RNA / DNA Therapy

Genomic Analysis of Hereditary Hearing Loss Our primary interest is the genetic basis of hereditary hearing loss or deafness. Our group is working towards the identification, characterization and regulation of genes associated with hereditary hearing loss. For gene discovery, we focus on the Israeli Jewish and Palestinian Arab populations in the Middle East. Our studies […] Read More >

Prof. Benhar is an expert and opinion leader in the field of antibody engineering. Over the 25 years of being active in that field, he prepared several phage display libraries from which antibodies against numerous targets were isolated. Prof. Benhar publishes over 100research papers, wrote 10 book chapters and submitted 19 patent applications. Research in Prof. […] Read More >

Research Molecular Analysis of Cancer Immunoresistance The long-term goal of our research is to develop a novel treatment for immune resistant cancers. Our research includes characterization of the mechanism of complement-dependent cytotoxicity and of the basis for elevated resistance of cancer cells to cell death, and design of novel reagents that sensitize cancer cells to […] Read More >

Research topics: Microbial ecology, The human microbiome in IBD, Selfish genetic elements, Microbial defense systems, Systems biology, Halophilic archaea Research methods: Deep sequencing/massively parallel sequencing, microbiology, gene cloning, quantitative RT-PCR, immunofluorescence, Metagenomics , bioinformatics. Main projects in the lab include: > Microorganisms as biomarkers, and mediators of inflammation in IBD > Evolutionary roles of CRISPR-Cas […] Read More >

Research Areas Computational Biology Machine Learning Algorithms Population Genetics Statistical Genetics Read More >

Research Interests HK022 bacteriophage site specific recombinase Integrase is the tool for human genome manipulation and gene therapy. Site specific recombinases (SSRs) catalase the site-specific recombination reaction between two specific short DNA sequences of 30-40 bp that serve as recombination sites that included integration, excision and inversion. These enzymes are widely used for the genome manipulations […] Read More >

Professor Leor received an M.D. degree from Tel-Aviv University, continued training in cardiovascular medicine at the Sheba Medical Center, and completed his post doctorate training at the University of Southern California, Los Angeles, under Robert A. Kloner, M.D., Ph.D. Today, his laboratory’s research focuses on infarct repair and the heart’s lack of intrinsic regenerative ability. […] Read More >

Research Interests 1. Micro- and nano-particulate drug delivery technologies for topical, regional and systemic applications:  Our efforts in the drug delivery arena focus on two drug delivery technologies, one veteran and one novel, that are inventions of our group. These technologies each yield, micro and nano sized particles that are composed of biomaterials with particular […] Read More >

Our lab is studying how to manipulate cells’ functions in order to generate novel strategies to treat inflammatory diseases and cancers. We are combining multidisciplinary approaches including immunology, cell and molecular biology, genetics, protein engineering, material sciences, nanotechnology and computational techniques for drug discovery and potentially for therapeutics. In addition, we are developing nanomedicines by […] Read More >

Our lab studies the recently identified adaptive immune system of bacteria, the CRISPR/Cas system. This fascinating system remarkably adapts specifically to defend against newly encountered phages and launches a specific RNA-mediated response against their nucleic acids. In addition, we study novel phage interactions with their bacterial hosts,  and particularly novel interactions of T7 with its […] Read More >

The Wnt signaling pathway is involved in virtually every aspect of human development, as well as in adult homeostasis. Hyperactivation of this pathway has been linked to a wide range of cancers and especially colorectal cancer. Our aim is to understand the molecular events underlying Wnt signal transduction, as well as develop novel therapeutic strategies […] Read More >

Our research interests include investigations related to tumor biology, tumor dormancy, mechanism of action of angiogenesis inhibitors, self-assembly of polymeric architectures and novel approaches to target cancer. Throughout, we have maintained an interest in understanding the biological rationale for the design of polymer therapeutics suitable for transfer into clinical testing. Our primary interests are the molecular […] Read More >

Noam has received his Bachelors degree in Biotechnology at Macquarie University in Sydney, Australia; his Masters degree in Gene Therapy at the Hebrew University of Jerusalem; and his graduate studies in Genetics at Tel Aviv University where he worked on regulatory RNA systems. As a Post-Doctorate affiliate at MIT in Cambridge, USA, Noam gained expertise […] Read More >

המטרה ארוכת הטווח שלנו היא זיהוי ואפיון של אינטראקציות של וירוסים עם תאי המארחים שלהם ברמות מרובות. אנו משתמשים בטכניקות מתקדמות של ביולוגיה מולקולרית, וירולוגיה והדמיה. מערכות המודל הנוכחיות שלנו כוללות נגיפי הפטיטיס D (HDV), אבולה ודנגי. זיהום בכל אחד מהנגיפים הללו עלול בסופו של דבר להיות קטלני. וירוסים אלה משפיעים על חייהם של מיליוני […] Read More >

Research topic: Cell based platforms for study, diagnosis, drug screening and therapy of neurodegenerative diseases. Research methods: Isolation and culture of human embryonic/adult stem cells models of diseases; Cell based-assays for High content analysis (HCA) screening of stem cells with and without disease; High throughput screening (HTS) of drugs using liquid handling robot, Drug development applications, Transcriptome […] Read More >