Metabolic

 

6 Results were found on Technologies

Leading Researchers:
2-2011-142

IAPP Oligomers as a Target for Type 2 Diabetes Novel Immunotherapy

TechnologyStabilized human IAPP (hIAPP) oligomers were used for the development of active immunization of type 2 diabetes. This promising novel approach for the treatment of type 2 diabetes is doable due to the establishment of a new protocol for the formation of stable islet amyloid polypeptide (IAPP) amyloidal soluble oligomers in vitro, leading to isolation […] Read More >

Leading Researchers:
5-2011-249

METHODS AND KITS FOR DETERMINING PREDISPOSITION TO DEVELOP KIDNEY DISEASES

Many rare kidney disorders exhibit a monogenic, Mendelian pattern of inheritance. Population-based genetic studies have identified many genetic variants associated with an increased risk of developing common kidney diseases. Strongly associated variants have potential clinical uses as predictive markers and may advance our understanding of disease pathogenesis. These principles are elegantly illustrated by a region […] Read More >

Leading Researchers:
5-2007-42

Non-invasive Diagnostics for Liver Diseases

The Technology The human asialoglycoprotein receptor (ASGPR) is expressed on the sinusoidal membrane of hepatocytes and serves in the clearance of asialoglycoproteins from the plasma. A soluble form of the ASGPR, termed sH2a, is formed by cleavage in the endoplasmic reticulum of its precursor. In healthy humans, sH2a is secreted to the serum at surprisingly […] Read More >

Leading Researchers:
2-2022-1756

Homocysteine fibrillar assemblies display crosstalk with Alzheimer’s disease amyloid polypeptide

High levels of homocysteine (Hcy) are reported as a risk factor for Alzheimer’s disease (AD). Correspondingly, inborn hyperhomocysteinemia is associated with an increased predisposition to the development of dementia in later stages of life. Furthermore, despite the apparent association between protein aggregation and AD, attempts to develop a therapy that targets explicitly this process have […] Read More >

Leading Researchers:
2023-0185

Development of Improved Peptide Inhibitors of the HIF/PHD Interaction – Anemia and HIF – Related Diseases

Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >

Leading Researchers:
2023-0072

Novel Immuno-Metabolism Pathways to Combat Obesity and Insulin Resistance

Nutritional unbalance develops the obesity led to diabetes and accompanied by insulin resistance is being the epidemics of the 21st century. Inflammation of adipose tissue serves one notable pathway that is driving the development of dysfunctional metabolic state, leading to hyperglycaemia and other pathophysiology complications. Within the adipose tissue, a pivotal role in modulating interactions […] Read More >

Prof. Efrat Shimon

Our research focuses on the development of a cell replacement therapy for diabetes, in which the insulin-producing pancreatic beta cells are destroyed or malfunction. Our approaches for generation of an abundant source of cells for transplantation include expansion and differentiation in tissue culture of beta cells from human organ donors, as well as differentiation of […] Read More >

Prof. Gazit Ehud

The central dogma in the study of protein folding suggests that the thermodynamically-favorable state of proteins under physiological conditions is their folded one. However, there are number of cases in which the favorable states of proteins are rather unfolded, partially folded (e.g., “molten globular”), or misfolded (e.g., nonspecific aggregates or amyloid fibrils). These observations lead […] Read More >

Prof. Gophna Uri

Research topics: Microbial ecology, The human microbiome in IBD, Selfish genetic elements, Microbial defense systems, Systems biology, Halophilic archaea Research methods: Deep sequencing/massively parallel sequencing, microbiology, gene cloning, quantitative RT-PCR, immunofluorescence, Metagenomics , bioinformatics. Main projects in the lab include: > Microorganisms as biomarkers, and mediators of inflammation in IBD > Evolutionary roles of CRISPR-Cas […] Read More >

Prof. LEDERKREMER Gerardo Zelmar

Research Prof. Lederkremer’s lab has been interested in the mechanisms of protein folding and trafficking in the early secretory pathway of mammalian cells. He has focused especially on mechanisms of ER protein quality control and on recognition and delivery of misfolded proteins from the ER to the cytosolic proteasomes for ERAD. These processes are intimately […] Read More >

Dr. Leikin-Frenkel Alicia

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Prof. Margalit Rimona

Research Interests 1. Micro- and nano-particulate drug delivery technologies for topical, regional and systemic applications:  Our efforts in the drug delivery arena focus on two drug delivery technologies, one veteran and one novel, that are inventions of our group. These technologies each yield, micro and nano sized particles that are composed of biomaterials with particular […] Read More >

Prof. Pitaru Sandu

Prof. Pitaru is an expert in bone, connective tissue and periodontal research, and one of the two inventors of ColBar LifeScience Ltd.’s technology. Read More >

Prof. Rosset Saharon

Statistical Genetics, Statistical Learning theory and applications and Data Mining. Read More >

Prof. Yovel Galit

Research topic: Cognitive and Neural basis of Face and Object recognition. Research methods: Psychophysics, functional MRI, EEG/Event related potentials (ERPs), Transcranial Magnetic Stimulation (TMS), Eye tracking. Simultaneous recording of EEG-fMRI and EEG-TMS Main projects in the lab include: How do face and body processing mechanisms interact to generate an image of a person? What is […] Read More >

Leading Researchers:

Biological and Bio-Inspired Molecular Self-Assembly- The Gazit Lab

MOLECULAR SELF-ASSEMBLY AMYLOID FIBRIL FORMATION NANOBIOTECHNOLOGY METABOLITE AMYLOIDS MOLECULAR SELF-ASSEMBLY We study one of the most important problems in contemporary life sciences and medicine: Understanding the molecular basis for the formation of amyloid nanostructures in degenerative disorders, a process underlying the pathophysiology of some of the most devastating health problems world-wide, such as Alzheimer’s disease, […] Read More >

Leading Researchers:
12-2015-949

The Strauss Computational Neuroimaging Center

Prof. Galit Yovel is the Head of the SCAN@TAU Center   SCAN@TAU Center The Strauss Computational Neuroimaging Center George S. Wise Faculty of Life Sciences  https://mri.tau.ac.il/about   The center’s services SCAN@TAU center is a new MRI multidisciplinary research center at Tel Aviv University that offers cutting edge MR technologies and innovative, high-resolution imaging methods. The […] Read More >

Leading Researchers:
12-2011-213

Bacterial Isolates Identification and Gene Sequencing

Webpage: https://www.tau.ac.il/lifesci/departments/biotech/members/gophna/gophna.html   Scientist Contact:Uri Gophna Ph.D.Senior lecturer,Deparment of Molecular Microbiology and BiotechnologyGeorge S. Wise Faculty of Life SciencesTel. +972-3-6409988Fax +972-3-6409407email: urigo@tauex.tau.ac.il   Read More >

Leading Researchers:

Bert Strassburger Lipid Center, Sheba,Tel Hashomer

Fatty Acid Metabolism and Desaturase enzymes, Cholesterol Metabolism and involved enzymes, Membrane composition and liposomes. The lab focuses on techniques for Lipid analysis, like total lipid quantification and analysis of lipid species like fatty acids, triglycerides, phospholipids,etc. using chromatography systems such as HPLC, GC and TLC.Services offered: Identification and quantification of total lipids and specific […] Read More >

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