Virtual Robot Facilitator for Small Group Discussions in an Online Environment
In the post-COVID era, many activities has transferred to a collaborative online environment. Both in the education system as well as the workplace, many classes and meetings are held in videoconferencing of small groups. These have been repeatedly shown to be the most effective mode of operation. The problemOnline meetings of small groups tend to […] Read More >
Mapping Transverse Relaxation in Preclinical MRI Scanners
UNMET NEEDAccurate quantitative magnetic resonance imaging (qMRI) is gradually becoming indispensable in clinical diagnostics and research. It’s application on preclinical MRI scanners, however, is hampered by the use of strong imaging gradients, which act to increase the effects of molecular diffusion, leading to bias of the measured signals. This inherent bias makes qMRI techniques irreproducible […] Read More >
Amyotrophic Lateral Sclerosis (ALS) is a devastating and fatal neurodegenerative disease affecting motor neurons, leading to progressive paralysis. With a lifetime risk of 1:400 and no effective treatment available, there is an urgent need for novel therapeutic strategies to slow disease progression and improve patient outcomes. OUR SOLUTION We have identified miR126-5p as a novel […] Read More >
An Effective Sema3A Antibody as a Therapy for Optic Nerve Neurodegenerative Diseases
Glaucoma and ischemic or neuro-degenerative diseases of the optic nerve lead to vision loss and blindness. These pathologies are associated with progressive apoptosis of the retinal ganglion cells (RGC), a process which involves expression of Semaphorin 3A protein in the axonal guidance pathways. The identified Sema3A antibody provides a potentially innovative therapeutic tool for these […] Read More >
Ultra-low doses of tetrahydrocannabinol (THC) for cognitive deficits
Ultra-low doses of THC for the treatment of cognitive deficits Prof. Sarne has published several studies on neuroprotection induced by ultra-low doses of THC against cognitive damage that results from various insults, including hypoxia, epileptic seizures, neurotoxicity and brain inflammation (see attached two articles). The advantage of using ultra low doses is […] Read More >
Synthetic 9-cis beta Carotene for treatment of retinal degeneration
9-cis β-carotene-rich is an effective treatment for retinal diseases. Its production in algae was a bottleneck of clinical trials. Now there is a new a synthetic method for its production. BACKGROUNDAge related macular degeneration (AMD) and Retinitis pigmentosa (RP) are a leading cause of vision incapacitation and blindness worldwide (>30 million people). In recent clinical […] Read More >
Novel Specific Disease-Modifying PERK Activator for Huntington’s Disease
The need: There is no efficient therapy at present for Huntington’s disease (HD) nor for any other neurodegenerative disease, including Alzheimer’s and Parkinson’s diseases. No disease-modifying approaches exist. • Gene therapy-based clinical trials have failed so far, highlighting the need for other approaches. These include the recent interruption of antisense oligonucleotide clinical trials for HD. Background […] Read More >
High resolution deep tissue imaging of turbid media
TechnologyImaging through turbid media such as occluding body fluids (e.g. blood, urine, CSF) is restricted due to strong scattering. In applications such as intravascular optical imaging applications clearing of the imaging path (the lumen) are done by, e.g., locally stopping blood flow. The technology utilizes guided shaped light for minimally-invasive Angioscopy without the necessity to […] Read More >
A smartphone based psychiatrist-aid system to monitor and prevent recurring illnesses
Lifegraph enables early detection of disease deterioration in mental health patients,using proprietary machine-learning algorithms applied to data collected from thesmartphone sensors.VISIONImproving lives of patients with mental disorders and decreasing the burden of disease on patients,their families and society as a whole.NEED AND MARKET POTENTIALMental disorders are a leading cause for loss of productivity and hospital […] Read More >
Whole Brain Visualization of Distinct Cortical Layers by MRI
The TechnologyAn MRI platform including an imaging protocol and analysis software enabling in-vivo visualization, characterization and measurement of the distinct layers of the human cortex including width in 3D. The imaging protocol utilizes inversion recovery (IR-MRI) pulse sequencing. A set of inversion times, identified and correlated to the different cortical layers provides the sought distinction […] Read More >
Targeting Mitochondrial IGF-1 Receptors as Therapy for Neurodevelopmental Disorders
Neurodevelopmental brain disorders (NDDs) pose an immense burden on both the families of patients and the health and educational systems, without any effective therapies. We propose, based on our novel findings that are supported by recent clinical data, a potential gene therapy strategy that might restore the brain activity of patients to a healthy regime. […] Read More >
Deep Brain Stimulation of Thalamic Nucleus Reuniens as a New Therapeutic Tool to Prevent Neuronal and Cognitive Dysfunctions in Alzheimer’s Disease
We utilize the basic concepts of control theory and an integrative approach which spans brain-state, neural circuit, synaptic and molecular levels to boost cognitive resilience to AD pathology1,2. UNMET NEED There is no efficient, disease-modifying therapy at present for Alzheimer’s disease (AD). Even the most successful, recently FDA approved anti-amyloid drug lecanemab shows a great […] Read More >
iPONT- Israeli Platform for Online Neuropsychological Testing
ObstaclesTwo main obstacles in testing the cognitive status of patients with neurological disorders are: 1. Small and Unrepresentative Samples: The sample size of studies is small and not diverse, frequently with 50 or fewer participants from the same geographic area. 2. Time Required: It can take significant time to undertake a single study, let alone […] Read More >
Development of Alzheimer Disease therapy based on counteracting the pathological effects of ApoE4
Alzheimer’s disease (AD) is the most common cause of dementia and is the outcome of progressive brain cells death. Due to the disorder’s heterogeneity and in view of the variety of pathological mechanisms inducing the disease we have undertaken an innovative – science based (Animal model) approach, which is presented here. Our unique approach […] Read More >
Homocysteine fibrillar assemblies display crosstalk with Alzheimer’s disease amyloid polypeptide
High levels of homocysteine (Hcy) are reported as a risk factor for Alzheimer’s disease (AD). Correspondingly, inborn hyperhomocysteinemia is associated with an increased predisposition to the development of dementia in later stages of life. Furthermore, despite the apparent association between protein aggregation and AD, attempts to develop a therapy that targets explicitly this process have […] Read More >
Pioneering Pre-Clinical Research at the Heart of Innovation
For over 30 years, Tel-Aviv University’s Neufeld Heart Research Institute at Sheba Medical Center has been at the forefront of cardiovascular and other fields of research, combining the academic rigor of a university with the clinical expertise of Israel’s leading medical center. As a strategic partner to industry and researchers, we offer a comprehensive suite […] Read More >
Our lab strives to understand the mechanisms of chronic inflammation underlying neurologic diseases and translating these laboratory discoveries into new therapies. We take a transdisciplinary approach in this research endeavor combining immunologic, genomic, proteomic and metabolomic approaches to study brain inflammation. We are particularly interested in: Elucidating the immune function of the different glia, mainly […] Read More >
Prof. Galit Yovel is the Head of the SCAN@TAU Center SCAN@TAU Center The Strauss Computational Neuroimaging Center George S. Wise Faculty of Life Sciences https://mri.tau.ac.il/about The center’s services SCAN@TAU center is a new MRI multidisciplinary research center at Tel Aviv University that offers cutting edge MR technologies and innovative, high-resolution imaging methods. The […] Read More >
Lab Description Using the powerful combination of molecular biology, biophysics, biochemistry and electrophysiology. our research aims at elucidating the structural, biophysical and physiological attributes of normal and diseased ion channels in brain and heart and whose mutations in human lead to major neurological and cardiovascular disorders like epilepsy, autism, atrial or ventricular fibrillation. Main […] Read More >
Our main focus is on the psychological and neurobiological mechanisms that underlie psychiatric disorders, and in particular addiction We are using rodent models of addiction, anxiety, learning and memory. We focus on behavioral models relevant to different stages of addiction (craving, drug reward, intoxication, sensitization, tolerance, excessive alcohol consumption, withdrawal symptoms, relapse). We are looking […] Read More >
MULTI SENSOR – Multi Modal Recording System for Behavioral Tracking
It is clear today that brain activity of a restrained (or sedated) animal is completely different from that of a freely behaving animal.That is why neuroscientists are seeking to find ways to study animals freely behaving on their natural grounds.TAU’s interdisciplinary research has led to the development of the MULTI SENSOR – Multi Modal Recording […] Read More >
Lab DescriptionOur lab focuses on animal Bio-sonar and other sensory systems. We are interested in how the animal’s sensory system is adapted to the environment, how does the brain encode this information and how can these adaptations be applied. We are experts in bio-acoustics. Main Research TopicsBat bio-sonar, bio acoustics, animal communication, animal cognition, the […] Read More >
Lab of Signal transduction, Neurodegeneration and Autophagy
Research focus ErbB receptors interactions and functions Regulation of Autophagy Neurodegeneration Projects include: The crosstalk between ErbB receprots and nucleolin in cancer development Beclin 1 mediated autophagy Autophagy in neurodegenerative diseases Autophagy in cancer Potential services Laboratory services: To monitor autophagy Signal transduction assays Anti-cancer drugs examination Cell proliferation, death and migration examination Potential […] Read More >
The goal of the lab is to elucidate molecular mechanisms of motor neuron survival and proper function using ALS disease as a model. In our current efforts we are using cutting edge in vitro and in vivo technologies studying molecular mechanisms of: 1. Molecular communication of trophic factors (such as BDNF or GDNF) between […] Read More >
The Facility has an In Cell Analyzer 2000 (INCA 2000, GE healthcare), the first in Israel, which is a high throughput high content image screening analyzer capable of automatically acquiring multiple fluorescence-labeled images from live or fixed cells cultured in multi titter-well plates. We offer the possibility to analyze a wide range of cellular types […] Read More >
Drug Screening Animal Model for Anti-compulsive Activity
We have developed the signal attenuation rat model of obsessive-compulsive disorder (OCD). This model is based on the theoretical proposition that compulsive behaviors result from a deficit in the feedback, which is associated with the performance of normal goal-directed responses. In our model, the goal-directed behavior is lever-pressing for food. The feedback associated with making […] Read More >
Blast Brain Injury: a combat zone-like mouse model. From the experimental lab to the war against terror and back to the lab. Improvised explosive devices (IEDs) are one of the main causes for casualties among civilians and military personnel in the present war against terror. IEDs induce various degrees of cognitive, emotional and behavioral disturbances […] Read More >
Animal Models for CNS Disorders and Screening Method for Diabetes
In vitro and in vivo animal models for stroke, Alzheimer’s disease (AD), and multiple sclerosis (MS). Rapid screening method for selecting candidates with specific insulin-degrading enzyme inhibitor activity in Types I and II Diabetes. https://www.tau.ac.il/lifesci/departments/neuro/members/frenkel/frenkel.html Read More >
Neurodevelopmental, Gestational, Lactational and Maternal Immune Stimulation Animal Model for Schizophrenia
Fields of InterestPharmacology of schizophrenia, animal models of psychopathology, neurodevelopmental model of schizophrenia. Prof. Weiner’s lab has launched and developed the latent inhibition model of schizophrenia which mimics loss of normal attentional control in this disorder, with a focus on the pharmacology of latent inhibition as a basis for the search for novel drugs. In […] Read More >
Prof. Assaf Yaniv
Research topic: Measuring in-vivo brain micro-structure and neuroplasticity with magnetic resonance imaging (MRI) in humans and rodents Research methods: Magnetic Resonance Imaging: Diffusion Imaging, Diffusion Tensor Imaging, Tractography; Immuno-histochemistry, Histology. Main projects in the lab include: Investigation and localization of brain regions that undergo plasticity following a cognitive experience or training with MRI Development of MRI frameworks […] Read More >
Prof. Attali Bernard
Reaching an understanding in molecular terms of the mechanisms by which changes in membrane potential regulate cellular events is the main concern of our research. We focus our interest on potassium channels because they play crucial roles in many cellular functions such as shaping cardiac and neuronal action potentials, tuning neuronal firing patterns, synaptic integration […] Read More >
Prof. Barak Segev
Dr. Barak’s research focuses on the psychobiology and neurobiology of alcoholism and drug addiction. In particular, he is interested in the molecular and neuronal mechanisms that underlie learning and memory processes in alcohol addiction. In addition, Dr. Barak is interested in the pathophysiology of schizophrenia, with focus on cognitive impairments in this disorder. See lab […] Read More >
Dr. Ben-Eliezer Noam
Research in the lab resides on the interface between the development of novel methodologies for non-invasive MRI, and their application for studying tissues’ structure and function in biology and medicine. Our main research objective is to characterize the myeloarchitecture of the central nervous system, in order to gain more insight into the pathophysiology of multiple […] Read More >
Prof. Benhar Itai
Prof. Benhar is an expert and opinion leader in the field of antibody engineering. Over the 25 years of being active in that field, he prepared several phage display libraries from which antibodies against numerous targets were isolated. Prof. Benhar publishes over 100research papers, wrote 10 book chapters and submitted 19 patent applications. Research in Prof. […] Read More >
Prof. Dvir Tal
Microfluidics-based tissue engineering. Recreating stem cell niches, microfluidics bioreactors for tissue engineering. Nanotechnological strategies for engineering thick cardiac tissue. Engineering a 3D neuronal network for spinal cord and brain regeneration. Fabrication of Nanoelectronics/engineered tissue hybrids. Developing smart delivery systems that recruit stem cells to defected organs. Email: tdvir@tauex.tau.ac.il Phone: 03-6406514 Another phone: 03-6408604 Website: https://dvirlab.wixsite.com/dv… Office: […] Read More >
Prof. Eldar- Finkelman Hagit
My overall research is focused on elucidating the molecular and biochemical regulation of the protein kinase, glycogen synthase kinase-3 (GSK-3), and revealing its contribution to pathological disorders. GSK-3 is emerging as a prominent drug discovery target in neurodegenerative disorders including ALS, Parkinson’s, Huntington’s and Alzheimer’s disease. In a recent work we identified lysosomes as novel […] Read More >
Prof. Frenkel Dan
Research topic: The research in our laboratory is focused on the investigation of glial cell and to clarify their role in neurological diseases. We suggest that targeting glia activation in different pathological scenarios may allow us to define common pathways to further understand the role of glia in neuroprotection . We are using three models: 1) […] Read More >
Prof. Gazit Ehud
The central dogma in the study of protein folding suggests that the thermodynamically-favorable state of proteins under physiological conditions is their folded one. However, there are number of cases in which the favorable states of proteins are rather unfolded, partially folded (e.g., “molten globular”), or misfolded (e.g., nonspecific aggregates or amyloid fibrils). These observations lead […] Read More >
Prof. Gordon Goren
Machine learning, Social robots, Curiosity assessment Goren Gordon PhD, PhD MBA. Goren has six academic degrees, a BA, MSc and PhD in Quantum Physics, a BMSc, MBA and another PhD in Neurobiology. He did his postdoc in MIT Media Lab’s Personal Robots Group. Goren is the head of the Curiosity Lab in Tel-Aviv University. He […] Read More >
Prof. Gozes Illana
Our research is characterized by a multi-level approach to the study of brain function, behavior, memory and drug discovery, from molecules to cures. Targeting autism, schizophrenia as well as Alzheimer’s disease and related neurodegeneration and utilizing a multidisciplinary approach, our group investigates different aspects of neuronal plasticity and nerve cell protection, at the molecular, cellular […] Read More >
Prof. Joel Daphna
Prof. Joel studied the involvement of basal ganglia-thalamocortical circuits in normal and abnormal behavior, using mainly animal models of psychopathology. More recently Prof. Joel has expanded her work to research questions related to brain, sex and gender. Ongoing studies attempt to characterize the relations between sex and brain structure and function. Other studies focus on […] Read More >
Prof. LEDERKREMER Gerardo Zelmar
Research Prof. Lederkremer’s lab has been interested in the mechanisms of protein folding and trafficking in the early secretory pathway of mammalian cells. He has focused especially on mechanisms of ER protein quality control and on recognition and delivery of misfolded proteins from the ER to the cytosolic proteasomes for ERAD. These processes are intimately […] Read More >
Prof. Michaelson Daniel
The research in the Michaelson laboratory is directed at unraveling the basic cellular and molecular mechanisms underlying neurodegenration in Alzheimer’s disease and at the development of novel therapeutic approaches to counteract them. The research focuses on apolipoprotein E4 (apoE4), the most prevalent genetic risk factor of the disease ,and on it’s interaction with other risk […] Read More >
Prof. Nevo Uri
We search for simple biophysical and mathematical laws that define the behavior of cells, and specifically of neurons. Our primary biophysical goal is to understand and measure the relation between cellular events and water displacement. We wish to employ this knowledge for the development of MRI techniques for characterization of cellular microstructures and cellular events. […] Read More >
Prof. Offen Daniel
Research topic: Neurodegenerative diseases, etiology and new treatments. Research methods: Stem cells, Gene therapy, peptides, transgenic mice, animal models of Neurodegenerative diseases Main projects in the lab include: Induction of neurogenesis and transplantation of various adult stem cells in animal models of neurodegenerative diseases. Development of new therapies, small molecules, peptides and genes, for neurological […] Read More >
Prof. Perlson Eran
Research Interest Nanomotors and microfluidic platforms reveal neurodegeneration mechanisms Neuron cell death and synapse disruption seen in neurodegenerative diseases like ALS. It is a non-cell-autonomous process and involve a multi system progression. Neurons are highly polarized cells with very long axons. In order to maintain healthy and function properly the neurons depends on accurate and efficient long […] Read More >
Prof. Pick Chaim G.
Professor, Department of Anatomy & Anthropology, Faculty of Medicine Director, the Sylvan Adams Sports Institute Research Brain Injuries: Cognitive, Behavioral and Cellular Outcome My group has a long history in Traumatic Brain Injury research, not only in characterizing behavioral and biochemical sequelae of blunt head trauma, but also in developing preclinical models of mTBI of […] Read More >
Prof. pinkas-Kramarski Ronit
Research topic: Study the involvement of Autophagy in neurodegenerative diseases. Research methods: Cell biology, Biochemistry, Molecular Biology, microscopy, Immunohistochemistry. Projects in the lab include: The role of autophagy in nerve injury. Study the involvement of autophagy in Alzheimer’s. The molecular mechanism of autophagy regulation. Read More >
Prof. Portnoy Moshe
Dendrimers are branched, highly ordered macromolecules that are assembled in a modular, iterative fashion from polyfunctional building blocks. These macromolecules are not only aesthetically appealing, but offer chemists three-dimensional structures of nanometer-range size with a variety of interesting architecture-dictated properties for a wide spectrum of applications. The modular mode of assembly and highly ordered nature […] Read More >
Prof. Shimon Rochkind
Director, Peripheral Nerve Reconstruction division of the Department of Neurosurgery, Tel Aviv University Senior Neurosurgeon and Specialist in Neurosurgery & Microsurgery, Tel Aviv Sourasky Medical Center. Read More >
Dr. Roichman Yael
We are interested in studying the underlying physical processes that govern the mechanics, self-organization, dynamics, and statistics of complex fluids out of thermal equilibrium. Our belief is that by studying in detail many such driven systems we will be able to observe emergent shared characteristics, paving the way for a theoretical description. We use holographic […] Read More >
Our research interests include investigations related to tumor biology, tumor dormancy, mechanism of action of angiogenesis inhibitors, self-assembly of polymeric architectures and novel approaches to target cancer. Throughout, we have maintained an interest in understanding the biological rationale for the design of polymer therapeutics suitable for transfer into clinical testing. Our primary interests are the molecular […] Read More >
Prof. Shacham- Diamand Yosi
Research Interest Nano-chemical processes for Microelectronics and integration of biological material on chip for acute toxicity detection Nano-chemistry for electronics applications- Physical and electrical characterization of electronic devices for CMOS technologies made by various chemical techniques such as self assembled monolayers and surface catalyzed auto catalytic electrochemical processes. The research involves studying of the […] Read More >
Prof. Solomon Beka
My scientific interest is focused on investigation of biorecognition in general and on the nature of the interactions of antibodies and their corresponding antigens in particular. In my research work I am involved in the elucidation of the mode of action of monoclonal antibodies (mAbs) on the structure and function of their corresponding antigens in […] Read More >
Prof. Solomon Arieh S.
Research topic: Elucidating the degenerative and regenerative process of optic nerve following trauma, ischemia and disease. The research results will be applicable in same conditions that take place in the brain. Research methods: Immunocytochemistry analysis, Western blot analysis, confocal microscopy evaluation, electrophysiology functional recording, MRI. Projects in the lab include: Evaluation of the therapeutic potential of new […] Read More >
Prof. WEIL Miguel Enrique
Research topic: Cell based platforms for study, diagnosis, drug screening and therapy of neurodegenerative diseases. Research methods: Isolation and culture of human embryonic/adult stem cells models of diseases; Cell based-assays for High content analysis (HCA) screening of stem cells with and without disease; High throughput screening (HTS) of drugs using liquid handling robot, Drug development applications, Transcriptome […] Read More >
Prof. Weiner Ina
Research topic: Translational models of schizophrenia and depression as tools for understanding their development and prevention Research methods: Brain imaging, brain stimulation, neurodevelopmental manipulations, behavioral manipulations and analysis, systemic and intracerebral pharmacology, molecular biology/ proteomics/drug development (collaborations). Main projects: Delineating the developmental trajectories of schizophrenia-like and depression-like neuroanatomical changes and behavioral abnormalities following early exposure […] Read More >
Prof. Yovel Yosef
Research topic: Active sensing, sensory perception and cognition from the field through the lab and into the brain. I use the echolocating bat – a “champion” in active sensing to study these behaviors. Research methods: Behavior using highly developed technologies including ultrasonic microphone arrays, mini-cameras and mini-GPS devices. MRI to study brain anatomy and neural correlates of […] Read More >
Prof. Yovel Galit
Research topic: Cognitive and Neural basis of Face and Object recognition. Research methods: Psychophysics, functional MRI, EEG/Event related potentials (ERPs), Transcranial Magnetic Stimulation (TMS), Eye tracking. Simultaneous recording of EEG-fMRI and EEG-TMS Main projects in the lab include: How do face and body processing mechanisms interact to generate an image of a person? What is […] Read More >
