Research Tools
56 Results were found on Technologies
Sub Category Name
A Cost-Effective On-Site Cell-Free Biomolecules Manufacturing
ABSTRACT On-site biomolecules production is a need for many applications such as drug screening, personalized therapeutics, remote clinics, and more. CONTRALL is a silicone chip that enables cost-effective production and purification of biomolecules (proteins, Abs, etc.). The technology is especially useful for the on-site production of simple and complex biomolecules, thus surpassing the need for a […] Read More >
Antibacterial and Antibiofilm Activity of Self-Assembled Nanostuctures
The self-assembly of peptides and functionalized amino acids into supramolecular nanostructures has yielded a wide variety of nanomaterials with numerous biomedical applications. UNMET NEED Bacterial biofilm formation on wet surfaces represents a significant problem in medicine and environmental sciences. One of the strategies to prevent or eliminate surface adhesion of organisms is surface modification and […] Read More >
Plants Having Increase Tolerance to Drought and Salt Stress
Loss of function mutant of a specific gene in tomato, using CRISR/Cas9 genome editing, that results in plants with increase water use efficiency (WUE), drought and salt tolerance. Combined results from five different analyses demonstrate that the mutant tomatoes display increased WUE due to lower stomata conductance and transpiration while photosynthesis rates and yield are […] Read More >
A Novel Drug Discovery Platform for Inborn Errors of Metabolism
A yeast-based screening system designed for each specific disease that recapitulates the metabolic state of patients and allows fast compound screening. The use of high-throughput screening of small molecules can significantly accelerate both drug discovery and target identification.The formation of amyloid fibrils is the hallmark of aging and various human pathologies, including neurodegenerations such as […] Read More >
An Effective Sema3A Antibody as a Therapy for Optic Nerve Neurodegenerative Diseases
Glaucoma and ischemic or neuro-degenerative diseases of the optic nerve lead to vision loss and blindness. These pathologies are associated with progressive apoptosis of the retinal ganglion cells (RGC), a process which involves expression of Semaphorin 3A protein in the axonal guidance pathways. The identified Sema3A antibody provides a potentially innovative therapeutic tool for these […] Read More >
Therapeutic Vaccine for the Treatment of Cancer
An active cancer vaccine strategy targeting tumor-associated carbohydrate antigens expressed on tumor cells using biomimetic glyconanoparticles generated from unique red blood cells. The resulting sustained immune response inhibits tumor growth. THE NEED While envisioned already in 1891, only a few cancer vaccines have been approved by the FDA thus far. The key barriers to their […] Read More >
3D Bioprinting of Tumor Models for Personalized Drug Screening and Disease Modeling
This technology aims to provide a three-dimensional (3D) bioprinted tumor model based on natural and synthetic polymers containing several types of cells, which resembles cancer tissue. Our 3D-bioprinted tumor model has potential to predict the clinical outcome of a treatment compared to the other existing solutions, which either rely solely on genetic profiling or do […] Read More >
Novel Ionizable Lipids for Delivery of Nucleic Acids (mRNA, DNA, siRNA)
BackgroundChemotherapy treatment is generally accompanied by adverse effects, which can be significantly reduced using site specific, targeted delivery systems, such as antibody-coated LNPs (immuno-LNPs). However due to inter-and intra-tumor heterogeneity targeting with a single targeting moiety is not sufficient in many cases and in others may induce cancer relapse due to the survival of side […] Read More >
A Novel Nanoparticle that Selectively Delivers RNAi Oligonucelotides to Tumors, Preventing Side Effects to Tissues
UNMET NEEDPancreatic cancer numbers among the most aggressive cancers known today. The overwhelming majority of pancreatic cancer patients pass away within just a year of diagnosis. However, a small minority of patients may live several years with the disease. Our findings pinpoint the inverse correlation between a known oncogene (PLK1) and the expression of an […] Read More >
HYDEN (HighlY DEgeNerate primers) – A Software for designing pairs of degenerate primers for a given set of DNA sequences
Overview HYDEN (HighlY DEgeNerate primers) is a program for designing pairs of degenerate primers for a given set of DNA sequences. HYDEN works well for large input sets of genomic sequences (e.g., hundreds of sequences of length 1Kbp). HYDEN is a batch (i.e., command-line, as opposed to graphical interface) program, available for Windows XP (downloadable […] Read More >
