Genomics

 

6 Results were found on Technologies

Leading Researchers:
10-2013-551

Novel Integrase Based Cancer Treatment Technology

We have developed a new gene therapy technology for specific cancer cells killing and validated both efficacy and safety superiority of the proposed system over the conventional one in lung cancer mice model. The proposed system offers advantages over already known counterparts and may therefore be developed into a safer and efficient human cancer treatment […] Read More >

Leading Researchers:
2-2013-709

Computational Platform for Enhancing Gene Expression for Increased Protein Yield and Viral Titer

TechnologyDeciphering Gene Expression Code – We perform large-scale analyses of genomic data to discern the rules behind the various aspects of gene expression encoded in the transcript. Computational Modeling of Gene Expression – We develop predictive computational models to mathematically analyze and simulate the different stages of gene expression, focusing on gene translation. Engineering Gene […] Read More >

Leading Researchers:
3-2015-871

In Vitro CRISPR/Cas9 Assisted Targeting Scheme (CATsCH) for Low-Cost, Ultra-Deep and High Throughput Region of Interest Genomic Analysis

Abstract CRISPR/Cas9 assisted targeting scheme (CATsCH) is an in vitro method that targets long sequence specific genomic regions of interest. The RNA-guided Cas9 digestion system was adjusted to in vitro conditions in combination with cloning technique to facilitate the integration of long genomic region to a vector in a single step. In combination with sequencing […] Read More >

Leading Researchers:
10-2020-1360

Targeting Human Brain Cells With Adeno-Associated Virus (AAV) for a Prospective Therapeutic Approach

The AAV therapeutic approach for various central nervous system (CNS) illnesses has been rapidly growing. Unfortunately, existing present technologies utilize AAV administration that is injected locally into the brain. This process requires a high level of expertise and is not applicable in more diffused brain targets like cortex and stiratum. Systemic administration of AAV vectors through […] Read More >

Leading Researchers:
2-2022-1764

Efficient information coding in living organisms

It is clear that DNA can be used as a storage medium, each nucleotide carrying two information bits, which can store vast amounts of data for very long periods of time and with high reliability; as overtime, humans remain human just as cats remain cats. However, it is also clear that it is a very […] Read More >

Leading Researchers:
2-2020-1451

Leveraging Gene Panel Sequencing Data for Mutational Signature Analysis with Applications to Personalized Treatment

UNMET NEED Mutational signatures and their exposures are key to understanding the processes that shape cancer genomes with applications to diagnosis and treatment. Yet current signature analysis approaches are limited to relatively rich mutation data that comes from whole-genome or whole-exome sequencing. Recently, orders of magnitude sparser data sets from gene panel sequencing have become […] Read More >

Prof. Avraham Karen B.

Genomic Analysis of Hereditary Hearing Loss Our primary interest is the genetic basis of hereditary hearing loss or deafness. Our group is working towards the identification, characterization and regulation of genes associated with hereditary hearing loss. For gene discovery, we focus on the Israeli Jewish and Palestinian Arab populations in the Middle East. Our studies […] Read More >

Prof. Barzel Adi

Our lab will focus on gene therapy using viral vectors. We will tackle diseases ranging from cancer to viral infections and diabetes. Devising safe and efficient gene therapies combines challenges in biochemistry and molecular biology with challenges in physiology, immunology, virology and more. We will focus on genome editing- the site specific manipulation of the […] Read More >

Prof. Ebenstein Yuval

Our lab specializes in many areas of optical imaging and spectroscopy with emphasis on single molecule detection and development of imaging based techniques. Our research is focused on the application of novel imaging and optical detection approaches to genomic studies and biomarker detection. We are developing new spectroscopy and microscopy methodologies that combine advanced optics […] Read More >

Mr. Goz Eli

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Dr. Katz Aviva

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Prof. Kolot Mikhail

Research Interests HK022 bacteriophage site specific recombinase Integrase is the tool for human genome manipulation and gene therapy. Site specific recombinases (SSRs) catalase the site-specific recombination reaction between two specific short DNA sequences of 30-40 bp that serve as recombination sites that included integration, excision and inversion. These enzymes are widely used for the genome manipulations […] Read More >

Prof. Jonathan Leor

Professor Leor received an M.D. degree from Tel-Aviv University, continued training in cardiovascular medicine at the Sheba Medical Center, and completed his post doctorate training at the University of Southern California, Los Angeles, under Robert A. Kloner, M.D., Ph.D. Today, his laboratory’s research focuses on infarct repair and the heart’s lack of intrinsic regenerative ability. […] Read More >

Prof. Ohad Nir

Prof. Nir Ohad received his B.Sc. in Biology and Earth sciences and his M.Sc. and Ph.D. in Genetics from Hebrew University.  Since 1998, Prof. Ohad has been a member of The School of Plant Sciences and Food Security at Tel-Aviv University. Prof. Ohad is studying the role of DNA and Histone methylation as part of […] Read More >

Dr. Pasmanik-Chor Metsada

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Prof. Peer Dan

Our lab is studying how to manipulate cells’ functions in order to generate novel strategies to treat inflammatory diseases and cancers. We are combining multidisciplinary approaches including immunology, cell and molecular biology, genetics, protein engineering, material sciences, nanotechnology and computational techniques for drug discovery and potentially for therapeutics. In addition, we are developing nanomedicines by […] Read More >

Leading Researchers:

Nano BioPhotonix Lab

Our lab specializes in many areas of optical imaging and spectroscopy with emphasis on single molecule detection and development of imaging based techniques. Our research is focused on the application of novel imaging and optical detection approaches to genomic studies and biomarker detection. We are developing new spectroscopy and microscopy methodologies that combine advanced optics […] Read More >

Leading Researchers:

Immune Gene Editing

Using novel gene editing technology, we engineer T cells and B cells to better fight cancer, infections and autoimmune diseases Our researchOur primary objective is to develop safe, efficient and scalable methods to engineer lymphocytes for immunotherapy. We provide a novel technology for the engineering of B cells as well as T cells, in vivo […] Read More >

Leading Researchers:
12-2011-221

Bioinformatic Analysis

  The Bioinformatics Unit at the Faculty of Life Sciences   The Bioinformatics Unit at the Faculty of Life-Science at Tel-Aviv University is part of the Israeli Center of Bioinformatics Infrastructure (COBI) and offer various activitities to the bio-medical research community of Tel Aviv University and outside TAU. Bioinformatics training Bioinformatics consultation Microarray experiments support […] Read More >

12-2011-209

Functional genomics

The Shomron research team focuses on the analysis of genomics aimed at understanding human diseases. Combining high-throughput methods and bioinformatics (such as AI and deep learning), our team’s research explores DNA changes and gene regulators. Our goal is to reach a global perspective on the roles DNA and RNA play during disease development. Among our […] Read More >

Leading Researchers:
12-2011-203

Cardiovascular and Physiological Assessment in Animal Models

Neufeld Cardiac Research Institute at Sheba Medical Center, Tel-Aviv University comprises a fully equipped laboratory to conduct cardiovascular and physiological experiments in small (mice, rat) and large animals (swine, sheep, calf) including heart function studies with special echocardiography system designed for small animals (Vevo660 ultrasound biomicroscope; VisualSonics), molecular imaging, pressure‐volume loop machine (Millar/Power Lab) and […] Read More >

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