Homocysteine fibrillar assemblies display crosstalk with Alzheimer’s disease amyloid polypeptide
High levels of homocysteine (Hcy) are reported as a risk factor for Alzheimer’s disease (AD). Correspondingly, inborn hyperhomocysteinemia is associated with an increased predisposition to the development of dementia in later stages of life. Furthermore, despite the apparent association between protein aggregation and AD, attempts to develop a therapy that targets explicitly this process have […] Read More >
Development of Alzheimer Disease therapy based on counteracting the pathological effects of ApoE4
Alzheimer’s disease (AD) is the most common cause of dementia and is the outcome of progressive brain cells death. Due to the disorder’s heterogeneity and in view of the variety of pathological mechanisms inducing the disease we have undertaken an innovative – science based (Animal model) approach, which is presented here. Our unique approach […] Read More >
It is clear that DNA can be used as a storage medium, each nucleotide carrying two information bits, which can store vast amounts of data for very long periods of time and with high reliability; as overtime, humans remain human just as cats remain cats. However, it is also clear that it is a very […] Read More >
Leveraging Gene Panel Sequencing Data for Mutational Signature Analysis with Applications to Personalized Treatment
UNMET NEED Mutational signatures and their exposures are key to understanding the processes that shape cancer genomes with applications to diagnosis and treatment. Yet current signature analysis approaches are limited to relatively rich mutation data that comes from whole-genome or whole-exome sequencing. Recently, orders of magnitude sparser data sets from gene panel sequencing have become […] Read More >
Therapeutic Targeting of PD-1/PD-L1 blockade by Novel Small-molecule Inhibitors
Interactions between programmed cell death ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1) lead to the evasion of cancer cells from an efficient immune response. The inhibition of PD-L1/PD-1 has prevented or reversed exhausted T cells, thus enhancing antitumor T-cell responses. In fact, immune checkpoint blockade targeting the PD-1 axis has become one […] Read More >
Stable enzyme-responsive nanocarriers with a-two step activation mechanism
The Challenge: Polymeric nanocarriers that can release their covalently attached or encapsulated cargo in response to specific stimuli can offer many advantages such as greater selectivity and consequently reduced side-effects. Among the different types of stimuli-responsive nanocarriers, enzyme-responsive delivery systems can act as a Trojan horse and release their active payload in response to specific […] Read More >
A-Traumatic Teeth Extraction and Immediate Implant Placement
The global dental services market is expected to reach 554.5 billion USD by 2028, with dental implants dominating the market as R&D in this field continues to excel with better biomaterials, improved designs, and surface modifications. Tooth extraction is a crucial step in dental implants procedure. The standard extraction method is based on mechanical rocking […] Read More >
Therapeutic Monoclonal Antibodies to Combat Multidrug-Resistant Pathogenic Bacteria
It is predicted that a failure to address the problem of antibiotic-resistant pathogens will result in the death of 10 million people annually, costing the economy more than 100 trillion dollars by the year 2050. In high-income countries where antibiotics are heavily used in the community and agriculture, the strong selection pressure and non-completed antibiotic […] Read More >
Method for Isolating Oral Mucosa-Derived Mesenchymal Stem Cells for Tissue and Organ Regeneration
Identification and isolation of the mesenchymal stem cells from the general population of oral mucosa-derived cells may further improve regenerative therapies. Using cutting edge technology, we’ve been able to identify the subpopulation of mesenchymal stem cells with superior osteogenic capacity and furthermore, to unveil a list of unique markers to isolate these cells. Our findings […] Read More >
Therapeutic Targeting of CD45 by Novel Agents to Immunotherapy Non-Responders Tumors
Therapeutic advances in cancer immunotherapy have rapidly emerged in the past few years, reflecting the importance of the interaction between the human immune system and cancer. Despite the successful application of immunotherapy across a broad range of human cancers, only a minority of patients with terminal cancer experience life-altering durable survival from these therapies. These […] Read More >
Prof. Assaf Yaniv
Research topic: Measuring in-vivo brain micro-structure and neuroplasticity with magnetic resonance imaging (MRI) in humans and rodents Research methods: Magnetic Resonance Imaging: Diffusion Imaging, Diffusion Tensor Imaging, Tractography; Immuno-histochemistry, Histology. Main projects in the lab include: Investigation and localization of brain regions that undergo plasticity following a cognitive experience or training with MRI Development of MRI frameworks […] Read More >
Prof. Attali Bernard
Reaching an understanding in molecular terms of the mechanisms by which changes in membrane potential regulate cellular events is the main concern of our research. We focus our interest on potassium channels because they play crucial roles in many cellular functions such as shaping cardiac and neuronal action potentials, tuning neuronal firing patterns, synaptic integration […] Read More >
Prof. Avraham Karen B.
Genomic Analysis of Hereditary Hearing Loss Our primary interest is the genetic basis of hereditary hearing loss or deafness. Our group is working towards the identification, characterization and regulation of genes associated with hereditary hearing loss. For gene discovery, we focus on the Israeli Jewish and Palestinian Arab populations in the Middle East. Our studies […] Read More >
Prof. Bacharach Eran
Eran Bacharach is the head of a research laboratory for molecular virology at the Department of Cell Research and Immunology, and teaches courses on microbiology, molecular virology and cell biology, at the Faculty of Life Sciences, where he has been on the faculty since 2000. He received his B.Sc., M.Sc. and Ph.D. degrees from the […] Read More >
Dr. Bar Daniel Zvi
Advances in biomedical science have cured multiple diseases and greatly improved healthspan and lifespan. However, aging is the strongest risk factor for most causes of death in the western world, and thus these advances have resulted in a relatively small increase in maximal lifespan. Without a systematic approach to understand and treat the aging process, […] Read More >
Prof. Barak Segev
Dr. Barak’s research focuses on the psychobiology and neurobiology of alcoholism and drug addiction. In particular, he is interested in the molecular and neuronal mechanisms that underlie learning and memory processes in alcohol addiction. In addition, Dr. Barak is interested in the pathophysiology of schizophrenia, with focus on cognitive impairments in this disorder. See lab […] Read More >
Prof. BARNEA Ofer
Patient specific models: Assessment of fetal cardiovascular development Optimization Propofol administration during anesthesia Optimization of fluid resuscitation Assessment of cerebral blood flow autoregulation Multiscale models of physiological systems 3D fiber based model of the contracting heart Oxygen transfer to tissue Biomedical measurements and instrumentation Optimally controlled fluid administration system Detection of bubbles in blood to […] Read More >
Prof. Barzel Adi
Our lab will focus on gene therapy using viral vectors. We will tackle diseases ranging from cancer to viral infections and diabetes. Devising safe and efficient gene therapies combines challenges in biochemistry and molecular biology with challenges in physiology, immunology, virology and more. We will focus on genome editing- the site specific manipulation of the […] Read More >
Dr. Beck-Barkai Roy
Research Cytoskeleton protein complexes – Interaction between cytoskeleton protein complexes and their effect on the structure and elasticity of the cell. Intrinsically disordered protein – Statistical structural characterization of proteins that do not completely fold into 3d fixed structures in solutions. Nanoscopic complex – characterizing and manipulating nanoscopic complexes by grafted biopolymer. Membrane physics – stabilization of membrane to […] Read More >
Prof. Belkin Michael
Prof. Belkin has been involved in the establishment of many medical start-ups in ophthalmology and other fields. One of his noted contributions was inventing and developing the Ex-PRESS Glaucoma Filtration Device. The ExPRESS, after being sold to global eye care leader Alcon, is now routinely used in glaucoma surgery worldwide. He is now developing his […] Read More >
The lab investigates high-level cognition, both at the behavioral and neural level. More specifically, we are interested in the following questions: 1. What is consciousness, how does it come about, and what are its functions? The latter entails two additional questions; first, how deep does unconscious processing run and how it differs from conscious processing. […] Read More >
The Laboratory of Oral-Mucosal Stem Cell Regeneration and Enzymatic Dental Therapeutics
The Laboratory of Oral-Mucosal Stem Cell Regeneration and Enzymatic Dental Therapeutics is charting new frontiers in the realm of regenerative medicine and dental care. Harnessing the potent capabilities of stem cells derived from the oral mucosa, the research endeavors not only target the restoration of oral structures but also broader applications, such as bone regeneration […] Read More >
Biological and Bio-Inspired Molecular Self-Assembly- The Gazit Lab
MOLECULAR SELF-ASSEMBLY AMYLOID FIBRIL FORMATION NANOBIOTECHNOLOGY METABOLITE AMYLOIDS MOLECULAR SELF-ASSEMBLY We study one of the most important problems in contemporary life sciences and medicine: Understanding the molecular basis for the formation of amyloid nanostructures in degenerative disorders, a process underlying the pathophysiology of some of the most devastating health problems world-wide, such as Alzheimer’s disease, […] Read More >
Advances in biomedical science have cured multiple diseases and greatly improved healthspan and lifespan. However, aging is the strongest risk factor for most causes of death in the western world, and thus these advances have resulted in a relatively small increase in maximal lifespan. Without a systematic approach to understand and treat the aging process, […] Read More >
Our research focuses on understanding the impact of exercise training, combined with dietary strategies on physiology and metabolic changes across a range of populations. Specific Research interests/topics: Our primary research interests revolve around comprehending the effects of exercise training and dietary strategies on muscle mass, adipose distribution, metabolism, and performance across diverse populations. We employs a […] Read More >
The Lab for Protein Engineering and Drug Discovery
Modulation of protein-protein interactions is a key for a broad range of biotechnological applications. In our lab, we are developing unique approaches from small molecules, peptides, and optimized proteins to inhibit specific interactions. We are utilizing advanced computational, biophysical and cellular biology techniques. Specific Research interests: • Engineering of unique Immune modulators • Engineering of optimized proteins […] Read More >
Sessa Lab- Boosting plant immunity to increase crop yields
The main interest of our laboratory is to study of molecular mechanisms that govern plant immunity and susceptibility to bacterial pathogens. On the plant side, we use molecular biology, functional genomics and proteomics approaches to dissect recognition events and signal transduction pathways that mediate immunity. On the bacterial side, we apply genetic and biochemical strategies […] Read More >
Research in the laboratory focusses on the interfaces of development and cell biology with abiotic stress responses in plants. We study signaling mechanisms that increase plant tolerance to drought and salt stress and increase water use efficiency. We are also interested in signaling mechanisms which regulate secondary cell wall formation in plants and the regulation […] Read More >
We explore and consolidate the novel idea of plant-based sensors, a new approach where the plants are used as sensors and the output is based directly on the plant response. Our biosensor is composed of amalgamated technology, comprising a biological component- the plant itself, and an electrical or optical component- a sensing modality that includes […] Read More >
Our lab strives to understand the mechanisms of chronic inflammation underlying neurologic diseases and translating these laboratory discoveries into new therapies. We take a transdisciplinary approach in this research endeavor combining immunologic, genomic, proteomic and metabolomic approaches to study brain inflammation. We are particularly interested in: Elucidating the immune function of the different glia, mainly […] Read More >
