Diagnostics
15 Results were found on Technologies
Sub Category Name
Multi-Sample Array Chip for DNA Modification Quantification
Introducing an advanced multi-sample array chip that enables precise quantification of epigenetic DNA modifications, including 5-hydroxymethylcytosine (5-hmC) and DNA damage. This technology bridges the gap between sensitivity and throughput, providing a robust platform for cancer diagnostics and personalized medicine. Unmet Need Current methods for analyzing DNA modifications suffer from limitations such as low sensitivity, high […] Read More >
Simultaneous Analysis of Large Genomic Structural Variations and Their Epigenetic Profile
This innovative technology enables simultaneous quantification of DNA repeat sequences, large deletions, insertion, inversion and translocations, together with CpG methylation and hydromethylation patterns in individual molecules. By leveraging state-of-the-art optical mapping and fluorescence-based methylation detection, this method provides unprecedented precision in diagnosing diseases like facioscapulohumeral muscular dystrophy (FSHD) and cancers. Unmet Need Current technologies for […] Read More >
Evaluation of Single Strand DNA Damage in Sperm Using a novel Damage Detection Technique
The Damage Detection technique is an innovative approach to assessing Single Strand DNA (ssDNA) damage by utilizing DNA repair enzymes to identify DNA adducts and single-strand breaks. Spermatozoa are characterized by high levels of DNA fragmentation, despite their condensed nuclear DNA packaging. Sublethal DNA damage, such as single strand breaks and adducts, can occur and […] Read More >
Automatic Detection of Spinal Pathologies Based on MRI Scans
This study introduces an automated system for detecting spinal pathologies in MRI scans, aiming to enhance efficiency and accuracy in medical diagnostics. By leveraging deep learning, the tool can assist radiologists in identifying and classifying pathological vertebrae, potentially improving diagnostic workflows. Background MRI scans are essential for diagnosing various lumbar spine conditions, including infections, inflammations, […] Read More >
Restoring Immunity Against GI Cancers
BACKGROUND GI cancers cause over 3.5 million deaths per year globally, accounting for 35% of all cancer-related deaths. Colorectal carcinoma (CRC) is the world’s second leading cause of cancer death. Current immunotherapy treatments for CRC are hamstrung by low response rate, acquired resistance, relapse and severe side effects. ImmuNovation presents a disruptive nanomodular technology utilizing […] Read More >
Deep Cell-Type Deconvolution From Bulk Gene Expression Data
It is becoming clear that bulk gene expression measurements represent an average over very different cells. Elucidating the expression and abundance of each of the encompassed cells is key to disease understanding and precision medicine approaches. A first step in any such deconvolution is the inference of cell type abundances in the given mixture. To […] Read More >
Dense Speed of Sound Shift Imaging for Ultrasonic Thermometry
During thermal therapeutic applications such as high-intensity focused ultrasound (HIFU), hyperthermia, and cryoablation, it is crucial to monitor internal tissue temperature to provide feedback on the procedure. Non-invasive MRI techniques for thermal monitoring are limited by their availability and cost. Ultrasonic thermometry is an emerging adaptable alternative due to the advantages of ultrasound in accessibility, […] Read More >
New Chemiluminescent Protease Probe for Rapid, Sensitive, and Inexpensive Detection of Live Mycobacterium tuberculosis
Tuberculosis (TB) is a top-ten cause of death worldwide. Successful treatment is often limited by insufficient diagnostic capabilities, especially at the point of care in low-resource settings. The ideal diagnostic must be fast, be cheap, and require minimal clinical resources while providing high sensitivity, selectivity, and the ability to differentiate live from dead bacteria.OUR SOLUTION• We […] Read More >
Antibody-Based Biosensor Diagnostic tool for Pathogenic Bacteria Detection
UNMET NEED• Antibiotic resistance crisis is driven by extensive and inappropriate usage of antibiotics and is predicted to result in an annual death toll of 10 million people by 2050. The ability to provide a rapid and accurate surveillance and diagnosis of multiple-drug resistant (MDR) bacteria is pivotal to the efficiency of controlling the growing crisis. […] Read More >
3D Bioprinting of Tumor Models for Personalized Drug Screening and Disease Modeling
This technology aims to provide a three-dimensional (3D) bioprinted tumor model based on natural and synthetic polymers containing several types of cells, which resembles cancer tissue. Our 3D-bioprinted tumor model has potential to predict the clinical outcome of a treatment compared to the other existing solutions, which either rely solely on genetic profiling or do […] Read More >