Synthetic Biology
16 Results were found on Technologies
Sub Category Name
Bio-Inspired Liquid Compartments for Efficient Encapsulation and Controlled Release of Payloads
Tunable peptide-RNA microcompartments inspired by viral structures that have high encapsulation efficiency of small organic molecules and large macromolecules that their release is triggered by light. UNMET NEED Current drug delivery or microreactor systems are lipid-based nanoparticles (NPs) that has shown a wide range of applications as drug delivery vehicles and are used for various […] Read More >
Next Generation of the mRNA Therapy: Targeting Cancer Cells Via Boolean Circuits Based on mRNA Molecules
Currently most cancer treatment target proteins that are modified or activated in cancer cells; usually this is done by producing a relevant antibody. The process of finding a new therapy that targets a protein is long and tedious and in addition, in many cancer types there is no therapy at all. Specifically, today there are […] Read More >
Enhancing Plasmid Conjugation Efficiency for Transformative Biotechnological Applications
This technology enhances plasmid-based gene transfer by utilizing a leading region enriched with anti-defense genes. It enables more efficient overcoming of bacterial immune systems, improving applications in biotechnology and microbial engineering. ABSTRACT Our groundbreaking technology dramatically improves plasmid-based gene transfer by utilizing a strategically designed leading region enriched with anti-defense genes. We revealed that the […] Read More >
3D Printing of 3-Layered Retina and Choroid Tissue
We present a sequential fabrication of a three-layer retina-like structure. This innovative approach aims to address the challenges associated with age-related macular degeneration (AMD) and other retinal degenerative diseases by creating a bioengineered retinal implant that mimics the natural structure and function of the human retina. Unmet Need: Age-related macular degeneration is the leading cause […] Read More >
A Computational Based Approach For Designing Plasmids’ Copy Number
We used plasmids in any biotechnological objective (both in the academia and in the industry) and in all model organisms. For example, plasmids are used in fields such as FoodTech, pharma, agriculture, etc. Currently, researchers chose between two possibilities: high copy plasmid (e.g. 500 copies) and low copy plasmid (e.g. 10 copies). However, the ability […] Read More >
A Dedicated Hardware for Accelerating Whole Cell Simulations of mRNA Translation for Various Biotechnological Pharma Applications
Gene expression (is a fundamental process defining all type of life where information encoded in the genetic material is used for generating proteins. Gene expression is a multi-steps process mediated by millions of intracellular biological machines (e.g. RNA polymerases, transcription factors, ribosomes, tRNAs, miRNAs), with complex interactions among them. Recently, intracellular biophysical simulations of gene […] Read More >
A Generic Approach Constructing an Evolutionary Stable Genetic Circuit
Any genetic circuit engineered in any organism will cause a huge metabolic load on its host, compiling the organism to manufacture numerous proteins against his own benefit thus greatly decreasing its fitness. Random mutations that arise during normal DNA replication or during DNA damage repair dictate that it’s unavoidable outcome that the genetic circuit will […] Read More >
A Wheat Leaf and Stipe Rust Resistance Gene
Background Rusts are a group of plant diseases that are caused by certain types of plant pathogenic fungi. Three types of rust diseases, namely leaf, stem and stripe rusts, are the most widespread diseases of wheat, each causing great yield losses globally; Modern wheat cultivars contain many resistance (R) genes that have been used to […] Read More >
A Cost-Effective On-Site Cell-Free Biomolecules Manufacturing
ABSTRACT On-site biomolecules production is a need for many applications such as drug screening, personalized therapeutics, remote clinics, and more. CONTRALL is a silicone chip that enables cost-effective production and purification of biomolecules (proteins, Abs, etc.). The technology is especially useful for the on-site production of simple and complex biomolecules, thus surpassing the need for a […] Read More >
Gene Expression for Improved Crop Pproductivity
Enhancing crop productivity by optimizing gene expression in plants, using proprietary and proven computational tools, together with genome base editing capabilities. Tapping into gene expression for improved crop UNMET NEED Crop productivity needs to substantially increase to meet global food and feed demand for a rapidly growing world population. Agricultural technology developers are pursuing a […] Read More >
