Drug Delivery

 

3 Results were found on Technologies

Leading Researchers:
2-2016-991

A Novel Nanoparticle that Selectively Delivers RNAi Oligonucelotides to Tumors, Preventing Side Effects to Tissues

UNMET NEEDPancreatic cancer numbers among the most aggressive cancers known today. The overwhelming majority of pancreatic cancer patients pass away within just a year of diagnosis. However, a small minority of patients may live several years with the disease. Our findings pinpoint the inverse correlation between a known oncogene (PLK1) and the expression of an […] Read More >

Leading Researchers:
2-2016-1041

Novel Ionizable Lipids for Delivery of Nucleic Acids (mRNA, DNA, siRNA)

BackgroundChemotherapy treatment is generally accompanied by adverse effects, which can be significantly reduced using site specific, targeted delivery systems, such as antibody-coated LNPs (immuno-LNPs). However due to inter-and intra-tumor heterogeneity targeting with a single targeting moiety is not sufficient in many cases and in others may induce cancer relapse due to the survival of side […] Read More >

Leading Researchers:
3-2022-1813

Stable enzyme-responsive nanocarriers with a-two step activation mechanism

The Challenge: Polymeric nanocarriers that can release their covalently attached or encapsulated cargo in response to specific stimuli can offer many advantages such as greater selectivity and consequently reduced side-effects. Among the different types of stimuli-responsive nanocarriers, enzyme-responsive delivery systems can act as a Trojan horse and release their active payload in response to specific […] Read More >

Prof. Benhar Itai

Prof. Benhar is an expert and opinion leader in the field of antibody engineering. Over the 25 years of being active in that field, he prepared several phage display libraries from which antibodies against numerous targets were isolated. Prof. Benhar publishes over 100research papers, wrote 10 book chapters and submitted 19 patent applications. Research in Prof. […] Read More >

Prof. Fleminger Gideon

Our laboratory is engaged in the study of structure-function relationships in proteins and peptides involved in biorecognition processes. In these studies we apply sophisticated separation methods for the purification with advanced methods of structural analysis of these materials.  Specific research activities include: Structure-function relationships in Ca+2-binding proteins:  We are engaged in the study of the […] Read More >

Prof. Goldbourt Amir

    Research Bacteriophages: Filamentous bacteriophagescomprise a family of bacteria-infecting viruses that share a similar virion structure and life cycle. The virion is composed of a circular ssDNA wrapped by thousands of similar copies of a major coat protein and several different minor coat proteins in both ends. In our group we prepare, purify and […] Read More >

Dr. Gothilf Yoav

Research Activity The Circadian Clock system All organisms demonstrate a wide variety of behavioral and physiological daily rhythms that are driven by an evolutionary conserved endogenous circadian clock mechanism. Maintenance of circadian rhythms is crucial for the physical and mental wellbeing, and disruption of the rhythms increases susceptibility to diseases and psychiatric disorders. Utilizing the […] Read More >

Prof. Horowitz Mia

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Prof. LEDERKREMER Gerardo Zelmar

Research Prof. Lederkremer’s lab has been interested in the mechanisms of protein folding and trafficking in the early secretory pathway of mammalian cells. He has focused especially on mechanisms of ER protein quality control and on recognition and delivery of misfolded proteins from the ER to the cytosolic proteasomes for ERAD. These processes are intimately […] Read More >

Dr. Leikin-Frenkel Alicia

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Prof. Jonathan Leor

Professor Leor received an M.D. degree from Tel-Aviv University, continued training in cardiovascular medicine at the Sheba Medical Center, and completed his post doctorate training at the University of Southern California, Los Angeles, under Robert A. Kloner, M.D., Ph.D. Today, his laboratory’s research focuses on infarct repair and the heart’s lack of intrinsic regenerative ability. […] Read More >

Prof. Margalit Rimona

Research Interests 1. Micro- and nano-particulate drug delivery technologies for topical, regional and systemic applications:  Our efforts in the drug delivery arena focus on two drug delivery technologies, one veteran and one novel, that are inventions of our group. These technologies each yield, micro and nano sized particles that are composed of biomaterials with particular […] Read More >

Prof. Osherov Nir

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Leading Researchers:

Immune Gene Editing

Using novel gene editing technology, we engineer T cells and B cells to better fight cancer, infections and autoimmune diseases Our researchOur primary objective is to develop safe, efficient and scalable methods to engineer lymphocytes for immunotherapy. We provide a novel technology for the engineering of B cells as well as T cells, in vivo […] Read More >

Leading Researchers:
12-2013-622

Laboratory of endoplasmic reticulum (ER) quality control and protein misfolding diseases

Lab DescriptionMain areas of interest are in the mechanisms of protein folding and trafficking in the early secretory pathway of mammalian cells and the development of ER stress upon their malfunction, particularly in neurodegenerative diseases.  Specific research topics are:• Protein misfolding diseases, including neurodegenerative diseases.• ER stress.• Mechanisms of endoplasmic reticulum (ER) protein folding and quality control.• Sugar chain […] Read More >

Leading Researchers:
12-2013-434

The Cohen Rosenthal Diabetic Hypertensive Rat (CRDH) model

The construction of the Cohen Rosenthal Diabetic Hypertensive Rat (CRDH) model was initiated nearly a decade ago by cross-breeding between the Cohen Diabetic rat (CDR) and the SHR. The CDR is a rodent model that expresses the following phenotypes: when fed regular diet, it is non-diabetic; when fed a diabetogenic diet, it invariably develops diabetes […] Read More >

Leading Researchers:
12-2016-1018

Lab of Signal transduction, Neurodegeneration and Autophagy

Research focus ErbB receptors interactions and functions Regulation of Autophagy Neurodegeneration  Projects include:The crosstalk between ErbB receprots and nucleolin in cancer developmentBeclin 1 mediated autophagyAutophagy in neurodegenerative diseasesAutophagy in cancer Potential servicesLaboratory services:To monitor autophagySignal transduction assaysAnti-cancer drugs examinationCell proliferation, death and migration examination   Potential industries1.    Pharma2.    BiotechContact InformationProf. Pinkas-Kramarski RonitDept. of Neurobiology, Life […] Read More >

Leading Researchers:
12-2011-223

Characterization of organic, inorganic and biological materials by Solid state NMR

Magic-angle spinning solid-state NMR (MAS SSNMR) is a well-established technique for the characterization of crystalline, non-crystalline and non-soluble materials including simple molecules, drug formulations, glass, ceramics, powders, nanocrystals and biological samples. There are numerous applications of solid-state NMR covering a large range of scientific disciplines. In our laboratory at the school of chemistry we have […] Read More >

Leading Researchers:
12-2011-205

Lipid Solutions and Animal Model

SERVICES“ Lipid Solutions” Prof. Alicia Leikin-Frenkel “Lipid Solutions” covering:1. Expert support for questions on: lipid metabolism, isolation, identification and quantitation of lipids in different species and different matrixes.2. Guidance to discover the pathway to physiological and biochemical implications following overexpressed or suppressed gene linked to lipids.3. Counseling to analyze lipids in:• Simple molecules: fatty acids: Saturated, Monounsaturated n7, n9, Polyunsaturated: […] Read More >

Leading Researchers:
12-2011-203

Cardiovascular and Physiological Assessment in Animal Models

Neufeld Cardiac Research Institute at Sheba Medical Center, Tel-Aviv University comprises a fully equipped laboratory to conduct cardiovascular and physiological experiments in small (mice, rat) and large animals (swine, sheep, calf) including heart function studies with special echocardiography system designed for small animals (Vevo660 ultrasound biomicroscope; VisualSonics), molecular imaging, pressure‐volume loop machine (Millar/Power Lab) and […] Read More >

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