Pharmaceutical Indications

 

42 Results were found on Technologies

Leading Researchers:
2-2022-1756

Homocysteine fibrillar assemblies display crosstalk with Alzheimer’s disease amyloid polypeptide

High levels of homocysteine (Hcy) are reported as a risk factor for Alzheimer’s disease (AD). Correspondingly, inborn hyperhomocysteinemia is associated with an increased predisposition to the development of dementia in later stages of life. Furthermore, despite the apparent association between protein aggregation and AD, attempts to develop a therapy that targets explicitly this process have […] Read More >

Leading Researchers:
2-2016-1039

Development of Alzheimer Disease therapy based on counteracting the pathological effects of ApoE4

Alzheimer’s disease (AD) is the most common cause of dementia and is the outcome of progressive brain cells death. Due to the disorder’s heterogeneity and in view of the variety of pathological mechanisms inducing the disease    we have undertaken an innovative – science based (Animal model) approach, which is presented here. Our unique approach […] Read More >

Leading Researchers:
2-2020-1451

Leveraging Gene Panel Sequencing Data for Mutational Signature Analysis with Applications to Personalized Treatment

UNMET NEED Mutational signatures and their exposures are key to understanding the processes that shape cancer genomes with applications to diagnosis and treatment. Yet current signature analysis approaches are limited to relatively rich mutation data that comes from whole-genome or whole-exome sequencing. Recently, orders of magnitude sparser data sets from gene panel sequencing have become […] Read More >

1-2022-1849

Enhanced production of collagen in mammalian cells

Collagen is the most abundant protein in the body. It has variety of applications in the fields of food, cosmetics, and pharma. However, the challenges associated to the production of recombinant collagen dictate the use of collagen from animal tissues. Our invention boosts the production of collagen in mammalian cells, making the use of a […] Read More >

Leading Researchers:
2-2021-1566

Therapeutic Targeting of PD-1/PD-L1 blockade by Novel Small-molecule Inhibitors

Interactions between programmed cell death ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1) lead to the evasion of cancer cells from an efficient immune response. The inhibition of PD-L1/PD-1 has prevented or reversed exhausted T cells, thus enhancing antitumor T-cell responses. In fact, immune checkpoint blockade targeting the PD-1 axis has become one […] Read More >

Leading Researchers:
2022-0195

Therapeutic Monoclonal Antibodies to Combat Multidrug-Resistant Pathogenic Bacteria

It is predicted that a failure to address the problem of antibiotic-resistant pathogens will result in the death of 10 million people annually, costing the economy more than 100 trillion dollars by the year 2050. In high-income countries where antibiotics are heavily used in the community and agriculture, the strong selection pressure and non-completed antibiotic […] Read More >

Leading Researchers:
2022-0201

Glioblastoma Regression by Regulating Astrocytes’ Immunometabolic Signaling

Malignant brain tumors are the cause of a disproportionate level of morbidity and mortality among cancer patients, an unfortunate statistic that has remained constant for decades. Despite considerable advances in the molecular characterization of these tumors, targeting the cancer cells has yet to produce significant advances in treatment OUR SOLUTIONAn alternative strategy is to target […] Read More >

2022-0205

Automated Processing Of Non-Invasive Thermal Imaging Of Organ-Specific Diseases To Detect Inflammation And Vascular Dysfunction

During the COVID-19 worldwide pandemic, rapid and sensitive screening tools for SARS-CoV2 infection were defined critical for limiting the spread of COVID-19 and for allocating national resources properly. Researchers have developed and tested a new point-of-care, non-contact, thermal camera that connects directly to smartphones combined with image-processing algorithms, and machine learning-based analysis, to detect inflammation […] Read More >

Leading Researchers:
10-2012-306

Therapeutic Targeting of CD45 by Novel Agents to Immunotherapy Non-Responders Tumors

Therapeutic advances in cancer immunotherapy  have rapidly emerged in the past few years, reflecting the importance of the interaction between the human immune system and cancer. Despite the successful application of immunotherapy across a broad range of human cancers, only a minority of patients with terminal cancer experience life-altering durable survival from these therapies. These […] Read More >

10-2008-86

Targeting Bone Neoplasms and Other Cancers with Novel Combined Anticancer and Anti-Angiogenic Polymer Therapeutics

Anti-cancer NanoTherapyUtilizing unique nano-technology to develop targeted combination nanomedicines that were shown to be synergistic, effective and safe for treating cancer TechnologyWe have developed a new platform technology for the treatment of cancer and bone metastases using combined targeted nano-sized polymers that deliver chemotherapeutics creating a new class of effective and safer molecules. The novel […] Read More >

Prof. Ashery Uri

Research topic: Elucidating the molecular mechanisms of synaptic transmission and plasticity under normal conditions, during neurodegenerative diseases and in aging. Research methods: Electrophysiology, Slice recording, Total Internal Reflection Fluorescence (TIRF), stochastic optical reconstruction microscopy (STORM), Fluorescence Resonance Energy Transfer (FRET), Molecular biology, Model simulation, Multi electrode array recording, Immunohistochemistry, Behavioral tests. Main projects in the […] Read More >

Prof. Attali Bernard

Reaching an understanding in molecular terms of the mechanisms by which changes in membrane potential regulate cellular events is the main concern of our research. We focus our interest on potassium channels because they play crucial roles in many cellular functions such as shaping cardiac and neuronal action potentials, tuning neuronal firing patterns, synaptic integration […] Read More >

Prof. Avraham Karen B.

Genomic Analysis of Hereditary Hearing Loss Our primary interest is the genetic basis of hereditary hearing loss or deafness. Our group is working towards the identification, characterization and regulation of genes associated with hereditary hearing loss. For gene discovery, we focus on the Israeli Jewish and Palestinian Arab populations in the Middle East. Our studies […] Read More >

Prof. Bacharach Eran

Eran Bacharach is the head of a research laboratory for molecular virology at the Department of Cell Research and Immunology, and teaches courses on microbiology, molecular virology and cell biology, at the Faculty of Life Sciences, where he has been on the faculty since 2000. He received his B.Sc., M.Sc. and Ph.D. degrees from the […] Read More >

Prof. Barak Segev

Dr. Barak’s research focuses on the psychobiology and neurobiology of alcoholism and drug addiction. In particular, he is interested in the molecular and neuronal mechanisms that underlie learning and memory processes in alcohol addiction.  In addition, Dr. Barak is interested in the  pathophysiology  of schizophrenia, with focus on cognitive impairments in this disorder. See lab […] Read More >

Prof. BARNEA Ofer

Patient specific models: Assessment of fetal cardiovascular development Optimization Propofol administration during anesthesia Optimization of fluid resuscitation Assessment of cerebral blood flow autoregulation Multiscale models of physiological systems 3D fiber based model of the contracting heart Oxygen transfer to tissue Biomedical measurements and instrumentation Optimally controlled fluid administration system Detection of bubbles in blood to […] Read More >

Prof. Barzel Adi

Our lab will focus on gene therapy using viral vectors. We will tackle diseases ranging from cancer to viral infections and diabetes. Devising safe and efficient gene therapies combines challenges in biochemistry and molecular biology with challenges in physiology, immunology, virology and more. We will focus on genome editing- the site specific manipulation of the […] Read More >

Dr. Beck-Barkai Roy

Research Cytoskeleton protein complexes – Interaction between cytoskeleton protein complexes and their effect on the structure and elasticity of the cell. Intrinsically disordered protein – Statistical structural characterization of proteins that do not completely fold into 3d fixed structures in solutions. Nanoscopic complex – characterizing and manipulating nanoscopic complexes by grafted biopolymer. Membrane physics – stabilization of membrane to […] Read More >

Prof. Belkin Michael

Prof. Belkin has been involved in the establishment of many medical start-ups in ophthalmology and other fields. One of his noted contributions was inventing and developing the Ex-PRESS Glaucoma Filtration Device. The ExPRESS, after being sold to global eye care leader Alcon, is now routinely used in glaucoma surgery worldwide. He is now developing his […] Read More >

Prof. Ben-Baruch Adit

Breast cancer is a leading cause of death for women in the Western world. The battle against breast cancer has been challenged by the fact that, generally, each component is studied meticulously, but singly. Too little attention is paid to the interactions between the tumor cells and their intimate microenvironment, consisting of various cells and […] Read More >

Leading Researchers:

The Laboratory of Oral-Mucosal Stem Cell Regeneration and Enzymatic Dental Therapeutics

The Laboratory of Oral-Mucosal Stem Cell Regeneration and Enzymatic Dental Therapeutics is charting new frontiers in the realm of regenerative medicine and dental care. Harnessing the potent capabilities of stem cells derived from the oral mucosa, the research endeavors not only target the restoration of oral structures but also broader applications, such as bone regeneration […] Read More >

Leading Researchers:

Biological and Bio-Inspired Molecular Self-Assembly- The Gazit Lab

MOLECULAR SELF-ASSEMBLY AMYLOID FIBRIL FORMATION NANOBIOTECHNOLOGY METABOLITE AMYLOIDS MOLECULAR SELF-ASSEMBLY We study one of the most important problems in contemporary life sciences and medicine: Understanding the molecular basis for the formation of amyloid nanostructures in degenerative disorders, a process underlying the pathophysiology of some of the most devastating health problems world-wide, such as Alzheimer’s disease, […] Read More >

Leading Researchers:

The lab for Molecular Biology of Aging

Advances in biomedical science have cured multiple diseases and greatly improved healthspan and lifespan. However, aging is the strongest risk factor for most causes of death in the western world, and thus these advances have resulted in a relatively small increase in maximal lifespan. Without a systematic approach to understand and treat the aging process, […] Read More >

Leading Researchers:

The Lab for Protein Engineering and Drug Discovery

Modulation of protein-protein interactions is a key for a broad range of biotechnological applications. In our lab, we are developing unique approaches from small molecules, peptides, and optimized proteins to inhibit specific interactions. We are utilizing advanced computational, biophysical and cellular biology techniques.  Specific Research interests: • Engineering of unique Immune modulators • Engineering of optimized proteins […] Read More >

Leading Researchers:

Medical Ultrasound Technologies for Diagnostics, Monitoring, and Therapy for Clinically Relevant Problems

The Ilovitsh lab at Tel-Aviv University- We develop noninvasive medical ultrasound technologies for diagnostics, monitoring, and therapy for clinically relevant problems. Our research is highly multidisciplinary, combining engineering, physics, biology, chemistry and medicine. We utilize the unique ability of sound waves to penetrate deep into the body, in some cases even through an intact skull, […] Read More >

Leading Researchers:
12-2017-1098

Reproduction in Animal Models and in Humans

Our research focuses on Reproductive Physiology in animal models and in humans. The current research directions investigated in the laboratory are: The role of Fyn kinase, member of the Src family kinases, during meiosis and early events of oocyte activation, as well as in cancer cells (Figure-left panel). Fertility preservation – the signaling pathway leading […] Read More >

Leading Researchers:

The Myers Neuro-Behavioral Core Facility

Unit description:The Myers Neuro-Behavioral Core Facility provides researchers with state-of-the-art technology for performing neuro-behavioral tests in mice. Services: The Core Facility provides expertise in design, implementation, and analysis of behavioral experiments. The Core Facility includes five behavior rooms, which can operate simultaneously, and two animal maintenance rooms with IVC cages operating on a reversed light […] Read More >

Leading Researchers:
12-2015-949

The Strauss Computational Neuroimaging Center

Prof. Galit Yovel is the Head of the SCAN@TAU Center   SCAN@TAU Center The Strauss Computational Neuroimaging Center George S. Wise Faculty of Life Sciences  https://mri.tau.ac.il/about   The center’s services SCAN@TAU center is a new MRI multidisciplinary research center at Tel Aviv University that offers cutting edge MR technologies and innovative, high-resolution imaging methods. The […] Read More >

Leading Researchers:
12-2014-774

laboratory of neuronal and cardiac ion channels

Lab Description Using the powerful combination of molecular biology, biophysics, biochemistry and electrophysiology. our research aims at elucidating the structural, biophysical and physiological attributes of normal and diseased ion channels in brain and heart and whose mutations in human lead to major neurological and cardiovascular disorders like epilepsy, autism, atrial or ventricular fibrillation. Main Research […] Read More >

Leading Researchers:
12-2014-771

Animal models of Addiction and Psychopathologies

Our main focus is on the psychological and neurobiological mechanisms that underlie psychiatric disorders, and in particular addiction We are using rodent models of addiction, anxiety, learning and memory. We focus on behavioral models relevant to different stages of addiction (craving, drug reward, intoxication, sensitization, tolerance, excessive alcohol consumption, withdrawal symptoms, relapse). We are looking […] Read More >

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