Pharmaceutical Indications

 

37 Results were found on Technologies

Leading Researchers:
2-2022-1756

Homocysteine fibrillar assemblies display crosstalk with Alzheimer’s disease amyloid polypeptide

High levels of homocysteine (Hcy) are reported as a risk factor for Alzheimer’s disease (AD). Correspondingly, inborn hyperhomocysteinemia is associated with an increased predisposition to the development of dementia in later stages of life. Furthermore, despite the apparent association between protein aggregation and AD, attempts to develop a therapy that targets explicitly this process have […] Read More >

Leading Researchers:
2-2016-1039

Development of Alzheimer Disease therapy based on counteracting the pathological effects of ApoE4

Alzheimer’s disease (AD) is the most common cause of dementia and is the outcome of progressive brain cells death. Due to the disorder’s heterogeneity and in view of the variety of pathological mechanisms inducing the disease    we have undertaken an innovative – science based (Animal model) approach, which is presented here. Our unique approach […] Read More >

Leading Researchers:
2-2020-1451

Leveraging Gene Panel Sequencing Data for Mutational Signature Analysis with Applications to Personalized Treatment

UNMET NEED Mutational signatures and their exposures are key to understanding the processes that shape cancer genomes with applications to diagnosis and treatment. Yet current signature analysis approaches are limited to relatively rich mutation data that comes from whole-genome or whole-exome sequencing. Recently, orders of magnitude sparser data sets from gene panel sequencing have become […] Read More >

Leading Researchers:
1-2022-1849

Enhanced production of collagen in mammalian cells

Collagen is the most abundant protein in the body. It has variety of applications in the fields of food, cosmetics, and pharma. However, the challenges associated to the production of recombinant collagen dictate the use of collagen from animal tissues. Our invention boosts the production of collagen in mammalian cells, making the use of a […] Read More >

Leading Researchers:
2-2021-1566

Therapeutic Targeting of PD-1/PD-L1 blockade by Novel Small-molecule Inhibitors

Interactions between programmed cell death ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1) lead to the evasion of cancer cells from an efficient immune response. The inhibition of PD-L1/PD-1 has prevented or reversed exhausted T cells, thus enhancing antitumor T-cell responses. In fact, immune checkpoint blockade targeting the PD-1 axis has become one […] Read More >

Leading Researchers:
2022-0195

Therapeutic Monoclonal Antibodies to Combat Multidrug-Resistant Pathogenic Bacteria

It is predicted that a failure to address the problem of antibiotic-resistant pathogens will result in the death of 10 million people annually, costing the economy more than 100 trillion dollars by the year 2050. In high-income countries where antibiotics are heavily used in the community and agriculture, the strong selection pressure and non-completed antibiotic […] Read More >

Leading Researchers:
2022-0201

Glioblastoma Regression by Regulating Astrocytes’ Immunometabolic Signaling

Malignant brain tumors are the cause of a disproportionate level of morbidity and mortality among cancer patients, an unfortunate statistic that has remained constant for decades. Despite considerable advances in the molecular characterization of these tumors, targeting the cancer cells has yet to produce significant advances in treatment OUR SOLUTIONAn alternative strategy is to target […] Read More >

Leading Researchers:
2022-0205

Automated Processing Of Non-Invasive Thermal Imaging Of Organ-Specific Diseases To Detect Inflammation And Vascular Dysfunction

During the COVID-19 worldwide pandemic, rapid and sensitive screening tools for SARS-CoV2 infection were defined critical for limiting the spread of COVID-19 and for allocating national resources properly. Researchers have developed and tested a new point-of-care, non-contact, thermal camera that connects directly to smartphones combined with image-processing algorithms, and machine learning-based analysis, to detect inflammation […] Read More >

Leading Researchers:
10-2012-306

Therapeutic Targeting of CD45 by Novel Agents to Immunotherapy Non-Responders Tumors

Therapeutic advances in cancer immunotherapy  have rapidly emerged in the past few years, reflecting the importance of the interaction between the human immune system and cancer. Despite the successful application of immunotherapy across a broad range of human cancers, only a minority of patients with terminal cancer experience life-altering durable survival from these therapies. These […] Read More >

Leading Researchers:
10-2008-86

Targeting Bone Neoplasms and Other Cancers with Novel Combined Anticancer and Anti-Angiogenic Polymer Therapeutics

Anti-cancer NanoTherapyUtilizing unique nano-technology to develop targeted combination nanomedicines that were shown to be synergistic, effective and safe for treating cancer TechnologyWe have developed a new platform technology for the treatment of cancer and bone metastases using combined targeted nano-sized polymers that deliver chemotherapeutics creating a new class of effective and safer molecules. The novel […] Read More >

Leading Researchers:
10-2017-1064

SK4 K+ channel blockers: a new treatment for cardiac atrial fibrillation

We discovered a previously unidentified target in the heart, namely the SK4 calcium-activated K+ channels, which are functionally expressed in pacemaker cells as well as in atrial and ventricular cardiomyocytes. They are crucial for proper cardiac function and represent a completely new therapeutic target for the treatment of cardiac arrhythmias. SK4 channel blockers successfully prevented […] Read More >

Leading Researchers:
2-2021-1621

Molecular Signatures of Inflammation and Uses for Personalized Therapy

OUR SOLUTIONOur work is focused on four molecular states that impact the inflammatory status:i. Disease tolerance activity. Maintenance of health in the presence of stress, injury, infection. Healing through tissue repair and renewal mechanisms. ii. Antimicrobial activity. Detects, neutralizes, and eliminates the invading pathogen (“resistance”). iii. Metabolic status. Reflects the abnormal cardiometabolic status related to hypertension, diabetes […] Read More >

Prof. Ashery Uri

Research topic: Elucidating the molecular mechanisms of synaptic transmission and plasticity under normal conditions, during neurodegenerative diseases and in aging. Research methods: Electrophysiology, Slice recording, Total Internal Reflection Fluorescence (TIRF), stochastic optical reconstruction microscopy (STORM), Fluorescence Resonance Energy Transfer (FRET), Molecular biology, Model simulation, Multi electrode array recording, Immunohistochemistry, Behavioral tests. Main projects in the […] Read More >

Prof. Attali Bernard

Reaching an understanding in molecular terms of the mechanisms by which changes in membrane potential regulate cellular events is the main concern of our research. We focus our interest on potassium channels because they play crucial roles in many cellular functions such as shaping cardiac and neuronal action potentials, tuning neuronal firing patterns, synaptic integration […] Read More >

Prof. Avraham Karen B.

Genomic Analysis of Hereditary Hearing Loss Our primary interest is the genetic basis of hereditary hearing loss or deafness. Our group is working towards the identification, characterization and regulation of genes associated with hereditary hearing loss. For gene discovery, we focus on the Israeli Jewish and Palestinian Arab populations in the Middle East. Our studies […] Read More >

Prof. Bacharach Eran

Eran Bacharach is the head of a research laboratory for molecular virology at the Department of Cell Research and Immunology, and teaches courses on microbiology, molecular virology and cell biology, at the Faculty of Life Sciences, where he has been on the faculty since 2000. He received his B.Sc., M.Sc. and Ph.D. degrees from the […] Read More >

Prof. Barak Segev

Dr. Barak’s research focuses on the psychobiology and neurobiology of alcoholism and drug addiction. In particular, he is interested in the molecular and neuronal mechanisms that underlie learning and memory processes in alcohol addiction.  In addition, Dr. Barak is interested in the  pathophysiology  of schizophrenia, with focus on cognitive impairments in this disorder. See lab […] Read More >

Prof. BARNEA Ofer

Patient specific models: Assessment of fetal cardiovascular development Optimization Propofol administration during anesthesia Optimization of fluid resuscitation Assessment of cerebral blood flow autoregulation Multiscale models of physiological systems 3D fiber based model of the contracting heart Oxygen transfer to tissue Biomedical measurements and instrumentation Optimally controlled fluid administration system Detection of bubbles in blood to […] Read More >

Prof. Barzel Adi

Our lab will focus on gene therapy using viral vectors. We will tackle diseases ranging from cancer to viral infections and diabetes. Devising safe and efficient gene therapies combines challenges in biochemistry and molecular biology with challenges in physiology, immunology, virology and more. We will focus on genome editing- the site specific manipulation of the […] Read More >

Dr. Beck-Barkai Roy

Research Cytoskeleton protein complexes – Interaction between cytoskeleton protein complexes and their effect on the structure and elasticity of the cell. Intrinsically disordered protein – Statistical structural characterization of proteins that do not completely fold into 3d fixed structures in solutions. Nanoscopic complex – characterizing and manipulating nanoscopic complexes by grafted biopolymer. Membrane physics – stabilization of membrane to […] Read More >

Prof. Belkin Michael

Prof. Belkin has been involved in the establishment of many medical start-ups in ophthalmology and other fields. One of his noted contributions was inventing and developing the Ex-PRESS Glaucoma Filtration Device. The ExPRESS, after being sold to global eye care leader Alcon, is now routinely used in glaucoma surgery worldwide. He is now developing his […] Read More >

Prof. Ben-Baruch Adit

Breast cancer is a leading cause of death for women in the Western world. The battle against breast cancer has been challenged by the fact that, generally, each component is studied meticulously, but singly. Too little attention is paid to the interactions between the tumor cells and their intimate microenvironment, consisting of various cells and […] Read More >

Leading Researchers:
12-2011-198

Unique Animal Models for Inflammatory Lung, GI, and Bowel Diseases

The Laboratory of Mucosal Immunology The Laboratory of Mucosal Immunology is new at the Sackler faculty of Medicine and deals primarily with mucosal inflammation. We focus on diseases affecting the lungs, such as asthma, COPD (chronic obstructive pulmonary disease), acute lung injury and gastrointestinal (GI) tract, inflammatory bowel disease (IBD) and colorectal cancer.   In lungs […] Read More >

Leading Researchers:
10-2011-141

Neurodevelopmental, Gestational, Lactational and Maternal Immune Stimulation Animal Model for Schizophrenia

Fields of InterestPharmacology of schizophrenia, animal models of psychopathology, neurodevelopmental model of schizophrenia. Prof. Weiner’s lab has launched and developed the latent inhibition model of schizophrenia which mimics loss of normal attentional control in this disorder, with a focus on the pharmacology of latent inhibition as a basis for the search for novel drugs. In […] Read More >

Leading Researchers:
12-2011-198

Animal Eye Models

    Animal eye models for evaluation of systemic and topical use of new medications, devices and delivery systems. The models include external eye, intraocular, orbital, and optic nerve applications. Webpages:https://www.sheba.co.il/Institutes/Eye_Institute/Eye_Clinics/78.htmhttps://www.tau.ac.il/medicine/ophthalmology/ophth_con.html CONTACT  Department of OpthalmologySackler Faculty of MedicineTel Aviv UniversityRamat Aviv 69978, IsraelFax: 972-3-6405354   Head of the Department:Prof. Arieh S Solomon, MD,PhDEmail: asolomon@post.tau.ac.ilPhone: 972-3-5350702Fax: […] Read More >

Leading Researchers:
12-2011-199

Animal Models for CNS Disorders and Screening Method for Diabetes

In vitro and in vivo animal models for stroke, Alzheimer’s disease (AD), and multiple sclerosis (MS). Rapid screening method for selecting candidates with specific insulin-degrading enzyme inhibitor activity in Types I and II  Diabetes.   https://www.tau.ac.il/lifesci/departments/neuro/members/frenkel/frenkel.html Read More >

Leading Researchers:
12-2011-200

Brain Injury Animal Models

Blast Brain Injury: a combat zone-like mouse model. From the experimental lab to the war against terror and back to the lab. Improvised explosive devices (IEDs) are one of the main causes for casualties among civilians and military personnel in the present war against terror. IEDs induce various degrees of cognitive, emotional and behavioral disturbances […] Read More >

Leading Researchers:
12-2011-201

Behavioral Animal Models

Laboratory of Biological Psychiatry & Behavioral research- Felsenstein Institute   Main Research Topics Cognition, Memory, Social behavior, Motility. Disease: Schizophrenia, Anxiety, Neuropathy pain and Depression Drug Development: Schizophrenia, Depression, Cognition, Pain . Lab facilities The lab is well equipped with the required instruments for molecular and cellular research. At the institute, we have a modern animal room […] Read More >

Leading Researchers:
12-2011-203

Cardiovascular and Physiological Assessment in Animal Models

Neufeld Cardiac Research Institute at Sheba Medical Center, Tel-Aviv University comprises a fully equipped laboratory to conduct cardiovascular and physiological experiments in small (mice, rat) and large animals (swine, sheep, calf) including heart function studies with special echocardiography system designed for small animals (Vevo660 ultrasound biomicroscope; VisualSonics), molecular imaging, pressure‐volume loop machine (Millar/Power Lab) and […] Read More >

Leading Researchers:
12-2011-204

Drug Screening Animal Model for Anti-compulsive Activity

We have developed the signal attenuation rat model of obsessive-compulsive disorder (OCD). This model is based on the theoretical proposition that compulsive behaviors result from a deficit in the feedback, which is associated with the performance of normal goal-directed responses.  In our model, the goal-directed behavior is lever-pressing for food. The feedback associated with making […] Read More >

Leading Researchers:
12-2011-205

Lipid Solutions and Animal Model

SERVICES“ Lipid Solutions” Prof. Alicia Leikin-Frenkel “Lipid Solutions” covering:1. Expert support for questions on: lipid metabolism, isolation, identification and quantitation of lipids in different species and different matrixes.2. Guidance to discover the pathway to physiological and biochemical implications following overexpressed or suppressed gene linked to lipids.3. Counseling to analyze lipids in:• Simple molecules: fatty acids: Saturated, Monounsaturated n7, n9, Polyunsaturated: […] Read More >

Leading Researchers:
12-2011-207

Precision Nanomedicine: Preparation and Characterization of Nanocarriers Made from Natural Biopolymers

The laboratory of Precision Nanomedicine at TAU have capabilities for preparation and characterization of nanocarriers made from natural biopolymers such as lipids (liposomes, micelles) , sugars and proteins. Lab Description• State-of-the-art preparation and process development of lipid based nanoparticles including sythesisi capabilities of lipids.• cell culture facility including the culturing of hybridomas and antibody purification.• […] Read More >

Leading Researchers:
12-2014-774

laboratory of neuronal and cardiac ion channels

Lab Description Using the powerful combination of molecular biology, biophysics, biochemistry and electrophysiology. our research aims at elucidating the structural, biophysical and physiological attributes of normal and diseased ion channels in brain and heart and whose mutations in human lead to major neurological and cardiovascular disorders like epilepsy, autism, atrial or ventricular fibrillation. Main Research […] Read More >

Leading Researchers:
12-2011-209

Functional genomics

The Shomron research team focuses on the analysis of genomics aimed at understanding human diseases. Combining high-throughput methods and bioinformatics (such as AI and deep learning), our team’s research explores DNA changes and gene regulators. Our goal is to reach a global perspective on the roles DNA and RNA play during disease development. Among our […] Read More >

Leading Researchers:
12-2014-771

Animal models of Addiction and Psychopathologies

Our main focus is on the psychological and neurobiological mechanisms that underlie psychiatric disorders, and in particular addiction We are using rodent models of addiction, anxiety, learning and memory. We focus on behavioral models relevant to different stages of addiction (craving, drug reward, intoxication, sensitization, tolerance, excessive alcohol consumption, withdrawal symptoms, relapse). We are looking […] Read More >

Leading Researchers:
12-2011-219

Cardiovascular Engineering

Department of Biomedical Engineering – Prof. Ofer Barnea   Ofer Barnea is a Professor of Biomedical Engineering at Tel Aviv University and is the Director of the Ela Kodesz Institute for Biomedical Physics and Engineering. He was the chairman of the Department of Biomedical Engineering and the chairman of the Israeli Chapter of the IEEE […] Read More >

Leading Researchers:

Immune Gene Editing

Using novel gene editing technology, we engineer T cells and B cells to better fight cancer, infections and autoimmune diseases Our researchOur primary objective is to develop safe, efficient and scalable methods to engineer lymphocytes for immunotherapy. We provide a novel technology for the engineering of B cells as well as T cells, in vivo […] Read More >

Leading Researchers:
12-2011-220

State-of-the-art X-ray Scattering Systems

Laboratory of Experimental BiophysicsSchool of Physics and Astronomy, Faculty of Exact ScienceThe Center for NanoScience and NanoTechnology   Services:Small Angle X-ray Scattering (SAXS), Wide Angle X-ray Scattering (WAXS), Grazing Incident Small Angle X-ray Scatter (GISAXS) X-ray scattering provide structural information (shape and size) in non-destructive and stain free conditions. Small angle scattering is an ideal characterization […] Read More >

Leading Researchers:
12-2011-212

Ophthalmic Testing

Consultation and lab services are offered, with a focus on eye-related medical innovations from concept through to clinical trials.   Lab Website:https://www.tau.ac.il/medicine/Goldschleger/Goldschleger.html Scientist: Michael Belkin, MA, MD Professor of Ophthalmology Director, Ophthalmic Technologies Laboratory  Goldschleger Eye Research Institute  Tel Aviv University  Sheba Medical Center  Tel Hashomer 52621  Israel Phone:  +972-3-530-2956 Fax:    +972-3-535-1577 Skype:  Belkin E-mail: belkin@netvision.net.il   Read More >

Leading Researchers:
12-2013-415

Laboratory of Immunological and Inflammatory Modules in Malignancy

Research focusProf. Ben-Baruch is an immunologist who investigates the roles of immune and inflammatory elements in physiological and pathological conditions, with major emphasis on malignancy. The studies in her laboratory determine the complex regulatory networks established between chemokines and cytokines of the tumor microenvironment, intrinsic oncogenic modifications in tumor cells, and stroma cells. The research […] Read More >

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