Pharmaceutical Indications

 

42 Results were found on Technologies

Leading Researchers:
10-2017-1064

SK4 K+ channel blockers: a new treatment for cardiac atrial fibrillation

We discovered a previously unidentified target in the heart, namely the SK4 calcium-activated K+ channels, which are functionally expressed in pacemaker cells as well as in atrial and ventricular cardiomyocytes. They are crucial for proper cardiac function and represent a completely new therapeutic target for the treatment of cardiac arrhythmias. SK4 channel blockers successfully prevented […] Read More >

Leading Researchers:
2-2019-1243

Therapeutic Vaccine for the Treatment of Cancer

An active cancer vaccine strategy targeting tumor-associated carbohydrate antigens expressed on tumor cells using biomimetic glyconanoparticles generated from unique red blood cells. The resulting sustained immune response inhibits tumor growth. THE NEED While envisioned already in 1891, only a few cancer vaccines have been approved by the FDA thus far.  The key barriers to their […] Read More >

2-2019-1277

An Effective Sema3A Antibody as a Therapy for Optic Nerve Neurodegenerative Diseases

Glaucoma and ischemic or neuro-degenerative diseases of the optic nerve lead to vision loss and blindness. These pathologies are associated with progressive apoptosis of the retinal ganglion cells (RGC), a process which involves expression of Semaphorin 3A protein in the axonal guidance pathways. The identified Sema3A antibody provides a potentially innovative therapeutic tool for these […] Read More >

Leading Researchers:
10-2007-109

Macrolid Induced Correction of Premature Stop Codons: A novel Treatment for Colorectal Cancer

Restoration of premature termination codons (PTCs) caused by nonsense mutations for the treatment   of Familial Adenomatous Polyposis. The Need Familial Adenomatous Polyposis (FAP) is a high penetrance devastating syndrome manifested by dozens to thousands of colonic adenomas. FAP patients require tight supervision and eventually undergo surgery, to prevent inevitable development of colorectal cancer (CRC) by […] Read More >

Leading Researchers:
10-2012-314

Repurposing of Antibiotics for treating APC (Adenomatous Polyposis Coli) Related Colorectal Cancer

Restoration of Adenomatous Polyposis Coli (APC) gene expression by means of antibiotic erythromycin for the treatment of Familial Adenomatous Polyposis. The Technology:Treatment for APC by   conventional antibiotics to regulate adenoma growth and delay the need for preventive surgery in Familial Adenomatous Polyposis (FAP) patients.  The Need: FAP is a high penetrance devastating syndrome manifested by dozens […] Read More >

Leading Researchers:
10-2019-1337

Anti-Cancer Nanotherapy: Targeted Potent Conjugated BRAF/MEK Inhibitors

In the last decade, deep understanding of key oncogenes and signaling pathways, involved in cancer pathogenesis and progression were achieved, leading to new treatment options. However, the number  of patients with metastatic melanoma continue to rise. This may be attributed to the prolonged life-span of cancer patients with primary tumors, enabling metastatic spread later on. […] Read More >

Leading Researchers:
5-2020-1362

An early stage screening tool for distinguishing pregnant women having an increased risk of developing preeclampsia

Preeclampsia is one of the most dangerous pregnancy complications occurs in the second or third trimester, affecting 3–8% of pregnancies; it is the leading cause of maternal and perinatal mortality and morbidity. Preeclampsia cannot reliably be predicted as no tests available in early pregnancy.OUR INNOVATIONThe invention is based in part on the finding that plasma […] Read More >

Leading Researchers:
10-2020-1476

Unique Cocktail of Neutralizing Antibodies against SARS-CoV-2

We have identified eight potent neutralizing antibodies (mAbs) from recovered COVID-19 patients for COVID-19 treatment. These antibodies may be used as pre-exposure prophylaxis, i.e., as short-term protection from infection for populations at risk and highly exposed medical teams or those that did not develop enough antibodies post vaccinationUNMET NEEDThe COVID-19 pandemic caused by SARS-CoV-2, has […] Read More >

Leading Researchers:
10-2020-1438

Plant-Derived Anti- Herpesvirus Composition

Herpes simplex virus infection is commonly known as herpes. The two types of herpes simplex virus are HSV-1 (known to cause orofacial disease such as cold sores) and HSV-2 (causes genital infections). Over 80% of herpes infections is asymptomatic. Symptomatic infections are presented with blistering sores, pain during urination, swollen lymph nodes, and fever. Acyclovir […] Read More >

Leading Researchers:
2-2020-1376

New Chemiluminescent Protease Probe for Rapid, Sensitive, and Inexpensive Detection of Live Mycobacterium tuberculosis

Tuberculosis (TB) is a top-ten cause of death worldwide. Successful treatment is often limited by insufficient diagnostic capabilities, especially at the point of care in low-resource settings. The ideal diagnostic must be fast, be cheap, and require minimal clinical resources while providing high sensitivity, selectivity, and the ability to differentiate live from dead bacteria.OUR SOLUTION• We […] Read More >

Prof. Einav Shmuel

Research Interests: Flow in biological systems; cardiac blood flow; Blood flow in obstructed arteries and in bypasses; blood flow through artificial heart valves; Cardiac-assist devices; magnetic resonance imaging of blood flow Read More >

Prof. Eldar- Finkelman Hagit

My overall research is focused on elucidating the molecular and biochemical regulation of the protein kinase, glycogen synthase kinase-3 (GSK-3), and revealing its contribution to pathological disorders. GSK-3 is emerging as a prominent drug discovery target in neurodegenerative disorders including ALS, Parkinson’s, Huntington’s and Alzheimer’s disease. In a recent work we identified lysosomes as novel […] Read More >

Prof. Eliaz Noam

Research: Biomaterials (e.g. electrochemically-assisted deposition of calcium phosphates) and medical devices. Bio-Ferrography (e.g. for orthopaedic applications and cancer diagnostics). Environment-induced degradation of materials and hydrogen interaction with materials. Electrodeposition and electroless plating of special alloys (e.g. rhenium-based) and electropolishing. Failure analysis. Quality control of raw materials and products; consultation services for materials and processes selection. Read More >

Prof. Erez Neta

Associate Professor, Chair of the Department of Pathology, Faculty of Medicine, Tel Aviv University Research Cancer Related Inflammation in Tumor Progression and Metastasis The main goal of our laboratory is to uncover stromal pathways that contribute to tumorigenesis and metastasis. Extensive research has led to the understanding that tumors are more than just cancer cells: […] Read More >

Ms. Farberov Luba

Read More >

Prof. Fishelson Zvi

Research Molecular Analysis of Cancer Immunoresistance The long-term goal of our research is to develop a novel treatment for immune resistant cancers. Our research includes characterization of the mechanism of complement-dependent cytotoxicity and of the basis for elevated resistance of cancer cells to cell death, and design of novel reagents that sensitize cancer cells to […] Read More >

Prof. Freeman Amihay

Research interests include: Biomedical applications of enzymes and cells. Protein Nano-biotechnology: protein mediated biotemplating for the integration of biologically active protein-metal hybrid with microelectronics and development of new composite materials. Bioprocessing aspects of biocatalysis Read More >

Prof. FRENKEL Niza

Current research projects: Molecular mechanisms of herpesvirus replication and gene expression Disease associations of the lymphotropic Human herpesviruseses 6A, 6B and 7 (HHV-6A, HHV-6B and HHV-7). Derivation of herpesvirus vectors towards their use in gene therapy and vaccination. Molecular Virology: Studies of viral DNA replication and packaging; Virus-host cell interactions including HSV-1 host shutoff by […] Read More >

Prof. Frenkel Dan

Research topic: The research in our laboratory is focused on the investigation of glial cell and to clarify their role in neurological diseases. We suggest that targeting glia activation in different pathological scenarios may allow us to define common pathways to further understand the role of glia in neuroprotection . We are using three models: 1) […] Read More >

Dr. Freund Natalia

Senior Lecturer (Guest), Department of Clinical Microbiology and Immunology, Faculty of Medicine Research My laboratory is interested in understanding the molecular basis of human antibody responses to diseases. Antibodies are key components of most licensed vaccines; nevertheless many aspects of how antibodies recognize and neutralize their targets are still unknown. Pathogen-specific B cells are stimulated […] Read More >

Leading Researchers:
12-2011-220

State-of-the-art X-ray Scattering Systems

Laboratory of Experimental BiophysicsSchool of Physics and Astronomy, Faculty of Exact ScienceThe Center for NanoScience and NanoTechnology   Services:Small Angle X-ray Scattering (SAXS), Wide Angle X-ray Scattering (WAXS), Grazing Incident Small Angle X-ray Scatter (GISAXS) X-ray scattering provide structural information (shape and size) in non-destructive and stain free conditions. Small angle scattering is an ideal characterization […] Read More >

Leading Researchers:
12-2011-219

Cardiovascular Engineering

Department of Biomedical Engineering – Prof. Ofer Barnea   Ofer Barnea is a Professor of Biomedical Engineering at Tel Aviv University and is the Director of the Ela Kodesz Institute for Biomedical Physics and Engineering. He was the chairman of the Department of Biomedical Engineering and the chairman of the Israeli Chapter of the IEEE […] Read More >

Leading Researchers:
12-2011-218

Cardiovascular Testing and Measurements

The general goal of our laboratory is to research design and build in vitro systems that simulate cardiovascular flows, hemodynamic shear forces, and blood-tissue interaction. In addition, the laboratory conducts a wide program of numerical bio-simulations. Focus In Vitro Biological Flows. Hemodynamics. Endothelial Cell and Platelets activation. Digital Particle Image Velocimetry (DPIV). Vulnerable Plaque. Blood-Tissue […] Read More >

Leading Researchers:
12-2011-213

Bacterial Isolates Identification and Gene Sequencing

Webpage: https://www.tau.ac.il/lifesci/departments/biotech/members/gophna/gophna.html   Scientist Contact:Uri Gophna Ph.D.Senior lecturer,Deparment of Molecular Microbiology and BiotechnologyGeorge S. Wise Faculty of Life SciencesTel. +972-3-6409988Fax +972-3-6409407email: urigo@tauex.tau.ac.il   Read More >

Leading Researchers:
12-2011-212

Ophthalmic Testing

Consultation and lab services are offered, with a focus on eye-related medical innovations from concept through to clinical trials.   Lab Website:https://www.tau.ac.il/medicine/Goldschleger/Goldschleger.html Scientist: Michael Belkin, MA, MD Professor of Ophthalmology Director, Ophthalmic Technologies Laboratory  Goldschleger Eye Research Institute  Tel Aviv University  Sheba Medical Center  Tel Hashomer 52621  Israel Phone:  +972-3-530-2956 Fax:    +972-3-535-1577 Skype:  Belkin E-mail: belkin@netvision.net.il   Read More >

Leading Researchers:

Bert Strassburger Lipid Center, Sheba,Tel Hashomer

Fatty Acid Metabolism and Desaturase enzymes, Cholesterol Metabolism and involved enzymes, Membrane composition and liposomes. The lab focuses on techniques for Lipid analysis, like total lipid quantification and analysis of lipid species like fatty acids, triglycerides, phospholipids,etc. using chromatography systems such as HPLC, GC and TLC.Services offered: Identification and quantification of total lipids and specific […] Read More >

Leading Researchers:
12-2011-210

Cellular Functional Testing and Acquisition

Industrial Research Services:   1. Bone cells in culture – We offer a bone marrow derived bone-like tissue in culture for testing the effect of various factors, hormones, drugs etc. on bone cells proliferation, differentiation and mineralization.  The model is described in the following papers:a. S. Pitaru, S. Kotev-Emeth, D. Noff, S. Kaffuler, N. Savion; Effect of […] Read More >

12-2011-209

Functional genomics

The Shomron research team focuses on the analysis of genomics aimed at understanding human diseases. Combining high-throughput methods and bioinformatics (such as AI and deep learning), our team’s research explores DNA changes and gene regulators. Our goal is to reach a global perspective on the roles DNA and RNA play during disease development. Among our […] Read More >

Leading Researchers:
12-2011-207

Precision Nanomedicine: Preparation and Characterization of Nanocarriers Made from Natural Biopolymers

The laboratory of Precision Nanomedicine at TAU have capabilities for preparation and characterization of nanocarriers made from natural biopolymers such as lipids (liposomes, micelles) , sugars and proteins. Lab Description• State-of-the-art preparation and process development of lipid based nanoparticles including sythesisi capabilities of lipids.• cell culture facility including the culturing of hybridomas and antibody purification.• […] Read More >

Leading Researchers:
12-2011-205

Lipid Solutions and Animal Model

SERVICES“ Lipid Solutions” Prof. Alicia Leikin-Frenkel “Lipid Solutions” covering:1. Expert support for questions on: lipid metabolism, isolation, identification and quantitation of lipids in different species and different matrixes.2. Guidance to discover the pathway to physiological and biochemical implications following overexpressed or suppressed gene linked to lipids.3. Counseling to analyze lipids in:• Simple molecules: fatty acids: Saturated, Monounsaturated n7, n9, Polyunsaturated: […] Read More >

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