only a few cancer vaccines have been approved by the FDA thus far.  The key barriers to their […] Read More >

Leading Researchers:
2-2017-1081

3D Bioprinting of Tumor Models for Personalized Drug Screening and Disease Modeling

This technology aims to provide a three-dimensional (3D) bioprinted tumor model based on natural and synthetic polymers containing several types of cells, which resembles cancer tissue. Our 3D-bioprinted tumor model has potential to predict the clinical outcome of a treatment compared to the other existing solutions, which either rely solely on genetic profiling or do […] Read More >

Leading Researchers:
2-2016-1041

Novel Ionizable Lipids for Delivery of Nucleic Acids (mRNA, DNA, siRNA)

BackgroundChemotherapy treatment is generally accompanied by adverse effects, which can be significantly reduced using site specific, targeted delivery systems, such as antibody-coated LNPs (immuno-LNPs). However due to inter-and intra-tumor heterogeneity targeting with a single targeting moiety is not sufficient in many cases and in others may induce cancer relapse due to the survival of side […] Read More >

Leading Researchers:

The Ben-Tal Lab of Computational Structural Biology

Our research is focused on studying the interplay between protein sequence, structure, motion and function using computational tools. The understanding of these relations provides a molecular dimension to our understanding of protein functions and their involvement in genetic disorders and other diseases. Within the broad fields of structural- bioinformatics and phylogeny, we limit our research […] Read More >

Leading Researchers:

The Wine Lab- Systems Immunotechnology Laboratory

Anti-Drug Antibodies Over 30 years since the approval of the first therapeutic monoclonal antibody (mAb) for clinical use, the mAb industry has expanded exponentially and comprises the fastest growing class of pharmaceutics.  While mAbs hold significant promise for improving human health, repeated administration of mAb often leads to the induction of undesirable Anti-Drug Antibodies (ADAs), […] Read More >

Leading Researchers:

Carmi Lab- Cancer Immunobiology and Immunotherapy

The goal of our lab is to provide a detailed understanding of the mechanisms, which regulate and control the discrimination between self and non-self, and thereby give rise to cytotoxic T cell immunity specifically directed against tumor targets. The ultimate goals of our research are embodied in the following specific aims: What are the cellular […] Read More >

Leading Researchers:

Mesenchymal Stem Cell Biology Lab

Research topics:  Mesemchymal cells (MSCs) lineage fate [osteogenic/adipogenic/myogenic] in aging/metabolic disease (osteoporosis/diabeties) and cancer  MSCs molecular markers (CHD9-chromatin remodeling, SVEP1-cell adhesion)  MSCs biomechanics/substrate rigidity (2D/3D) in differentiation fate  Connective tissue protein component and structure  Novel bio-composites scaffolds for tissue regeneration For more information: Email: dafnab@tauex.tau.ac.il Phone: 03-6406187 Website:https://benayahulab.wixsite.co… Office: School of Medicine, 310 Read More >

Leading Researchers:

The Biomedical Optical Microscopy, Nanoscopy and Interferometry Research Group

The Biomedical Optical Microscopy, Nanoscopy and Interferometry Research Group is a part of the Department of Biomedical Engineering and the Nano Center of Tel Aviv University, Tel Aviv, Israel. Directed by Prof. Natan T. Shaked and located on three labs spaces, the group performs multidisciplinary research involving optical engineering, imaging and sensing in biological systems, […] Read More >

Leading Researchers:

Immune Gene Editing

Using novel gene editing technology, we engineer T cells and B cells to better fight cancer, infections and autoimmune diseases Our research Our primary objective is to develop safe, efficient and scalable methods to engineer lymphocytes for immunotherapy. We provide a novel technology for the engineering of B cells as well as T cells, in […] Read More >

Leading Researchers:
12-2018-1172

High Throughput Genomics

The Shomron research team focuses on the analysis of genomics aimed at understanding human disease. Combining high-throughput methods and bioinformatics, our team’s research explores gene regulators, such as microRNAs, in order to reach a global, systems perspective on the mechanistic roles small RNA play during disease development. Among our projects:  Identification of a microRNAs that […] Read More >

Leading Researchers:
12-2018-1171

Computational Modeling of Gene Expression

Prof. Tuller’s lab is a leading computational lab that primarily focuses on and has extensive expertise studying and modeling diverse gene expression mechanisms and engineering gene expression based on computational and synthetic biology tools. Computational Modeling of Gene Expression Development of computational predictive models to mathematically analyze and simulate the different stages of gene expression. […] Read More >

Leading Researchers:
12-2013-415

Laboratory of Immunological and Inflammatory Modules in Malignancy

Research focus Prof. Ben-Baruch is an immunologist who investigates the roles of immune and inflammatory elements in physiological and pathological conditions, with major emphasis on malignancy. The studies in her laboratory determine the complex regulatory networks established between chemokines and cytokines of the tumor microenvironment, intrinsic oncogenic modifications in tumor cells, and stroma cells. The […] Read More >

Leading Researchers:
12-2016-1018

Lab of Signal transduction, Neurodegeneration and Autophagy

Research focus ErbB receptors interactions and functions Regulation of Autophagy Neurodegeneration Projects include: The crosstalk between ErbB receprots and nucleolin in cancer development Beclin 1 mediated autophagy Autophagy in neurodegenerative diseases Autophagy in cancer Potential services Laboratory services: To monitor autophagy Signal transduction assays Anti-cancer drugs examination Cell proliferation, death and migration examination   Potential […] Read More >

Dr. Ben-David Uri

Senior Lecturer (Assistant Professor), Department of Human Molecular Genetics & Biochemistry, Faculty of Medicine, Tel-Aviv University Research Cancer Aneuploidy Aneuploidy – the presence of an abnormal number of chromosomes in cancer cells — is characteristic of most tumors, and is rarely observed in normal tissues. It is not fully understood how aneuploidy contributes to tumor […] Read More >

Prof. Ben-Tal Nir

Our research is focused on studying the interplay between protein sequence, structure, motion and function using computational tools. The understanding of these relations provides a molecular dimension to our understanding of protein functions and their involvement in genetic disorders and other diseases. Within the broad fields of structural-bioinformatics and phylogeny, we limit our research to […] Read More >

Dr. Carmi Yaron

Senior Lecturer, Department of Pathology, Faculty of Medicine Cellular and Molecular Mechanisms of Antigen-Restricted Rumor Immunity The goal of our work is to provide a detailed understanding of the mechanisms, signals and molecular pathways that regulate discriminating self from non-self and give rise to tumor-specific cytotoxic T cell immunity. Our specific aims are to address […] Read More >

Prof. Ebenstein Yuval

Our lab specializes in many areas of optical imaging and spectroscopy with emphasis on single molecule detection and development of imaging based techniques. Our research is focused on the application of novel imaging and optical detection approaches to genomic studies and biomarker detection. We are developing new spectroscopy and microscopy methodologies that combine advanced optics […] Read More >

Prof. Ehrlich Marcelo

I am interested on the dynamic aspects of the cell’s trafficking machinery, with a special focus on endocytic dynamics. More specifically, our study centers on the mechanisms by which the cell modulates vesicular traffic by altering: The rate of formation of vesicular carriers, such as clathrin coated vesicles. The spatio-temporal distribution of the process of […] Read More >

Dr. Freund Natalia

Senior Lecturer (Guest), Department of Clinical Microbiology and Immunology, Faculty of Medicine Research My laboratory is interested in understanding the molecular basis of human antibody responses to diseases. Antibodies are key components of most licensed vaccines; nevertheless many aspects of how antibodies recognize and neutralize their targets are still unknown. Pathogen-specific B cells are stimulated […] Read More >

Prof. Friedmann- Morvinski Dinorah

Our lab studies the mechanisms of cancer cell reprogramming and the contributions of the tumor microenvironment to this process. Using an integrative approach to study brain tumor (glioma)-specific neurobiology and oncobiology, the research in my lab currently explores the following directions: Examining the parallel changes in oncogenesis and the induction of pluripotency Elucidating the mechanisms […] Read More >

Dr. Gal Maayan

Senior Lecturer – Faculty of Medicine Research My lab is focused on the discovery and development of novel protein modulators as the basis for new therapeutics. Of main interest are the challenging targets belonging to the biological space of protein-protein interactions (PPIs). For this purpose, we are integrating cutting-edge computational, biophysical and cellular biology tools. […] Read More >

Prof. Tamar Geiger

Dr. Geiger is an associate professor at the department of Human Molecular Genetics and Biochemistry at the Faculty of Medicine at Tel Aviv University. Geiger completed her BSc studies in life sciences at the Hebrew University of Jerusalem. She then continued and performed her MSc and PhD studies in the same university studying cancer signaling […] Read More >

Dr. Ilovitsh Tali

I received my B.Sc. (2010), M.Sc. in a direct track (2011), and Ph.D. (2016) degrees in electrical engineering from Bar Ilan University, Israel. My Ph.D. research in the field of optical imaging was focused on the development of super-resolution techniques for microscopy. Between 2016-2019 I was a postdoctoral researcher at Prof. Katherine Ferrara lab, initially […] Read More >

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