Therapeutic Targeting of CD45: A Novel Approach to Overcome Immunotherapy Resistance
Revolutionizing Cancer Immunotherapy While immune checkpoint inhibitors have transformed cancer treatment, only 50% of patients fail to respond, with resistance being a major challenge, particularly in aggressive cancers such as triple-negative breast cancer (TNBC). TNBC accounts for 15–20% of breast cancer cases and is often diagnosed at advanced stages, with current therapies offering limited efficacy. […] Read More >
Pharmacological Activation of the cAMP Signaling Pathway Enhances the Function of Cord Blood – Hematopoietic Stem Cells
Allogeneic Hematopoietic Stem Cell Transplantation is a curative therapy for many blood disorders, including leukemias and inherited blood diseases. It involves depleting a patient’s diseased bone marrow by cytotoxic therapies and then regenerating a healthy hematopoietic system by transplantation of healthy Hematopoietic Stem Cells (HSCs). UNMET NEED Cord blood is an attractive source for stem […] Read More >
Development Of Improved Immunosuppressant Targeting Calcineurin-NFAT Protein-Protein Interaction Via Novel Peptides
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
Development Of Improved Immunosuppressant Targeting Calcineurin-NFAT Protein-Protein Interaction Via Small Molecule Drugs
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
Influenza A virus infection is one of the most common respiratory tract diseases in humans. It is the cause of typical seasonal flu as well as major human pandemics worldwide. According to the World Health Organization (WHO) in October 2023, around 3 to 5 million severe influenza cases were recorded, leading to 290,000 to 650,000 […] Read More >
BACKGROUND GI cancers cause over 3.5 million deaths per year globally, accounting for 35% of all cancer-related deaths. Colorectal carcinoma (CRC) is the world’s second leading cause of cancer death. Current immunotherapy treatments for CRC are hamstrung by low response rate, acquired resistance, relapse and severe side effects. ImmuNovation presents a disruptive nanomodular technology utilizing […] Read More >
New MicroRNAs as Candidates for Depression Therapy
Major depressive disorder (MDD) is a complex, common, and recurrent mental disorder (1). The current first-line treatment for MDD is selective serotonin reuptake inhibitors (SSRIs), which are antidepressant drugs that block serotonin reuptake. Two microRNA (miRNAs) molecules namely miR-30b-5p and miR-101a-3p were found to be downregulated in the raphe nuclei (RN) of mice following chronic […] Read More >
Novel Immuno-Metabolism Pathways to Combat Obesity and Insulin Resistance
Nutritional unbalance develops the obesity led to diabetes and accompanied by insulin resistance is being the epidemics of the 21st century. Inflammation of adipose tissue serves one notable pathway that is driving the development of dysfunctional metabolic state, leading to hyperglycaemia and other pathophysiology complications. Within the adipose tissue, a pivotal role in modulating interactions […] Read More >
Development of Improved Peptide Inhibitors of the HIF/PHD Interaction – Anemia and HIF – Related Diseases
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
Flaviviridae are a family of positive, single-stranded enveloped RNA viruses that are typically transmitted to humans via mosquitoes and ticks. Yellow Fever virus, West Nile virus and Dengue virus are examples of human Flavivirus pathogens. Dengue virus has 4 serotypes, and getting infected by one serotype, does not protect against the other three. Moreover, pre-infection […] Read More >
Repurposing FDA-Approved Drugs for the Treatment of Aniridia
Aniridia is a panocular disease causing progressive severe visual impairment and blindness. The disease is characterized by abnormal development of almost all eye structures, caused by dominantly inherited heterozygous mutations in primarily the PAX6 gene. Although aniridia is a developmental disorder, corneal opacification begins late in childhood, leaving a large time window for therapy. Unfortunately, […] Read More >
Novel Anti-Tumor Response treatment targeting ErbB receptors and Nucleolin interactions
ErbBs subfamily receptors are mediators of cell growth signals. They have long been associated with a wide variety of lung, ovarian, colon, breast, prostate, and other carcinomas. Nucleolin is a major nucleolar protein of growing eukaryotic cells and is present on the cell surface of a range of cancers. Recently, a robust oncogenic interaction between […] Read More >
New Chemiluminescent Protease Probe for Rapid, Sensitive, and Inexpensive Detection of Live Mycobacterium tuberculosis
Tuberculosis (TB) is a top-ten cause of death worldwide. Successful treatment is often limited by insufficient diagnostic capabilities, especially at the point of care in low-resource settings. The ideal diagnostic must be fast, be cheap, and require minimal clinical resources while providing high sensitivity, selectivity, and the ability to differentiate live from dead bacteria.OUR SOLUTION• We […] Read More >
Leading Researchers:
10-2020-1438
Plant-Derived Anti- Herpesvirus Composition
Herpes simplex virus infection is commonly known as herpes. The two types of herpes simplex virus are HSV-1 (known to cause orofacial disease such as cold sores) and HSV-2 (causes genital infections). Over 80% of herpes infections is asymptomatic. Symptomatic infections are presented with blistering sores, pain during urination, swollen lymph nodes, and fever. Acyclovir […] Read More >
An early stage screening tool for distinguishing pregnant women having an increased risk of developing preeclampsia
Preeclampsia is one of the most dangerous pregnancy complications occurs in the second or third trimester, affecting 3–8% of pregnancies; it is the leading cause of maternal and perinatal mortality and morbidity. Preeclampsia cannot reliably be predicted as no tests available in early pregnancy. OUR INNOVATION The invention is based in part on the finding […] Read More >
Repurposing of Antibiotics for treating APC (Adenomatous Polyposis Coli) Related Colorectal Cancer
Restoration of Adenomatous Polyposis Coli (APC) gene expression by means of antibiotic erythromycin for the treatment of Familial Adenomatous Polyposis. The Technology: Treatment for APC by conventional antibiotics to regulate adenoma growth and delay the need for preventive surgery in Familial Adenomatous Polyposis (FAP) patients. The Need: FAP is a high penetrance devastating syndrome manifested […] Read More >
Macrolid Induced Correction of Premature Stop Codons: A novel Treatment for Colorectal Cancer
Restoration of premature termination codons (PTCs) caused by nonsense mutations for the treatment of Familial Adenomatous Polyposis. The Need Familial Adenomatous Polyposis (FAP) is a high penetrance devastating syndrome manifested by dozens to thousands of colonic adenomas. FAP patients require tight supervision and eventually undergo surgery, to prevent inevitable development of colorectal cancer (CRC) by […] Read More >
An Effective Sema3A Antibody as a Therapy for Optic Nerve Neurodegenerative Diseases
Glaucoma and ischemic or neuro-degenerative diseases of the optic nerve lead to vision loss and blindness. These pathologies are associated with progressive apoptosis of the retinal ganglion cells (RGC), a process which involves expression of Semaphorin 3A protein in the axonal guidance pathways. The identified Sema3A antibody provides a potentially innovative therapeutic tool for these […] Read More >
An active cancer vaccine strategy targeting tumor-associated carbohydrate antigens expressed on tumor cells using biomimetic glyconanoparticles generated from unique red blood cells. The resulting sustained immune response inhibits tumor growth. THE NEED While envisioned already in 1891, only a few cancer vaccines have been approved by the FDA thus far. The key barriers to their […] Read More >
SK4 K+ channel blockers: a new treatment for cardiac atrial fibrillation
We discovered a previously unidentified target in the heart, namely the SK4 calcium-activated K+ channels, which are functionally expressed in pacemaker cells as well as in atrial and ventricular cardiomyocytes. They are crucial for proper cardiac function and represent a completely new therapeutic target for the treatment of cardiac arrhythmias. SK4 channel blockers successfully prevented […] Read More >
A Novel Nanoparticle that Selectively Delivers RNAi Oligonucelotides to Tumors, Preventing Side Effects to Tissues
UNMET NEEDPancreatic cancer numbers among the most aggressive cancers known today. The overwhelming majority of pancreatic cancer patients pass away within just a year of diagnosis. However, a small minority of patients may live several years with the disease. Our findings pinpoint the inverse correlation between a known oncogene (PLK1) and the expression of an […] Read More >
An Oncolytic Virus That Exploits Immune Defects of Cancer Cells
An oncolytic virus for tumors of different etiology presenting defects in interferon signaling, designed as a potent, specific and safe therapy. Promising in-vivo murine melanoma model shows potential for development as a mono or an add-on to chemotherapy or check-point inhibitors. UNMET NEED On Nov. 2015 the FDA approved the first oncolytic virus based treatment. […] Read More >
Novel Specific Disease-Modifying PERK Activator for Huntington’s Disease
The need: There is no efficient therapy at present for Huntington’s disease (HD) nor for any other neurodegenerative disease, including Alzheimer’s and Parkinson’s diseases. No disease-modifying approaches exist. • Gene therapy-based clinical trials have failed so far, highlighting the need for other approaches. These include the recent interruption of antisense oligonucleotide clinical trials for HD. Background […] Read More >
METHODS AND KITS FOR DETERMINING PREDISPOSITION TO DEVELOP KIDNEY DISEASES
Many rare kidney disorders exhibit a monogenic, Mendelian pattern of inheritance. Population-based genetic studies have identified many genetic variants associated with an increased risk of developing common kidney diseases. Strongly associated variants have potential clinical uses as predictive markers and may advance our understanding of disease pathogenesis. These principles are elegantly illustrated by a region […] Read More >
TechnologyThe aggregation site on human calcitonin has been identified, paving the way for development of specific inhibitors of calcitonin amyloid fibril formation. Such inhibitors will enable development of improved calcitonin therapeutics as well as greatly facilitate in vitro calcitonin manipulations. The NeedThe therapeutic use of human calcitonin is severely limited by its tendency to associate […] Read More >
Glioblastoma Regression by Regulating Astrocytes’ Immunometabolic Signaling
Malignant brain tumors are the cause of a disproportionate level of morbidity and mortality among cancer patients, an unfortunate statistic that has remained constant for decades. Despite considerable advances in the molecular characterization of these tumors, targeting the cancer cells has yet to produce significant advances in treatment OUR SOLUTIONAn alternative strategy is to target […] Read More >
Therapeutic Monoclonal Antibodies to Combat Multidrug-Resistant Pathogenic Bacteria
It is predicted that a failure to address the problem of antibiotic-resistant pathogens will result in the death of 10 million people annually, costing the economy more than 100 trillion dollars by the year 2050. In high-income countries where antibiotics are heavily used in the community and agriculture, the strong selection pressure and non-completed antibiotic […] Read More >
Therapeutic Targeting of PD-1/PD-L1 blockade by Novel Small-molecule Inhibitors
Interactions between programmed cell death ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1) lead to the evasion of cancer cells from an efficient immune response. The inhibition of PD-L1/PD-1 has prevented or reversed exhausted T cells, thus enhancing antitumor T-cell responses. In fact, immune checkpoint blockade targeting the PD-1 axis has become one […] Read More >
Leveraging Gene Panel Sequencing Data for Mutational Signature Analysis with Applications to Personalized Treatment
UNMET NEED Mutational signatures and their exposures are key to understanding the processes that shape cancer genomes with applications to diagnosis and treatment. Yet current signature analysis approaches are limited to relatively rich mutation data that comes from whole-genome or whole-exome sequencing. Recently, orders of magnitude sparser data sets from gene panel sequencing have become […] Read More >
Development of Alzheimer Disease therapy based on counteracting the pathological effects of ApoE4
Alzheimer’s disease (AD) is the most common cause of dementia and is the outcome of progressive brain cells death. Due to the disorder’s heterogeneity and in view of the variety of pathological mechanisms inducing the disease we have undertaken an innovative – science based (Animal model) approach, which is presented here. Our unique approach […] Read More >
Homocysteine fibrillar assemblies display crosstalk with Alzheimer’s disease amyloid polypeptide
High levels of homocysteine (Hcy) are reported as a risk factor for Alzheimer’s disease (AD). Correspondingly, inborn hyperhomocysteinemia is associated with an increased predisposition to the development of dementia in later stages of life. Furthermore, despite the apparent association between protein aggregation and AD, attempts to develop a therapy that targets explicitly this process have […] Read More >
Pioneering Pre-Clinical Research at the Heart of Innovation
For over 30 years, Tel-Aviv University’s Neufeld Heart Research Institute at Sheba Medical Center has been at the forefront of cardiovascular and other fields of research, combining the academic rigor of a university with the clinical expertise of Israel’s leading medical center. As a strategic partner to industry and researchers, we offer a comprehensive suite […] Read More >
The lab focuses on uncovering the dynamics and cellular processing governing neurovascular coupling under healthy and pathological conditions Specific Research interests/topics: • Neurovascular coupling • Multiphoton imaging • Ischemia, gray matter vascular occlusions • Microglia and neuro-immune responses Research methods: • In vivo imaging methods: two-photon microscopy, wide-field calcium imaging, MRI. • Novel spatial decision […] Read More >
The Laboratory of Oral-Mucosal Stem Cell Regeneration and Enzymatic Dental Therapeutics
The Laboratory of Oral-Mucosal Stem Cell Regeneration and Enzymatic Dental Therapeutics is charting new frontiers in the realm of regenerative medicine and dental care. Harnessing the potent capabilities of stem cells derived from the oral mucosa, the research endeavors not only target the restoration of oral structures but also broader applications, such as bone regeneration […] Read More >
Biological and Bio-Inspired Molecular Self-Assembly- The Gazit Lab
MOLECULAR SELF-ASSEMBLY AMYLOID FIBRIL FORMATION NANOBIOTECHNOLOGY METABOLITE AMYLOIDS MOLECULAR SELF-ASSEMBLY We study one of the most important problems in contemporary life sciences and medicine: Understanding the molecular basis for the formation of amyloid nanostructures in degenerative disorders, a process underlying the pathophysiology of some of the most devastating health problems world-wide, such as Alzheimer’s disease, […] Read More >
Advances in biomedical science have cured multiple diseases and greatly improved healthspan and lifespan. However, aging is the strongest risk factor for most causes of death in the western world, and thus these advances have resulted in a relatively small increase in maximal lifespan. Without a systematic approach to understand and treat the aging process, […] Read More >
The Lab for Protein Engineering and Drug Discovery
Modulation of protein-protein interactions is a key for a broad range of biotechnological applications. In our lab, we are developing unique approaches from small molecules, peptides, and optimized proteins to inhibit specific interactions. We are utilizing advanced computational, biophysical and cellular biology techniques. Specific Research interests: • Engineering of unique Immune modulators • Engineering of optimized proteins […] Read More >
Medical Ultrasound Technologies for Diagnostics, Monitoring, and Therapy for Clinically Relevant Problems
The Ilovitsh lab at Tel-Aviv University- We develop noninvasive medical ultrasound technologies for diagnostics, monitoring, and therapy for clinically relevant problems. Our research is highly multidisciplinary, combining engineering, physics, biology, chemistry and medicine. We utilize the unique ability of sound waves to penetrate deep into the body, in some cases even through an intact skull, […] Read More >
Our research focuses on Reproductive Physiology in animal models and in humans. The current research directions investigated in the laboratory are: The role of Fyn kinase, member of the Src family kinases, during meiosis and early events of oocyte activation, as well as in cancer cells (Figure-left panel). Fertility preservation – the signaling pathway leading […] Read More >
Leading Researchers:
The Myers Neuro-Behavioral Core Facility
Unit description:The Myers Neuro-Behavioral Core Facility provides researchers with state-of-the-art technology for performing neuro-behavioral tests in mice. Services: The Core Facility provides expertise in design, implementation, and analysis of behavioral experiments. The Core Facility includes five behavior rooms, which can operate simultaneously, and two animal maintenance rooms with IVC cages operating on a reversed light […] Read More >
Prof. Galit Yovel is the Head of the SCAN@TAU Center SCAN@TAU Center The Strauss Computational Neuroimaging Center George S. Wise Faculty of Life Sciences https://mri.tau.ac.il/about The center’s services SCAN@TAU center is a new MRI multidisciplinary research center at Tel Aviv University that offers cutting edge MR technologies and innovative, high-resolution imaging methods. The […] Read More >
Lab Description Using the powerful combination of molecular biology, biophysics, biochemistry and electrophysiology. our research aims at elucidating the structural, biophysical and physiological attributes of normal and diseased ion channels in brain and heart and whose mutations in human lead to major neurological and cardiovascular disorders like epilepsy, autism, atrial or ventricular fibrillation. Main […] Read More >
Our main focus is on the psychological and neurobiological mechanisms that underlie psychiatric disorders, and in particular addiction We are using rodent models of addiction, anxiety, learning and memory. We focus on behavioral models relevant to different stages of addiction (craving, drug reward, intoxication, sensitization, tolerance, excessive alcohol consumption, withdrawal symptoms, relapse). We are looking […] Read More >
MULTI SENSOR – Multi Modal Recording System for Behavioral Tracking
It is clear today that brain activity of a restrained (or sedated) animal is completely different from that of a freely behaving animal.That is why neuroscientists are seeking to find ways to study animals freely behaving on their natural grounds.TAU’s interdisciplinary research has led to the development of the MULTI SENSOR – Multi Modal Recording […] Read More >
The general purpose of my research is to describe the genetic and endocrine regulation of bone metabolism. To this end, we developed expertise in most aspects of bone research, from in vivo models, imaging of bone microarchitecture, in vitro cell cultures and molecular biology. Main Research Topics Regulation of bone metabolism by sex steroids Role […] Read More >
Laboratory of endoplasmic reticulum (ER) quality control and protein misfolding diseases
Lab DescriptionMain areas of interest are in the mechanisms of protein folding and trafficking in the early secretory pathway of mammalian cells and the development of ER stress upon their malfunction, particularly in neurodegenerative diseases. Specific research topics are:• Protein misfolding diseases, including neurodegenerative diseases.• ER stress.• Mechanisms of endoplasmic reticulum (ER) protein folding and quality control.• Sugar chain […] Read More >
The Cohen Rosenthal Diabetic Hypertensive Rat (CRDH) model
The construction of the Cohen Rosenthal Diabetic Hypertensive Rat (CRDH) model was initiated nearly a decade ago by cross-breeding between the Cohen Diabetic rat (CDR) and the SHR. The CDR is a rodent model that expresses the following phenotypes: when fed regular diet, it is non-diabetic; when fed a diabetogenic diet, it invariably develops diabetes […] Read More >
Laboratory of Immunological and Inflammatory Modules in Malignancy
Research focus Prof. Ben-Baruch is an immunologist who investigates the roles of immune and inflammatory elements in physiological and pathological conditions, with major emphasis on malignancy. The studies in her laboratory determine the complex regulatory networks established between chemokines and cytokines of the tumor microenvironment, intrinsic oncogenic modifications in tumor cells, and stroma cells. The […] Read More >
The Biomaterials and Corrosion LaboratoryIby and Aladar Fleischman Faculty of Engineering, Tel-Aviv University, Israel In line with the demands of modern society, the multidisciplinary Biomaterials and Corrosion Laboratory is conducting strategic R&D on advanced materials ranging from biomaterials and nanomaterials, to materials for space applications, alloy deposition and archaeology. The Lab also provides materials […] Read More >
Lab of Signal transduction, Neurodegeneration and Autophagy
Research focus ErbB receptors interactions and functions Regulation of Autophagy Neurodegeneration Projects include: The crosstalk between ErbB receprots and nucleolin in cancer development Beclin 1 mediated autophagy Autophagy in neurodegenerative diseases Autophagy in cancer Potential services Laboratory services: To monitor autophagy Signal transduction assays Anti-cancer drugs examination Cell proliferation, death and migration examination Potential […] Read More >
The goal of the lab is to elucidate molecular mechanisms of motor neuron survival and proper function using ALS disease as a model. In our current efforts we are using cutting edge in vitro and in vivo technologies studying molecular mechanisms of: 1. Molecular communication of trophic factors (such as BDNF or GDNF) between […] Read More >
Selective therapy remains a key issue for successful treatment in cancer therapy. Prolonged administration of effective concentrations of chemotherapeutic or anti-angiogenic agents is usually not possible because of dose-limiting systemic toxicities involving non-malignant tissues. Therefore, a constant effort has been the development of new drug delivery systems that mediate drug release selectively at the tumor […] Read More >
Custom synthesis of organic compounds Industrial Research Services: We offer services for custom synthesis of small organic compounds. Our laboratories in Tel Aviv University have all the basic state-of-the-art instrumentation for synthetic capabilities. The School of Chemistry also has an Analytical Research and Instrumentation Unit, which provides services for organic analyses. The Department of Chemistry […] Read More >
Laboratory of Experimental BiophysicsSchool of Physics and Astronomy, Faculty of Exact ScienceThe Center for NanoScience and NanoTechnology Services:Small Angle X-ray Scattering (SAXS), Wide Angle X-ray Scattering (WAXS), Grazing Incident Small Angle X-ray Scatter (GISAXS) X-ray scattering provide structural information (shape and size) in non-destructive and stain free conditions. Small angle scattering is an ideal characterization […] Read More >
Department of Biomedical Engineering – Prof. Ofer Barnea Ofer Barnea is a Professor of Biomedical Engineering at Tel Aviv University and is the Director of the Ela Kodesz Institute for Biomedical Physics and Engineering. He was the chairman of the Department of Biomedical Engineering and the chairman of the Israeli Chapter of the IEEE […] Read More >
The general goal of our laboratory is to research design and build in vitro systems that simulate cardiovascular flows, hemodynamic shear forces, and blood-tissue interaction. In addition, the laboratory conducts a wide program of numerical bio-simulations. Focus In Vitro Biological Flows. Hemodynamics. Endothelial Cell and Platelets activation. Digital Particle Image Velocimetry (DPIV). Vulnerable Plaque. Blood-Tissue […] Read More >
Bacterial Isolates Identification and Gene Sequencing
Webpage: https://www.tau.ac.il/lifesci/departments/biotech/members/gophna/gophna.html Scientist Contact:Uri Gophna Ph.D.Senior lecturer,Deparment of Molecular Microbiology and BiotechnologyGeorge S. Wise Faculty of Life SciencesTel. +972-3-6409988Fax +972-3-6409407email: urigo@tauex.tau.ac.il Read More >
Consultation and lab services are offered, with a focus on eye-related medical innovations from concept through to clinical trials. Lab Website:https://www.tau.ac.il/medicine/Goldschleger/Goldschleger.html Scientist: Michael Belkin, MA, MD Professor of Ophthalmology Director, Ophthalmic Technologies Laboratory Goldschleger Eye Research Institute Tel Aviv University Sheba Medical Center Tel Hashomer 52621 Israel Phone: +972-3-530-2956 Fax: +972-3-535-1577 Skype: Belkin E-mail: belkin@netvision.net.il Read More >
Leading Researchers:
Bert Strassburger Lipid Center, Sheba,Tel Hashomer
Fatty Acid Metabolism and Desaturase enzymes, Cholesterol Metabolism and involved enzymes, Membrane composition and liposomes. The lab focuses on techniques for Lipid analysis, like total lipid quantification and analysis of lipid species like fatty acids, triglycerides, phospholipids,etc. using chromatography systems such as HPLC, GC and TLC.Services offered: Identification and quantification of total lipids and specific […] Read More >
Precision Nanomedicine: Preparation and Characterization of Nanocarriers Made from Natural Biopolymers
The laboratory of Precision Nanomedicine at TAU have capabilities for preparation and characterization of nanocarriers made from natural biopolymers such as lipids (liposomes, micelles) , sugars and proteins. Lab Description • State-of-the-art preparation and process development of lipid based nanoparticles including sythesisi capabilities of lipids. • cell culture facility including the culturing of hybridomas and […] Read More >
SERVICES“ Lipid Solutions” Prof. Alicia Leikin-Frenkel “Lipid Solutions” covering:1. Expert support for questions on: lipid metabolism, isolation, identification and quantitation of lipids in different species and different matrixes.2. Guidance to discover the pathway to physiological and biochemical implications following overexpressed or suppressed gene linked to lipids.3. Counseling to analyze lipids in:• Simple molecules: fatty acids: Saturated, Monounsaturated n7, n9, Polyunsaturated: […] Read More >
Drug Screening Animal Model for Anti-compulsive Activity
We have developed the signal attenuation rat model of obsessive-compulsive disorder (OCD). This model is based on the theoretical proposition that compulsive behaviors result from a deficit in the feedback, which is associated with the performance of normal goal-directed responses. In our model, the goal-directed behavior is lever-pressing for food. The feedback associated with making […] Read More >
Cardiovascular and Physiological Assessment in Animal Models
Neufeld Cardiac Research Institute at Sheba Medical Center, Tel-Aviv University comprises a fully equipped laboratory to conduct cardiovascular and physiological experiments in small (mice, rat) and large animals (swine, sheep, calf) including heart function studies with special echocardiography system designed for small animals (Vevo660 ultrasound biomicroscope; VisualSonics), molecular imaging, pressure‐volume loop machine (Millar/Power Lab) and […] Read More >
Laboratory of Biological Psychiatry & Behavioral research- Felsenstein Institute Main Research Topics Cognition, Memory, Social behavior, Motility. Disease: Schizophrenia, Anxiety, Neuropathy pain and Depression Drug Development: Schizophrenia, Depression, Cognition, Pain . Lab facilities The lab is well equipped with the required instruments for molecular and cellular research. At the institute, we have a modern animal room […] Read More >
Blast Brain Injury: a combat zone-like mouse model. From the experimental lab to the war against terror and back to the lab. Improvised explosive devices (IEDs) are one of the main causes for casualties among civilians and military personnel in the present war against terror. IEDs induce various degrees of cognitive, emotional and behavioral disturbances […] Read More >
Animal Models for CNS Disorders and Screening Method for Diabetes
In vitro and in vivo animal models for stroke, Alzheimer’s disease (AD), and multiple sclerosis (MS). Rapid screening method for selecting candidates with specific insulin-degrading enzyme inhibitor activity in Types I and II Diabetes. https://www.tau.ac.il/lifesci/departments/neuro/members/frenkel/frenkel.html Read More >
Animal eye models for evaluation of systemic and topical use of new medications, devices and delivery systems. The models include external eye, intraocular, orbital, and optic nerve applications. Webpages:https://www.sheba.co.il/Institutes/Eye_Institute/Eye_Clinics/78.htmhttps://www.tau.ac.il/medicine/ophthalmology/ophth_con.html CONTACT Department of Opthalmology Faculty of MedicineTel Aviv UniversityRamat Aviv 69978, IsraelFax: 972-3-6405354 Head of the Department:Prof. Arieh S Solomon, MD,PhDEmail: asolomon@post.tau.ac.ilPhone: 972-3-5350702Fax: […] Read More >
Neurodevelopmental, Gestational, Lactational and Maternal Immune Stimulation Animal Model for Schizophrenia
Fields of InterestPharmacology of schizophrenia, animal models of psychopathology, neurodevelopmental model of schizophrenia. Prof. Weiner’s lab has launched and developed the latent inhibition model of schizophrenia which mimics loss of normal attentional control in this disorder, with a focus on the pharmacology of latent inhibition as a basis for the search for novel drugs. In […] Read More >
Unique Animal Models for Inflammatory Lung, GI, and Bowel Diseases
The Laboratory of Mucosal Immunology The Laboratory of Mucosal Immunology is new at the faculty of Medicine and deals primarily with mucosal inflammation. We focus on diseases affecting the lungs, such as asthma, COPD (chronic obstructive pulmonary disease), acute lung injury and gastrointestinal (GI) tract, inflammatory bowel disease (IBD) and colorectal cancer. In lungs models […] Read More >
Prof. Ashery Uri
Research topic: Elucidating the molecular mechanisms of synaptic transmission and plasticity under normal conditions, during neurodegenerative diseases and in aging. Research methods: Electrophysiology, Slice recording, Total Internal Reflection Fluorescence (TIRF), stochastic optical reconstruction microscopy (STORM), Fluorescence Resonance Energy Transfer (FRET), Molecular biology, Model simulation, Multi electrode array recording, Immunohistochemistry, Behavioral tests. Main projects in the […] Read More >
Prof. Attali Bernard
Reaching an understanding in molecular terms of the mechanisms by which changes in membrane potential regulate cellular events is the main concern of our research. We focus our interest on potassium channels because they play crucial roles in many cellular functions such as shaping cardiac and neuronal action potentials, tuning neuronal firing patterns, synaptic integration […] Read More >
Prof. Avraham Karen B.
Genomic Analysis of Hereditary Hearing Loss Our primary interest is the genetic basis of hereditary hearing loss or deafness. Our group is working towards the identification, characterization and regulation of genes associated with hereditary hearing loss. For gene discovery, we focus on the Israeli Jewish and Palestinian Arab populations in the Middle East. Our studies […] Read More >
Prof. Bacharach Eran
Eran Bacharach is the head of a research laboratory for molecular virology at the Department of Cell Research and Immunology, and teaches courses on microbiology, molecular virology and cell biology, at the Faculty of Life Sciences, where he has been on the faculty since 2000. He received his B.Sc., M.Sc. and Ph.D. degrees from the […] Read More >
Prof. Barak Segev
Dr. Barak’s research focuses on the psychobiology and neurobiology of alcoholism and drug addiction. In particular, he is interested in the molecular and neuronal mechanisms that underlie learning and memory processes in alcohol addiction. In addition, Dr. Barak is interested in the pathophysiology of schizophrenia, with focus on cognitive impairments in this disorder. See lab […] Read More >
Prof. BARNEA Ofer
Patient specific models: Assessment of fetal cardiovascular development Optimization Propofol administration during anesthesia Optimization of fluid resuscitation Assessment of cerebral blood flow autoregulation Multiscale models of physiological systems 3D fiber based model of the contracting heart Oxygen transfer to tissue Biomedical measurements and instrumentation Optimally controlled fluid administration system Detection of bubbles in blood to […] Read More >
Prof. Barzel Adi
Our lab will focus on gene therapy using viral vectors. We will tackle diseases ranging from cancer to viral infections and diabetes. Devising safe and efficient gene therapies combines challenges in biochemistry and molecular biology with challenges in physiology, immunology, virology and more. We will focus on genome editing- the site specific manipulation of the […] Read More >
Dr. Beck-Barkai Roy
Research Cytoskeleton protein complexes – Interaction between cytoskeleton protein complexes and their effect on the structure and elasticity of the cell. Intrinsically disordered protein – Statistical structural characterization of proteins that do not completely fold into 3d fixed structures in solutions. Nanoscopic complex – characterizing and manipulating nanoscopic complexes by grafted biopolymer. Membrane physics – stabilization of membrane to […] Read More >
Prof. Belkin Michael
Prof. Belkin has been involved in the establishment of many medical start-ups in ophthalmology and other fields. One of his noted contributions was inventing and developing the Ex-PRESS Glaucoma Filtration Device. The ExPRESS, after being sold to global eye care leader Alcon, is now routinely used in glaucoma surgery worldwide. He is now developing his […] Read More >
Prof. Ben-Baruch Adit
Breast cancer is a leading cause of death for women in the Western world. The battle against breast cancer has been challenged by the fact that, generally, each component is studied meticulously, but singly. Too little attention is paid to the interactions between the tumor cells and their intimate microenvironment, consisting of various cells and […] Read More >
Prof. Ben-Eliyahu Shamgar
I am a neuroscientist specializing in Psycho-Neuro-Immunology (PNI). The field of PNI studies interactions between the central nervous system (CNS), the endocrine system, and the immune system. Bidirectional influences between these systems affect susceptibility to diseases, cognition, mood, and behavior, as well as neurodevelopmental processes. Within the realm of PNI, my main research interests are […] Read More >
Prof. Benayahu Dafna
Nanomedicine is medical treatment at the level of single molecules or molecular assemblies that provide structure, control, signaling, homeostasis, and motility in cells, i.e., at the “nano” scale of about 100 mm or less. There have been many scientific and technological advances in both physical and biological sciences over the past several years that make nano medicine […] Read More >
Prof. Benhar is an expert and opinion leader in the field of antibody engineering. Over the 25 years of being active in that field, he prepared several phage display libraries from which antibodies against numerous targets were isolated. Prof. Benhar publishes over 100research papers, wrote 10 book chapters and submitted 19 patent applications. Research in Prof. […] Read More >
Dr. Burstein is a faculty member in The Shmunis School of Biomedicine and Cancer Research in the Life Science Faculty at Tel Aviv University. His research focuses on CRISPR-Cas systems, secretion systems of pathogens, and the discovery of novel antibiotic resistance genes to better understand fundamental interaction mechanisms within microbial communities and to promote their […] Read More >
Prof. Canaani Dan
Preface Previously, my laboratory has concentrated on isolation of human DNA repair genes, and in particular checkpoint genes for DNA damage. For this purpose we introduced the approach of isolating human DNA repair genes by expression cloning of cDNA libraries (Teitz et al., 1987; 1988; 1989). This approach has initially resulted in our identification of […] Read More >
Prof. Dvir Tal
Microfluidics-based tissue engineering. Recreating stem cell niches, microfluidics bioreactors for tissue engineering. Nanotechnological strategies for engineering thick cardiac tissue. Engineering a 3D neuronal network for spinal cord and brain regeneration. Fabrication of Nanoelectronics/engineered tissue hybrids. Developing smart delivery systems that recruit stem cells to defected organs. Email: tdvir@tauex.tau.ac.il Phone: 03-6406514 Another phone: 03-6408604 Website: https://dvirlab.wixsite.com/dv… Office: […] Read More >
Prof. Efrat Shimon
Our research focuses on the development of a cell replacement therapy for diabetes, in which the insulin-producing pancreatic beta cells are destroyed or malfunction. Our approaches for generation of an abundant source of cells for transplantation include expansion and differentiation in tissue culture of beta cells from human organ donors, as well as differentiation of […] Read More >
Prof. Ehrlich Marcelo
I am interested on the dynamic aspects of the cell’s trafficking machinery, with a special focus on endocytic dynamics. More specifically, our study centers on the mechanisms by which the cell modulates vesicular traffic by altering: The rate of formation of vesicular carriers, such as clathrin coated vesicles. The spatio-temporal distribution of the process of […] Read More >
Prof. Einav Shmuel
Research Interests: Flow in biological systems; cardiac blood flow; Blood flow in obstructed arteries and in bypasses; blood flow through artificial heart valves; Cardiac-assist devices; magnetic resonance imaging of blood flow Read More >
Prof. Eldar- Finkelman Hagit
My overall research is focused on elucidating the molecular and biochemical regulation of the protein kinase, glycogen synthase kinase-3 (GSK-3), and revealing its contribution to pathological disorders. GSK-3 is emerging as a prominent drug discovery target in neurodegenerative disorders including ALS, Parkinson’s, Huntington’s and Alzheimer’s disease. In a recent work we identified lysosomes as novel […] Read More >
Prof. Eliaz Noam
Research: Biomaterials (e.g. electrochemically-assisted deposition of calcium phosphates) and medical devices. Bio-Ferrography (e.g. for orthopaedic applications and cancer diagnostics). Environment-induced degradation of materials and hydrogen interaction with materials. Electrodeposition and electroless plating of special alloys (e.g. rhenium-based) and electropolishing. Failure analysis. Quality control of raw materials and products; consultation services for materials and processes selection. Read More >
Prof. Erez Neta
Associate Professor, Chair of the Department of Pathology, Faculty of Medicine, Tel Aviv University Research Cancer Related Inflammation in Tumor Progression and Metastasis The main goal of our laboratory is to uncover stromal pathways that contribute to tumorigenesis and metastasis. Extensive research has led to the understanding that tumors are more than just cancer cells: […] Read More >
Research Molecular Analysis of Cancer Immunoresistance The long-term goal of our research is to develop a novel treatment for immune resistant cancers. Our research includes characterization of the mechanism of complement-dependent cytotoxicity and of the basis for elevated resistance of cancer cells to cell death, and design of novel reagents that sensitize cancer cells to […] Read More >
Prof. Freeman Amihay
Research interests include: Biomedical applications of enzymes and cells. Protein Nano-biotechnology: protein mediated biotemplating for the integration of biologically active protein-metal hybrid with microelectronics and development of new composite materials. Bioprocessing aspects of biocatalysis Read More >
Prof. Frenkel Dan
Research topic: The research in our laboratory is focused on the investigation of glial cell and to clarify their role in neurological diseases. We suggest that targeting glia activation in different pathological scenarios may allow us to define common pathways to further understand the role of glia in neuroprotection . We are using three models: 1) […] Read More >
Dr. Freund Natalia
Senior Lecturer (Guest), Department of Clinical Microbiology and Immunology, Faculty of Medicine Research My laboratory is interested in understanding the molecular basis of human antibody responses to diseases. Antibodies are key components of most licensed vaccines; nevertheless many aspects of how antibodies recognize and neutralize their targets are still unknown. Pathogen-specific B cells are stimulated […] Read More >
Prof. Fridman Micha
The Fridman laboratory is engaged in the use of organic chemistry, especially carbohydrate chemistry, to solve key biological and medicinal problems. Our interdisciplinary studies involve the use of organic chemistry, microbiology, cell biology, molecular biology, and confocal microscopy to study and/or alter the mode of action of biologically active molecules with the focus on novel […] Read More >
Prof. Gabet Yankel
Genetics: Our laboratory focuses on the genetic and hormonal regulation of bone remodeling, microarchitecture and strength. These traits have a high degree of heritability, and one aspect of our research is to characterize new genetic determinants of bone remodeling as well as elucidate the mechanism of action of selected genes. Our GWAS confirmed the role of […] Read More >
Prof. Gannot Israel
Research Interests: Optical biopsy -optical diagnostic methods in medicine Laser tissue interaction Fibers and waveguides for medical applications Lasers and optics in medicine Read More >
Prof. Gazit Ehud
The central dogma in the study of protein folding suggests that the thermodynamically-favorable state of proteins under physiological conditions is their folded one. However, there are number of cases in which the favorable states of proteins are rather unfolded, partially folded (e.g., “molten globular”), or misfolded (e.g., nonspecific aggregates or amyloid fibrils). These observations lead […] Read More >
Prof. Gefen Amit
Musculoskeletal Biomechanics Laboratory The Musculoskeletal Biomechanics Laboratory of Professor Amit Gefen (@AmitGefen) has versatile in-house testing equipment for state-of-the-art experimental (test bench) and computer modeling and simulation studies of medical devices and consumables. Professor Gefen has more than 20 years of experience in developing and executing laboratory tests and modeling and simulation work. Together with […] Read More >
Prof. Tamar Geiger
Dr. Geiger is an associate professor at the department of Human Molecular Genetics and Biochemistry at the Faculty of Medicine at Tel Aviv University. Geiger completed her BSc studies in life sciences at the Hebrew University of Jerusalem. She then continued and performed her MSc and PhD studies in the same university studying cancer signaling […] Read More >
Prof. GERBER Alexander
1. Nanoscale magnetic systems. a) Spin-dependent electronic transport in ultra-thin magnetic films and granular ferromagnet – normal metal and ferromagnet – insulator mixtures. b) Giant magnetoresistance (GMR) and tunneling magnetoresistance (TMR). c) Extraordinary Hall effect in ultra-thin films and heterogeneous mixtures. d) Magnetic properties of single nanoscale magnetic clusters and their arrays. c) Development of […] Read More >
Prof. Gershoni Jonathan M.
Research Interests Our objective is to elucidate molecular mechanisms of biorecognition. How do receptors bind their corresponding ligands? How do viruses recognize their target cells? What enables the immune system to identify self antigens and to eliminate foreign invaders? The research is a combination of protein biochemistry, monoclonal antibody technology and combinatorial phage display systems […] Read More >
Our goal is to generative fundamental knowledge on biological systems organization and function, and to apply this knowledge to develop technologies that address critical challenges in energy generation and health. Our laboratory conducts research in a wide range of research subjects including: BioEnergy systems Bioenergy systems efficiency analysis We develop models to analyze the efficiency […] Read More >
Prof. Gophna Uri
Research topics: Microbial ecology, The human microbiome in IBD, Selfish genetic elements, Microbial defense systems, Systems biology, Halophilic archaea Research methods: Deep sequencing/massively parallel sequencing, microbiology, gene cloning, quantitative RT-PCR, immunofluorescence, Metagenomics , bioinformatics. Main projects in the lab include: > Microorganisms as biomarkers, and mediators of inflammation in IBD > Evolutionary roles of CRISPR-Cas […] Read More >
Dr. Gothilf Yoav
Research Activity The Circadian Clock system All organisms demonstrate a wide variety of behavioral and physiological daily rhythms that are driven by an evolutionary conserved endogenous circadian clock mechanism. Maintenance of circadian rhythms is crucial for the physical and mental wellbeing, and disruption of the rhythms increases susceptibility to diseases and psychiatric disorders. Utilizing the […] Read More >
Prof. Gozes Illana
Our research is characterized by a multi-level approach to the study of brain function, behavior, memory and drug discovery, from molecules to cures. Targeting autism, schizophrenia as well as Alzheimer’s disease and related neurodegeneration and utilizing a multidisciplinary approach, our group investigates different aspects of neuronal plasticity and nerve cell protection, at the molecular, cellular […] Read More >
Prof. Joel studied the involvement of basal ganglia-thalamocortical circuits in normal and abnormal behavior, using mainly animal models of psychopathology. More recently Prof. Joel has expanded her work to research questions related to brain, sex and gender. Ongoing studies attempt to characterize the relations between sex and brain structure and function. Other studies focus on […] Read More >
Prof. Kashman Yoel
Research Isolation of bio active natural compounds, mainly , anti bacterial , anti viral and/or cytotoxic compounds from plants and mainly marine organisms ( soft corals, sponges and tunicates ). The compounds belong to the various bio-synthetic groups , namely , terpenoids , polyketides and nitrogen containing compounds ( alkaloids ? ) . The structure […] Read More >
Prof. Kolot Mikhail
Research Interests HK022 bacteriophage site specific recombinase Integrase is the tool for human genome manipulation and gene therapy. Site specific recombinases (SSRs) catalase the site-specific recombination reaction between two specific short DNA sequences of 30-40 bp that serve as recombination sites that included integration, excision and inversion. These enzymes are widely used for the genome manipulations […] Read More >
Prof. LEDERKREMER Gerardo Zelmar
Research Prof. Lederkremer’s lab has been interested in the mechanisms of protein folding and trafficking in the early secretory pathway of mammalian cells. He has focused especially on mechanisms of ER protein quality control and on recognition and delivery of misfolded proteins from the ER to the cytosolic proteasomes for ERAD. These processes are intimately […] Read More >
Professor Leor received an M.D. degree from Tel-Aviv University, continued training in cardiovascular medicine at the Sheba Medical Center, and completed his post doctorate training at the University of Southern California, Los Angeles, under Robert A. Kloner, M.D., Ph.D. Today, his laboratory’s research focuses on infarct repair and the heart’s lack of intrinsic regenerative ability. […] Read More >
I am a faculty member in the Department of Biomedical Engineering, and Sagol School of Neuroscience at Tel Aviv University. I accomplished my Ph.D in Chemistry in Tel Aviv University under the supervision of Prof. Gil Markovich. I returned to Israel after completing his post-doctoral fellowship at the Wyss Institute at Harvard University, under the […] Read More >
Prof. Margalit Rimona
Research Interests 1. Micro- and nano-particulate drug delivery technologies for topical, regional and systemic applications: Our efforts in the drug delivery arena focus on two drug delivery technologies, one veteran and one novel, that are inventions of our group. These technologies each yield, micro and nano sized particles that are composed of biomaterials with particular […] Read More >
Prof. Michaelson Daniel
The research in the Michaelson laboratory is directed at unraveling the basic cellular and molecular mechanisms underlying neurodegenration in Alzheimer’s disease and at the development of novel therapeutic approaches to counteract them. The research focuses on apolipoprotein E4 (apoE4), the most prevalent genetic risk factor of the disease ,and on it’s interaction with other risk […] Read More >
Dr. Moran Anan
The general aim of the lab is to study how sensory information is coded and processed in the brain to guide behavior, and how learning through experience is incorporated into this process. Specifically, my lab studies how taste information is processed by a complex network of interconnected nuclei (including the amygdala, taste cortex and pre-frontal […] Read More >
Prof. Munitz Ariel
Our laboratory is focused on elucidating cellular and molecular mechanisms that are involved in mucosal inflammation. Specifically, we are interested in the roles of immune inhibitory receptors in the lung and gastrointestinal tract especially in type-2-associated and innate immune responses. Read More >
Research topic: Neurodegenerative diseases, etiology and new treatments. Research methods: Stem cells, Gene therapy, peptides, transgenic mice, animal models of Neurodegenerative diseases Main projects in the lab include: Induction of neurogenesis and transplantation of various adult stem cells in animal models of neurodegenerative diseases. Development of new therapies, small molecules, peptides and genes, for neurological […] Read More >
Prof. Oron Uri
Uri Oron’s main field of interest lies in regenerative medicine. His current project involves the beneficial effects of recruiting low-level laser stimulated stem cells (derived from autologous bone marrow) to enhance recovery of the ischemic heart and ischemic kidney in mammals. As promising results have been obtained regarding small animal models, his current research is […] Read More >
Our lab is studying the mechanisms that govern glycan immune recognition and responses in animal models and humans, both in vitro and in vivo. We combine glycobiology, immunology, biotechnology and cancer research, and use cutting edge technologies within these disciplines, including glycan microarray and glyco-nanotechnology. Current interests include: Immunological mechanisms of unique anti-carbohydrate antibodies. Glycoimmunology […] Read More >
Prof. Patolsky Fernando
Research Novel Nano materials synthesis (Nanowires) in advanced methods in solid/liquid/gas states and Chemo Physical characterization Synthesis of “Intelligent” Nano materials with optical, electrical and magnetic controlled properties Development and construction of electronic Nano devices for sensing of Chemical and Biological spices Development of Nano Pillars for monitoring of In-cell parameters Development of Nano devices […] Read More >
Prof. Peer Dan
Our lab is studying how to manipulate cells’ functions in order to generate novel strategies to treat inflammatory diseases and cancers. We are combining multidisciplinary approaches including immunology, cell and molecular biology, genetics, protein engineering, material sciences, nanotechnology and computational techniques for drug discovery and potentially for therapeutics. In addition, we are developing nanomedicines by […] Read More >
Research Interest Nanomotors and microfluidic platforms reveal neurodegeneration mechanisms Neuron cell death and synapse disruption seen in neurodegenerative diseases like ALS. It is a non-cell-autonomous process and involve a multi system progression. Neurons are highly polarized cells with very long axons. In order to maintain healthy and function properly the neurons depends on accurate and efficient long […] Read More >
Prof. Pick Chaim G.
Professor, Department of Anatomy & Anthropology, Faculty of Medicine Director, the Sylvan Adams Sports Institute Research Brain Injuries: Cognitive, Behavioral and Cellular Outcome My group has a long history in Traumatic Brain Injury research, not only in characterizing behavioral and biochemical sequelae of blunt head trauma, but also in developing preclinical models of mTBI of […] Read More >
Prof. pinkas-Kramarski Ronit
Research topic: Study the involvement of Autophagy in neurodegenerative diseases. Research methods: Cell biology, Biochemistry, Molecular Biology, microscopy, Immunohistochemistry. Projects in the lab include: The role of autophagy in nerve injury. Study the involvement of autophagy in Alzheimer’s. The molecular mechanism of autophagy regulation. Read More >
Prof. Pitaru Sandu
Prof. Pitaru is an expert in bone, connective tissue and periodontal research, and one of the two inventors of ColBar LifeScience Ltd.’s technology. Read More >
Prof. Portnoy Moshe
Dendrimers are branched, highly ordered macromolecules that are assembled in a modular, iterative fashion from polyfunctional building blocks. These macromolecules are not only aesthetically appealing, but offer chemists three-dimensional structures of nanometer-range size with a variety of interesting architecture-dictated properties for a wide spectrum of applications. The modular mode of assembly and highly ordered nature […] Read More >
Prof. Prag Gali
Research topic: Elucidating the decoding mechanisms of ubiquitin signals and their significance in neurodegenerative diseases Research methods: Biophysical measurements including SPR, AUC, MST and SEC, X-ray crystallography, Bioinformatics, Biochemistry and bacterial genetics Projects in the lab include: Molecular mechanisms that regulate membrane protein trafficking and Parkinson’s disease Mechanisms for regulation of sodium / potassium channels and dopamine transporter. The molecular […] Read More >
Dr. Raiter Annat
Immunotherapy is a new modality which has revolutionized the treatment of cancer for multiple types of tumors. However, breast cancer has shown only modest benefit from immunomodulatory therapies, if at al. This is principally due to tumor escape mechanisms. We have only limited understanding of these mechanisms. Our focus on translational research aims to better […] Read More >
Prof. Rechavi Oded
Prof. Oded Rechavi’s mission is to challenge fundamental long-held scientific dogmas. He found an exception to the original “Cell Theory”, provided the first direct evidence that an acquired trait can be inherited, elucidated an alternative transgenerational inheritance mechanism (that depends on inherited small RNA molecules, not DNA molecules), discovered a mechanism that allows nematodes’ brains […] Read More >
The construction of the Cohen Rosenthal Diabetic Hypertensive Rat (CRDH) model was initiated nearly a decade ago by cross-breeding between the Cohen Diabetic rat (CDR) and the SHR. The CDR is a rodent model that expresses the following phenotypes: when fed regular diet, it is non-diabetic; when fed a diabetogenic diet, it invariably develops diabetes […] Read More >
Prof. Rosin-Arbesfeld Rina
The Wnt signaling pathway is involved in virtually every aspect of human development, as well as in adult homeostasis. Hyperactivation of this pathway has been linked to a wide range of cancers and especially colorectal cancer. Our aim is to understand the molecular events underlying Wnt signal transduction, as well as develop novel therapeutic strategies […] Read More >
Prof. Rosset Saharon
Statistical Genetics, Statistical Learning theory and applications and Data Mining. Read More >
Steyer School of Health Professions Sagol School of Neuroscience Faculty of Medicine building, Room 740 angellruban@tauex.tau.ac.il Read More >
Prof. Ruppin Eytan
Research in Eytan Ruppin‘s lab is focused on the computational study of biological networks within the general framework of Systems Biology. This is done primarily in four research topics: 1. The study of metabolism and metabolic networks: Our current focus is on developing genomic-scale metabolic models of human tissues and studying their role in understanding an […] Read More >
Prof. Satchi-Fainaro Ronit
Our research interests include investigations related to tumor biology, tumor dormancy, mechanism of action of angiogenesis inhibitors, self-assembly of polymeric architectures and novel approaches to target cancer. Throughout, we have maintained an interest in understanding the biological rationale for the design of polymer therapeutics suitable for transfer into clinical testing. Our primary interests are the molecular […] Read More >
Prof. Savion Naphtali
Novel Antioxidant for Treatment of Age-related Degenerative Diseases We are studying the potential of S-allylmercapto-N-acetylcysteine (ASSNAC) a newly developed derivative of allicin (the active component in garlic) to serve as a treatment for oxidative stress associated degenerative diseases. The research involves cell biology tools and animal models. The following specific subjects are studied: Demonstrating the […] Read More >
Prof. Segal Daniel
‘Conformational diseases’ are diseases caused by misfolding of a protein, often as a result of a missense mutation that does not necessarily disrupt the active site of the protein. As a result, the protein may lose its function, and often the misfolded monomers self-assemble to form cytotoxic aggregates. We study the structural causes of such […] Read More >
Prof. Shabat Doron
Research Self-immolative dendrimers are unique structural molecules that can release all of their tail units, through a domino-like chain fragmentation, which is initiated by a single cleavage at the dendrimer’s core. Incorporation of drug molecules as the tail units and an enzyme substrate as the trigger, can generate a multi-prodrug unit that is activated with […] Read More >
Prof. Shacham- Diamand Yosi
Research Interest Nano-chemical processes for Microelectronics and integration of biological material on chip for acute toxicity detection Nano-chemistry for electronics applications- Physical and electrical characterization of electronic devices for CMOS technologies made by various chemical techniques such as self assembled monolayers and surface catalyzed auto catalytic electrochemical processes. The research involves studying of the […] Read More >
Prof. Shalgi Ruth
Our research focuses on Reproductive Physiology in animal models and in humans. The current research directions investigated in the laboratory are: The role of Fyn kinase, member of the Src family kinases, during meiosis and early events of oocyte activation, as well as in cancer cells. Fertility preservation – the signaling pathway leading to apoptosis […] Read More >
Prof. Shomron Noam
Noam has received his Bachelors degree in Biotechnology at Macquarie University in Sydney, Australia; his Masters degree in Gene Therapy at the Hebrew University of Jerusalem; and his graduate studies in Genetics at Tel Aviv University where he worked on regulatory RNA systems. As a Post-Doctorate affiliate at MIT in Cambridge, USA, Noam gained expertise […] Read More >
Dr. Sklan Ella
המטרה ארוכת הטווח שלנו היא זיהוי ואפיון של אינטראקציות של וירוסים עם תאי המארחים שלהם ברמות מרובות. אנו משתמשים בטכניקות מתקדמות של ביולוגיה מולקולרית, וירולוגיה והדמיה. מערכות המודל הנוכחיות שלנו כוללות נגיפי הפטיטיס D (HDV), אבולה ודנגי. זיהום בכל אחד מהנגיפים הללו עלול בסופו של דבר להיות קטלני. וירוסים אלה משפיעים על חייהם של מיליוני […] Read More >
Prof. Slutsky Inna
The research in the laboratory is focused on understanding the basic mechanisms underlying synaptic function and primary mechanisms initiating synaptic dysfunction at very early stages of Alzheimer’s Disease. To achieve this goal, we developed an integrated system that enables simultaneous real-time visualization of structural reorganization in spatially-restricted signaling complexes and functional modifications of single synapses […] Read More >
Prof. Socher Eran
Current Research Interests · RFICs at mm-wave and THz frequencies · Short-range ultra-fast wireless links · RF interconnect in deep sub-micron CMOS · Sensing and imaging in IR, THz and mm-wave frequencies · Ultra-fast ADCs for future optical links Other Research Interests · CMOS compatible thermal imaging · MEMS and integrated sensors · CMOS readout circuits Read More >
Prof. Solomon Arieh S.
Research topic: Elucidating the degenerative and regenerative process of optic nerve following trauma, ischemia and disease. The research results will be applicable in same conditions that take place in the brain. Research methods: Immunocytochemistry analysis, Western blot analysis, confocal microscopy evaluation, electrophysiology functional recording, MRI. Projects in the lab include: Evaluation of the therapeutic potential of new […] Read More >
Prof. Solomon Beka
My scientific interest is focused on investigation of biorecognition in general and on the nature of the interactions of antibodies and their corresponding antigens in particular. In my research work I am involved in the elucidation of the mode of action of monoclonal antibodies (mAbs) on the structure and function of their corresponding antigens in […] Read More >
Prof. Stein Reuven
Research topic: Alzheimer’s disease (AD) focusing on microglia and astrocytes; The role of microenvironment (microglia) on brain tumors; Cognitive decline after brain irradiation; Mechanism of cell death and survival. Research methods: Manipulation of gene expression in cell lines; Immunostaining of cell cultures and brain sections, Microscopic imaging (e.g., confocal, STED and two photon), Neuronal, astrocytic and microglial […] Read More >
Prof. Tuller Tamir
Research Interests: computational biology and bioinformatics systems biology developing mathematical and physical models of biological systems (usually intra-cellular process such as gene translation) and biological phenomena developing algorithms and statistical approaches for solving problems in molecular biology theoretical analysis of algorithms in the field analysis of large-scale genomic data Contact: Email: tamirtul@post.tau.ac.il Phone: 03-6405836 Website: […] Read More >
Research topic: Cell based platforms for study, diagnosis, drug screening and therapy of neurodegenerative diseases. Research methods: Isolation and culture of human embryonic/adult stem cells models of diseases; Cell based-assays for High content analysis (HCA) screening of stem cells with and without disease; High throughput screening (HTS) of drugs using liquid handling robot, Drug development applications, Transcriptome […] Read More >
Prof. Weiner Ina
Research topic: Translational models of schizophrenia and depression as tools for understanding their development and prevention Research methods: Brain imaging, brain stimulation, neurodevelopmental manipulations, behavioral manipulations and analysis, systemic and intracerebral pharmacology, molecular biology/ proteomics/drug development (collaborations). Main projects: Delineating the developmental trajectories of schizophrenia-like and depression-like neuroanatomical changes and behavioral abnormalities following early exposure […] Read More >
My fascination with antibody repertoire, along with the lack of technologies for its study, led me to develop a pioneering technology specifically aimed at analyzing antibody repertoire in serum and secretions at health, following disease or vaccine. The approach we use provides us the means to broaden our understanding regarding the development of the adaptive […] Read More >
Prof. Wreschner Daniel H.
Molecular analysis of the human cancer cell with special emphasis on membrane proteins, tumor-associated antigens, ligand-receptor interactions and cell signaling. We work on a breast-cancer associated protein designated MUC1 (CA-15-3) that is a membrane protein participating in cell signaling. Email: danielhw@tauex.tau.ac.il Phone: 03-6407425 Another phone: 03-6409915 Fax: 03-6422046 Office: Britannia-Porter, 203 Read More >
Prof. Yekutieli Daniel
Current Research Interests: · RFICs at mm-wave frequencies and beyond · Short-range ultra-fast wireless links · RF interconnect in deep sub-micron CMOS · 60GHz radio in CMOS · Sensing and imaging in IR, THz and mm-wave frequencies Read More >
Prof. Yovel Yosef
Research topic: Active sensing, sensory perception and cognition from the field through the lab and into the brain. I use the echolocating bat – a “champion” in active sensing to study these behaviors. Research methods: Behavior using highly developed technologies including ultrasonic microphone arrays, mini-cameras and mini-GPS devices. MRI to study brain anatomy and neural correlates of […] Read More >
Prof. Yovel Galit
Research topic: Cognitive and Neural basis of Face and Object recognition. Research methods: Psychophysics, functional MRI, EEG/Event related potentials (ERPs), Transcranial Magnetic Stimulation (TMS), Eye tracking. Simultaneous recording of EEG-fMRI and EEG-TMS Main projects in the lab include: How do face and body processing mechanisms interact to generate an image of a person? What is […] Read More >
Active implants can provide life-giving help to many systems in the body. When made of a biodegradable polymer, the degradation of such implants occurs by hydrolytic cleavage and the end products (carbon dioxide and water) are non-toxic. These implants can remain intact in the body for a predicted period of time – from weeks to […] Read More >
Prof. Zisapel Nava
Research Activity: The Biological Clock and Melatonin Receptors- The daily light/dark cycle provides a reliable signal for coordination and seasonal adaptation of thermoregulation, reproduction, development, sleep and mood. The daily rhythm in production of melatonin by the pineal gland reflects the environmental light /dark cycles and thus plays an important role in the time-keeping system. […] Read More >
