RNA / DNA Therapy

 

6 Results were found on Technologies

Leading Researchers:
10-2013-551

Novel Integrase Based Cancer Treatment Technology

We have developed a new gene therapy technology for specific cancer cells killing and validated both efficacy and safety superiority of the proposed system over the conventional one in lung cancer mice model. The proposed system offers advantages over already known counterparts and may therefore be developed into a safer and efficient human cancer treatment […] Read More >

Leading Researchers:
10-2016-962

Harnessing Inhibitory RNA Based- Nanoparticles for Therapeutic Intervention in Blood Cancers

The current treatment of multiple myeloma (MM) included standard chemotherapy and small molecules such as the proteasome inhibitor and the immunomodulatory drugs.  Although these drugs have improved the response and survival of MM patients, MM is still an incurable disease. Drug resistance and disease refractoriness are the common terminal pathways leading to patients’ mortality. Therefore, […] Read More >

Leading Researchers:
2-2016-991

A Novel Nanoparticle that Selectively Delivers RNAi Oligonucelotides to Tumors, Preventing Side Effects to Tissues

UNMET NEEDPancreatic cancer numbers among the most aggressive cancers known today. The overwhelming majority of pancreatic cancer patients pass away within just a year of diagnosis. However, a small minority of patients may live several years with the disease. Our findings pinpoint the inverse correlation between a known oncogene (PLK1) and the expression of an […] Read More >

Leading Researchers:
2-2016-1041

Novel Ionizable Lipids for Delivery of Nucleic Acids (mRNA, DNA, siRNA)

BackgroundChemotherapy treatment is generally accompanied by adverse effects, which can be significantly reduced using site specific, targeted delivery systems, such as antibody-coated LNPs (immuno-LNPs). However due to inter-and intra-tumor heterogeneity targeting with a single targeting moiety is not sufficient in many cases and in others may induce cancer relapse due to the survival of side […] Read More >

Leading Researchers:
10-2020-1360

Targeting Human Brain Cells With Adeno-Associated Virus (AAV) for a Prospective Therapeutic Approach

The AAV therapeutic approach for various central nervous system (CNS) illnesses has been rapidly growing. Unfortunately, existing present technologies utilize AAV administration that is injected locally into the brain. This process requires a high level of expertise and is not applicable in more diffused brain targets like cortex and stiratum. Systemic administration of AAV vectors through […] Read More >

Leading Researchers:
2023-0129

New MicroRNAs as Candidates for Depression Therapy

Major depressive disorder (MDD) is a complex, common, and recurrent mental disorder (1). The current first-line treatment for MDD is selective serotonin reuptake inhibitors (SSRIs), which are antidepressant drugs that block serotonin reuptake. Two microRNA (miRNAs) molecules namely miR-30b-5p and miR-101a-3p were found to be downregulated in the raphe nuclei (RN) of mice following chronic […] Read More >

Prof. Avraham Karen B.

Genomic Analysis of Hereditary Hearing Loss Our primary interest is the genetic basis of hereditary hearing loss or deafness. Our group is working towards the identification, characterization and regulation of genes associated with hereditary hearing loss. For gene discovery, we focus on the Israeli Jewish and Palestinian Arab populations in the Middle East. Our studies […] Read More >

Prof. Benhar Itai

Prof. Benhar is an expert and opinion leader in the field of antibody engineering. Over the 25 years of being active in that field, he prepared several phage display libraries from which antibodies against numerous targets were isolated. Prof. Benhar publishes over 100research papers, wrote 10 book chapters and submitted 19 patent applications. Research in Prof. […] Read More >

Prof. Fishelson Zvi

Research Molecular Analysis of Cancer Immunoresistance The long-term goal of our research is to develop a novel treatment for immune resistant cancers. Our research includes characterization of the mechanism of complement-dependent cytotoxicity and of the basis for elevated resistance of cancer cells to cell death, and design of novel reagents that sensitize cancer cells to […] Read More >

Prof. Gophna Uri

Research topics: Microbial ecology, The human microbiome in IBD, Selfish genetic elements, Microbial defense systems, Systems biology, Halophilic archaea Research methods: Deep sequencing/massively parallel sequencing, microbiology, gene cloning, quantitative RT-PCR, immunofluorescence, Metagenomics , bioinformatics. Main projects in the lab include: > Microorganisms as biomarkers, and mediators of inflammation in IBD > Evolutionary roles of CRISPR-Cas […] Read More >

Prof. Halperin Eran

Research Areas Computational Biology Machine Learning Algorithms Population Genetics Statistical Genetics Read More >

Prof. Kolot Mikhail

Research Interests HK022 bacteriophage site specific recombinase Integrase is the tool for human genome manipulation and gene therapy. Site specific recombinases (SSRs) catalase the site-specific recombination reaction between two specific short DNA sequences of 30-40 bp that serve as recombination sites that included integration, excision and inversion. These enzymes are widely used for the genome manipulations […] Read More >

Prof. Jonathan Leor

Professor Leor received an M.D. degree from Tel-Aviv University, continued training in cardiovascular medicine at the Sheba Medical Center, and completed his post doctorate training at the University of Southern California, Los Angeles, under Robert A. Kloner, M.D., Ph.D. Today, his laboratory’s research focuses on infarct repair and the heart’s lack of intrinsic regenerative ability. […] Read More >

Prof. Margalit Rimona

Research Interests 1. Micro- and nano-particulate drug delivery technologies for topical, regional and systemic applications:  Our efforts in the drug delivery arena focus on two drug delivery technologies, one veteran and one novel, that are inventions of our group. These technologies each yield, micro and nano sized particles that are composed of biomaterials with particular […] Read More >

Prof. Peer Dan

Our lab is studying how to manipulate cells’ functions in order to generate novel strategies to treat inflammatory diseases and cancers. We are combining multidisciplinary approaches including immunology, cell and molecular biology, genetics, protein engineering, material sciences, nanotechnology and computational techniques for drug discovery and potentially for therapeutics. In addition, we are developing nanomedicines by […] Read More >

Prof. Qimron Ehud

Our lab studies the recently identified adaptive immune system of bacteria, the CRISPR/Cas system. This fascinating system remarkably adapts specifically to defend against newly encountered phages and launches a specific RNA-mediated response against their nucleic acids. In addition, we study novel phage interactions with their bacterial hosts,  and particularly novel interactions of T7 with its […] Read More >

Leading Researchers:
12-2011-213

Bacterial Isolates Identification and Gene Sequencing

Webpage: https://www.tau.ac.il/lifesci/departments/biotech/members/gophna/gophna.html   Scientist Contact:Uri Gophna Ph.D.Senior lecturer,Deparment of Molecular Microbiology and BiotechnologyGeorge S. Wise Faculty of Life SciencesTel. +972-3-6409988Fax +972-3-6409407email: urigo@tauex.tau.ac.il   Read More >

12-2011-209

Functional genomics

The Shomron research team focuses on the analysis of genomics aimed at understanding human diseases. Combining high-throughput methods and bioinformatics (such as AI and deep learning), our team’s research explores DNA changes and gene regulators. Our goal is to reach a global perspective on the roles DNA and RNA play during disease development. Among our […] Read More >

Leading Researchers:
12-2011-206

High Content Screening Facility

The Facility has an In Cell Analyzer 2000 (INCA 2000, GE healthcare), the first in Israel, which is a high throughput high content image screening analyzer capable of automatically acquiring multiple fluorescence-labeled images from live or fixed cells cultured in multi titter-well plates. We offer the possibility to analyze a wide range of cellular types […] Read More >

Leading Researchers:
12-2011-203

Cardiovascular and Physiological Assessment in Animal Models

Neufeld Cardiac Research Institute at Sheba Medical Center, Tel-Aviv University comprises a fully equipped laboratory to conduct cardiovascular and physiological experiments in small (mice, rat) and large animals (swine, sheep, calf) including heart function studies with special echocardiography system designed for small animals (Vevo660 ultrasound biomicroscope; VisualSonics), molecular imaging, pressure‐volume loop machine (Millar/Power Lab) and […] Read More >

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