Pharmaceutical
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37 Results were found on Technologies
Sub Category Name
An Oncolytic Virus That Exploits Immune Defects of Cancer Cells
An oncolytic virus for tumors of different etiology presenting defects in interferon signaling, designed as a potent, specific and safe therapy. Promising in-vivo murine melanoma model shows potential for development as a mono or an add-on to... Read More >
Novel Bcr-Abl1 Inhibitors for Treating Imatinib Resistance Cancer
The BCR-ABL1 fusion gene is the hallmark of the Philadelphia chromosome-positive (Ph+) leukemia, creating a constitutively active ABL1 tyrosine kinase. Current therapy relies on the FDA-approved tyrosine kinase inhibitors (TKIs) such as imatinib... Read More >
Automated Processing Of Non-Invasive Thermal Imaging Of Organ-Specific Diseases To Detect Inflammation And Vascular Dysfunction
During the COVID-19 worldwide pandemic, rapid and sensitive screening tools for SARS-CoV2 infection were defined critical for limiting the spread of COVID-19 and for allocating national resources properly. Researchers have developed and tested a... Read More >
Anti-Cancer Nanotherapy: Targeted Potent Conjugated BRAF/MEK Inhibitors
In the last decade, deep understanding of key oncogenes and signaling pathways, involved in cancer pathogenesis and progression were achieved, leading to new treatment options. However, the number of patients with metastatic melanoma continue... Read More >
Development of Alzheimer Disease therapy based on counteracting the pathological effects of ApoE4
Alzheimer’s disease (AD) is the most common cause of dementia and is the outcome of progressive brain cells death. Due to the disorder’s heterogeneity and in view of the variety of pathological mechanisms inducing the disease we... Read More >
A Novel Nanoparticle that Selectively Delivers RNAi Oligonucelotides to Tumors, Preventing Side Effects to Tissues
UNMET NEEDPancreatic cancer numbers among the most aggressive cancers known today. The overwhelming majority of pancreatic cancer patients pass away within just a year of diagnosis. However, a small minority of patients may live several years with... Read More >
Therapeutic Targeting of CD45 by Novel Agents to Immunotherapy Non-Responders Tumors
Therapeutic advances in cancer immunotherapy have rapidly emerged in the past few years, reflecting the importance of the interaction between the human immune system and cancer. Despite the successful application of immunotherapy across a... Read More >
An early stage screening tool for distinguishing pregnant women having an increased risk of developing preeclampsia
Preeclampsia is one of the most dangerous pregnancy complications occurs in the second or third trimester, affecting 3–8% of pregnancies; it is the leading cause of maternal and perinatal mortality and morbidity. Preeclampsia cannot reliably be... Read More >
Leveraging Gene Panel Sequencing Data for Mutational Signature Analysis with Applications to Personalized Treatment
UNMET NEEDMutational signatures and their exposures are key to understanding the processes that shape cancer genomes with applications to diagnosis and treatment. Yet current signature analysis approaches are limited to relatively rich mutation... Read More >
SK4 K+ channel blockers: a new treatment for cardiac atrial fibrillation
We discovered a previously unidentified target in the heart, namely the SK4 calcium-activated K+ channels, which are functionally expressed in pacemaker cells as well as in atrial and ventricular cardiomyocytes. They are crucial for proper cardiac... Read More >
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