Research Tools
55 Results were found on Technologies
Sub Category Name
Development Of Improved Immunosuppressant Targeting Calcineurin-NFAT Protein-Protein Interaction Via Novel Peptides
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
Anti-Influenza A Virus Drug Discovery
Influenza A virus infection is one of the most common respiratory tract diseases in humans. It is the cause of typical seasonal flu as well as major human pandemics worldwide. According to the World Health Organization (WHO) in October 2023, around 3 to 5 million severe influenza cases were recorded, leading to 290,000 to 650,000 […] Read More >
Evaluation of Single Strand DNA Damage in Sperm Using a novel Damage Detection Technique
The Damage Detection technique is an innovative approach to assessing Single Strand DNA (ssDNA) damage by utilizing DNA repair enzymes to identify DNA adducts and single-strand breaks. Spermatozoa are characterized by high levels of DNA fragmentation, despite their condensed nuclear DNA packaging. Sublethal DNA damage, such as single strand breaks and adducts, can occur and […] Read More >
3D Printing of 3-Layered Retina and Choroid Tissue
We present a sequential fabrication of a three-layer retina-like structure. This innovative approach aims to address the challenges associated with age-related macular degeneration (AMD) and other retinal degenerative diseases by creating a bioengineered retinal implant that mimics the natural structure and function of the human retina. Unmet Need: Age-related macular degeneration is the leading cause […] Read More >
Skewed Sex Ratio Technology for Livestock and Pets: Reducing Resource Wastage and Labor in Animal Breeding
Our innovative genetic engineering technology offers a transformative solution for livestock and pet industries by generating offspring with a skewed sex ratio. The technology, proven in mice, is now aimed at practical application in cattle, swine, poultry, and other farm animals, as well as pets. The Problem: Current breeding practices lead to significant waste due […] Read More >
New Formulation for Repurposing of a Drug to Treat Retinitis Pigmentosa
Heterozygous mutations in the gene encoding the RNA splicing factor pre-mRNA processing factor 31 (PRPF31) have been identified as a major cause of autosomal dominant retinitis pigmentosa (RP), a debilitating and currently incurable blinding disease. The severity and progression of RP vary significantly among patients, with some carriers remaining asymptomatic. Intriguingly, asymptomatic mutation carriers exhibit […] Read More >
Novel Immuno-Metabolism Pathways to Combat Obesity and Insulin Resistance
Nutritional unbalance develops the obesity led to diabetes and accompanied by insulin resistance is being the epidemics of the 21st century. Inflammation of adipose tissue serves one notable pathway that is driving the development of dysfunctional metabolic state, leading to hyperglycaemia and other pathophysiology complications. Within the adipose tissue, a pivotal role in modulating interactions […] Read More >
Development of Improved Peptide Inhibitors of the HIF/PHD Interaction – Anemia and HIF – Related Diseases
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
A Computational Based Approach For Designing Plasmids’ Copy Number
We used plasmids in any biotechnological objective (both in the academia and in the industry) and in all model organisms. For example, plasmids are used in fields such as FoodTech, pharma, agriculture, etc. Currently, researchers chose between two possibilities: high copy plasmid (e.g. 500 copies) and low copy plasmid (e.g. 10 copies). However, the ability […] Read More >
A Dedicated Hardware for Accelerating Whole Cell Simulations of mRNA Translation for Various Biotechnological Pharma Applications
Gene expression (is a fundamental process defining all type of life where information encoded in the genetic material is used for generating proteins. Gene expression is a multi-steps process mediated by millions of intracellular biological machines (e.g. RNA polymerases, transcription factors, ribosomes, tRNAs, miRNAs), with complex interactions among them. Recently, intracellular biophysical simulations of gene […] Read More >
