Experimental Models

 

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Prof. Ashery Uri

Research topic: Elucidating the molecular mechanisms of synaptic transmission and plasticity under normal conditions, during neurodegenerative diseases and in aging. Research methods: Electrophysiology, Slice recording, Total Internal Reflection Fluorescence (TIRF), stochastic optical reconstruction microscopy (STORM), Fluorescence Resonance Energy Transfer (FRET), Molecular biology, Model simulation, Multi electrode array recording, Immunohistochemistry, Behavioral tests. Main projects in the […] Read More >

Prof. Bacharach Eran

Eran Bacharach is the head of a research laboratory for molecular virology at the Department of Cell Research and Immunology, and teaches courses on microbiology, molecular virology and cell biology, at the Faculty of Life Sciences, where he has been on the faculty since 2000. He received his B.Sc., M.Sc. and Ph.D. degrees from the […] Read More >

Prof. EHRLICH Marcelo

I am interested on the dynamic aspects of the cell’s trafficking machinery, with a special focus on endocytic dynamics. More specifically, our study centers on the mechanisms by which the cell modulates vesicular traffic by altering: The rate of formation of vesicular carriers, such as clathrin coated vesicles. The spatio-temporal distribution of the process of […] Read More >

Prof. Frenkel Dan

Research topic: The research in our laboratory is focused on the investigation of glial cell and to clarify their role in neurological diseases. We suggest that targeting glia activation in different pathological scenarios may allow us to define common pathways to further understand the role of glia in neuroprotection . We are using three models: 1) […] Read More >

Dr. Gil-Ad Irit

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Prof. Joel Daphna

Prof. Joel studied the involvement of basal ganglia-thalamocortical circuits in normal and abnormal behavior, using mainly animal models of psychopathology. More recently Prof. Joel has expanded her work to research questions related to brain, sex and gender. Ongoing studies attempt to characterize the relations between sex and brain structure and function. Other studies focus on […] Read More >

Dr. Leikin-Frenkel Alicia

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Prof. Jonathan Leor

Professor Leor received an M.D. degree from Tel-Aviv University, continued training in cardiovascular medicine at the Sheba Medical Center, and completed his post doctorate training at the University of Southern California, Los Angeles, under Robert A. Kloner, M.D., Ph.D. Today, his laboratory’s research focuses on infarct repair and the heart’s lack of intrinsic regenerative ability. […] Read More >

Dr. Ben M. Maoz

I am a faculty member in the Department of Biomedical Engineering, and Sagol School of Neuroscience at Tel Aviv University. I accomplished my Ph.D in Chemistry in Tel Aviv University under the supervision of Prof. Gil Markovich. I returned to Israel after completing his post-doctoral fellowship at the Wyss Institute at Harvard University, under the […] Read More >

Prof. Munitz Ariel

Our laboratory is focused on elucidating cellular and molecular mechanisms that are involved in mucosal inflammation. Specifically, we are interested in the roles of immune inhibitory receptors in the lung and gastrointestinal tract especially in type-2-associated and innate immune responses. Read More >

Leading Researchers:

The Myers Neuro-Behavioral Core Facility

Unit description:The Myers Neuro-Behavioral Core Facility provides researchers with state-of-the-art technology for performing neuro-behavioral tests in mice. Services: The Core Facility provides expertise in design, implementation, and analysis of behavioral experiments. The Core Facility includes five behavior rooms, which can operate simultaneously, and two animal maintenance rooms with IVC cages operating on a reversed light […] Read More >

Leading Researchers:
12-2016-972

Lab of Cancer Angiogenesis and Nanomedicine

Selective therapy remains a key issue for successful treatment in cancer therapy. Prolonged administration of effective concentrations of chemotherapeutic or anti-angiogenic agents is usually not possible because of dose-limiting systemic toxicities involving non-malignant tissues. Therefore, a constant effort has been the development of new drug delivery systems that mediate drug release selectively at the tumor […] Read More >

Leading Researchers:
12-2011-205

Lipid Solutions and Animal Model

SERVICES“ Lipid Solutions” Prof. Alicia Leikin-Frenkel “Lipid Solutions” covering:1. Expert support for questions on: lipid metabolism, isolation, identification and quantitation of lipids in different species and different matrixes.2. Guidance to discover the pathway to physiological and biochemical implications following overexpressed or suppressed gene linked to lipids.3. Counseling to analyze lipids in:• Simple molecules: fatty acids: Saturated, Monounsaturated n7, n9, Polyunsaturated: […] Read More >

Leading Researchers:
12-2011-204

Drug Screening Animal Model for Anti-compulsive Activity

We have developed the signal attenuation rat model of obsessive-compulsive disorder (OCD). This model is based on the theoretical proposition that compulsive behaviors result from a deficit in the feedback, which is associated with the performance of normal goal-directed responses.  In our model, the goal-directed behavior is lever-pressing for food. The feedback associated with making […] Read More >

Leading Researchers:
12-2011-203

Cardiovascular and Physiological Assessment in Animal Models

Neufeld Cardiac Research Institute at Sheba Medical Center, Tel-Aviv University comprises a fully equipped laboratory to conduct cardiovascular and physiological experiments in small (mice, rat) and large animals (swine, sheep, calf) including heart function studies with special echocardiography system designed for small animals (Vevo660 ultrasound biomicroscope; VisualSonics), molecular imaging, pressure‐volume loop machine (Millar/Power Lab) and […] Read More >

Leading Researchers:
12-2011-201

Behavioral Animal Models

Laboratory of Biological Psychiatry & Behavioral research- Felsenstein Institute   Main Research Topics Cognition, Memory, Social behavior, Motility. Disease: Schizophrenia, Anxiety, Neuropathy pain and Depression Drug Development: Schizophrenia, Depression, Cognition, Pain . Lab facilities The lab is well equipped with the required instruments for molecular and cellular research. At the institute, we have a modern animal room […] Read More >

Leading Researchers:
12-2011-200

Brain Injury Animal Models

Blast Brain Injury: a combat zone-like mouse model. From the experimental lab to the war against terror and back to the lab. Improvised explosive devices (IEDs) are one of the main causes for casualties among civilians and military personnel in the present war against terror. IEDs induce various degrees of cognitive, emotional and behavioral disturbances […] Read More >

Leading Researchers:
12-2011-199

Animal Models for CNS Disorders and Screening Method for Diabetes

In vitro and in vivo animal models for stroke, Alzheimer’s disease (AD), and multiple sclerosis (MS). Rapid screening method for selecting candidates with specific insulin-degrading enzyme inhibitor activity in Types I and II  Diabetes.   https://www.tau.ac.il/lifesci/departments/neuro/members/frenkel/frenkel.html Read More >

Leading Researchers:
12-2011-198

Animal Eye Models

    Animal eye models for evaluation of systemic and topical use of new medications, devices and delivery systems. The models include external eye, intraocular, orbital, and optic nerve applications. Webpages:https://www.sheba.co.il/Institutes/Eye_Institute/Eye_Clinics/78.htmhttps://www.tau.ac.il/medicine/ophthalmology/ophth_con.html CONTACT  Department of Opthalmology Faculty of MedicineTel Aviv UniversityRamat Aviv 69978, IsraelFax: 972-3-6405354   Head of the Department:Prof. Arieh S Solomon, MD,PhDEmail: asolomon@post.tau.ac.ilPhone: 972-3-5350702Fax: […] Read More >

Leading Researchers:
12-2011-198

Unique Animal Models for Inflammatory Lung, GI, and Bowel Diseases

The Laboratory of Mucosal Immunology The Laboratory of Mucosal Immunology is new at the faculty of Medicine and deals primarily with mucosal inflammation. We focus on diseases affecting the lungs, such as asthma, COPD (chronic obstructive pulmonary disease), acute lung injury and gastrointestinal (GI) tract, inflammatory bowel disease (IBD) and colorectal cancer.   In lungs models […] Read More >

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