Targeting Human Brain Cells With Adeno-Associated Virus (AAV) for a Prospective Therapeutic Approach
The AAV therapeutic approach for various central nervous system (CNS) illnesses has been rapidly growing. Unfortunately, existing present technologies utilize AAV administration that is injected locally into the brain. This process requires a high level of expertise and is not applicable in more diffused brain targets like cortex and stiratum. Systemic administration of AAV vectors through […] Read More >
Therapeutic Targeting of PD-1/PD-L1 blockade by Novel Small-molecule Inhibitors
Interactions between programmed cell death ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1) lead to the evasion of cancer cells from an efficient immune response. The inhibition of PD-L1/PD-1 has prevented or reversed exhausted T cells, thus enhancing antitumor T-cell responses. In fact, immune checkpoint blockade targeting the PD-1 axis has become one […] Read More >
Glioblastoma Regression by Regulating Astrocytes’ Immunometabolic Signaling
Malignant brain tumors are the cause of a disproportionate level of morbidity and mortality among cancer patients, an unfortunate statistic that has remained constant for decades. Despite considerable advances in the molecular characterization of these tumors, targeting the cancer cells has yet to produce significant advances in treatment OUR SOLUTIONAn alternative strategy is to target […] Read More >
BACKGROUND GI cancers cause over 3.5 million deaths per year globally, accounting for 35% of all cancer-related deaths. Colorectal carcinoma (CRC) is the world’s second leading cause of cancer death. Current immunotherapy treatments for CRC are hamstrung by low response rate, acquired resistance, relapse and severe side effects. ImmuNovation presents a disruptive nanomodular technology utilizing […] Read More >
Prof. Ben-Baruch Adit
Breast cancer is a leading cause of death for women in the Western world. The battle against breast cancer has been challenged by the fact that, generally, each component is studied meticulously, but singly. Too little attention is paid to the interactions between the tumor cells and their intimate microenvironment, consisting of various cells and […] Read More >
Prof. Dvir Tal
Microfluidics-based tissue engineering. Recreating stem cell niches, microfluidics bioreactors for tissue engineering. Nanotechnological strategies for engineering thick cardiac tissue. Engineering a 3D neuronal network for spinal cord and brain regeneration. Fabrication of Nanoelectronics/engineered tissue hybrids. Developing smart delivery systems that recruit stem cells to defected organs. Email: tdvir@tauex.tau.ac.il Phone: 03-6406514 Another phone: 03-6408604 Website: https://dvirlab.wixsite.com/dv… Office: […] Read More >
Prof. Frenkel Dan
Research topic: The research in our laboratory is focused on the investigation of glial cell and to clarify their role in neurological diseases. We suggest that targeting glia activation in different pathological scenarios may allow us to define common pathways to further understand the role of glia in neuroprotection . We are using three models: 1) […] Read More >
Prof. Gazit Ehud
The central dogma in the study of protein folding suggests that the thermodynamically-favorable state of proteins under physiological conditions is their folded one. However, there are number of cases in which the favorable states of proteins are rather unfolded, partially folded (e.g., “molten globular”), or misfolded (e.g., nonspecific aggregates or amyloid fibrils). These observations lead […] Read More >
Prof. Munitz Ariel
Our laboratory is focused on elucidating cellular and molecular mechanisms that are involved in mucosal inflammation. Specifically, we are interested in the roles of immune inhibitory receptors in the lung and gastrointestinal tract especially in type-2-associated and innate immune responses. Read More >
Prof. Peer Dan
Our lab is studying how to manipulate cells’ functions in order to generate novel strategies to treat inflammatory diseases and cancers. We are combining multidisciplinary approaches including immunology, cell and molecular biology, genetics, protein engineering, material sciences, nanotechnology and computational techniques for drug discovery and potentially for therapeutics. In addition, we are developing nanomedicines by […] Read More >
Laboratory of Immunological and Inflammatory Modules in Malignancy
Research focusProf. Ben-Baruch is an immunologist who investigates the roles of immune and inflammatory elements in physiological and pathological conditions, with major emphasis on malignancy. The studies in her laboratory determine the complex regulatory networks established between chemokines and cytokines of the tumor microenvironment, intrinsic oncogenic modifications in tumor cells, and stroma cells. The research […] Read More >
Precision Nanomedicine: Preparation and Characterization of Nanocarriers Made from Natural Biopolymers
The laboratory of Precision Nanomedicine at TAU have capabilities for preparation and characterization of nanocarriers made from natural biopolymers such as lipids (liposomes, micelles) , sugars and proteins. Lab Description• State-of-the-art preparation and process development of lipid based nanoparticles including sythesisi capabilities of lipids.• cell culture facility including the culturing of hybridomas and antibody purification.• […] Read More >
Animal Models for CNS Disorders and Screening Method for Diabetes
In vitro and in vivo animal models for stroke, Alzheimer’s disease (AD), and multiple sclerosis (MS). Rapid screening method for selecting candidates with specific insulin-degrading enzyme inhibitor activity in Types I and II Diabetes. https://www.tau.ac.il/lifesci/departments/neuro/members/frenkel/frenkel.html Read More >
Unique Animal Models for Inflammatory Lung, GI, and Bowel Diseases
The Laboratory of Mucosal Immunology The Laboratory of Mucosal Immunology is new at the faculty of Medicine and deals primarily with mucosal inflammation. We focus on diseases affecting the lungs, such as asthma, COPD (chronic obstructive pulmonary disease), acute lung injury and gastrointestinal (GI) tract, inflammatory bowel disease (IBD) and colorectal cancer. In lungs models […] Read More >
