Oncology / Cancer

 

16 Results were found on Technologies

Leading Researchers:
2-2020-1440

Novel Anti-Tumor Response treatment targeting ErbB receptors and Nucleolin interactions

ErbBs subfamily receptors are mediators of cell growth signals. They have long been associated with a wide variety of lung, ovarian, colon, breast, prostate, and other carcinomas. Nucleolin is a major nucleolar protein of growing eukaryotic cells and is present on the cell surface of a range of cancers. Recently, a robust oncogenic interaction between […] Read More >

Leading Researchers:
10-2020-1360

Targeting Human Brain Cells With Adeno-Associated Virus (AAV) for a Prospective Therapeutic Approach

The AAV therapeutic approach for various central nervous system (CNS) illnesses has been rapidly growing. Unfortunately, existing present technologies utilize AAV administration that is injected locally into the brain. This process requires a high level of expertise and is not applicable in more diffused brain targets like cortex and stiratum. Systemic administration of AAV vectors through […] Read More >

Leading Researchers:
2-2022-1756

Homocysteine fibrillar assemblies display crosstalk with Alzheimer’s disease amyloid polypeptide

High levels of homocysteine (Hcy) are reported as a risk factor for Alzheimer’s disease (AD). Correspondingly, inborn hyperhomocysteinemia is associated with an increased predisposition to the development of dementia in later stages of life. Furthermore, despite the apparent association between protein aggregation and AD, attempts to develop a therapy that targets explicitly this process have […] Read More >

Leading Researchers:
2-2020-1451

Leveraging Gene Panel Sequencing Data for Mutational Signature Analysis with Applications to Personalized Treatment

UNMET NEED Mutational signatures and their exposures are key to understanding the processes that shape cancer genomes with applications to diagnosis and treatment. Yet current signature analysis approaches are limited to relatively rich mutation data that comes from whole-genome or whole-exome sequencing. Recently, orders of magnitude sparser data sets from gene panel sequencing have become […] Read More >

Leading Researchers:
2-2021-1566

Therapeutic Targeting of PD-1/PD-L1 blockade by Novel Small-molecule Inhibitors

Interactions between programmed cell death ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1) lead to the evasion of cancer cells from an efficient immune response. The inhibition of PD-L1/PD-1 has prevented or reversed exhausted T cells, thus enhancing antitumor T-cell responses. In fact, immune checkpoint blockade targeting the PD-1 axis has become one […] Read More >

Leading Researchers:
2022-0176

Restoring Immunity Against GI Cancers

BACKGROUND GI cancers cause over 3.5 million deaths per year globally, accounting for 35% of all cancer-related deaths. Colorectal carcinoma (CRC) is the world’s second leading cause of cancer death. Current immunotherapy treatments for CRC are hamstrung by low response rate, acquired resistance, relapse and severe side effects. ImmuNovation presents a disruptive nanomodular technology utilizing […] Read More >

Prof. Frenkel Dan

Research topic: The research in our laboratory is focused on the investigation of glial cell and to clarify their role in neurological diseases. We suggest that targeting glia activation in different pathological scenarios may allow us to define common pathways to further understand the role of glia in neuroprotection . We are using three models: 1) […] Read More >

Prof. Fridman Micha

The Fridman laboratory is engaged in the use of organic chemistry, especially carbohydrate chemistry, to solve key biological and medicinal problems. Our interdisciplinary studies involve the use of organic chemistry, microbiology, cell biology, molecular biology, and confocal microscopy to study and/or alter the mode of action of biologically active molecules with the focus on novel […] Read More >

Prof. Kolot Mikhail

Research Interests HK022 bacteriophage site specific recombinase Integrase is the tool for human genome manipulation and gene therapy. Site specific recombinases (SSRs) catalase the site-specific recombination reaction between two specific short DNA sequences of 30-40 bp that serve as recombination sites that included integration, excision and inversion. These enzymes are widely used for the genome manipulations […] Read More >

Prof. Margalit Rimona

Research Interests 1. Micro- and nano-particulate drug delivery technologies for topical, regional and systemic applications:  Our efforts in the drug delivery arena focus on two drug delivery technologies, one veteran and one novel, that are inventions of our group. These technologies each yield, micro and nano sized particles that are composed of biomaterials with particular […] Read More >

Prof. Padler-Karavani Vered

Our lab is studying the mechanisms that govern glycan immune recognition and responses in animal models and humans, both in vitro and in vivo. We combine glycobiology, immunology, biotechnology and cancer research, and use cutting edge technologies within these disciplines, including glycan microarray and glyco-nanotechnology. Current interests include: Immunological mechanisms of unique anti-carbohydrate antibodies. Glycoimmunology […] Read More >

Prof. Peer Dan

Our lab is studying how to manipulate cells’ functions in order to generate novel strategies to treat inflammatory diseases and cancers. We are combining multidisciplinary approaches including immunology, cell and molecular biology, genetics, protein engineering, material sciences, nanotechnology and computational techniques for drug discovery and potentially for therapeutics. In addition, we are developing nanomedicines by […] Read More >

Prof. pinkas-Kramarski Ronit

Research topic: Study the involvement of Autophagy in neurodegenerative diseases. Research methods: Cell biology, Biochemistry, Molecular Biology, microscopy, Immunohistochemistry. Projects in the lab include: The role of autophagy in nerve injury. Study the involvement of autophagy in Alzheimer’s. The molecular mechanism of autophagy regulation. Read More >

Prof. Prag Gali

Research topic: Elucidating the decoding mechanisms of ubiquitin signals and their significance in neurodegenerative diseases Research methods: Biophysical measurements including SPR, AUC, MST and SEC, X-ray crystallography, Bioinformatics, Biochemistry and bacterial genetics Projects in the lab include: Molecular mechanisms that regulate membrane protein trafficking and Parkinson’s disease Mechanisms for regulation of sodium / potassium channels and dopamine transporter. The molecular […] Read More >

Dr. Raiter Annat

Immunotherapy is a new modality which has revolutionized the treatment of cancer for multiple types of tumors. However, breast cancer has shown only modest benefit from immunomodulatory therapies, if at al. This is principally due to tumor escape mechanisms. We have only limited understanding of these mechanisms. Our focus on translational research aims to better […] Read More >

Prof. Rechavi Oded

Prof. Oded Rechavi’s mission is to challenge fundamental long-held scientific dogmas. He found an exception to the original “Cell Theory”, provided the first direct evidence that an acquired trait can be inherited, elucidated an alternative transgenerational inheritance mechanism (that depends on inherited small RNA molecules, not DNA molecules), discovered a mechanism that allows nematodes’ brains […] Read More >

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