Structure-Guided Platform for Allosteric Inhibition of HECT E3 Ligases
Targeting “Pocketless” Enzymes to Treat Cancer, Immune, and Other Diseases Short Description: Our platform enables the selective inhibition of HECT E3 ubiquitin ligases, key regulators of protein degradation-through a novel allosteric mechanism. Using advanced structural biology and machine learning-driven screening, we access a previously unreachable druggable space. Lead compounds identified by this approach have demonstrated […] Read More >
P32-Specific Antibodies and CAR T Cells for Glioblastoma and P32-Expressing Tumors
This innovative immunotherapy platform leverages p32-specific antibodies to create Chimeric Antigen Receptor (CAR) T cells, specifically targeting p32—a tumor-associated antigen expressed in glioblastomas and other aggressive cancers. The approach combines tumor elimination with antiangiogenic effects, paving the way for enhanced therapeutic outcomes in solid tumors. Unmet Need Glioblastoma, a highly aggressive brain cancer, has limited […] Read More >
Next Generation of the mRNA Therapy: Targeting Cancer Cells Via Boolean Circuits Based on mRNA Molecules
Currently most cancer treatment target proteins that are modified or activated in cancer cells; usually this is done by producing a relevant antibody. The process of finding a new therapy that targets a protein is long and tedious and in addition, in many cancer types there is no therapy at all. Specifically, today there are […] Read More >
Pharmacological Activation of the cAMP Signaling Pathway Enhances the Function of Cord Blood – Hematopoietic Stem Cells
Allogeneic Hematopoietic Stem Cell Transplantation is a curative therapy for many blood disorders, including leukemias and inherited blood diseases. It involves depleting a patient’s diseased bone marrow by cytotoxic therapies and then regenerating a healthy hematopoietic system by transplantation of healthy Hematopoietic Stem Cells (HSCs). UNMET NEED Cord blood is an attractive source for stem […] Read More >
Development Of Improved Immunosuppressant Targeting Calcineurin-NFAT Protein-Protein Interaction Via Novel Peptides
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
Development Of Improved Immunosuppressant Targeting Calcineurin-NFAT Protein-Protein Interaction Via Small Molecule Drugs
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
Influenza A virus infection is one of the most common respiratory tract diseases in humans. It is the cause of typical seasonal flu as well as major human pandemics worldwide. According to the World Health Organization (WHO) in October 2023, around 3 to 5 million severe influenza cases were recorded, leading to 290,000 to 650,000 […] Read More >
Evaluation of Single Strand DNA Damage in Sperm Using a novel Damage Detection Technique
The Damage Detection technique is an innovative approach to assessing Single Strand DNA (ssDNA) damage by utilizing DNA repair enzymes to identify DNA adducts and single-strand breaks. Spermatozoa are characterized by high levels of DNA fragmentation, despite their condensed nuclear DNA packaging. Sublethal DNA damage, such as single strand breaks and adducts, can occur and […] Read More >
Skewed Sex Ratio Technology for Livestock and Pets: Reducing Resource Wastage and Labor in Animal Breeding
Our innovative genetic engineering technology offers a transformative solution for livestock and pet industries by generating offspring with a skewed sex ratio. The technology, proven in mice, is now aimed at practical application in cattle, swine, poultry, and other farm animals, as well as pets. The Problem: Current breeding practices lead to significant waste due […] Read More >
New Formulation for Repurposing of a Drug to Treat Retinitis Pigmentosa
Heterozygous mutations in the gene encoding the RNA splicing factor pre-mRNA processing factor 31 (PRPF31) have been identified as a major cause of autosomal dominant retinitis pigmentosa (RP), a debilitating and currently incurable blinding disease. The severity and progression of RP vary significantly among patients, with some carriers remaining asymptomatic. Intriguingly, asymptomatic mutation carriers exhibit […] Read More >
BACKGROUND GI cancers cause over 3.5 million deaths per year globally, accounting for 35% of all cancer-related deaths. Colorectal carcinoma (CRC) is the world’s second leading cause of cancer death. Current immunotherapy treatments for CRC are hamstrung by low response rate, acquired resistance, relapse and severe side effects. ImmuNovation presents a disruptive nanomodular technology utilizing […] Read More >
New MicroRNAs as Candidates for Depression Therapy
Major depressive disorder (MDD) is a complex, common, and recurrent mental disorder (1). The current first-line treatment for MDD is selective serotonin reuptake inhibitors (SSRIs), which are antidepressant drugs that block serotonin reuptake. Two microRNA (miRNAs) molecules namely miR-30b-5p and miR-101a-3p were found to be downregulated in the raphe nuclei (RN) of mice following chronic […] Read More >
Novel Immuno-Metabolism Pathways to Combat Obesity and Insulin Resistance
Nutritional unbalance develops the obesity led to diabetes and accompanied by insulin resistance is being the epidemics of the 21st century. Inflammation of adipose tissue serves one notable pathway that is driving the development of dysfunctional metabolic state, leading to hyperglycaemia and other pathophysiology complications. Within the adipose tissue, a pivotal role in modulating interactions […] Read More >
Development of Improved Peptide Inhibitors of the HIF/PHD Interaction – Anemia and HIF – Related Diseases
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
A Computational Based Approach For Designing Plasmids’ Copy Number
We used plasmids in any biotechnological objective (both in the academia and in the industry) and in all model organisms. For example, plasmids are used in fields such as FoodTech, pharma, agriculture, etc. Currently, researchers chose between two possibilities: high copy plasmid (e.g. 500 copies) and low copy plasmid (e.g. 10 copies). However, the ability […] Read More >
Deep Cell-Type Deconvolution From Bulk Gene Expression Data
It is becoming clear that bulk gene expression measurements represent an average over very different cells. Elucidating the expression and abundance of each of the encompassed cells is key to disease understanding and precision medicine approaches. A first step in any such deconvolution is the inference of cell type abundances in the given mixture. To […] Read More >
Designing Novel Protein-protein Interaction Modulators with Generative Models
UNMET NEED• Protein-protein interactions (PPIs) are essential components of all cell signaling pathways and important therapeutic targets. However, the design of PPI modulators, especially in the form of small molecules, remains a major challenge.• Interfering with PPIs is especially challenging when one of the interactors is a disordered protein (i.e., with no stable structure).• Peptides, […] Read More >
Spatially Targeted Transfection of Mammalian Cells
Mammalian cell transfection with DNA, RNA, small molecules, and proteins is a widely used molecular biology technique. The primary method of cell transfection is electropermeabilization, which increases the permeability of the cell membrane, allowing chemicals, drugs or DNA to be introduced into the cell. Bulk electroporation has been used for DNA transfection in suspension cells […] Read More >
Jellyfish׳ Collagen-Based Smart Wound Dressing with Antibacterial Properties
Collagen-based dressing in wounds greatly benefits the healing process. Unfortunately, most collagen is extracted from bovine tissues, which bears a significant risk of transmitting various biological contaminations. Moreover, the collagen extraction process from bovine tissue involves time and cost-consuming steps, reducing the total collagen yield and increasing the overall cost of goods. In addition, the […] Read More >
Repurposing FDA-Approved Drugs for the Treatment of Aniridia
Aniridia is a panocular disease causing progressive severe visual impairment and blindness. The disease is characterized by abnormal development of almost all eye structures, caused by dominantly inherited heterozygous mutations in primarily the PAX6 gene. Although aniridia is a developmental disorder, corneal opacification begins late in childhood, leaving a large time window for therapy. Unfortunately, […] Read More >
Anti-Oxidation Agent to be Incorporated Into Cosmetics Leading to More Stable and Longer Shelf-Life Products
Oxidation is the reaction of Oxygen with a wide array of reactants. In cosmetics, product oxidation leads to spoilage of ingredients used in the manufacturing products, the inactivation of oxygen-sensitive enzymes, shortening of product shelf-life, and discolorations of end-product. Self-assembling peptide-based hydrogels are simple hydrogels that can be combined with a wide variety of ingredients […] Read More >
Protection of Oxygen-Sensitive-Enzymes by Peptide Hydrogel
Molecular oxygen (O2) is a highly reactive oxidizing agent harmful to many biological and industrial systems. A simple encapsulation in a protective aqueous environment of O2 -sensitive reactions is of need. Self-assembling peptide-based hydrogels are simple hydrogels that can be combined with a wide variety of reagents and are able to encage O2 and significantly limit its […] Read More >
Culturing a plurality of cell types on a 3D-printed microfluidic chip
Organ-on-a-Chip platforms provide rich opportunities to observe interactions between different cell types under in vivo-like conditions. Co-culturing and the application of flow and other mechanical forces organoids, mimic 3D tissue structure and greatly enrich the data collection from such platforms. ‘Insert-chip’ is a cost-efficient, reusable, modular organ-on-a-chip platform that allows co-culturing and overcome scientific data […] Read More >
Novel Anti-Tumor Response treatment targeting ErbB receptors and Nucleolin interactions
ErbBs subfamily receptors are mediators of cell growth signals. They have long been associated with a wide variety of lung, ovarian, colon, breast, prostate, and other carcinomas. Nucleolin is a major nucleolar protein of growing eukaryotic cells and is present on the cell surface of a range of cancers. Recently, a robust oncogenic interaction between […] Read More >
Ulva sp. (Chlorophyta) intensive cultivation in a coastal area of the Eastern Mediterranean Sea.
The Need Global population growth together with enhanced quality of life, in the era of climate change, is expected to cause doubling of the world’s food and energy demand by 2050. Furthermore, there is a strong interest in the replacement of fossil-based industries towards economical, environmentally friendly, and sustainable resource, for food, chemical and energy […] Read More >
New Chemiluminescent Protease Probe for Rapid, Sensitive, and Inexpensive Detection of Live Mycobacterium tuberculosis
Tuberculosis (TB) is a top-ten cause of death worldwide. Successful treatment is often limited by insufficient diagnostic capabilities, especially at the point of care in low-resource settings. The ideal diagnostic must be fast, be cheap, and require minimal clinical resources while providing high sensitivity, selectivity, and the ability to differentiate live from dead bacteria.OUR SOLUTION• We […] Read More >
Antibody-Based Biosensor Diagnostic tool for Pathogenic Bacteria Detection
UNMET NEED • Antibiotic resistance crisis is driven by extensive and inappropriate usage of antibiotics and is predicted to result in an annual death toll of 10 million people by 2050. The ability to provide a rapid and accurate surveillance and diagnosis of multiple-drug resistant (MDR) bacteria is pivotal to the efficiency of controlling the growing […] Read More >
An early stage screening tool for distinguishing pregnant women having an increased risk of developing preeclampsia
Preeclampsia is one of the most dangerous pregnancy complications occurs in the second or third trimester, affecting 3–8% of pregnancies; it is the leading cause of maternal and perinatal mortality and morbidity. Preeclampsia cannot reliably be predicted as no tests available in early pregnancy. OUR INNOVATION The invention is based in part on the finding […] Read More >
Repurposing of Antibiotics for treating APC (Adenomatous Polyposis Coli) Related Colorectal Cancer
Restoration of Adenomatous Polyposis Coli (APC) gene expression by means of antibiotic erythromycin for the treatment of Familial Adenomatous Polyposis. The Technology: Treatment for APC by conventional antibiotics to regulate adenoma growth and delay the need for preventive surgery in Familial Adenomatous Polyposis (FAP) patients. The Need: FAP is a high penetrance devastating syndrome manifested […] Read More >
Macrolid Induced Correction of Premature Stop Codons: A novel Treatment for Colorectal Cancer
Restoration of premature termination codons (PTCs) caused by nonsense mutations for the treatment of Familial Adenomatous Polyposis. The Need Familial Adenomatous Polyposis (FAP) is a high penetrance devastating syndrome manifested by dozens to thousands of colonic adenomas. FAP patients require tight supervision and eventually undergo surgery, to prevent inevitable development of colorectal cancer (CRC) by […] Read More >
An Effective Sema3A Antibody as a Therapy for Optic Nerve Neurodegenerative Diseases
Glaucoma and ischemic or neuro-degenerative diseases of the optic nerve lead to vision loss and blindness. These pathologies are associated with progressive apoptosis of the retinal ganglion cells (RGC), a process which involves expression of Semaphorin 3A protein in the axonal guidance pathways. The identified Sema3A antibody provides a potentially innovative therapeutic tool for these […] Read More >
An active cancer vaccine strategy targeting tumor-associated carbohydrate antigens expressed on tumor cells using biomimetic glyconanoparticles generated from unique red blood cells. The resulting sustained immune response inhibits tumor growth. THE NEED While envisioned already in 1891, only a few cancer vaccines have been approved by the FDA thus far. The key barriers to their […] Read More >
SK4 K+ channel blockers: a new treatment for cardiac atrial fibrillation
We discovered a previously unidentified target in the heart, namely the SK4 calcium-activated K+ channels, which are functionally expressed in pacemaker cells as well as in atrial and ventricular cardiomyocytes. They are crucial for proper cardiac function and represent a completely new therapeutic target for the treatment of cardiac arrhythmias. SK4 channel blockers successfully prevented […] Read More >
3D Bioprinting of Tumor Models for Personalized Drug Screening and Disease Modeling
This technology aims to provide a three-dimensional (3D) bioprinted tumor model based on natural and synthetic polymers containing several types of cells, which resembles cancer tissue. Our 3D-bioprinted tumor model has potential to predict the clinical outcome of a treatment compared to the other existing solutions, which either rely solely on genetic profiling or do […] Read More >
Novel Ionizable Lipids for Delivery of Nucleic Acids (mRNA, DNA, siRNA)
BackgroundChemotherapy treatment is generally accompanied by adverse effects, which can be significantly reduced using site specific, targeted delivery systems, such as antibody-coated LNPs (immuno-LNPs). However due to inter-and intra-tumor heterogeneity targeting with a single targeting moiety is not sufficient in many cases and in others may induce cancer relapse due to the survival of side […] Read More >
A Novel Nanoparticle that Selectively Delivers RNAi Oligonucelotides to Tumors, Preventing Side Effects to Tissues
UNMET NEEDPancreatic cancer numbers among the most aggressive cancers known today. The overwhelming majority of pancreatic cancer patients pass away within just a year of diagnosis. However, a small minority of patients may live several years with the disease. Our findings pinpoint the inverse correlation between a known oncogene (PLK1) and the expression of an […] Read More >
An Oncolytic Virus That Exploits Immune Defects of Cancer Cells
An oncolytic virus for tumors of different etiology presenting defects in interferon signaling, designed as a potent, specific and safe therapy. Promising in-vivo murine melanoma model shows potential for development as a mono or an add-on to chemotherapy or check-point inhibitors. UNMET NEED On Nov. 2015 the FDA approved the first oncolytic virus based treatment. […] Read More >
Inhibition of the Pax8 Transcription Factor as a Novel Therapeutic Approach for Ovarian and Endometrial Cancer
OUTLINEThe PAX8 transcription factor is essential for ovarian cancer proliferation, and its silencing in ovarian and endometrial cancer cells leads to apoptosis 1,2. PAX8 expression in other tissues is restricted to non-essential organs, suggesting that it is a good target for therapy with minimal side effects 3,4. We propose a novel anti-ovarian and -endometrial cancer […] Read More >
TechnologyWe developed nanostructures based on Peptide-Nucleic Acid (PNA) derivatives which show highly promising performance characteristics. The unique electroluminescence/photoluminescence materials can be used as emissive materials in manufacturing Organic Light-Emitting Diodes (OLED) with high emission efficiencies, tunable colors, and improved charge-transport and film-forming properties. The NeedSignificant progress has been made over the past decade in producing […] Read More >
An Add-On Optical Interferometer Chamber to Phase Microscopes for Sub-Nanometer 3D and Dynamic Information
TechnologyAn add-on optical module for microscopes allowing for single frame and dynamic capture of amplitude and phase profiles of transparent or semi-transparent biological and non-biological samples. This easyto-use interferometric device is simply positioned in the camera port of a conventional inverted microscope, enabling quantitative structural, thickness and refractive index measurements in a noncontact, label-free manner. […] Read More >
Self-Assembling Aromatic di-Peptide Materials for Cosmetic Applications
TechnologyOrganic, aromatic di-peptide self-assemble into close-caged structures of tubes, spheres and hydrogels. These exhibit excellent properties such as stability, solubility, transparency and rigidness alongside the basic peptide features utilized in cosmetics. The materials can be prepared as powder or hydrogel and be easily mixed with common cosmetic foundations. In addition to these native characteristics, methods […] Read More >
TechnologyThe aggregation site on human calcitonin has been identified, paving the way for development of specific inhibitors of calcitonin amyloid fibril formation. Such inhibitors will enable development of improved calcitonin therapeutics as well as greatly facilitate in vitro calcitonin manipulations. The NeedThe therapeutic use of human calcitonin is severely limited by its tendency to associate […] Read More >
The Technology A breakthrough Self Assembled Peptide Hydrogel (SAPH) has been developed. SAPH is a safe, self-assembled, biocompatible, remarkably strong hydrogel with modulated stability that is suitable for various medicinal and cosmetic applications. SAPH is based on the highly efficient self-assembly of the short aromatic peptides diphenylalanine. The discovery and development of SAPH is the […] Read More >
Computational Platform for Enhancing Gene Expression for Increased Protein Yield and Viral Titer
Technology Deciphering Gene Expression Code – We perform large-scale analyses of genomic data to discern the rules behind the various aspects of gene expression encoded in the transcript. Computational Modeling of Gene Expression – We develop predictive computational models to mathematically analyze and simulate the different stages of gene expression, focusing on gene translation. Engineering […] Read More >
Novel Class of Turn-ON Near-Infrared Probes for Diagnosis and Imaging of Inflammation and Cancer
Complete tumor removal during surgery has a great impact on patient survival. To that end, the surgeon should detect the tumor, remove it and validate that there are no residual cancer cells left behind. Residual cells at the incision margin of the tissue removed during surgery are associated with tumor recurrence and poor prognosis for […] Read More >
Methods of Treating Diseases Associated with Polyalanine Expansion Mutations
The invention describes the inhibition of ubiquitin like modifier activating enzyme 6 (UBA6) by disease-causing polyalanine expanded mutant proteins in a variety of cell types. Polyalanine-expanded proteins can interact with UBA6 and inhibit UBA6-mediated protein degradation of downstream targets, such as the neurodevelopmental E3-ubiquitin ligase E6-AP. Ectopic administration of vectors expressing UBA6 in patient cells […] Read More >
Incidental Detection of Colon Cancer Using AI Analysis of Abdominal CT Scans
Detecting colon cancer in general abdominal CT scans, i.e. without bowel emptying performed before colonoscopy, is extremely challenging. With nowadays technology, it is not possible to automatically detect cancer in the large intestine without prior preparation of the intestine as required in colonoscopy. A study has revealed that more than 20% of malignant findings in […] Read More >
Development of a Biological Safe Anti-Candida Agent for the Treatment of Denture Stomatitis
UNMET NEED● Denture stomatitis is a common form of oral candidiasis afflicting according to some reports up to 65% of dentures wearers.● Current treatments are based on toxic chemical agents and are non-effective.● Ani candida solution can be extended towards a broad range of other indications. Treating denture stomatitis holds clinical and patient-related significance. Firstly, […] Read More >
Low Frequency Nanobubbles-Enhanced Ultrasound Mechanotherapy for Noninvasive Cancer Surgery
A unique theranostic ultrasound-based technology for low-energy mechanical ablation of tissues. Noninvasive ultrasound surgery can be achieved using focused ultrasound to locally affect the targeted site without damaging intervening tissues. Mechanical ablation and histotripsy use short and intense acoustic pulses to destroy the tissue via a purely mechanical effect. Here we show that coupled with […] Read More >
Models for Protein Levels Optimization in Chloroplasts Based on mRNA-rRNA Folding and Interactions
Chloroplasts which have evolved from an ancestral bacterium can be the target very efficient expression of heterologous protein with huge economical potential. However, translation in chloroplasts, which have evolved from an ancestral bacterium is not well understood and currently there is no generic quantitative model related to these aspects in the chloroplast. The patent includes […] Read More >
Stabilizing Gelatin-Based Bioinks under Physiological Conditions by Incorporation of Ethylene-Glycol-Conjugated Fmoc-Ff Peptides
Peptide-based bioinks that stabilize gelatin-based 3D printed scaffolds under physiological conditions. UNMET NEED Gelatin is one of the most widely-used materials for the fabrication of 3D scaffolds. In order to fabricate stable scaffolds under physiological conditions, gelatin need to be methacrylated, allowing the crosslinking and therefore the stabilization of the hydrogel through UV treatment. However, […] Read More >
Method for Isolating Oral Mucosa-Derived Mesenchymal Stem Cells for Tissue and Organ Regeneration
Identification and isolation of the mesenchymal stem cells from the general population of oral mucosa-derived cells may further improve regenerative therapies. Using cutting edge technology, we’ve been able to identify the subpopulation of mesenchymal stem cells with superior osteogenic capacity and furthermore, to unveil a list of unique markers to isolate these cells. Our findings […] Read More >
Therapeutic Monoclonal Antibodies to Combat Multidrug-Resistant Pathogenic Bacteria
It is predicted that a failure to address the problem of antibiotic-resistant pathogens will result in the death of 10 million people annually, costing the economy more than 100 trillion dollars by the year 2050. In high-income countries where antibiotics are heavily used in the community and agriculture, the strong selection pressure and non-completed antibiotic […] Read More >
A-Traumatic Teeth Extraction and Immediate Implant Placement
The global dental services market is expected to reach 554.5 billion USD by 2028, with dental implants dominating the market as R&D in this field continues to excel with better biomaterials, improved designs, and surface modifications. Tooth extraction is a crucial step in dental implants procedure. The standard extraction method is based on mechanical rocking […] Read More >
Stable enzyme-responsive nanocarriers with a-two step activation mechanism
The Challenge: Polymeric nanocarriers that can release their covalently attached or encapsulated cargo in response to specific stimuli can offer many advantages such as greater selectivity and consequently reduced side-effects. Among the different types of stimuli-responsive nanocarriers, enzyme-responsive delivery systems can act as a Trojan horse and release their active payload in response to specific […] Read More >
Therapeutic Targeting of PD-1/PD-L1 blockade by Novel Small-molecule Inhibitors
Interactions between programmed cell death ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1) lead to the evasion of cancer cells from an efficient immune response. The inhibition of PD-L1/PD-1 has prevented or reversed exhausted T cells, thus enhancing antitumor T-cell responses. In fact, immune checkpoint blockade targeting the PD-1 axis has become one […] Read More >
Leveraging Gene Panel Sequencing Data for Mutational Signature Analysis with Applications to Personalized Treatment
UNMET NEED Mutational signatures and their exposures are key to understanding the processes that shape cancer genomes with applications to diagnosis and treatment. Yet current signature analysis approaches are limited to relatively rich mutation data that comes from whole-genome or whole-exome sequencing. Recently, orders of magnitude sparser data sets from gene panel sequencing have become […] Read More >
It is clear that DNA can be used as a storage medium, each nucleotide carrying two information bits, which can store vast amounts of data for very long periods of time and with high reliability; as overtime, humans remain human just as cats remain cats. However, it is also clear that it is a very […] Read More >
Development of Alzheimer Disease therapy based on counteracting the pathological effects of ApoE4
Alzheimer’s disease (AD) is the most common cause of dementia and is the outcome of progressive brain cells death. Due to the disorder’s heterogeneity and in view of the variety of pathological mechanisms inducing the disease we have undertaken an innovative – science based (Animal model) approach, which is presented here. Our unique approach […] Read More >
Homocysteine fibrillar assemblies display crosstalk with Alzheimer’s disease amyloid polypeptide
High levels of homocysteine (Hcy) are reported as a risk factor for Alzheimer’s disease (AD). Correspondingly, inborn hyperhomocysteinemia is associated with an increased predisposition to the development of dementia in later stages of life. Furthermore, despite the apparent association between protein aggregation and AD, attempts to develop a therapy that targets explicitly this process have […] Read More >
Pioneering Pre-Clinical Research at the Heart of Innovation
For over 30 years, Tel-Aviv University’s Neufeld Heart Research Institute at Sheba Medical Center has been at the forefront of cardiovascular and other fields of research, combining the academic rigor of a university with the clinical expertise of Israel’s leading medical center. As a strategic partner to industry and researchers, we offer a comprehensive suite […] Read More >
The lab investigates high-level cognition, both at the behavioral and neural level. More specifically, we are interested in the following questions: 1. What is consciousness, how does it come about, and what are its functions? The latter entails two additional questions; first, how deep does unconscious processing run and how it differs from conscious processing. […] Read More >
The Laboratory of Oral-Mucosal Stem Cell Regeneration and Enzymatic Dental Therapeutics
The Laboratory of Oral-Mucosal Stem Cell Regeneration and Enzymatic Dental Therapeutics is charting new frontiers in the realm of regenerative medicine and dental care. Harnessing the potent capabilities of stem cells derived from the oral mucosa, the research endeavors not only target the restoration of oral structures but also broader applications, such as bone regeneration […] Read More >
Biological and Bio-Inspired Molecular Self-Assembly- The Gazit Lab
MOLECULAR SELF-ASSEMBLY AMYLOID FIBRIL FORMATION NANOBIOTECHNOLOGY METABOLITE AMYLOIDS MOLECULAR SELF-ASSEMBLY We study one of the most important problems in contemporary life sciences and medicine: Understanding the molecular basis for the formation of amyloid nanostructures in degenerative disorders, a process underlying the pathophysiology of some of the most devastating health problems world-wide, such as Alzheimer’s disease, […] Read More >
Advances in biomedical science have cured multiple diseases and greatly improved healthspan and lifespan. However, aging is the strongest risk factor for most causes of death in the western world, and thus these advances have resulted in a relatively small increase in maximal lifespan. Without a systematic approach to understand and treat the aging process, […] Read More >
Our research focuses on understanding the impact of exercise training, combined with dietary strategies on physiology and metabolic changes across a range of populations. Specific Research interests/topics: Our primary research interests revolve around comprehending the effects of exercise training and dietary strategies on muscle mass, adipose distribution, metabolism, and performance across diverse populations. We employs […] Read More >
The Lab for Protein Engineering and Drug Discovery
Modulation of protein-protein interactions is a key for a broad range of biotechnological applications. In our lab, we are developing unique approaches from small molecules, peptides, and optimized proteins to inhibit specific interactions. We are utilizing advanced computational, biophysical and cellular biology techniques. Specific Research interests: • Engineering of unique Immune modulators • Engineering of optimized proteins […] Read More >
Sessa Lab- Boosting plant immunity to increase crop yields
The main interest of our laboratory is to study of molecular mechanisms that govern plant immunity and susceptibility to bacterial pathogens. On the plant side, we use molecular biology, functional genomics and proteomics approaches to dissect recognition events and signal transduction pathways that mediate immunity. On the bacterial side, we apply genetic and biochemical strategies […] Read More >
Research in the laboratory focusses on the interfaces of development and cell biology with abiotic stress responses in plants. We study signaling mechanisms that increase plant tolerance to drought and salt stress and increase water use efficiency. We are also interested in signaling mechanisms which regulate secondary cell wall formation in plants and the regulation […] Read More >
We explore and consolidate the novel idea of plant-based sensors, a new approach where the plants are used as sensors and the output is based directly on the plant response. Our biosensor is composed of amalgamated technology, comprising a biological component- the plant itself, and an electrical or optical component- a sensing modality that includes […] Read More >
Our lab strives to understand the mechanisms of chronic inflammation underlying neurologic diseases and translating these laboratory discoveries into new therapies. We take a transdisciplinary approach in this research endeavor combining immunologic, genomic, proteomic and metabolomic approaches to study brain inflammation. We are particularly interested in: Elucidating the immune function of the different glia, mainly […] Read More >
Dvir Laboratory for Tissue Engineering and Regenerative Medicine
In our lab, we focus on research and development of new technologies, based on cutting-edge materials and stem cells for engineering and regenerating tissues and organs. We investigate approaches to control stem cells differentiation and assembly of functioning tissues, including the heart, brain, spinal cord, eyes, intestine and more. Among the technologies developed in our […] Read More >
Our lab specializes in many areas of optical imaging and spectroscopy with emphasis on single molecule detection and development of imaging based techniques. Our research is focused on the application of novel imaging and optical detection approaches to genomic studies and biomarker detection. We are developing new spectroscopy and microscopy methodologies that combine advanced optics […] Read More >
Using novel gene editing technology, we engineer T cells and B cells to better fight cancer, infections and autoimmune diseases Our research Our primary objective is to develop safe, efficient and scalable methods to engineer lymphocytes for immunotherapy. We provide a novel technology for the engineering of B cells as well as T cells, in […] Read More >
Our research focuses on Reproductive Physiology in animal models and in humans. The current research directions investigated in the laboratory are: The role of Fyn kinase, member of the Src family kinases, during meiosis and early events of oocyte activation, as well as in cancer cells (Figure-left panel). Fertility preservation – the signaling pathway leading […] Read More >
Leading Researchers:
The Myers Neuro-Behavioral Core Facility
Unit description:The Myers Neuro-Behavioral Core Facility provides researchers with state-of-the-art technology for performing neuro-behavioral tests in mice. Services: The Core Facility provides expertise in design, implementation, and analysis of behavioral experiments. The Core Facility includes five behavior rooms, which can operate simultaneously, and two animal maintenance rooms with IVC cages operating on a reversed light […] Read More >
Prof. Galit Yovel is the Head of the SCAN@TAU Center SCAN@TAU Center The Strauss Computational Neuroimaging Center George S. Wise Faculty of Life Sciences https://mri.tau.ac.il/about The center’s services SCAN@TAU center is a new MRI multidisciplinary research center at Tel Aviv University that offers cutting edge MR technologies and innovative, high-resolution imaging methods. The […] Read More >
Lab Description Using the powerful combination of molecular biology, biophysics, biochemistry and electrophysiology. our research aims at elucidating the structural, biophysical and physiological attributes of normal and diseased ion channels in brain and heart and whose mutations in human lead to major neurological and cardiovascular disorders like epilepsy, autism, atrial or ventricular fibrillation. Main […] Read More >
Our main focus is on the psychological and neurobiological mechanisms that underlie psychiatric disorders, and in particular addiction We are using rodent models of addiction, anxiety, learning and memory. We focus on behavioral models relevant to different stages of addiction (craving, drug reward, intoxication, sensitization, tolerance, excessive alcohol consumption, withdrawal symptoms, relapse). We are looking […] Read More >
MULTI SENSOR – Multi Modal Recording System for Behavioral Tracking
It is clear today that brain activity of a restrained (or sedated) animal is completely different from that of a freely behaving animal.That is why neuroscientists are seeking to find ways to study animals freely behaving on their natural grounds.TAU’s interdisciplinary research has led to the development of the MULTI SENSOR – Multi Modal Recording […] Read More >
The general purpose of my research is to describe the genetic and endocrine regulation of bone metabolism. To this end, we developed expertise in most aspects of bone research, from in vivo models, imaging of bone microarchitecture, in vitro cell cultures and molecular biology. Main Research Topics Regulation of bone metabolism by sex steroids Role […] Read More >
Laboratory of endoplasmic reticulum (ER) quality control and protein misfolding diseases
Lab DescriptionMain areas of interest are in the mechanisms of protein folding and trafficking in the early secretory pathway of mammalian cells and the development of ER stress upon their malfunction, particularly in neurodegenerative diseases. Specific research topics are:• Protein misfolding diseases, including neurodegenerative diseases.• ER stress.• Mechanisms of endoplasmic reticulum (ER) protein folding and quality control.• Sugar chain […] Read More >
Lab DescriptionOur lab focuses on animal Bio-sonar and other sensory systems. We are interested in how the animal’s sensory system is adapted to the environment, how does the brain encode this information and how can these adaptations be applied. We are experts in bio-acoustics. Main Research TopicsBat bio-sonar, bio acoustics, animal communication, animal cognition, the […] Read More >
The Cohen Rosenthal Diabetic Hypertensive Rat (CRDH) model
The construction of the Cohen Rosenthal Diabetic Hypertensive Rat (CRDH) model was initiated nearly a decade ago by cross-breeding between the Cohen Diabetic rat (CDR) and the SHR. The CDR is a rodent model that expresses the following phenotypes: when fed regular diet, it is non-diabetic; when fed a diabetogenic diet, it invariably develops diabetes […] Read More >
Laboratory of Immunological and Inflammatory Modules in Malignancy
Research focus Prof. Ben-Baruch is an immunologist who investigates the roles of immune and inflammatory elements in physiological and pathological conditions, with major emphasis on malignancy. The studies in her laboratory determine the complex regulatory networks established between chemokines and cytokines of the tumor microenvironment, intrinsic oncogenic modifications in tumor cells, and stroma cells. The […] Read More >
Histopathological evaluation of hard tissues and biomedical devices in their tissue implantation surrounding, using a Plastic Embedding Technique
Plastic embedding is a method that allows histological examination of soft and hard tissues (e.g., blood vessels, bones, teeth, joints and skin tissue), containing solid medical devices of different sizes and made of various materials. In addition to the standard histological observations, such as necrosis, inflammation and fibrosis, this technique provides reliable data on size […] Read More >
Lab of Signal transduction, Neurodegeneration and Autophagy
Research focus ErbB receptors interactions and functions Regulation of Autophagy Neurodegeneration Projects include: The crosstalk between ErbB receprots and nucleolin in cancer development Beclin 1 mediated autophagy Autophagy in neurodegenerative diseases Autophagy in cancer Potential services Laboratory services: To monitor autophagy Signal transduction assays Anti-cancer drugs examination Cell proliferation, death and migration examination Potential […] Read More >
The goal of the lab is to elucidate molecular mechanisms of motor neuron survival and proper function using ALS disease as a model. In our current efforts we are using cutting edge in vitro and in vivo technologies studying molecular mechanisms of: 1. Molecular communication of trophic factors (such as BDNF or GDNF) between […] Read More >
Selective therapy remains a key issue for successful treatment in cancer therapy. Prolonged administration of effective concentrations of chemotherapeutic or anti-angiogenic agents is usually not possible because of dose-limiting systemic toxicities involving non-malignant tissues. Therefore, a constant effort has been the development of new drug delivery systems that mediate drug release selectively at the tumor […] Read More >
We combine glycobiology, immunology, biotechnology and cancer research, and use cutting edge technologies within these disciplines, including glycan microarray and glyco-nanotechnology. Current interests include: Immunological mechanisms of unique anti-carbohydrate antibodies. Glycoimmunology in xenotransplantation, as members of the EU TRANSLINK consortium. Anti-carbohydrate antibodies in mucosal secretions and sera. Development novel diagnostics and therapeutics to chronic inflammation […] Read More >
The circadian clock system: from molecular mechanisms to physiology and behavior Research methods: Molecular genetics in whole animal, the zebrafsh; Transgenesis and gene manipulation; Behavior (mainly locomotor activity rhythms). Available Research Services Analysis of circadian rhythms of locomotor activity of wild type zebrafish and of mutants with advanced (short) or delayed (long) circadian […] Read More >
Custom synthesis of organic compounds Industrial Research Services: We offer services for custom synthesis of small organic compounds. Our laboratories in Tel Aviv University have all the basic state-of-the-art instrumentation for synthetic capabilities. The School of Chemistry also has an Analytical Research and Instrumentation Unit, which provides services for organic analyses. The Department of Chemistry […] Read More >
The Bioinformatics Unit at the Faculty of Life Sciences The Bioinformatics Unit at the Faculty of Life-Science at Tel-Aviv University is part of the Israeli Center of Bioinformatics Infrastructure (COBI) and offer various activitities to the bio-medical research community of Tel Aviv University and outside TAU. Bioinformatics training Bioinformatics consultation Microarray experiments support […] Read More >
Laboratory of Experimental BiophysicsSchool of Physics and Astronomy, Faculty of Exact ScienceThe Center for NanoScience and NanoTechnology Services:Small Angle X-ray Scattering (SAXS), Wide Angle X-ray Scattering (WAXS), Grazing Incident Small Angle X-ray Scatter (GISAXS) X-ray scattering provide structural information (shape and size) in non-destructive and stain free conditions. Small angle scattering is an ideal characterization […] Read More >
Department of Biomedical Engineering – Prof. Ofer Barnea Ofer Barnea is a Professor of Biomedical Engineering at Tel Aviv University and is the Director of the Ela Kodesz Institute for Biomedical Physics and Engineering. He was the chairman of the Department of Biomedical Engineering and the chairman of the Israeli Chapter of the IEEE […] Read More >
The general goal of our laboratory is to research design and build in vitro systems that simulate cardiovascular flows, hemodynamic shear forces, and blood-tissue interaction. In addition, the laboratory conducts a wide program of numerical bio-simulations. Focus In Vitro Biological Flows. Hemodynamics. Endothelial Cell and Platelets activation. Digital Particle Image Velocimetry (DPIV). Vulnerable Plaque. Blood-Tissue […] Read More >
The Musculoskeletal Biomechanics Laboratory has in-house facilities for experimental and numerical studies of tissue and whole body biomechanics as well as implant systems. Equipment Material and tissue testing facilities: Computer- controlled uniaxial electromechanical material testing system (Instron 5544) with various load cells and jigs for tension, compression and bending (3,4-point) loading modes Computer-controlled pendulum […] Read More >
Development of optical methodologies for non-invasive diagnosis, development of tools for minimally invasive surgery using fibers and waveguides, and development of smart medical devices. Prof. Israel Gannot. Lab web page: https://www.eng.tau.ac.il/~bmoptics/ Read More >
SCMIC offers a wide variety of Imaging services, covering confocal and high-throughput microscopy, whole animal imaging and image analysis. All devices and instruments are centralized under one roof, providing a continuum of complete in-depth studies and projects in vivo and in vitro, from the micro to the macro level. Whole animal imaging includes Fluorescence […] Read More >
Bacterial Isolates Identification and Gene Sequencing
Webpage: https://www.tau.ac.il/lifesci/departments/biotech/members/gophna/gophna.html Scientist Contact:Uri Gophna Ph.D.Senior lecturer,Deparment of Molecular Microbiology and BiotechnologyGeorge S. Wise Faculty of Life SciencesTel. +972-3-6409988Fax +972-3-6409407email: urigo@tauex.tau.ac.il Read More >
Consultation and lab services are offered, with a focus on eye-related medical innovations from concept through to clinical trials. Lab Website:https://www.tau.ac.il/medicine/Goldschleger/Goldschleger.html Scientist: Michael Belkin, MA, MD Professor of Ophthalmology Director, Ophthalmic Technologies Laboratory Goldschleger Eye Research Institute Tel Aviv University Sheba Medical Center Tel Hashomer 52621 Israel Phone: +972-3-530-2956 Fax: +972-3-535-1577 Skype: Belkin E-mail: belkin@netvision.net.il Read More >
Leading Researchers:
Bert Strassburger Lipid Center, Sheba,Tel Hashomer
Fatty Acid Metabolism and Desaturase enzymes, Cholesterol Metabolism and involved enzymes, Membrane composition and liposomes. The lab focuses on techniques for Lipid analysis, like total lipid quantification and analysis of lipid species like fatty acids, triglycerides, phospholipids,etc. using chromatography systems such as HPLC, GC and TLC.Services offered: Identification and quantification of total lipids and specific […] Read More >
Precision Nanomedicine: Preparation and Characterization of Nanocarriers Made from Natural Biopolymers
The laboratory of Precision Nanomedicine at TAU have capabilities for preparation and characterization of nanocarriers made from natural biopolymers such as lipids (liposomes, micelles) , sugars and proteins. Lab Description • State-of-the-art preparation and process development of lipid based nanoparticles including sythesisi capabilities of lipids. • cell culture facility including the culturing of hybridomas and […] Read More >
The Facility has an In Cell Analyzer 2000 (INCA 2000, GE healthcare), the first in Israel, which is a high throughput high content image screening analyzer capable of automatically acquiring multiple fluorescence-labeled images from live or fixed cells cultured in multi titter-well plates. We offer the possibility to analyze a wide range of cellular types […] Read More >
SERVICES“ Lipid Solutions” Prof. Alicia Leikin-Frenkel “Lipid Solutions” covering:1. Expert support for questions on: lipid metabolism, isolation, identification and quantitation of lipids in different species and different matrixes.2. Guidance to discover the pathway to physiological and biochemical implications following overexpressed or suppressed gene linked to lipids.3. Counseling to analyze lipids in:• Simple molecules: fatty acids: Saturated, Monounsaturated n7, n9, Polyunsaturated: […] Read More >
Drug Screening Animal Model for Anti-compulsive Activity
We have developed the signal attenuation rat model of obsessive-compulsive disorder (OCD). This model is based on the theoretical proposition that compulsive behaviors result from a deficit in the feedback, which is associated with the performance of normal goal-directed responses. In our model, the goal-directed behavior is lever-pressing for food. The feedback associated with making […] Read More >
Cardiovascular and Physiological Assessment in Animal Models
Neufeld Cardiac Research Institute at Sheba Medical Center, Tel-Aviv University comprises a fully equipped laboratory to conduct cardiovascular and physiological experiments in small (mice, rat) and large animals (swine, sheep, calf) including heart function studies with special echocardiography system designed for small animals (Vevo660 ultrasound biomicroscope; VisualSonics), molecular imaging, pressure‐volume loop machine (Millar/Power Lab) and […] Read More >
Laboratory of Biological Psychiatry & Behavioral research- Felsenstein Institute Main Research Topics Cognition, Memory, Social behavior, Motility. Disease: Schizophrenia, Anxiety, Neuropathy pain and Depression Drug Development: Schizophrenia, Depression, Cognition, Pain . Lab facilities The lab is well equipped with the required instruments for molecular and cellular research. At the institute, we have a modern animal room […] Read More >
Blast Brain Injury: a combat zone-like mouse model. From the experimental lab to the war against terror and back to the lab. Improvised explosive devices (IEDs) are one of the main causes for casualties among civilians and military personnel in the present war against terror. IEDs induce various degrees of cognitive, emotional and behavioral disturbances […] Read More >
Animal Models for CNS Disorders and Screening Method for Diabetes
In vitro and in vivo animal models for stroke, Alzheimer’s disease (AD), and multiple sclerosis (MS). Rapid screening method for selecting candidates with specific insulin-degrading enzyme inhibitor activity in Types I and II Diabetes. https://www.tau.ac.il/lifesci/departments/neuro/members/frenkel/frenkel.html Read More >
Animal eye models for evaluation of systemic and topical use of new medications, devices and delivery systems. The models include external eye, intraocular, orbital, and optic nerve applications. Webpages:https://www.sheba.co.il/Institutes/Eye_Institute/Eye_Clinics/78.htmhttps://www.tau.ac.il/medicine/ophthalmology/ophth_con.html CONTACT Department of Opthalmology Faculty of MedicineTel Aviv UniversityRamat Aviv 69978, IsraelFax: 972-3-6405354 Head of the Department:Prof. Arieh S Solomon, MD,PhDEmail: asolomon@post.tau.ac.ilPhone: 972-3-5350702Fax: […] Read More >
Animal Research Services in Specific Pathogen Free (SPF) and Standard Facilities
Tel-Aviv University (TAU) holds several regular and SPF (Specific Pathogen Free) animal care facilities, providing state-of-the-art non-clinical and pre-clinical laboratory research services. We can perform multi-level studies, using a large variety of animals and supply veterinarian services, to our TAU researchers and to external companies and institutes. We provide a continuum of […] Read More >
Neurodevelopmental, Gestational, Lactational and Maternal Immune Stimulation Animal Model for Schizophrenia
Fields of InterestPharmacology of schizophrenia, animal models of psychopathology, neurodevelopmental model of schizophrenia. Prof. Weiner’s lab has launched and developed the latent inhibition model of schizophrenia which mimics loss of normal attentional control in this disorder, with a focus on the pharmacology of latent inhibition as a basis for the search for novel drugs. In […] Read More >
Unique Animal Models for Inflammatory Lung, GI, and Bowel Diseases
The Laboratory of Mucosal Immunology The Laboratory of Mucosal Immunology is new at the faculty of Medicine and deals primarily with mucosal inflammation. We focus on diseases affecting the lungs, such as asthma, COPD (chronic obstructive pulmonary disease), acute lung injury and gastrointestinal (GI) tract, inflammatory bowel disease (IBD) and colorectal cancer. In lungs models […] Read More >
Prof. Assaf Yaniv
Research topic: Measuring in-vivo brain micro-structure and neuroplasticity with magnetic resonance imaging (MRI) in humans and rodents Research methods: Magnetic Resonance Imaging: Diffusion Imaging, Diffusion Tensor Imaging, Tractography; Immuno-histochemistry, Histology. Main projects in the lab include: Investigation and localization of brain regions that undergo plasticity following a cognitive experience or training with MRI Development of MRI frameworks […] Read More >
Prof. Attali Bernard
Reaching an understanding in molecular terms of the mechanisms by which changes in membrane potential regulate cellular events is the main concern of our research. We focus our interest on potassium channels because they play crucial roles in many cellular functions such as shaping cardiac and neuronal action potentials, tuning neuronal firing patterns, synaptic integration […] Read More >
Prof. Avraham Karen B.
Genomic Analysis of Hereditary Hearing Loss Our primary interest is the genetic basis of hereditary hearing loss or deafness. Our group is working towards the identification, characterization and regulation of genes associated with hereditary hearing loss. For gene discovery, we focus on the Israeli Jewish and Palestinian Arab populations in the Middle East. Our studies […] Read More >
Prof. Bacharach Eran
Eran Bacharach is the head of a research laboratory for molecular virology at the Department of Cell Research and Immunology, and teaches courses on microbiology, molecular virology and cell biology, at the Faculty of Life Sciences, where he has been on the faculty since 2000. He received his B.Sc., M.Sc. and Ph.D. degrees from the […] Read More >
Dr. Bar Daniel Zvi
Advances in biomedical science have cured multiple diseases and greatly improved healthspan and lifespan. However, aging is the strongest risk factor for most causes of death in the western world, and thus these advances have resulted in a relatively small increase in maximal lifespan. Without a systematic approach to understand and treat the aging process, […] Read More >
Prof. Barak Segev
Dr. Barak’s research focuses on the psychobiology and neurobiology of alcoholism and drug addiction. In particular, he is interested in the molecular and neuronal mechanisms that underlie learning and memory processes in alcohol addiction. In addition, Dr. Barak is interested in the pathophysiology of schizophrenia, with focus on cognitive impairments in this disorder. See lab […] Read More >
Prof. BARNEA Ofer
Patient specific models: Assessment of fetal cardiovascular development Optimization Propofol administration during anesthesia Optimization of fluid resuscitation Assessment of cerebral blood flow autoregulation Multiscale models of physiological systems 3D fiber based model of the contracting heart Oxygen transfer to tissue Biomedical measurements and instrumentation Optimally controlled fluid administration system Detection of bubbles in blood to […] Read More >
Prof. Barzel Adi
Our lab will focus on gene therapy using viral vectors. We will tackle diseases ranging from cancer to viral infections and diabetes. Devising safe and efficient gene therapies combines challenges in biochemistry and molecular biology with challenges in physiology, immunology, virology and more. We will focus on genome editing- the site specific manipulation of the […] Read More >
Dr. Beck-Barkai Roy
Research Cytoskeleton protein complexes – Interaction between cytoskeleton protein complexes and their effect on the structure and elasticity of the cell. Intrinsically disordered protein – Statistical structural characterization of proteins that do not completely fold into 3d fixed structures in solutions. Nanoscopic complex – characterizing and manipulating nanoscopic complexes by grafted biopolymer. Membrane physics – stabilization of membrane to […] Read More >
Prof. Belkin Michael
Prof. Belkin has been involved in the establishment of many medical start-ups in ophthalmology and other fields. One of his noted contributions was inventing and developing the Ex-PRESS Glaucoma Filtration Device. The ExPRESS, after being sold to global eye care leader Alcon, is now routinely used in glaucoma surgery worldwide. He is now developing his […] Read More >
Prof. Ben-Baruch Adit
Breast cancer is a leading cause of death for women in the Western world. The battle against breast cancer has been challenged by the fact that, generally, each component is studied meticulously, but singly. Too little attention is paid to the interactions between the tumor cells and their intimate microenvironment, consisting of various cells and […] Read More >
Prof. Ben-Tal Nir
Our research is focused on studying the interplay between protein sequence, structure, motion and function using computational tools. The understanding of these relations provides a molecular dimension to our understanding of protein functions and their involvement in genetic disorders and other diseases. Within the broad fields of structural-bioinformatics and phylogeny, we limit our research to […] Read More >
Prof. Benayahu Dafna
Nanomedicine is medical treatment at the level of single molecules or molecular assemblies that provide structure, control, signaling, homeostasis, and motility in cells, i.e., at the “nano” scale of about 100 mm or less. There have been many scientific and technological advances in both physical and biological sciences over the past several years that make nano medicine […] Read More >
Prof. Benhar is an expert and opinion leader in the field of antibody engineering. Over the 25 years of being active in that field, he prepared several phage display libraries from which antibodies against numerous targets were isolated. Prof. Benhar publishes over 100research papers, wrote 10 book chapters and submitted 19 patent applications. Research in Prof. […] Read More >
Prof. Benjamini Yoav
My scientific work combines theoretical research in statistical methodology with applied research that involves complex problems with massive data. The methodological work is on selective and simultaneous inference (multiple comparisons), and centers on the “False Discovery Rate” (FDR) criterion, as well as on general methods for data analysis, data mining and data visualization. My current […] Read More >
Prof. Burstein David
Dr. Burstein is a faculty member in The Shmunis School of Biomedicine and Cancer Research in the Life Science Faculty at Tel Aviv University. His research focuses on CRISPR-Cas systems, secretion systems of pathogens, and the discovery of novel antibiotic resistance genes to better understand fundamental interaction mechanisms within microbial communities and to promote their […] Read More >
Dr. Cohen lab focuses on dissecting the intercellular communication between immune cells and tissue resident cells in the tumor microenvironment. Recent genomic and proteomic technology advances have led to breakthroughs in our understanding of single cell states, and the cellular composition of complex environments, such as the tumor microenvironment; however, molecular characteristics of interacting cells […] Read More >
Prof. Dvir Tal
Microfluidics-based tissue engineering. Recreating stem cell niches, microfluidics bioreactors for tissue engineering. Nanotechnological strategies for engineering thick cardiac tissue. Engineering a 3D neuronal network for spinal cord and brain regeneration. Fabrication of Nanoelectronics/engineered tissue hybrids. Developing smart delivery systems that recruit stem cells to defected organs. Email: tdvir@tauex.tau.ac.il Phone: 03-6406514 Another phone: 03-6408604 Website: https://dvirlab.wixsite.com/dv… Office: […] Read More >
Prof. Ebenstein Yuval
Our lab specializes in many areas of optical imaging and spectroscopy with emphasis on single molecule detection and development of imaging based techniques. Our research is focused on the application of novel imaging and optical detection approaches to genomic studies and biomarker detection. We are developing new spectroscopy and microscopy methodologies that combine advanced optics […] Read More >
Prof. Efrat Shimon
Our research focuses on the development of a cell replacement therapy for diabetes, in which the insulin-producing pancreatic beta cells are destroyed or malfunction. Our approaches for generation of an abundant source of cells for transplantation include expansion and differentiation in tissue culture of beta cells from human organ donors, as well as differentiation of […] Read More >
Prof. Ehrlich Marcelo
I am interested on the dynamic aspects of the cell’s trafficking machinery, with a special focus on endocytic dynamics. More specifically, our study centers on the mechanisms by which the cell modulates vesicular traffic by altering: The rate of formation of vesicular carriers, such as clathrin coated vesicles. The spatio-temporal distribution of the process of […] Read More >
Prof. Einav Shmuel
Research Interests: Flow in biological systems; cardiac blood flow; Blood flow in obstructed arteries and in bypasses; blood flow through artificial heart valves; Cardiac-assist devices; magnetic resonance imaging of blood flow Read More >
Prof. Eldar- Finkelman Hagit
My overall research is focused on elucidating the molecular and biochemical regulation of the protein kinase, glycogen synthase kinase-3 (GSK-3), and revealing its contribution to pathological disorders. GSK-3 is emerging as a prominent drug discovery target in neurodegenerative disorders including ALS, Parkinson’s, Huntington’s and Alzheimer’s disease. In a recent work we identified lysosomes as novel […] Read More >
Prof. Orna Elroy-Stein is a Full professor in the Department of Cell Research and Immunology at the Faculty of Life Sciences, Tel Aviv University, and a member of the Sagol School of Neuroscience. She received her B.Sc. and M.Sc. from the Technion, her Ph.D. on Human Molecular Genetics at the Weizmann Institute of Science, Israel, and […] Read More >
Prof. Erez Neta
Associate Professor, Chair of the Department of Pathology, Faculty of Medicine, Tel Aviv University Research Cancer Related Inflammation in Tumor Progression and Metastasis The main goal of our laboratory is to uncover stromal pathways that contribute to tumorigenesis and metastasis. Extensive research has led to the understanding that tumors are more than just cancer cells: […] Read More >
Prof. Fishelson Zvi
Research Molecular Analysis of Cancer Immunoresistance The long-term goal of our research is to develop a novel treatment for immune resistant cancers. Our research includes characterization of the mechanism of complement-dependent cytotoxicity and of the basis for elevated resistance of cancer cells to cell death, and design of novel reagents that sensitize cancer cells to […] Read More >
Prof. Fleminger Gideon
Our laboratory is engaged in the study of structure-function relationships in proteins and peptides involved in biorecognition processes. In these studies we apply sophisticated separation methods for the purification with advanced methods of structural analysis of these materials. Specific research activities include: Structure-function relationships in Ca+2-binding proteins: We are engaged in the study of the […] Read More >
Prof. Freeman Amihay
Research interests include: Biomedical applications of enzymes and cells. Protein Nano-biotechnology: protein mediated biotemplating for the integration of biologically active protein-metal hybrid with microelectronics and development of new composite materials. Bioprocessing aspects of biocatalysis Read More >
Prof. Frenkel Dan
Research topic: The research in our laboratory is focused on the investigation of glial cell and to clarify their role in neurological diseases. We suggest that targeting glia activation in different pathological scenarios may allow us to define common pathways to further understand the role of glia in neuroprotection . We are using three models: 1) […] Read More >
Dr. Freund Natalia
Senior Lecturer (Guest), Department of Clinical Microbiology and Immunology, Faculty of Medicine Research My laboratory is interested in understanding the molecular basis of human antibody responses to diseases. Antibodies are key components of most licensed vaccines; nevertheless many aspects of how antibodies recognize and neutralize their targets are still unknown. Pathogen-specific B cells are stimulated […] Read More >
Prof. Fridman Micha
The Fridman laboratory is engaged in the use of organic chemistry, especially carbohydrate chemistry, to solve key biological and medicinal problems. Our interdisciplinary studies involve the use of organic chemistry, microbiology, cell biology, molecular biology, and confocal microscopy to study and/or alter the mode of action of biologically active molecules with the focus on novel […] Read More >
Prof. Gabet Yankel
Genetics: Our laboratory focuses on the genetic and hormonal regulation of bone remodeling, microarchitecture and strength. These traits have a high degree of heritability, and one aspect of our research is to characterize new genetic determinants of bone remodeling as well as elucidate the mechanism of action of selected genes. Our GWAS confirmed the role of […] Read More >
Prof. Gannot Israel
Research Interests: Optical biopsy -optical diagnostic methods in medicine Laser tissue interaction Fibers and waveguides for medical applications Lasers and optics in medicine Read More >
Prof. Gazit Ehud
The central dogma in the study of protein folding suggests that the thermodynamically-favorable state of proteins under physiological conditions is their folded one. However, there are number of cases in which the favorable states of proteins are rather unfolded, partially folded (e.g., “molten globular”), or misfolded (e.g., nonspecific aggregates or amyloid fibrils). These observations lead […] Read More >
Prof. Gefen Amit
Musculoskeletal Biomechanics Laboratory The Musculoskeletal Biomechanics Laboratory of Professor Amit Gefen (@AmitGefen) has versatile in-house testing equipment for state-of-the-art experimental (test bench) and computer modeling and simulation studies of medical devices and consumables. Professor Gefen has more than 20 years of experience in developing and executing laboratory tests and modeling and simulation work. Together with […] Read More >
Prof. Tamar Geiger
Dr. Geiger is an associate professor at the department of Human Molecular Genetics and Biochemistry at the Faculty of Medicine at Tel Aviv University. Geiger completed her BSc studies in life sciences at the Hebrew University of Jerusalem. She then continued and performed her MSc and PhD studies in the same university studying cancer signaling […] Read More >
Prof. Gershoni Jonathan M.
Research Interests Our objective is to elucidate molecular mechanisms of biorecognition. How do receptors bind their corresponding ligands? How do viruses recognize their target cells? What enables the immune system to identify self antigens and to eliminate foreign invaders? The research is a combination of protein biochemistry, monoclonal antibody technology and combinatorial phage display systems […] Read More >
Our goal is to generative fundamental knowledge on biological systems organization and function, and to apply this knowledge to develop technologies that address critical challenges in energy generation and health. Our laboratory conducts research in a wide range of research subjects including: BioEnergy systems Bioenergy systems efficiency analysis We develop models to analyze the efficiency […] Read More >
Prof. Goldbourt Amir
Research in the group of Prof. Amir Goldbourt: Our group develops and applies solid-state NMR techniques to study structure and dynamics at atomic-resolution for a variety of materials across different disciplines. Structural chemistry: We develop novel solid-state NMR techniques to study the chemical environment of metal ions, halogens and other NMR-active isotopes that experience strong […] Read More >
Prof. Gophna Uri
Research topics: Microbial ecology, The human microbiome in IBD, Selfish genetic elements, Microbial defense systems, Systems biology, Halophilic archaea Research methods: Deep sequencing/massively parallel sequencing, microbiology, gene cloning, quantitative RT-PCR, immunofluorescence, Metagenomics , bioinformatics. Main projects in the lab include: > Microorganisms as biomarkers, and mediators of inflammation in IBD > Evolutionary roles of CRISPR-Cas […] Read More >
Dr. Gothilf Yoav
Research Activity The Circadian Clock system All organisms demonstrate a wide variety of behavioral and physiological daily rhythms that are driven by an evolutionary conserved endogenous circadian clock mechanism. Maintenance of circadian rhythms is crucial for the physical and mental wellbeing, and disruption of the rhythms increases susceptibility to diseases and psychiatric disorders. Utilizing the […] Read More >
Our research is characterized by a multi-level approach to the study of brain function, behavior, memory and drug discovery, from molecules to cures. Targeting autism, schizophrenia as well as Alzheimer’s disease and related neurodegeneration and utilizing a multidisciplinary approach, our group investigates different aspects of neuronal plasticity and nerve cell protection, at the molecular, cellular […] Read More >
Research Areas Computational Biology Machine Learning Algorithms Population Genetics Statistical Genetics Read More >
Dr. Harlev Mickey
The Tel-Aviv University (TAU) holds several regular and SPF (Specific Pathogen Free) animal care facilities, providing state-of-the-art non-clinical and pre-clinical laboratory research services. We can perform multi-level studies, using a large variety of animals and supply veterinarian services, to our TAU researchers and to external companies and institutes. We provide a continuum of complete tailor-made […] Read More >
Prof. Hershkovitz Israel
Research Areas include: Biohistory: The social and biological impact the transition from foraging and hunting to farming had on human populations. Although a rapid event in human evolution, the ‘agriculuture revolution’ was the most significant cultural process in human history, something that forever changed the face of humanity (culturally and biologically). Unlike many other paleoanthropological studies, […] Read More >
Prof. Joel studied the involvement of basal ganglia-thalamocortical circuits in normal and abnormal behavior, using mainly animal models of psychopathology. More recently Prof. Joel has expanded her work to research questions related to brain, sex and gender. Ongoing studies attempt to characterize the relations between sex and brain structure and function. Other studies focus on […] Read More >
Prof. Kashman Yoel
Research Isolation of bio active natural compounds, mainly , anti bacterial , anti viral and/or cytotoxic compounds from plants and mainly marine organisms ( soft corals, sponges and tunicates ). The compounds belong to the various bio-synthetic groups , namely , terpenoids , polyketides and nitrogen containing compounds ( alkaloids ? ) . The structure […] Read More >
Research Interests HK022 bacteriophage site specific recombinase Integrase is the tool for human genome manipulation and gene therapy. Site specific recombinases (SSRs) catalase the site-specific recombination reaction between two specific short DNA sequences of 30-40 bp that serve as recombination sites that included integration, excision and inversion. These enzymes are widely used for the genome manipulations […] Read More >
Prof. Korenstein Rafi
Department of Physiology-Pharmacology Faculty of Medicine, Tel Aviv University Read More >
Prof. LEDERKREMER Gerardo Zelmar
Research Prof. Lederkremer’s lab has been interested in the mechanisms of protein folding and trafficking in the early secretory pathway of mammalian cells. He has focused especially on mechanisms of ER protein quality control and on recognition and delivery of misfolded proteins from the ER to the cytosolic proteasomes for ERAD. These processes are intimately […] Read More >
Professor Leor received an M.D. degree from Tel-Aviv University, continued training in cardiovascular medicine at the Sheba Medical Center, and completed his post doctorate training at the University of Southern California, Los Angeles, under Robert A. Kloner, M.D., Ph.D. Today, his laboratory’s research focuses on infarct repair and the heart’s lack of intrinsic regenerative ability. […] Read More >
Research Interests 1. Micro- and nano-particulate drug delivery technologies for topical, regional and systemic applications: Our efforts in the drug delivery arena focus on two drug delivery technologies, one veteran and one novel, that are inventions of our group. These technologies each yield, micro and nano sized particles that are composed of biomaterials with particular […] Read More >
Prof. Munitz Ariel
Our laboratory is focused on elucidating cellular and molecular mechanisms that are involved in mucosal inflammation. Specifically, we are interested in the roles of immune inhibitory receptors in the lung and gastrointestinal tract especially in type-2-associated and innate immune responses. Read More >
Prof. Nelson Nathan
Structure, function and molecular biology of photosystem I and other membrane complexes in higher plant chloroplasts. We solve the structure of plant PSI super-complex including its four light-harvesting complexes at 2.8 Å resolution. We intend to obtain atomic resolution of plant PSI. Structural determination of super-complexes in biological membranes. Crystal structure of PSI-ferredoxin, PSI-plastocyanin, PSI- […] Read More >
Research topic: Neurodegenerative diseases, etiology and new treatments. Research methods: Stem cells, Gene therapy, peptides, transgenic mice, animal models of Neurodegenerative diseases Main projects in the lab include: Induction of neurogenesis and transplantation of various adult stem cells in animal models of neurodegenerative diseases. Development of new therapies, small molecules, peptides and genes, for neurological […] Read More >
Prof. Ohad Nir
Prof. Nir Ohad received his B.Sc. in Biology and Earth sciences and his M.Sc. and Ph.D. in Genetics from Hebrew University. Since 1998, Prof. Ohad has been a member of The School of Plant Sciences and Food Security at Tel-Aviv University. Prof. Ohad is studying the role of DNA and Histone methylation as part of […] Read More >
Our lab is studying the mechanisms that govern glycan immune recognition and responses in animal models and humans, both in vitro and in vivo. We combine glycobiology, immunology, biotechnology and cancer research, and use cutting edge technologies within these disciplines, including glycan microarray and glyco-nanotechnology. Current interests include: Immunological mechanisms of unique anti-carbohydrate antibodies. Glycoimmunology […] Read More >
Research Novel Nano materials synthesis (Nanowires) in advanced methods in solid/liquid/gas states and Chemo Physical characterization Synthesis of “Intelligent” Nano materials with optical, electrical and magnetic controlled properties Development and construction of electronic Nano devices for sensing of Chemical and Biological spices Development of Nano Pillars for monitoring of In-cell parameters Development of Nano devices […] Read More >
Prof. Peer Dan
Our lab is studying how to manipulate cells’ functions in order to generate novel strategies to treat inflammatory diseases and cancers. We are combining multidisciplinary approaches including immunology, cell and molecular biology, genetics, protein engineering, material sciences, nanotechnology and computational techniques for drug discovery and potentially for therapeutics. In addition, we are developing nanomedicines by […] Read More >
Research Interest Nanomotors and microfluidic platforms reveal neurodegeneration mechanisms Neuron cell death and synapse disruption seen in neurodegenerative diseases like ALS. It is a non-cell-autonomous process and involve a multi system progression. Neurons are highly polarized cells with very long axons. In order to maintain healthy and function properly the neurons depends on accurate and efficient long […] Read More >
Prof. Pick Chaim G.
Professor, Department of Anatomy & Anthropology, Faculty of Medicine Director, the Sylvan Adams Sports Institute Research Brain Injuries: Cognitive, Behavioral and Cellular Outcome My group has a long history in Traumatic Brain Injury research, not only in characterizing behavioral and biochemical sequelae of blunt head trauma, but also in developing preclinical models of mTBI of […] Read More >
Prof. pinkas-Kramarski Ronit
Research topic: Study the involvement of Autophagy in neurodegenerative diseases. Research methods: Cell biology, Biochemistry, Molecular Biology, microscopy, Immunohistochemistry. Projects in the lab include: The role of autophagy in nerve injury. Study the involvement of autophagy in Alzheimer’s. The molecular mechanism of autophagy regulation. Read More >
Prof. Pitaru Sandu
Prof. Pitaru is an expert in bone, connective tissue and periodontal research, and one of the two inventors of ColBar LifeScience Ltd.’s technology. Read More >
Prof. Prag Gali
Research topic: Elucidating the decoding mechanisms of ubiquitin signals and their significance in neurodegenerative diseases Research methods: Biophysical measurements including SPR, AUC, MST and SEC, X-ray crystallography, Bioinformatics, Biochemistry and bacterial genetics Projects in the lab include: Molecular mechanisms that regulate membrane protein trafficking and Parkinson’s disease Mechanisms for regulation of sodium / potassium channels and dopamine transporter. The molecular […] Read More >
Prof. Qimron Ehud
Our lab studies the recently identified adaptive immune system of bacteria, the CRISPR/Cas system. This fascinating system remarkably adapts specifically to defend against newly encountered phages and launches a specific RNA-mediated response against their nucleic acids. In addition, we study novel phage interactions with their bacterial hosts, and particularly novel interactions of T7 with its […] Read More >
Prof. Rabani Eran
Research Prof. Rabani’s research involves the development of theoretical and computational tools to investigate fundamental properties of nanostructures. His research covers structural, electronic and optical properties of nanocrystals, doping of nanoparticles, exciton and multiexciton dynamics at the nanoscale, and transport in correlated nano-junctions. Much of this relies on the development of stochastic electronic structure techniques […] Read More >
Dr. Raiter Annat
Immunotherapy is a new modality which has revolutionized the treatment of cancer for multiple types of tumors. However, breast cancer has shown only modest benefit from immunomodulatory therapies, if at al. This is principally due to tumor escape mechanisms. We have only limited understanding of these mechanisms. Our focus on translational research aims to better […] Read More >
Prof. Rechavi Oded
Prof. Oded Rechavi’s mission is to challenge fundamental long-held scientific dogmas. He found an exception to the original “Cell Theory”, provided the first direct evidence that an acquired trait can be inherited, elucidated an alternative transgenerational inheritance mechanism (that depends on inherited small RNA molecules, not DNA molecules), discovered a mechanism that allows nematodes’ brains […] Read More >
Current research includes: Novel immunosensors based on enzyme channeling. Biosensors based on enzyme cascades. Electrochemical and optical investigation of the electron transfer reactions of macrocyclic and polymeric mediators and application of their catalytic activity in biosensors. NO sensors; Investigation of the action of the enzyme nitric oxide synthase; measurement of NO in cancer cells. Electrochemical […] Read More >
Prof. Shimon Rochkind
Director, Peripheral Nerve Reconstruction division of the Department of Neurosurgery, Tel Aviv University Senior Neurosurgeon and Specialist in Neurosurgery & Microsurgery, Tel Aviv Sourasky Medical Center. Read More >
Prof. Rosenman Gil
Research Interests: Ferroelectricity. Nanodomain reversal effect in ferroelectrics. High Voltage Atomic Force Microscopy; New generation of photonic devices based on nanodomain engineering; Studies of physical properties of biological materials developed for medical implants; Electron emission spectroscopy of High-K ultrathin multilayer dielectric stacks for microflash memory cells; High current density ferroelectric electron cathodes for microwave tubes, […] Read More >
Prof. Rosenthal Talma
The construction of the Cohen Rosenthal Diabetic Hypertensive Rat (CRDH) model was initiated nearly a decade ago by cross-breeding between the Cohen Diabetic rat (CDR) and the SHR. The CDR is a rodent model that expresses the following phenotypes: when fed regular diet, it is non-diabetic; when fed a diabetogenic diet, it invariably develops diabetes […] Read More >
Prof. Rosin-Arbesfeld Rina
The Wnt signaling pathway is involved in virtually every aspect of human development, as well as in adult homeostasis. Hyperactivation of this pathway has been linked to a wide range of cancers and especially colorectal cancer. Our aim is to understand the molecular events underlying Wnt signal transduction, as well as develop novel therapeutic strategies […] Read More >
Dr. Ruban Angela
Steyer School of Health Professions Sagol School of Neuroscience Faculty of Medicine building, Room 740 angellruban@tauex.tau.ac.il Read More >
Prof. Ruppin Eytan
Research in Eytan Ruppin‘s lab is focused on the computational study of biological networks within the general framework of Systems Biology. This is done primarily in four research topics: 1. The study of metabolism and metabolic networks: Our current focus is on developing genomic-scale metabolic models of human tissues and studying their role in understanding an […] Read More >
Prof. Satchi-Fainaro Ronit
Our research interests include investigations related to tumor biology, tumor dormancy, mechanism of action of angiogenesis inhibitors, self-assembly of polymeric architectures and novel approaches to target cancer. Throughout, we have maintained an interest in understanding the biological rationale for the design of polymer therapeutics suitable for transfer into clinical testing. Our primary interests are the molecular […] Read More >
Prof. Savion Naphtali
Novel Antioxidant for Treatment of Age-related Degenerative Diseases We are studying the potential of S-allylmercapto-N-acetylcysteine (ASSNAC) a newly developed derivative of allicin (the active component in garlic) to serve as a treatment for oxidative stress associated degenerative diseases. The research involves cell biology tools and animal models. The following specific subjects are studied: Demonstrating the […] Read More >
‘Conformational diseases’ are diseases caused by misfolding of a protein, often as a result of a missense mutation that does not necessarily disrupt the active site of the protein. As a result, the protein may lose its function, and often the misfolded monomers self-assemble to form cytotoxic aggregates. We study the structural causes of such […] Read More >
Prof. Shabat Doron
Research Self-immolative dendrimers are unique structural molecules that can release all of their tail units, through a domino-like chain fragmentation, which is initiated by a single cleavage at the dendrimer’s core. Incorporation of drug molecules as the tail units and an enzyme substrate as the trigger, can generate a multi-prodrug unit that is activated with […] Read More >
Prof. Shacham- Diamand Yosi
Research Interest Nano-chemical processes for Microelectronics and integration of biological material on chip for acute toxicity detection Nano-chemistry for electronics applications- Physical and electrical characterization of electronic devices for CMOS technologies made by various chemical techniques such as self assembled monolayers and surface catalyzed auto catalytic electrochemical processes. The research involves studying of the […] Read More >
Prof. Shaked Natan Tzvi
Prof. Shaked heads the Biomedical Optical Microscopy, Nanoscopy and Interferometry Research Group, a large experimental group performing a multidisciplinary research involving optical engineering, imaging and sensing in biological systems, optical therapy, and biophysics. Specific interests of research include: biomedical optical microscopy and nanoscopy, optical interferometric systems (including interferometric phase microscopy and optical coherence tomography), optical imaging […] Read More >
Prof. Shalgi Ruth
Our research focuses on Reproductive Physiology in animal models and in humans. The current research directions investigated in the laboratory are: The role of Fyn kinase, member of the Src family kinases, during meiosis and early events of oocyte activation, as well as in cancer cells. Fertility preservation – the signaling pathway leading to apoptosis […] Read More >
Prof. Shomron Noam
Noam has received his Bachelors degree in Biotechnology at Macquarie University in Sydney, Australia; his Masters degree in Gene Therapy at the Hebrew University of Jerusalem; and his graduate studies in Genetics at Tel Aviv University where he worked on regulatory RNA systems. As a Post-Doctorate affiliate at MIT in Cambridge, USA, Noam gained expertise […] Read More >
Dr. Sklan Ella
המטרה ארוכת הטווח שלנו היא זיהוי ואפיון של אינטראקציות של וירוסים עם תאי המארחים שלהם ברמות מרובות. אנו משתמשים בטכניקות מתקדמות של ביולוגיה מולקולרית, וירולוגיה והדמיה. מערכות המודל הנוכחיות שלנו כוללות נגיפי הפטיטיס D (HDV), אבולה ודנגי. זיהום בכל אחד מהנגיפים הללו עלול בסופו של דבר להיות קטלני. וירוסים אלה משפיעים על חייהם של מיליוני […] Read More >
Prof. Socher Eran
Current Research Interests · RFICs at mm-wave and THz frequencies · Short-range ultra-fast wireless links · RF interconnect in deep sub-micron CMOS · Sensing and imaging in IR, THz and mm-wave frequencies · Ultra-fast ADCs for future optical links Other Research Interests · CMOS compatible thermal imaging · MEMS and integrated sensors · CMOS readout circuits Read More >
Prof. Solomon Arieh S.
Research topic: Elucidating the degenerative and regenerative process of optic nerve following trauma, ischemia and disease. The research results will be applicable in same conditions that take place in the brain. Research methods: Immunocytochemistry analysis, Western blot analysis, confocal microscopy evaluation, electrophysiology functional recording, MRI. Projects in the lab include: Evaluation of the therapeutic potential of new […] Read More >
Prof. Solomon Beka
My scientific interest is focused on investigation of biorecognition in general and on the nature of the interactions of antibodies and their corresponding antigens in particular. In my research work I am involved in the elucidation of the mode of action of monoclonal antibodies (mAbs) on the structure and function of their corresponding antigens in […] Read More >
Prof. Stein Reuven
Research topic: Alzheimer’s disease (AD) focusing on microglia and astrocytes; The role of microenvironment (microglia) on brain tumors; Cognitive decline after brain irradiation; Mechanism of cell death and survival. Research methods: Manipulation of gene expression in cell lines; Immunostaining of cell cultures and brain sections, Microscopic imaging (e.g., confocal, STED and two photon), Neuronal, astrocytic and microglial […] Read More >
Prof. Tsarfaty Ilan
Research Interest Nanoparticles based Met-HGF/SF molecular imaging Breast cancer is the most common malignant disease in western women. In the majority of cases the cause of death in cancer patients is not the primary tumors, but complications derived from metastases at distant sites. The met proto-oncogene product (Met – a receptor tyrosine kinase) and its […] Read More >
Prof. Tuller Tamir
Research Interests: computational biology and bioinformatics systems biology developing mathematical and physical models of biological systems (usually intra-cellular process such as gene translation) and biological phenomena developing algorithms and statistical approaches for solving problems in molecular biology theoretical analysis of algorithms in the field analysis of large-scale genomic data Contact: Email: tamirtul@post.tau.ac.il Phone: 03-6405836 Website: […] Read More >
Research topic: Cell based platforms for study, diagnosis, drug screening and therapy of neurodegenerative diseases. Research methods: Isolation and culture of human embryonic/adult stem cells models of diseases; Cell based-assays for High content analysis (HCA) screening of stem cells with and without disease; High throughput screening (HTS) of drugs using liquid handling robot, Drug development applications, Transcriptome […] Read More >
Prof. Weiner Ina
Research topic: Translational models of schizophrenia and depression as tools for understanding their development and prevention Research methods: Brain imaging, brain stimulation, neurodevelopmental manipulations, behavioral manipulations and analysis, systemic and intracerebral pharmacology, molecular biology/ proteomics/drug development (collaborations). Main projects: Delineating the developmental trajectories of schizophrenia-like and depression-like neuroanatomical changes and behavioral abnormalities following early exposure […] Read More >
Dr. Wine Yariv
My fascination with antibody repertoire, along with the lack of technologies for its study, led me to develop a pioneering technology specifically aimed at analyzing antibody repertoire in serum and secretions at health, following disease or vaccine. The approach we use provides us the means to broaden our understanding regarding the development of the adaptive […] Read More >
Prof. Wreschner Daniel H.
Molecular analysis of the human cancer cell with special emphasis on membrane proteins, tumor-associated antigens, ligand-receptor interactions and cell signaling. We work on a breast-cancer associated protein designated MUC1 (CA-15-3) that is a membrane protein participating in cell signaling. Email: danielhw@tauex.tau.ac.il Phone: 03-6407425 Another phone: 03-6409915 Fax: 03-6422046 Office: Britannia-Porter, 203 Read More >
Prof. Yekutieli Daniel
Current Research Interests: · RFICs at mm-wave frequencies and beyond · Short-range ultra-fast wireless links · RF interconnect in deep sub-micron CMOS · 60GHz radio in CMOS · Sensing and imaging in IR, THz and mm-wave frequencies Read More >
Prof. Yovel Yosef
Research topic: Active sensing, sensory perception and cognition from the field through the lab and into the brain. I use the echolocating bat – a “champion” in active sensing to study these behaviors. Research methods: Behavior using highly developed technologies including ultrasonic microphone arrays, mini-cameras and mini-GPS devices. MRI to study brain anatomy and neural correlates of […] Read More >
Prof. Yovel Galit
Research topic: Cognitive and Neural basis of Face and Object recognition. Research methods: Psychophysics, functional MRI, EEG/Event related potentials (ERPs), Transcranial Magnetic Stimulation (TMS), Eye tracking. Simultaneous recording of EEG-fMRI and EEG-TMS Main projects in the lab include: How do face and body processing mechanisms interact to generate an image of a person? What is […] Read More >
Active implants can provide life-giving help to many systems in the body. When made of a biodegradable polymer, the degradation of such implants occurs by hydrolytic cleavage and the end products (carbon dioxide and water) are non-toxic. These implants can remain intact in the body for a predicted period of time – from weeks to […] Read More >
