Computational Platform for Enhancing Gene Expression for Increased Protein Yield and Viral Titer
TechnologyDeciphering Gene Expression Code – We perform large-scale analyses of genomic data to discern the rules behind the various aspects of gene expression encoded in the transcript. Computational Modeling of Gene Expression – We develop predictive computational models to mathematically analyze and simulate the different stages of gene expression, focusing on gene translation. Engineering Gene […] Read More >
Quantitative confluency measurement of culture growth
The invention is an image processing method of light microscopy images for the purpose of quantifying density of cells in cultures . A grayscale image of a cell culture is digitally captured using a light microscope and a CCD camera. Our method evaluates the culture’s confluency using an image processing algorithm on the image which […] Read More >
An Add-On Optical Interferometer Chamber to Phase Microscopes for Sub-Nanometer 3D and Dynamic Information
TechnologyAn add-on optical module for microscopes allowing for single frame and dynamic capture of amplitude and phase profiles of transparent or semi-transparent biological and non-biological samples. This easyto-use interferometric device is simply positioned in the camera port of a conventional inverted microscope, enabling quantitative structural, thickness and refractive index measurements in a noncontact, label-free manner. […] Read More >
Whole Brain Visualization of Distinct Cortical Layers by MRI
The TechnologyAn MRI platform including an imaging protocol and analysis software enabling in-vivo visualization, characterization and measurement of the distinct layers of the human cortex including width in 3D. The imaging protocol utilizes inversion recovery (IR-MRI) pulse sequencing. A set of inversion times, identified and correlated to the different cortical layers provides the sought distinction […] Read More >
3D Bioprinting of Tumor Models for Personalized Drug Screening and Disease Modeling
This technology aims to provide a three-dimensional (3D) bioprinted tumor model based on natural and synthetic polymers containing several types of cells, which resembles cancer tissue. Our 3D-bioprinted tumor model has potential to predict the clinical outcome of a treatment compared to the other existing solutions, which either rely solely on genetic profiling or do […] Read More >
Culturing a plurality of cell types on a 3D-printed microfluidic chip
Organ-on-a-Chip platforms provide rich opportunities to observe interactions between different cell types under in vivo-like conditions. Co-culturing and the application of flow and other mechanical forces organoids, mimic 3D tissue structure and greatly enrich the data collection from such platforms.‘Insert-chip’ is a cost-efficient, reusable, modular organ-on-a-chip platform that allows co-culturing and overcome scientific data collection […] Read More >
Protection of Oxygen-Sensitive-Enzymes by Peptide Hydrogel
Molecular oxygen (O2) is a highly reactive oxidizing agent harmful to many biological and industrial systems. A simple encapsulation in a protective aqueous environment of O2 -sensitive reactions is of need. Self-assembling peptide-based hydrogels are simple hydrogels that can be combined with a wide variety of reagents and are able to encage O2 and significantly limit its […] Read More >
Targeting Human Brain Cells With Adeno-Associated Virus (AAV) for a Prospective Therapeutic Approach
The AAV therapeutic approach for various central nervous system (CNS) illnesses has been rapidly growing. Unfortunately, existing present technologies utilize AAV administration that is injected locally into the brain. This process requires a high level of expertise and is not applicable in more diffused brain targets like cortex and stiratum. Systemic administration of AAV vectors through […] Read More >
Spatially Targeted Transfection of Mammalian Cells
Mammalian cell transfection with DNA, RNA, small molecules, and proteins is a widely used molecular biology technique. The primary method of cell transfection is electropermeabilization, which increases the permeability of the cell membrane, allowing chemicals, drugs or DNA to be introduced into the cell. Bulk electroporation has been used for DNA transfection in suspension cells […] Read More >
Homocysteine fibrillar assemblies display crosstalk with Alzheimer’s disease amyloid polypeptide
High levels of homocysteine (Hcy) are reported as a risk factor for Alzheimer’s disease (AD). Correspondingly, inborn hyperhomocysteinemia is associated with an increased predisposition to the development of dementia in later stages of life. Furthermore, despite the apparent association between protein aggregation and AD, attempts to develop a therapy that targets explicitly this process have […] Read More >
Prof. Assaf Yaniv
Research topic: Measuring in-vivo brain micro-structure and neuroplasticity with magnetic resonance imaging (MRI) in humans and rodents Research methods: Magnetic Resonance Imaging: Diffusion Imaging, Diffusion Tensor Imaging, Tractography; Immuno-histochemistry, Histology. Main projects in the lab include: Investigation and localization of brain regions that undergo plasticity following a cognitive experience or training with MRI Development of MRI frameworks […] Read More >
Prof. Attali Bernard
Reaching an understanding in molecular terms of the mechanisms by which changes in membrane potential regulate cellular events is the main concern of our research. We focus our interest on potassium channels because they play crucial roles in many cellular functions such as shaping cardiac and neuronal action potentials, tuning neuronal firing patterns, synaptic integration […] Read More >
Prof. Avraham Karen B.
Genomic Analysis of Hereditary Hearing Loss Our primary interest is the genetic basis of hereditary hearing loss or deafness. Our group is working towards the identification, characterization and regulation of genes associated with hereditary hearing loss. For gene discovery, we focus on the Israeli Jewish and Palestinian Arab populations in the Middle East. Our studies […] Read More >
Dr. Bar Daniel Zvi
Advances in biomedical science have cured multiple diseases and greatly improved healthspan and lifespan. However, aging is the strongest risk factor for most causes of death in the western world, and thus these advances have resulted in a relatively small increase in maximal lifespan. Without a systematic approach to understand and treat the aging process, […] Read More >
Prof. Barak Segev
Dr. Barak’s research focuses on the psychobiology and neurobiology of alcoholism and drug addiction. In particular, he is interested in the molecular and neuronal mechanisms that underlie learning and memory processes in alcohol addiction. In addition, Dr. Barak is interested in the pathophysiology of schizophrenia, with focus on cognitive impairments in this disorder. See lab […] Read More >
Prof. Ben-Tal Nir
Our research is focused on studying the interplay between protein sequence, structure, motion and function using computational tools. The understanding of these relations provides a molecular dimension to our understanding of protein functions and their involvement in genetic disorders and other diseases. Within the broad fields of structural-bioinformatics and phylogeny, we limit our research to […] Read More >
Prof. Benjamini Yoav
My scientific work combines theoretical research in statistical methodology with applied research that involves complex problems with massive data. The methodological work is on selective and simultaneous inference (multiple comparisons), and centers on the “False Discovery Rate” (FDR) criterion, as well as on general methods for data analysis, data mining and data visualization. My current […] Read More >
Prof. Dvir Tal
Microfluidics-based tissue engineering. Recreating stem cell niches, microfluidics bioreactors for tissue engineering. Nanotechnological strategies for engineering thick cardiac tissue. Engineering a 3D neuronal network for spinal cord and brain regeneration. Fabrication of Nanoelectronics/engineered tissue hybrids. Developing smart delivery systems that recruit stem cells to defected organs. Email: tdvir@tauex.tau.ac.il Phone: 03-6406514 Another phone: 03-6408604 Website: https://dvirlab.wixsite.com/dv… Office: […] Read More >
Prof. Ebenstein Yuval
Our lab specializes in many areas of optical imaging and spectroscopy with emphasis on single molecule detection and development of imaging based techniques. Our research is focused on the application of novel imaging and optical detection approaches to genomic studies and biomarker detection. We are developing new spectroscopy and microscopy methodologies that combine advanced optics […] Read More >
Prof. EHRLICH Marcelo
I am interested on the dynamic aspects of the cell’s trafficking machinery, with a special focus on endocytic dynamics. More specifically, our study centers on the mechanisms by which the cell modulates vesicular traffic by altering: The rate of formation of vesicular carriers, such as clathrin coated vesicles. The spatio-temporal distribution of the process of […] Read More >
Leading Researchers:
The Myers Neuro-Behavioral Core Facility
Unit description:The Myers Neuro-Behavioral Core Facility provides researchers with state-of-the-art technology for performing neuro-behavioral tests in mice. Services: The Core Facility provides expertise in design, implementation, and analysis of behavioral experiments. The Core Facility includes five behavior rooms, which can operate simultaneously, and two animal maintenance rooms with IVC cages operating on a reversed light […] Read More >
Lab Description Using the powerful combination of molecular biology, biophysics, biochemistry and electrophysiology. our research aims at elucidating the structural, biophysical and physiological attributes of normal and diseased ion channels in brain and heart and whose mutations in human lead to major neurological and cardiovascular disorders like epilepsy, autism, atrial or ventricular fibrillation. Main Research […] Read More >
Our main focus is on the psychological and neurobiological mechanisms that underlie psychiatric disorders, and in particular addiction We are using rodent models of addiction, anxiety, learning and memory. We focus on behavioral models relevant to different stages of addiction (craving, drug reward, intoxication, sensitization, tolerance, excessive alcohol consumption, withdrawal symptoms, relapse). We are looking […] Read More >
MULTI SENSOR – Multi Modal Recording System for Behavioral Tracking
It is clear today that brain activity of a restrained (or sedated) animal is completely different from that of a freely behaving animal.That is why neuroscientists are seeking to find ways to study animals freely behaving on their natural grounds.TAU’s interdisciplinary research has led to the development of the MULTI SENSOR – Multi Modal Recording […] Read More >
The general purpose of my research is to describe the genetic and endocrine regulation of bone metabolism. To this end, we developed expertise in most aspects of bone research, from in vivo models, imaging of bone microarchitecture, in vitro cell cultures and molecular biology. Main Research Topics Regulation of bone metabolism by sex steroids Role […] Read More >
Laboratory of endoplasmic reticulum (ER) quality control and protein misfolding diseases
Lab DescriptionMain areas of interest are in the mechanisms of protein folding and trafficking in the early secretory pathway of mammalian cells and the development of ER stress upon their malfunction, particularly in neurodegenerative diseases. Specific research topics are:• Protein misfolding diseases, including neurodegenerative diseases.• ER stress.• Mechanisms of endoplasmic reticulum (ER) protein folding and quality control.• Sugar chain […] Read More >
Lab DescriptionOur lab focuses on animal Bio-sonar and other sensory systems. We are interested in how the animal’s sensory system is adapted to the environment, how does the brain encode this information and how can these adaptations be applied. We are experts in bio-acoustics. Main Research TopicsBat bio-sonar, bio acoustics, animal communication, animal cognition, the […] Read More >
The Cohen Rosenthal Diabetic Hypertensive Rat (CRDH) model
The construction of the Cohen Rosenthal Diabetic Hypertensive Rat (CRDH) model was initiated nearly a decade ago by cross-breeding between the Cohen Diabetic rat (CDR) and the SHR. The CDR is a rodent model that expresses the following phenotypes: when fed regular diet, it is non-diabetic; when fed a diabetogenic diet, it invariably develops diabetes […] Read More >
Histopathological evaluation of hard tissues and biomedical devices in their tissue implantation surrounding, using a Plastic Embedding Technique
Plastic embedding is a method that allows histological examination of soft and hard tissues (e.g., blood vessels, bones, teeth, joints and skin tissue), containing solid medical devices of different sizes and made of various materials. In addition to the standard histological observations, such as necrosis, inflammation and fibrosis, this technique provides reliable data on size […] Read More >
Lab of Signal transduction, Neurodegeneration and Autophagy
Research focus ErbB receptors interactions and functions Regulation of Autophagy Neurodegeneration Projects include:The crosstalk between ErbB receprots and nucleolin in cancer developmentBeclin 1 mediated autophagyAutophagy in neurodegenerative diseasesAutophagy in cancer Potential servicesLaboratory services:To monitor autophagySignal transduction assaysAnti-cancer drugs examinationCell proliferation, death and migration examination Potential industries1. Pharma2. BiotechContact InformationProf. Pinkas-Kramarski RonitDept. of Neurobiology, Life […] Read More >
