Research / Development tools

 

14 Results were found on Technologies

Leading Researchers:
2-2022-1756

Homocysteine fibrillar assemblies display crosstalk with Alzheimer’s disease amyloid polypeptide

High levels of homocysteine (Hcy) are reported as a risk factor for Alzheimer’s disease (AD). Correspondingly, inborn hyperhomocysteinemia is associated with an increased predisposition to the development of dementia in later stages of life. Furthermore, despite the apparent association between protein aggregation and AD, attempts to develop a therapy that targets explicitly this process have […] Read More >

Leading Researchers:
2-2022-1737

Multi-Layered Modular Organ-on-a-Chip Platform

A modular organ-on-a-chip platform, configured for cultivating cells, tissues, organoids, and organelles and capable of performing high throughput analyses, including pharmacokinetic evaluations. UNMET NEEDThere is an unmet need for modular organ-on-a-chip, cost-effective, platforms and devices to approach the real complexity of human physiology and provide reliable extrapolations for clinical investigations and personalized medicine. OUR SOLUTIONA […] Read More >

Leading Researchers:
2023-0076

Designing Novel Protein-protein Interaction Modulators with Generative Models

UNMET NEED• Protein-protein interactions (PPIs) are essential components of all cell signaling pathways and important therapeutic targets. However, the design of PPI modulators, especially in the form of small molecules, remains a major challenge.• Interfering with PPIs is especially challenging when one of the interactors is a disordered protein (i.e., with no stable structure).• Peptides, […] Read More >

Leading Researchers:
2024-0011

A Computational Based Approach For Designing Plasmids’ Copy Number

We used plasmids in any biotechnological objective (both in the academia and in the industry) and in all model organisms. For example, plasmids are used in fields such as FoodTech, pharma, agriculture, etc. Currently, researchers chose between two possibilities: high copy plasmid (e.g. 500 copies) and low copy plasmid (e.g. 10 copies). However, the ability […] Read More >

Prof. Elroy-Stein Orna

Prof. Orna Elroy-Stein is a Full professor in the Department of Cell Research and Immunology at the Faculty of Life Sciences, Tel Aviv University, and a member of the Sagol School of Neuroscience. She received her B.Sc. and M.Sc. from the Technion, her Ph.D. on Human Molecular Genetics at the Weizmann Institute of Science, Israel, and […] Read More >

Prof. Frenkel Dan

Research topic: The research in our laboratory is focused on the investigation of glial cell and to clarify their role in neurological diseases. We suggest that targeting glia activation in different pathological scenarios may allow us to define common pathways to further understand the role of glia in neuroprotection . We are using three models: 1) […] Read More >

Prof. Fridman Micha

The Fridman laboratory is engaged in the use of organic chemistry, especially carbohydrate chemistry, to solve key biological and medicinal problems. Our interdisciplinary studies involve the use of organic chemistry, microbiology, cell biology, molecular biology, and confocal microscopy to study and/or alter the mode of action of biologically active molecules with the focus on novel […] Read More >

Prof. Gabet Yankel

Genetics: Our laboratory focuses on the genetic and hormonal regulation of bone remodeling, microarchitecture and strength. These traits have a high degree of heritability, and one aspect of our research is to characterize new genetic determinants of bone remodeling as well as elucidate the mechanism of action of selected genes. Our GWAS confirmed the role of […] Read More >

Prof. Gazit Ehud

The central dogma in the study of protein folding suggests that the thermodynamically-favorable state of proteins under physiological conditions is their folded one. However, there are number of cases in which the favorable states of proteins are rather unfolded, partially folded (e.g., “molten globular”), or misfolded (e.g., nonspecific aggregates or amyloid fibrils). These observations lead […] Read More >

Prof. Gefen Amit

Musculoskeletal Biomechanics Laboratory  The Musculoskeletal Biomechanics Laboratory of Professor Amit Gefen (@AmitGefen) has versatile in-house testing equipment for state-of-the-art experimental (test bench) and computer modeling and simulation studies of medical devices and consumables. Professor Gefen has more than 20 years of experience in developing and executing laboratory tests and modeling and simulation work. Together with […] Read More >

Dr. Gil-Ad Irit

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Prof. Gophna Uri

Research topics: Microbial ecology, The human microbiome in IBD, Selfish genetic elements, Microbial defense systems, Systems biology, Halophilic archaea Research methods: Deep sequencing/massively parallel sequencing, microbiology, gene cloning, quantitative RT-PCR, immunofluorescence, Metagenomics , bioinformatics. Main projects in the lab include: > Microorganisms as biomarkers, and mediators of inflammation in IBD > Evolutionary roles of CRISPR-Cas […] Read More >

Dr. Gothilf Yoav

Research Activity The Circadian Clock system All organisms demonstrate a wide variety of behavioral and physiological daily rhythms that are driven by an evolutionary conserved endogenous circadian clock mechanism. Maintenance of circadian rhythms is crucial for the physical and mental wellbeing, and disruption of the rhythms increases susceptibility to diseases and psychiatric disorders. Utilizing the […] Read More >

Prof. Halperin Eran

Research Areas Computational Biology Machine Learning Algorithms Population Genetics Statistical Genetics Read More >

Leading Researchers:
12-2016-982

Lab of Molecular Neurodegeneration

The goal of the lab is to elucidate molecular mechanisms of motor neuron survival and proper function using ALS disease as a model. In our current efforts we are using cutting edge in vitro and in vivo technologies studying molecular mechanisms of: 1.    Molecular communication of trophic factors (such as BDNF or GDNF) between […] Read More >

Leading Researchers:
12-2016-972

Lab of Cancer Angiogenesis and Nanomedicine

Selective therapy remains a key issue for successful treatment in cancer therapy. Prolonged administration of effective concentrations of chemotherapeutic or anti-angiogenic agents is usually not possible because of dose-limiting systemic toxicities involving non-malignant tissues. Therefore, a constant effort has been the development of new drug delivery systems that mediate drug release selectively at the tumor […] Read More >

Leading Researchers:
12-2016-971

Laboratory of Glycoimmunology

We combine glycobiology, immunology, biotechnology and cancer research, and use cutting edge technologies within these disciplines, including glycan microarray and glyco-nanotechnology. Current interests include: Immunological mechanisms of unique anti-carbohydrate antibodies. Glycoimmunology in xenotransplantation, as members of the EU TRANSLINK consortium. Anti-carbohydrate antibodies in mucosal secretions and sera. Development novel diagnostics and therapeutics to chronic inflammation […] Read More >

Leading Researchers:
12-2011-221

Bioinformatic Analysis

  The Bioinformatics Unit at the Faculty of Life Sciences   The Bioinformatics Unit at the Faculty of Life-Science at Tel-Aviv University is part of the Israeli Center of Bioinformatics Infrastructure (COBI) and offer various activitities to the bio-medical research community of Tel Aviv University and outside TAU. Bioinformatics training Bioinformatics consultation Microarray experiments support […] Read More >

Leading Researchers:
12-2011-217

Musculoskeletal Biomechanics Laboratory

  The Musculoskeletal Biomechanics Laboratory has in-house facilities for experimental and numerical studies of tissue and whole body biomechanics as well as implant systems. EquipmentMaterial and tissue testing facilities: Computer- controlled uniaxial electromechanical material testing system (Instron 5544) with various load cells and jigs for tension, compression and bending (3,4-point) loading modes Computer-controlled pendulum impact […] Read More >

Leading Researchers:
12-2011-215

Molecular Imaging Center: Confocal Microscopy, Whole Animal Imaging and Image Analyses

  SCMIC offers a wide variety of Imaging services, covering confocal and high-throughput microscopy, whole animal imaging and image analysis. All devices and instruments are centralized under one roof, providing a continuum of complete in-depth studies and projects in vivo and in vitro, from the micro to the macro level. Whole animal imaging includes Fluorescence […] Read More >

Leading Researchers:
12-2011-213

Bacterial Isolates Identification and Gene Sequencing

Webpage: https://www.tau.ac.il/lifesci/departments/biotech/members/gophna/gophna.html   Scientist Contact:Uri Gophna Ph.D.Senior lecturer,Deparment of Molecular Microbiology and BiotechnologyGeorge S. Wise Faculty of Life SciencesTel. +972-3-6409988Fax +972-3-6409407email: urigo@tauex.tau.ac.il   Read More >

Leading Researchers:
12-2011-210

Cellular Functional Testing and Acquisition

Industrial Research Services:   1. Bone cells in culture – We offer a bone marrow derived bone-like tissue in culture for testing the effect of various factors, hormones, drugs etc. on bone cells proliferation, differentiation and mineralization.  The model is described in the following papers:a. S. Pitaru, S. Kotev-Emeth, D. Noff, S. Kaffuler, N. Savion; Effect of […] Read More >

12-2011-209

Functional genomics

The Shomron research team focuses on the analysis of genomics aimed at understanding human diseases. Combining high-throughput methods and bioinformatics (such as AI and deep learning), our team’s research explores DNA changes and gene regulators. Our goal is to reach a global perspective on the roles DNA and RNA play during disease development. Among our […] Read More >

Leading Researchers:
12-2011-207

Precision Nanomedicine: Preparation and Characterization of Nanocarriers Made from Natural Biopolymers

The laboratory of Precision Nanomedicine at TAU have capabilities for preparation and characterization of nanocarriers made from natural biopolymers such as lipids (liposomes, micelles) , sugars and proteins. Lab Description• State-of-the-art preparation and process development of lipid based nanoparticles including sythesisi capabilities of lipids.• cell culture facility including the culturing of hybridomas and antibody purification.• […] Read More >

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