Small Molecules
13 Results were found on Technologies
Sub Category Name
Pharmacological Activation of the cAMP Signaling Pathway Enhances the Function of Cord Blood – Hematopoietic Stem Cells
Allogeneic Hematopoietic Stem Cell Transplantation is a curative therapy for many blood disorders, including leukemias and inherited blood diseases. It involves depleting a patient’s diseased bone marrow by cytotoxic therapies and then regenerating a healthy hematopoietic system by transplantation of healthy Hematopoietic Stem Cells (HSCs). UNMET NEED Cord blood is an attractive source for stem […] Read More >
Development Of Improved Immunosuppressant Targeting Calcineurin-NFAT Protein-Protein Interaction Via Novel Peptides
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
Development Of Improved Immunosuppressant Targeting Calcineurin-NFAT Protein-Protein Interaction Via Small Molecule Drugs
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
Anti-Influenza A Virus Drug Discovery
Influenza A virus infection is one of the most common respiratory tract diseases in humans. It is the cause of typical seasonal flu as well as major human pandemics worldwide. According to the World Health Organization (WHO) in October 2023, around 3 to 5 million severe influenza cases were recorded, leading to 290,000 to 650,000 […] Read More >
New Formulation for Repurposing of a Drug to Treat Retinitis Pigmentosa
Heterozygous mutations in the gene encoding the RNA splicing factor pre-mRNA processing factor 31 (PRPF31) have been identified as a major cause of autosomal dominant retinitis pigmentosa (RP), a debilitating and currently incurable blinding disease. The severity and progression of RP vary significantly among patients, with some carriers remaining asymptomatic. Intriguingly, asymptomatic mutation carriers exhibit […] Read More >
Protection of Oxygen-Sensitive-Enzymes by Peptide Hydrogel
Molecular oxygen (O2) is a highly reactive oxidizing agent harmful to many biological and industrial systems. A simple encapsulation in a protective aqueous environment of O2 -sensitive reactions is of need. Self-assembling peptide-based hydrogels are simple hydrogels that can be combined with a wide variety of reagents and are able to encage O2 and significantly limit its […] Read More >
Repurposing of Antibiotics for treating APC (Adenomatous Polyposis Coli) Related Colorectal Cancer
Restoration of Adenomatous Polyposis Coli (APC) gene expression by means of antibiotic erythromycin for the treatment of Familial Adenomatous Polyposis. The Technology: Treatment for APC by conventional antibiotics to regulate adenoma growth and delay the need for preventive surgery in Familial Adenomatous Polyposis (FAP) patients. The Need: FAP is a high penetrance devastating syndrome manifested […] Read More >
Macrolid Induced Correction of Premature Stop Codons: A novel Treatment for Colorectal Cancer
Restoration of premature termination codons (PTCs) caused by nonsense mutations for the treatment of Familial Adenomatous Polyposis. The Need Familial Adenomatous Polyposis (FAP) is a high penetrance devastating syndrome manifested by dozens to thousands of colonic adenomas. FAP patients require tight supervision and eventually undergo surgery, to prevent inevitable development of colorectal cancer (CRC) by […] Read More >
SK4 K+ channel blockers: a new treatment for cardiac atrial fibrillation
We discovered a previously unidentified target in the heart, namely the SK4 calcium-activated K+ channels, which are functionally expressed in pacemaker cells as well as in atrial and ventricular cardiomyocytes. They are crucial for proper cardiac function and represent a completely new therapeutic target for the treatment of cardiac arrhythmias. SK4 channel blockers successfully prevented […] Read More >
Inhibition of the Pax8 Transcription Factor as a Novel Therapeutic Approach for Ovarian and Endometrial Cancer
OUTLINEThe PAX8 transcription factor is essential for ovarian cancer proliferation, and its silencing in ovarian and endometrial cancer cells leads to apoptosis 1,2. PAX8 expression in other tissues is restricted to non-essential organs, suggesting that it is a good target for therapy with minimal side effects 3,4. We propose a novel anti-ovarian and -endometrial cancer […] Read More >
Therapeutic Targeting of PD-1/PD-L1 blockade by Novel Small-molecule Inhibitors
Interactions between programmed cell death ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1) lead to the evasion of cancer cells from an efficient immune response. The inhibition of PD-L1/PD-1 has prevented or reversed exhausted T cells, thus enhancing antitumor T-cell responses. In fact, immune checkpoint blockade targeting the PD-1 axis has become one […] Read More >
Development of Alzheimer Disease therapy based on counteracting the pathological effects of ApoE4
Alzheimer’s disease (AD) is the most common cause of dementia and is the outcome of progressive brain cells death. Due to the disorder’s heterogeneity and in view of the variety of pathological mechanisms inducing the disease we have undertaken an innovative – science based (Animal model) approach, which is presented here. Our unique approach […] Read More >
Homocysteine fibrillar assemblies display crosstalk with Alzheimer’s disease amyloid polypeptide
High levels of homocysteine (Hcy) are reported as a risk factor for Alzheimer’s disease (AD). Correspondingly, inborn hyperhomocysteinemia is associated with an increased predisposition to the development of dementia in later stages of life. Furthermore, despite the apparent association between protein aggregation and AD, attempts to develop a therapy that targets explicitly this process have […] Read More >
