Life Sciences and Biotechnology

 

69 Results were found on Technologies

11-2021-1544

Anti-Oxidation Agent to be Incorporated Into Cosmetics Leading to More Stable and Longer Shelf-Life Products

Oxidation is the reaction of Oxygen with a wide array of reactants. In cosmetics, product oxidation leads to spoilage of ingredients used in the manufacturing products, the inactivation of oxygen-sensitive enzymes, shortening of product shelf-life, and discolorations of end-product. Self-assembling peptide-based hydrogels are simple hydrogels that can be combined with a wide variety of ingredients […] Read More >

11-2021-1544

Protection of Oxygen-Sensitive-Enzymes by Peptide Hydrogel

Molecular oxygen (O2) is a highly reactive oxidizing agent harmful to many biological and industrial systems. A simple encapsulation in a protective aqueous environment of O2  -sensitive reactions is of need. Self-assembling peptide-based hydrogels are simple hydrogels that can be combined with a wide variety of reagents and are able to encage O2 and significantly limit its […] Read More >

Leading Researchers:
2-2021-1715

Culturing a plurality of cell types on a 3D-printed microfluidic chip

Organ-on-a-Chip platforms provide rich opportunities to observe interactions between different cell types under in vivo-like conditions. Co-culturing and the application of flow and other mechanical forces organoids, mimic 3D tissue structure and greatly enrich the data collection from such platforms.‘Insert-chip’ is a cost-efficient, reusable, modular organ-on-a-chip platform that allows co-culturing and overcome scientific data collection […] Read More >

Leading Researchers:
2-2020-1440

Novel Anti-Tumor Response treatment targeting ErbB receptors and Nucleolin interactions

ErbBs subfamily receptors are mediators of cell growth signals. They have long been associated with a wide variety of lung, ovarian, colon, breast, prostate, and other carcinomas. Nucleolin is a major nucleolar protein of growing eukaryotic cells and is present on the cell surface of a range of cancers. Recently, a robust oncogenic interaction between […] Read More >

Leading Researchers:
6-2019-1223

Ulva sp. (Chlorophyta) intensive cultivation in a coastal area of the Eastern Mediterranean Sea.

The Need  Global population growth together with enhanced quality of life, in the era of climate change, is expected to cause doubling of the world’s food and energy demand by 2050. Furthermore, there is a strong interest in the replacement of fossil-based industries towards economical, environmentally friendly, and sustainable resource, for food, chemical and energy […] Read More >

Leading Researchers:
2-2020-1376

New Chemiluminescent Protease Probe for Rapid, Sensitive, and Inexpensive Detection of Live Mycobacterium tuberculosis

Tuberculosis (TB) is a top-ten cause of death worldwide. Successful treatment is often limited by insufficient diagnostic capabilities, especially at the point of care in low-resource settings. The ideal diagnostic must be fast, be cheap, and require minimal clinical resources while providing high sensitivity, selectivity, and the ability to differentiate live from dead bacteria.OUR SOLUTION• We […] Read More >

Leading Researchers:
5-2021-1520

Antibody-Based Biosensor Diagnostic tool for Pathogenic Bacteria Detection

UNMET NEED• Antibiotic resistance crisis is driven by extensive and inappropriate usage of antibiotics and is predicted to result in an annual death toll of 10 million people by 2050. The ability to provide a rapid and accurate surveillance and diagnosis of multiple-drug resistant (MDR) bacteria is pivotal to the efficiency of controlling the growing crisis. […] Read More >

Leading Researchers:
5-2020-1362

An early stage screening tool for distinguishing pregnant women having an increased risk of developing preeclampsia

Preeclampsia is one of the most dangerous pregnancy complications occurs in the second or third trimester, affecting 3–8% of pregnancies; it is the leading cause of maternal and perinatal mortality and morbidity. Preeclampsia cannot reliably be predicted as no tests available in early pregnancy.OUR INNOVATIONThe invention is based in part on the finding that plasma […] Read More >

Leading Researchers:
10-2012-314

Repurposing of Antibiotics for treating APC (Adenomatous Polyposis Coli) Related Colorectal Cancer

Restoration of Adenomatous Polyposis Coli (APC) gene expression by means of antibiotic erythromycin for the treatment of Familial Adenomatous Polyposis. The Technology: Treatment for APC by   conventional antibiotics to regulate adenoma growth and delay the need for preventive surgery in Familial Adenomatous Polyposis (FAP) patients. The Need:  FAP is a high penetrance devastating syndrome manifested […] Read More >

Leading Researchers:
10-2007-109

Macrolid Induced Correction of Premature Stop Codons: A novel Treatment for Colorectal Cancer

Restoration of premature termination codons (PTCs) caused by nonsense mutations for the treatment   of Familial Adenomatous Polyposis. The Need Familial Adenomatous Polyposis (FAP) is a high penetrance devastating syndrome manifested by dozens to thousands of colonic adenomas. FAP patients require tight supervision and eventually undergo surgery, to prevent inevitable development of colorectal cancer (CRC) by […] Read More >

Leading Researchers:
12-2013-622

Laboratory of endoplasmic reticulum (ER) quality control and protein misfolding diseases

Lab DescriptionMain areas of interest are in the mechanisms of protein folding and trafficking in the early secretory pathway of mammalian cells and the development of ER stress upon their malfunction, particularly in neurodegenerative diseases.  Specific research topics are:• Protein misfolding diseases, including neurodegenerative diseases.• ER stress.• Mechanisms of endoplasmic reticulum (ER) protein folding and quality control.• Sugar chain […] Read More >

Leading Researchers:
12-2013-444

The lab for active sensing and sensory perception

Lab DescriptionOur lab focuses on animal Bio-sonar and other sensory systems. We are interested in how the animal’s sensory system is adapted to the environment, how does the brain encode this information and how can these adaptations be applied. We are experts in bio-acoustics. Main Research TopicsBat bio-sonar, bio acoustics, animal communication, animal cognition, the […] Read More >

Leading Researchers:
12-2013-434

The Cohen Rosenthal Diabetic Hypertensive Rat (CRDH) model

The construction of the Cohen Rosenthal Diabetic Hypertensive Rat (CRDH) model was initiated nearly a decade ago by cross-breeding between the Cohen Diabetic rat (CDR) and the SHR. The CDR is a rodent model that expresses the following phenotypes: when fed regular diet, it is non-diabetic; when fed a diabetogenic diet, it invariably develops diabetes […] Read More >

Leading Researchers:
12-2013-415

Laboratory of Immunological and Inflammatory Modules in Malignancy

Research focus Prof. Ben-Baruch is an immunologist who investigates the roles of immune and inflammatory elements in physiological and pathological conditions, with major emphasis on malignancy. The studies in her laboratory determine the complex regulatory networks established between chemokines and cytokines of the tumor microenvironment, intrinsic oncogenic modifications in tumor cells, and stroma cells. The […] Read More >

Leading Researchers:
12-2012-360

Histopathological evaluation of hard tissues and biomedical devices in their tissue implantation surrounding, using a Plastic Embedding Technique

Plastic embedding is a method that allows histological examination of soft and hard tissues (e.g., blood vessels, bones, teeth, joints and skin tissue), containing solid medical devices of different sizes and made of various materials. In addition to the standard histological observations, such as necrosis, inflammation and fibrosis, this technique provides reliable data on size […] Read More >

Leading Researchers:
12-2016-1018

Lab of Signal transduction, Neurodegeneration and Autophagy

Research focus ErbB receptors interactions and functions Regulation of Autophagy Neurodegeneration Projects include: The crosstalk between ErbB receprots and nucleolin in cancer development Beclin 1 mediated autophagy Autophagy in neurodegenerative diseases Autophagy in cancer Potential services Laboratory services: To monitor autophagy Signal transduction assays Anti-cancer drugs examination Cell proliferation, death and migration examination   Potential […] Read More >

Leading Researchers:
12-2016-982

Molecular Neurodegeneration

The goal of the lab is to elucidate molecular mechanisms of motor neuron survival and proper function using ALS disease as a model. In our current efforts we are using cutting edge in vitro and in vivo technologies studying molecular mechanisms of: 1.    Molecular communication of trophic factors (such as BDNF or GDNF) between […] Read More >

Leading Researchers:
12-2016-972

Cancer Angiogenesis and Nanomedicine

Selective therapy remains a key issue for successful treatment in cancer therapy. Prolonged administration of effective concentrations of chemotherapeutic or anti-angiogenic agents is usually not possible because of dose-limiting systemic toxicities involving non-malignant tissues. Therefore, a constant effort has been the development of new drug delivery systems that mediate drug release selectively at the tumor […] Read More >

Leading Researchers:
12-2016-971

Laboratory of Glycoimmunology

We combine glycobiology, immunology, biotechnology and cancer research, and use cutting edge technologies within these disciplines, including glycan microarray and glyco-nanotechnology. Current interests include: Immunological mechanisms of unique anti-carbohydrate antibodies. Glycoimmunology in xenotransplantation, as members of the EU TRANSLINK consortium. Anti-carbohydrate antibodies in mucosal secretions and sera. Development novel diagnostics and therapeutics to chronic inflammation […] Read More >

Leading Researchers:
12-2016-970

Zebra fish model

The circadian clock system: from molecular mechanisms to physiology and behavior    Research methods: Molecular genetics in whole animal, the zebrafsh; Transgenesis and gene manipulation; Behavior (mainly locomotor activity rhythms).   Available Research Services Analysis of circadian rhythms of locomotor activity of wild type zebrafish and of mutants with advanced (short) or delayed (long) circadian […] Read More >

Prof. Ebenstein Yuval

Our lab specializes in many areas of optical imaging and spectroscopy with emphasis on single molecule detection and development of imaging based techniques. Our research is focused on the application of novel imaging and optical detection approaches to genomic studies and biomarker detection. We are developing new spectroscopy and microscopy methodologies that combine advanced optics […] Read More >

Prof. Efrat Shimon

Our research focuses on the development of a cell replacement therapy for diabetes, in which the insulin-producing pancreatic beta cells are destroyed or malfunction. Our approaches for generation of an abundant source of cells for transplantation include expansion and differentiation in tissue culture of beta cells from human organ donors, as well as differentiation of […] Read More >

Prof. Ehrlich Marcelo

I am interested on the dynamic aspects of the cell’s trafficking machinery, with a special focus on endocytic dynamics. More specifically, our study centers on the mechanisms by which the cell modulates vesicular traffic by altering: The rate of formation of vesicular carriers, such as clathrin coated vesicles. The spatio-temporal distribution of the process of […] Read More >

Prof. Einav Shmuel

Research Interests: Flow in biological systems; cardiac blood flow; Blood flow in obstructed arteries and in bypasses; blood flow through artificial heart valves; Cardiac-assist devices; magnetic resonance imaging of blood flow Read More >

Prof. Eldar- Finkelman Hagit

My overall research is focused on elucidating the molecular and biochemical regulation of the protein kinase, glycogen synthase kinase-3 (GSK-3), and revealing its contribution to pathological disorders. GSK-3 is emerging as a prominent drug discovery target in neurodegenerative disorders including ALS, Parkinson’s, Huntington’s and Alzheimer’s disease. In a recent work we identified lysosomes as novel […] Read More >

Dr. Elkabetz Yechiel

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Prof. Elroy-Stein Orna

Prof. Orna Elroy-Stein is a Full professor in the Department of Cell Research and Immunology at the Faculty of Life Sciences, Tel Aviv University, and a member of the Sagol School of Neuroscience. She received her B.Sc. and M.Sc. from the Technion, her Ph.D. on Human Molecular Genetics at the Weizmann Institute of Science, Israel, and […] Read More >

Prof. Erez Neta

Associate Professor, Chair of the Department of Pathology, Faculty of Medicine, Tel Aviv University Research Cancer Related Inflammation in Tumor Progression and Metastasis The main goal of our laboratory is to uncover stromal pathways that contribute to tumorigenesis and metastasis. Extensive research has led to the understanding that tumors are more than just cancer cells: […] Read More >

Prof. Fishelson Zvi

Research Molecular Analysis of Cancer Immunoresistance The long-term goal of our research is to develop a novel treatment for immune resistant cancers. Our research includes characterization of the mechanism of complement-dependent cytotoxicity and of the basis for elevated resistance of cancer cells to cell death, and design of novel reagents that sensitize cancer cells to […] Read More >

Prof. Fleminger Gideon

Our laboratory is engaged in the study of structure-function relationships in proteins and peptides involved in biorecognition processes. In these studies we apply sophisticated separation methods for the purification with advanced methods of structural analysis of these materials.  Specific research activities include: Structure-function relationships in Ca+2-binding proteins:  We are engaged in the study of the […] Read More >

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