Research Tools
74 Results were found on Technologies
Sub Category Name
Ultrasound-Based Monitoring of Hemostatic Gelation
This novel, noninvasive ultrasound-based method enables real-time monitoring of gelation in hemostatic materials by tracking changes in the speed of sound (SoS) within the material. The system uses advanced image processing (dense optical flow) and acoustic modeling to detect viscosity changes during the transition from liquid to gel. Unmet Need Current wound care solutions lack […] Read More >
Cryoablation Temperature Monitoring with Dense Ultrasonic Speed-of-Sound Shift Imaging
Cryoablation is a minimally invasive procedure that destroys tumors using extreme cold. Monitoring temperature is essential but currently requires invasive probes or MRI, which are risky or expensive. We present a noninvasive, real-time ultrasound-based method that tracks temperature changes by measuring speed-of-sound (SoS) shifts in tissue, using advanced image analysis and acoustic modeling. Unmet Need […] Read More >
Rapid Evolutionary Conservation Mapping with Face Lifted ConSurf
The ConSurf pipeline provides a quick and accurate estimate of the evolutionary conservation profile of proteins, RNA and DNA. Mapping of the conservation profile on AlphaFold models readily reveals functionally important regions, e.g., catalytic and binding sites, which are often conserved. ConSurf is available for academic and commercial use using a web-server, as well as […] Read More >
Noncoding RNA-Based Strategy for Diagnosis and Monitoring of Pancreatic Cancer
Pancreatic Ductal Adenocarcinoma (PDAC) is one of the deadliest forms of cancer, with a five-year survival rate of less than 10%. A major contributor to this high mortality is the lack of effective tools for early detection — the disease is typically diagnosed at an advanced, often inoperable stage. Current diagnostic approaches, including imaging and […] Read More >
Structure-Guided Platform for Allosteric Inhibition of HECT E3 Ligases
Targeting “Pocketless” Enzymes to Treat Cancer, Immune, and Other Diseases Short Description: Our platform enables the selective inhibition of HECT E3 ubiquitin ligases, key regulators of protein degradation-through a novel allosteric mechanism. Using advanced structural biology and machine learning-driven screening, we access a previously unreachable druggable space. Lead compounds identified by this approach have demonstrated […] Read More >
Bio-Inspired Liquid Compartments for Efficient Encapsulation and Controlled Release of Payloads
Tunable peptide-RNA microcompartments inspired by viral structures that have high encapsulation efficiency of small organic molecules and large macromolecules that their release is triggered by light. UNMET NEED Current drug delivery or microreactor systems are lipid-based nanoparticles (NPs) that has shown a wide range of applications as drug delivery vehicles and are used for various […] Read More >
Diagnostic Tool for Assessing Breast Cancer Aggressiveness via Neutrophil-Tumor Cell Interactions
A novel diagnostic approach based on the discovery that neutrophils physically interact with tumor cells in breast cancer, creating a unique signaling niche that enhances cancer aggressiveness. This interaction can be used to assess the aggressiveness of breast cancer, offering a new way to predict patient outcomes and guide treatment strategies. Unmet Need Current diagnostic […] Read More >
Therapeutic Targeting of CD45: A Novel Approach to Overcome Immunotherapy Resistance
Revolutionizing Cancer Immunotherapy While immune checkpoint inhibitors have transformed cancer treatment, only 50% of patients fail to respond, with resistance being a major challenge, particularly in aggressive cancers such as triple-negative breast cancer (TNBC). TNBC accounts for 15–20% of breast cancer cases and is often diagnosed at advanced stages, with current therapies offering limited efficacy. […] Read More >
P32-Specific Antibodies and CAR T Cells for Glioblastoma and P32-Expressing Tumors
This innovative immunotherapy platform leverages p32-specific antibodies to create Chimeric Antigen Receptor (CAR) T cells, specifically targeting p32—a tumor-associated antigen expressed in glioblastomas and other aggressive cancers. The approach combines tumor elimination with antiangiogenic effects, paving the way for enhanced therapeutic outcomes in solid tumors. Unmet Need Glioblastoma, a highly aggressive brain cancer, has limited […] Read More >
Next Generation of the mRNA Therapy: Targeting Cancer Cells Via Boolean Circuits Based on mRNA Molecules
Currently most cancer treatment target proteins that are modified or activated in cancer cells; usually this is done by producing a relevant antibody. The process of finding a new therapy that targets a protein is long and tedious and in addition, in many cancer types there is no therapy at all. Specifically, today there are […] Read More >
