2 Results were found on Technologies
Sub Category Name
Development of Alzheimer Disease therapy based on counteracting the pathological effects of ApoE4
Alzheimer’s disease (AD) is the most common cause of dementia and is the outcome of progressive brain cells death. Due to the disorder’s heterogeneity and in view of the variety of pathological mechanisms inducing the disease we have undertaken an innovative – science based (Animal model) approach, which is presented here. Our unique approach […] Read More >
Homocysteine fibrillar assemblies display crosstalk with Alzheimer’s disease amyloid polypeptide
High levels of homocysteine (Hcy) are reported as a risk factor for Alzheimer’s disease (AD). Correspondingly, inborn hyperhomocysteinemia is associated with an increased predisposition to the development of dementia in later stages of life. Furthermore, despite the apparent association between protein aggregation and AD, attempts to develop a therapy that targets explicitly this process have […] Read More >
The lab for Molecular Biology of Aging
Advances in biomedical science have cured multiple diseases and greatly improved healthspan and lifespan. However, aging is the strongest risk factor for most causes of death in the western world, and thus these advances have resulted in a relatively small increase in maximal lifespan. Without a systematic approach to understand and treat the aging process, […] Read More >
The Strauss Computational Neuroimaging Center
Prof. Galit Yovel is the Head of the SCAN@TAU Center SCAN@TAU Center The Strauss Computational Neuroimaging Center George S. Wise Faculty of Life Sciences https://mri.tau.ac.il/about The center’s services SCAN@TAU center is a new MRI multidisciplinary research center at Tel Aviv University that offers cutting edge MR technologies and innovative, high-resolution imaging methods. The […] Read More >
laboratory of neuronal and cardiac ion channels
Lab Description Using the powerful combination of molecular biology, biophysics, biochemistry and electrophysiology. our research aims at elucidating the structural, biophysical and physiological attributes of normal and diseased ion channels in brain and heart and whose mutations in human lead to major neurological and cardiovascular disorders like epilepsy, autism, atrial or ventricular fibrillation. Main […] Read More >
Animal models of Addiction and Psychopathologies
Our main focus is on the psychological and neurobiological mechanisms that underlie psychiatric disorders, and in particular addiction We are using rodent models of addiction, anxiety, learning and memory. We focus on behavioral models relevant to different stages of addiction (craving, drug reward, intoxication, sensitization, tolerance, excessive alcohol consumption, withdrawal symptoms, relapse). We are looking […] Read More >
MULTI SENSOR – Multi Modal Recording System for Behavioral Tracking
It is clear today that brain activity of a restrained (or sedated) animal is completely different from that of a freely behaving animal.That is why neuroscientists are seeking to find ways to study animals freely behaving on their natural grounds.TAU’s interdisciplinary research has led to the development of the MULTI SENSOR – Multi Modal Recording […] Read More >
Laboratory of endoplasmic reticulum (ER) quality control and protein misfolding diseases
Lab DescriptionMain areas of interest are in the mechanisms of protein folding and trafficking in the early secretory pathway of mammalian cells and the development of ER stress upon their malfunction, particularly in neurodegenerative diseases. Specific research topics are:• Protein misfolding diseases, including neurodegenerative diseases.• ER stress.• Mechanisms of endoplasmic reticulum (ER) protein folding and quality control.• Sugar chain […] Read More >
Lab of Signal transduction, Neurodegeneration and Autophagy
Research focus ErbB receptors interactions and functions Regulation of Autophagy Neurodegeneration Projects include: The crosstalk between ErbB receprots and nucleolin in cancer development Beclin 1 mediated autophagy Autophagy in neurodegenerative diseases Autophagy in cancer Potential services Laboratory services: To monitor autophagy Signal transduction assays Anti-cancer drugs examination Cell proliferation, death and migration examination Potential […] Read More >
Molecular Neurodegeneration
The goal of the lab is to elucidate molecular mechanisms of motor neuron survival and proper function using ALS disease as a model. In our current efforts we are using cutting edge in vitro and in vivo technologies studying molecular mechanisms of: 1. Molecular communication of trophic factors (such as BDNF or GDNF) between […] Read More >
State-of-the-art X-ray Scattering Systems
Laboratory of Experimental BiophysicsSchool of Physics and Astronomy, Faculty of Exact ScienceThe Center for NanoScience and NanoTechnology Services:Small Angle X-ray Scattering (SAXS), Wide Angle X-ray Scattering (WAXS), Grazing Incident Small Angle X-ray Scatter (GISAXS) X-ray scattering provide structural information (shape and size) in non-destructive and stain free conditions. Small angle scattering is an ideal characterization […] Read More >
Drug Screening Animal Model for Anti-compulsive Activity
We have developed the signal attenuation rat model of obsessive-compulsive disorder (OCD). This model is based on the theoretical proposition that compulsive behaviors result from a deficit in the feedback, which is associated with the performance of normal goal-directed responses. In our model, the goal-directed behavior is lever-pressing for food. The feedback associated with making […] Read More >
Behavioral Animal Models
Laboratory of Biological Psychiatry & Behavioral research- Felsenstein Institute Main Research Topics Cognition, Memory, Social behavior, Motility. Disease: Schizophrenia, Anxiety, Neuropathy pain and Depression Drug Development: Schizophrenia, Depression, Cognition, Pain . Lab facilities The lab is well equipped with the required instruments for molecular and cellular research. At the institute, we have a modern animal room […] Read More >
Brain Injury Animal Models
Blast Brain Injury: a combat zone-like mouse model. From the experimental lab to the war against terror and back to the lab. Improvised explosive devices (IEDs) are one of the main causes for casualties among civilians and military personnel in the present war against terror. IEDs induce various degrees of cognitive, emotional and behavioral disturbances […] Read More >
Animal Models for CNS Disorders and Screening Method for Diabetes
In vitro and in vivo animal models for stroke, Alzheimer’s disease (AD), and multiple sclerosis (MS). Rapid screening method for selecting candidates with specific insulin-degrading enzyme inhibitor activity in Types I and II Diabetes. https://www.tau.ac.il/lifesci/departments/neuro/members/frenkel/frenkel.html Read More >
Animal Eye Models
Animal eye models for evaluation of systemic and topical use of new medications, devices and delivery systems. The models include external eye, intraocular, orbital, and optic nerve applications. Webpages:https://www.sheba.co.il/Institutes/Eye_Institute/Eye_Clinics/78.htmhttps://www.tau.ac.il/medicine/ophthalmology/ophth_con.html CONTACT Department of Opthalmology Faculty of MedicineTel Aviv UniversityRamat Aviv 69978, IsraelFax: 972-3-6405354 Head of the Department:Prof. Arieh S Solomon, MD,PhDEmail: asolomon@post.tau.ac.ilPhone: 972-3-5350702Fax: […] Read More >
Neurodevelopmental, Gestational, Lactational and Maternal Immune Stimulation Animal Model for Schizophrenia
Fields of InterestPharmacology of schizophrenia, animal models of psychopathology, neurodevelopmental model of schizophrenia. Prof. Weiner’s lab has launched and developed the latent inhibition model of schizophrenia which mimics loss of normal attentional control in this disorder, with a focus on the pharmacology of latent inhibition as a basis for the search for novel drugs. In […] Read More >
Prof. Attali Bernard
Reaching an understanding in molecular terms of the mechanisms by which changes in membrane potential regulate cellular events is the main concern of our research. We focus our interest on potassium channels because they play crucial roles in many cellular functions such as shaping cardiac and neuronal action potentials, tuning neuronal firing patterns, synaptic integration […] Read More >
Prof. Avraham Karen B.
Genomic Analysis of Hereditary Hearing Loss Our primary interest is the genetic basis of hereditary hearing loss or deafness. Our group is working towards the identification, characterization and regulation of genes associated with hereditary hearing loss. For gene discovery, we focus on the Israeli Jewish and Palestinian Arab populations in the Middle East. Our studies […] Read More >
Prof. Barak Segev
Dr. Barak’s research focuses on the psychobiology and neurobiology of alcoholism and drug addiction. In particular, he is interested in the molecular and neuronal mechanisms that underlie learning and memory processes in alcohol addiction. In addition, Dr. Barak is interested in the pathophysiology of schizophrenia, with focus on cognitive impairments in this disorder. See lab […] Read More >
Dr. Beck-Barkai Roy
Research Cytoskeleton protein complexes – Interaction between cytoskeleton protein complexes and their effect on the structure and elasticity of the cell. Intrinsically disordered protein – Statistical structural characterization of proteins that do not completely fold into 3d fixed structures in solutions. Nanoscopic complex – characterizing and manipulating nanoscopic complexes by grafted biopolymer. Membrane physics – stabilization of membrane to […] Read More >
Prof. Fishelson Zvi
Research Molecular Analysis of Cancer Immunoresistance The long-term goal of our research is to develop a novel treatment for immune resistant cancers. Our research includes characterization of the mechanism of complement-dependent cytotoxicity and of the basis for elevated resistance of cancer cells to cell death, and design of novel reagents that sensitize cancer cells to […] Read More >
Prof. Frenkel Dan
Research topic: The research in our laboratory is focused on the investigation of glial cell and to clarify their role in neurological diseases. We suggest that targeting glia activation in different pathological scenarios may allow us to define common pathways to further understand the role of glia in neuroprotection . We are using three models: 1) […] Read More >
Dr. Gil-Ad Irit
Dr. Gothilf Yoav
Research Activity The Circadian Clock system All organisms demonstrate a wide variety of behavioral and physiological daily rhythms that are driven by an evolutionary conserved endogenous circadian clock mechanism. Maintenance of circadian rhythms is crucial for the physical and mental wellbeing, and disruption of the rhythms increases susceptibility to diseases and psychiatric disorders. Utilizing the […] Read More >
Prof. LEDERKREMER Gerardo Zelmar
Research Prof. Lederkremer’s lab has been interested in the mechanisms of protein folding and trafficking in the early secretory pathway of mammalian cells. He has focused especially on mechanisms of ER protein quality control and on recognition and delivery of misfolded proteins from the ER to the cytosolic proteasomes for ERAD. These processes are intimately […] Read More >
Prof. Michaelson Daniel
The research in the Michaelson laboratory is directed at unraveling the basic cellular and molecular mechanisms underlying neurodegenration in Alzheimer’s disease and at the development of novel therapeutic approaches to counteract them. The research focuses on apolipoprotein E4 (apoE4), the most prevalent genetic risk factor of the disease ,and on it’s interaction with other risk […] Read More >
Dr. Moran Anan
The general aim of the lab is to study how sensory information is coded and processed in the brain to guide behavior, and how learning through experience is incorporated into this process. Specifically, my lab studies how taste information is processed by a complex network of interconnected nuclei (including the amygdala, taste cortex and pre-frontal […] Read More >
Prof. Offen Daniel
Research topic: Neurodegenerative diseases, etiology and new treatments. Research methods: Stem cells, Gene therapy, peptides, transgenic mice, animal models of Neurodegenerative diseases Main projects in the lab include: Induction of neurogenesis and transplantation of various adult stem cells in animal models of neurodegenerative diseases. Development of new therapies, small molecules, peptides and genes, for neurological […] Read More >
Prof. Perlson Eran
Research Interest Nanomotors and microfluidic platforms reveal neurodegeneration mechanisms Neuron cell death and synapse disruption seen in neurodegenerative diseases like ALS. It is a non-cell-autonomous process and involve a multi system progression. Neurons are highly polarized cells with very long axons. In order to maintain healthy and function properly the neurons depends on accurate and efficient long […] Read More >
Prof. Pick Chaim G.
Professor, Department of Anatomy & Anthropology, Faculty of Medicine Director, the Sylvan Adams Sports Institute Research Brain Injuries: Cognitive, Behavioral and Cellular Outcome My group has a long history in Traumatic Brain Injury research, not only in characterizing behavioral and biochemical sequelae of blunt head trauma, but also in developing preclinical models of mTBI of […] Read More >
Prof. pinkas-Kramarski Ronit
Research topic: Study the involvement of Autophagy in neurodegenerative diseases. Research methods: Cell biology, Biochemistry, Molecular Biology, microscopy, Immunohistochemistry. Projects in the lab include: The role of autophagy in nerve injury. Study the involvement of autophagy in Alzheimer’s. The molecular mechanism of autophagy regulation. Read More >
Prof. Savion Naphtali
Novel Antioxidant for Treatment of Age-related Degenerative Diseases We are studying the potential of S-allylmercapto-N-acetylcysteine (ASSNAC) a newly developed derivative of allicin (the active component in garlic) to serve as a treatment for oxidative stress associated degenerative diseases. The research involves cell biology tools and animal models. The following specific subjects are studied: Demonstrating the […] Read More >
Prof. Shomron Noam
Noam has received his Bachelors degree in Biotechnology at Macquarie University in Sydney, Australia; his Masters degree in Gene Therapy at the Hebrew University of Jerusalem; and his graduate studies in Genetics at Tel Aviv University where he worked on regulatory RNA systems. As a Post-Doctorate affiliate at MIT in Cambridge, USA, Noam gained expertise […] Read More >
Prof. Solomon Arieh S.
Research topic: Elucidating the degenerative and regenerative process of optic nerve following trauma, ischemia and disease. The research results will be applicable in same conditions that take place in the brain. Research methods: Immunocytochemistry analysis, Western blot analysis, confocal microscopy evaluation, electrophysiology functional recording, MRI. Projects in the lab include: Evaluation of the therapeutic potential of new […] Read More >
Prof. Weiner Ina
Research topic: Translational models of schizophrenia and depression as tools for understanding their development and prevention Research methods: Brain imaging, brain stimulation, neurodevelopmental manipulations, behavioral manipulations and analysis, systemic and intracerebral pharmacology, molecular biology/ proteomics/drug development (collaborations). Main projects: Delineating the developmental trajectories of schizophrenia-like and depression-like neuroanatomical changes and behavioral abnormalities following early exposure […] Read More >
Prof. Yovel Yosef
Research topic: Active sensing, sensory perception and cognition from the field through the lab and into the brain. I use the echolocating bat – a “champion” in active sensing to study these behaviors. Research methods: Behavior using highly developed technologies including ultrasonic microphone arrays, mini-cameras and mini-GPS devices. MRI to study brain anatomy and neural correlates of […] Read More >
Prof. Yovel Galit
Research topic: Cognitive and Neural basis of Face and Object recognition. Research methods: Psychophysics, functional MRI, EEG/Event related potentials (ERPs), Transcranial Magnetic Stimulation (TMS), Eye tracking. Simultaneous recording of EEG-fMRI and EEG-TMS Main projects in the lab include: How do face and body processing mechanisms interact to generate an image of a person? What is […] Read More >
