P32-Specific Antibodies and CAR T Cells for Glioblastoma and P32-Expressing Tumors
This innovative immunotherapy platform leverages p32-specific antibodies to create Chimeric Antigen Receptor (CAR) T cells, specifically targeting p32—a tumor-associated antigen expressed in glioblastomas and other aggressive cancers. The approach combines tumor elimination with antiangiogenic effects, paving the way for enhanced therapeutic outcomes in solid tumors. Unmet Need Glioblastoma, a highly aggressive brain cancer, has limited […] Read More >
Next Generation of the mRNA Therapy: Targeting Cancer Cells Via Boolean Circuits Based on mRNA Molecules
Currently most cancer treatment target proteins that are modified or activated in cancer cells; usually this is done by producing a relevant antibody. The process of finding a new therapy that targets a protein is long and tedious and in addition, in many cancer types there is no therapy at all. Specifically, today there are […] Read More >
Pharmacological Activation of the cAMP Signaling Pathway Enhances the Function of Cord Blood – Hematopoietic Stem Cells
Allogeneic Hematopoietic Stem Cell Transplantation is a curative therapy for many blood disorders, including leukemias and inherited blood diseases. It involves depleting a patient’s diseased bone marrow by cytotoxic therapies and then regenerating a healthy hematopoietic system by transplantation of healthy Hematopoietic Stem Cells (HSCs). UNMET NEED Cord blood is an attractive source for stem […] Read More >
Development Of Improved Immunosuppressant Targeting Calcineurin-NFAT Protein-Protein Interaction Via Novel Peptides
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
Development Of Improved Immunosuppressant Targeting Calcineurin-NFAT Protein-Protein Interaction Via Small Molecule Drugs
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
Influenza A virus infection is one of the most common respiratory tract diseases in humans. It is the cause of typical seasonal flu as well as major human pandemics worldwide. According to the World Health Organization (WHO) in October 2023, around 3 to 5 million severe influenza cases were recorded, leading to 290,000 to 650,000 […] Read More >
Evaluation of Single Strand DNA Damage in Sperm Using a novel Damage Detection Technique
The Damage Detection technique is an innovative approach to assessing Single Strand DNA (ssDNA) damage by utilizing DNA repair enzymes to identify DNA adducts and single-strand breaks. Spermatozoa are characterized by high levels of DNA fragmentation, despite their condensed nuclear DNA packaging. Sublethal DNA damage, such as single strand breaks and adducts, can occur and […] Read More >
Skewed Sex Ratio Technology for Livestock and Pets: Reducing Resource Wastage and Labor in Animal Breeding
Our innovative genetic engineering technology offers a transformative solution for livestock and pet industries by generating offspring with a skewed sex ratio. The technology, proven in mice, is now aimed at practical application in cattle, swine, poultry, and other farm animals, as well as pets. The Problem: Current breeding practices lead to significant waste due […] Read More >
New Formulation for Repurposing of a Drug to Treat Retinitis Pigmentosa
Heterozygous mutations in the gene encoding the RNA splicing factor pre-mRNA processing factor 31 (PRPF31) have been identified as a major cause of autosomal dominant retinitis pigmentosa (RP), a debilitating and currently incurable blinding disease. The severity and progression of RP vary significantly among patients, with some carriers remaining asymptomatic. Intriguingly, asymptomatic mutation carriers exhibit […] Read More >
Automatic Detection of Spinal Pathologies Based on MRI Scans
This study introduces an automated system for detecting spinal pathologies in MRI scans, aiming to enhance efficiency and accuracy in medical diagnostics. By leveraging deep learning, the tool can assist radiologists in identifying and classifying pathological vertebrae, potentially improving diagnostic workflows. Background MRI scans are essential for diagnosing various lumbar spine conditions, including infections, inflammations, […] Read More >
The lab investigates high-level cognition, both at the behavioral and neural level. More specifically, we are interested in the following questions: 1. What is consciousness, how does it come about, and what are its functions? The latter entails two additional questions; first, how deep does unconscious processing run and how it differs from conscious processing. […] Read More >
The Laboratory of Oral-Mucosal Stem Cell Regeneration and Enzymatic Dental Therapeutics
The Laboratory of Oral-Mucosal Stem Cell Regeneration and Enzymatic Dental Therapeutics is charting new frontiers in the realm of regenerative medicine and dental care. Harnessing the potent capabilities of stem cells derived from the oral mucosa, the research endeavors not only target the restoration of oral structures but also broader applications, such as bone regeneration […] Read More >
Biological and Bio-Inspired Molecular Self-Assembly- The Gazit Lab
MOLECULAR SELF-ASSEMBLY AMYLOID FIBRIL FORMATION NANOBIOTECHNOLOGY METABOLITE AMYLOIDS MOLECULAR SELF-ASSEMBLY We study one of the most important problems in contemporary life sciences and medicine: Understanding the molecular basis for the formation of amyloid nanostructures in degenerative disorders, a process underlying the pathophysiology of some of the most devastating health problems world-wide, such as Alzheimer’s disease, […] Read More >
Advances in biomedical science have cured multiple diseases and greatly improved healthspan and lifespan. However, aging is the strongest risk factor for most causes of death in the western world, and thus these advances have resulted in a relatively small increase in maximal lifespan. Without a systematic approach to understand and treat the aging process, […] Read More >
Our research focuses on understanding the impact of exercise training, combined with dietary strategies on physiology and metabolic changes across a range of populations. Specific Research interests/topics: Our primary research interests revolve around comprehending the effects of exercise training and dietary strategies on muscle mass, adipose distribution, metabolism, and performance across diverse populations. We employs […] Read More >
The Lab for Protein Engineering and Drug Discovery
Modulation of protein-protein interactions is a key for a broad range of biotechnological applications. In our lab, we are developing unique approaches from small molecules, peptides, and optimized proteins to inhibit specific interactions. We are utilizing advanced computational, biophysical and cellular biology techniques. Specific Research interests: • Engineering of unique Immune modulators • Engineering of optimized proteins […] Read More >
Sessa Lab- Boosting plant immunity to increase crop yields
The main interest of our laboratory is to study of molecular mechanisms that govern plant immunity and susceptibility to bacterial pathogens. On the plant side, we use molecular biology, functional genomics and proteomics approaches to dissect recognition events and signal transduction pathways that mediate immunity. On the bacterial side, we apply genetic and biochemical strategies […] Read More >
Research in the laboratory focusses on the interfaces of development and cell biology with abiotic stress responses in plants. We study signaling mechanisms that increase plant tolerance to drought and salt stress and increase water use efficiency. We are also interested in signaling mechanisms which regulate secondary cell wall formation in plants and the regulation […] Read More >
We explore and consolidate the novel idea of plant-based sensors, a new approach where the plants are used as sensors and the output is based directly on the plant response. Our biosensor is composed of amalgamated technology, comprising a biological component- the plant itself, and an electrical or optical component- a sensing modality that includes […] Read More >
Our lab strives to understand the mechanisms of chronic inflammation underlying neurologic diseases and translating these laboratory discoveries into new therapies. We take a transdisciplinary approach in this research endeavor combining immunologic, genomic, proteomic and metabolomic approaches to study brain inflammation. We are particularly interested in: Elucidating the immune function of the different glia, mainly […] Read More >
Prof. Assaf Yaniv
Research topic: Measuring in-vivo brain micro-structure and neuroplasticity with magnetic resonance imaging (MRI) in humans and rodents Research methods: Magnetic Resonance Imaging: Diffusion Imaging, Diffusion Tensor Imaging, Tractography; Immuno-histochemistry, Histology. Main projects in the lab include: Investigation and localization of brain regions that undergo plasticity following a cognitive experience or training with MRI Development of MRI frameworks […] Read More >
Prof. Attali Bernard
Reaching an understanding in molecular terms of the mechanisms by which changes in membrane potential regulate cellular events is the main concern of our research. We focus our interest on potassium channels because they play crucial roles in many cellular functions such as shaping cardiac and neuronal action potentials, tuning neuronal firing patterns, synaptic integration […] Read More >
Prof. Avraham Karen B.
Genomic Analysis of Hereditary Hearing Loss Our primary interest is the genetic basis of hereditary hearing loss or deafness. Our group is working towards the identification, characterization and regulation of genes associated with hereditary hearing loss. For gene discovery, we focus on the Israeli Jewish and Palestinian Arab populations in the Middle East. Our studies […] Read More >
Prof. Bacharach Eran
Eran Bacharach is the head of a research laboratory for molecular virology at the Department of Cell Research and Immunology, and teaches courses on microbiology, molecular virology and cell biology, at the Faculty of Life Sciences, where he has been on the faculty since 2000. He received his B.Sc., M.Sc. and Ph.D. degrees from the […] Read More >
Dr. Bar Daniel Zvi
Advances in biomedical science have cured multiple diseases and greatly improved healthspan and lifespan. However, aging is the strongest risk factor for most causes of death in the western world, and thus these advances have resulted in a relatively small increase in maximal lifespan. Without a systematic approach to understand and treat the aging process, […] Read More >
Prof. Barak Segev
Dr. Barak’s research focuses on the psychobiology and neurobiology of alcoholism and drug addiction. In particular, he is interested in the molecular and neuronal mechanisms that underlie learning and memory processes in alcohol addiction. In addition, Dr. Barak is interested in the pathophysiology of schizophrenia, with focus on cognitive impairments in this disorder. See lab […] Read More >
Prof. BARNEA Ofer
Patient specific models: Assessment of fetal cardiovascular development Optimization Propofol administration during anesthesia Optimization of fluid resuscitation Assessment of cerebral blood flow autoregulation Multiscale models of physiological systems 3D fiber based model of the contracting heart Oxygen transfer to tissue Biomedical measurements and instrumentation Optimally controlled fluid administration system Detection of bubbles in blood to […] Read More >
Prof. Barzel Adi
Our lab will focus on gene therapy using viral vectors. We will tackle diseases ranging from cancer to viral infections and diabetes. Devising safe and efficient gene therapies combines challenges in biochemistry and molecular biology with challenges in physiology, immunology, virology and more. We will focus on genome editing- the site specific manipulation of the […] Read More >
Dr. Beck-Barkai Roy
Research Cytoskeleton protein complexes – Interaction between cytoskeleton protein complexes and their effect on the structure and elasticity of the cell. Intrinsically disordered protein – Statistical structural characterization of proteins that do not completely fold into 3d fixed structures in solutions. Nanoscopic complex – characterizing and manipulating nanoscopic complexes by grafted biopolymer. Membrane physics – stabilization of membrane to […] Read More >
Prof. Belkin Michael
Prof. Belkin has been involved in the establishment of many medical start-ups in ophthalmology and other fields. One of his noted contributions was inventing and developing the Ex-PRESS Glaucoma Filtration Device. The ExPRESS, after being sold to global eye care leader Alcon, is now routinely used in glaucoma surgery worldwide. He is now developing his […] Read More >