Peptides / Proteins

 

16 Results were found on Technologies

Leading Researchers:
10-2011-259

Immunotherapy for Stroke and Cognition in a Cerebral Amyloid Angiopathy Animal Model

Cerebrovascular dysfunction is a fundamental part of the pathology of several neurodegenerative diseases and rated as one of the most prominent cause for dementia. Cerebral amyloid angiopathy (CAA) results in intra-parenchymal and subarachnoid bleeding, which is caused by cerebrovascular amyloid deposits and multiple infarcts, and can lead to hemorrhagic stroke and cognitive impairment (Greenberg et […] Read More >

Leading Researchers:
2-2007-14

Self Assembled Peptide Hydrogel

The Technology A breakthrough Self Assembled Peptide Hydrogel (SAPH) has been developed. SAPH is a safe, self-assembled, biocompatible, remarkably strong hydrogel with modulated stability that is suitable for various medicinal and cosmetic applications. SAPH is based on the highly efficient self-assembly of the short aromatic peptides diphenylalanine.  The discovery and development of SAPH is the […] Read More >

Leading Researchers:
10-2007-103

Improved Calcitonin-based Therapeutics

TechnologyThe aggregation site on human calcitonin has been identified, paving the way for development of specific inhibitors of calcitonin amyloid fibril formation. Such inhibitors will enable development of improved calcitonin therapeutics as well as greatly facilitate in vitro calcitonin manipulations. The NeedThe therapeutic use of human calcitonin is severely limited by its tendency to associate […] Read More >

Leading Researchers:
3-2011-161

Self-Assembling Aromatic di-Peptide Materials for Cosmetic Applications

TechnologyOrganic, aromatic di-peptide self-assemble into close-caged structures of tubes, spheres and hydrogels.  These exhibit excellent properties such as stability, solubility, transparency and rigidness alongside the basic peptide features utilized in cosmetics.  The materials can be prepared as powder or hydrogel and be easily mixed with common cosmetic foundations. In addition to these native characteristics, methods […] Read More >

7-2013-455

Molecular Electronics and Transistors based on Peptide Nanostructures

The TechnologyProprietary peptide nanostructures1 can be readily fabricated on various surfaces including electrodes2,4. A physical vapor deposition method (PVD) allows the precise control on the molecular dimensions of the structures using industry standard techniques. These nanostructures were used to fabricate metallic nanowires1 as well as trilayer metal-peptide-metal nano-cables3. Electrodes and storages devices were modified with […] Read More >

Leading Researchers:
2-2013-569

PNA – Self Assembled peptide nanostructures for OLED / Security applications

TechnologyWe developed nanostructures based on Peptide-Nucleic Acid (PNA) derivatives which show highly promising performance characteristics. The unique electroluminescence/photoluminescence materials can be used as emissive materials in manufacturing Organic Light-Emitting Diodes (OLED) with high emission efficiencies, tunable colors, and improved charge-transport and film-forming properties. The NeedSignificant progress has been made over the past decade in producing […] Read More >

Leading Researchers:
10-2020-1476

Unique Cocktail of Neutralizing Antibodies against SARS-CoV-2

We have identified eight potent neutralizing antibodies (mAbs) from recovered COVID-19 patients for COVID-19 treatment. These antibodies may be used as pre-exposure prophylaxis, i.e., as short-term protection from infection for populations at risk and highly exposed medical teams or those that did not develop enough antibodies post vaccinationUNMET NEEDThe COVID-19 pandemic caused by SARS-CoV-2, has […] Read More >

Leading Researchers:
2-2020-1440

Novel Anti-Tumor Response treatment targeting ErbB receptors and Nucleolin interactions

ErbBs subfamily receptors are mediators of cell growth signals. They have long been associated with a wide variety of lung, ovarian, colon, breast, prostate, and other carcinomas. Nucleolin is a major nucleolar protein of growing eukaryotic cells and is present on the cell surface of a range of cancers. Recently, a robust oncogenic interaction between […] Read More >

11-2021-1544

Protection of Oxygen-Sensitive-Enzymes by Peptide Hydrogel

Molecular oxygen (O2) is a highly reactive oxidizing agent harmful to many biological and industrial systems. A simple encapsulation in a protective aqueous environment of O2  -sensitive reactions is of need. Self-assembling peptide-based hydrogels are simple hydrogels that can be combined with a wide variety of reagents and are able to encage O2 and significantly limit its […] Read More >

11-2021-1544

Anti-Oxidation Agent to be Incorporated Into Cosmetics Leading to More Stable and Longer Shelf-Life Products

Oxidation is the reaction of Oxygen with a wide array of reactants. In cosmetics, product oxidation leads to spoilage of ingredients used in the manufacturing products, the inactivation of oxygen-sensitive enzymes, shortening of product shelf-life, and discolorations of end-product. Self-assembling peptide-based hydrogels are simple hydrogels that can be combined with a wide variety of ingredients […] Read More >

Dr. Beck-Barkai Roy

Research Cytoskeleton protein complexes – Interaction between cytoskeleton protein complexes and their effect on the structure and elasticity of the cell. Intrinsically disordered protein – Statistical structural characterization of proteins that do not completely fold into 3d fixed structures in solutions. Nanoscopic complex – characterizing and manipulating nanoscopic complexes by grafted biopolymer. Membrane physics – stabilization of membrane to […] Read More >

Prof. Benayahu Dafna

Nanomedicine is medical treatment at the level of single molecules or molecular assemblies that provide structure, control, signaling, homeostasis, and motility in cells, i.e., at the “nano” scale of about 100 mm or less. There have been many scientific and technological advances in both physical and biological sciences over the past several years that make nano medicine […] Read More >

Prof. BENAYAHU Yehuda

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Prof. Benhar Itai

Prof. Benhar is an expert and opinion leader in the field of antibody engineering. Over the 25 years of being active in that field, he prepared several phage display libraries from which antibodies against numerous targets were isolated. Prof. Benhar publishes over 100research papers, wrote 10 book chapters and submitted 19 patent applications. Research in Prof. […] Read More >

Dr. Burstein David

Dr. Burstein is a faculty member in The Shmunis School of Biomedicine and Cancer Research in the Life Science Faculty at Tel Aviv University. His research focuses on CRISPR-Cas systems, secretion systems of pathogens, and the discovery of novel antibiotic resistance genes to better understand fundamental interaction mechanisms within microbial communities and to promote their […] Read More >

Prof. Eldar- Finkelman Hagit

My overall research is focused on elucidating the molecular and biochemical regulation of the protein kinase, glycogen synthase kinase-3 (GSK-3), and revealing its contribution to pathological disorders. GSK-3 is emerging as a prominent drug discovery target in neurodegenerative disorders including ALS, Parkinson’s, Huntington’s and Alzheimer’s disease. In a recent work we identified lysosomes as novel […] Read More >

Prof. Fleminger Gideon

Our laboratory is engaged in the study of structure-function relationships in proteins and peptides involved in biorecognition processes. In these studies we apply sophisticated separation methods for the purification with advanced methods of structural analysis of these materials.  Specific research activities include: Structure-function relationships in Ca+2-binding proteins:  We are engaged in the study of the […] Read More >

Prof. Freeman Amihay

Research interests include: Biomedical applications of enzymes and cells. Protein Nano-biotechnology: protein mediated biotemplating for the integration of biologically active protein-metal hybrid with microelectronics and development of new composite materials. Bioprocessing aspects of biocatalysis Read More >

Prof. Frenkel Dan

Research topic: The research in our laboratory is focused on the investigation of glial cell and to clarify their role in neurological diseases. We suggest that targeting glia activation in different pathological scenarios may allow us to define common pathways to further understand the role of glia in neuroprotection . We are using three models: 1) […] Read More >

Dr. Freund Natalia

Senior Lecturer (Guest), Department of Clinical Microbiology and Immunology, Faculty of Medicine Research My laboratory is interested in understanding the molecular basis of human antibody responses to diseases. Antibodies are key components of most licensed vaccines; nevertheless many aspects of how antibodies recognize and neutralize their targets are still unknown. Pathogen-specific B cells are stimulated […] Read More >

Leading Researchers:

Biological and Bio-Inspired Molecular Self-Assembly- The Gazit Lab

MOLECULAR SELF-ASSEMBLY AMYLOID FIBRIL FORMATION NANOBIOTECHNOLOGY METABOLITE AMYLOIDS MOLECULAR SELF-ASSEMBLY We study one of the most important problems in contemporary life sciences and medicine: Understanding the molecular basis for the formation of amyloid nanostructures in degenerative disorders, a process underlying the pathophysiology of some of the most devastating health problems world-wide, such as Alzheimer’s disease, […] Read More >

Leading Researchers:

The lab for Molecular Biology of Aging

Advances in biomedical science have cured multiple diseases and greatly improved healthspan and lifespan. However, aging is the strongest risk factor for most causes of death in the western world, and thus these advances have resulted in a relatively small increase in maximal lifespan. Without a systematic approach to understand and treat the aging process, […] Read More >

Leading Researchers:
12-2017-1098

Reproduction in Animal Models and in Humans

Our research focuses on Reproductive Physiology in animal models and in humans. The current research directions investigated in the laboratory are: The role of Fyn kinase, member of the Src family kinases, during meiosis and early events of oocyte activation, as well as in cancer cells (Figure-left panel). Fertility preservation – the signaling pathway leading […] Read More >

Leading Researchers:
12-2013-622

Laboratory of endoplasmic reticulum (ER) quality control and protein misfolding diseases

Lab DescriptionMain areas of interest are in the mechanisms of protein folding and trafficking in the early secretory pathway of mammalian cells and the development of ER stress upon their malfunction, particularly in neurodegenerative diseases.  Specific research topics are:• Protein misfolding diseases, including neurodegenerative diseases.• ER stress.• Mechanisms of endoplasmic reticulum (ER) protein folding and quality control.• Sugar chain […] Read More >

Leading Researchers:
12-2011-223

Characterization of organic, inorganic and biological materials by Solid state NMR

Magic-angle spinning solid-state NMR (MAS SSNMR) is a well-established technique for the characterization of crystalline, non-crystalline and non-soluble materials including simple molecules, drug formulations, glass, ceramics, powders, nanocrystals and biological samples. There are numerous applications of solid-state NMR covering a large range of scientific disciplines. In our laboratory at the school of chemistry we have […] Read More >

Leading Researchers:
12-2011-221

Bioinformatic Analysis

  The Bioinformatics Unit at the Faculty of Life Sciences   The Bioinformatics Unit at the Faculty of Life-Science at Tel-Aviv University is part of the Israeli Center of Bioinformatics Infrastructure (COBI) and offer various activitities to the bio-medical research community of Tel Aviv University and outside TAU. Bioinformatics training Bioinformatics consultation Microarray experiments support […] Read More >

Leading Researchers:
12-2011-220

State-of-the-art X-ray Scattering Systems

Laboratory of Experimental BiophysicsSchool of Physics and Astronomy, Faculty of Exact ScienceThe Center for NanoScience and NanoTechnology   Services:Small Angle X-ray Scattering (SAXS), Wide Angle X-ray Scattering (WAXS), Grazing Incident Small Angle X-ray Scatter (GISAXS) X-ray scattering provide structural information (shape and size) in non-destructive and stain free conditions. Small angle scattering is an ideal characterization […] Read More >

Leading Researchers:
12-2011-205

Lipid Solutions and Animal Model

SERVICES“ Lipid Solutions” Prof. Alicia Leikin-Frenkel “Lipid Solutions” covering:1. Expert support for questions on: lipid metabolism, isolation, identification and quantitation of lipids in different species and different matrixes.2. Guidance to discover the pathway to physiological and biochemical implications following overexpressed or suppressed gene linked to lipids.3. Counseling to analyze lipids in:• Simple molecules: fatty acids: Saturated, Monounsaturated n7, n9, Polyunsaturated: […] Read More >

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