Therapeutics
17 Results were found on Technologies
Sub Category Name
Cell-Permeable Abiotic Transcription Factor Modulators with Enhanced Stability, Intrinsic Cell Pearmiability, and Specific DNA Binding
Cell-Permeable Miniproteins to target Myc oncoprotein Chemically engineered family of Max-derived transcription factor (TF) analogs (μMax modulators) with intrinsic cell permeability, nanomolar DNA binding, and enhanced stability. These abiotic proteins can directly modulate gene expression driven by Myc TF – offering a therapeutic strategy for drugging the undruggable Myc pathway. Unmet Need TFs, especially Myc, are among the […] Read More >
CRISPR-Cas3 Phage Platform Enabling Precision Gut Delivery of Biotherapeutics
This technology introduces a first-in-class engineered phage platform that delivers proprietary DNA Cargos into targeted E. coli strains of the human gut microbiome. Using CRISPR-Cas3–mediated in-vivo selection, the system converts bacterial populations and drives local production of human biotherapeutics directly inside the gut. The platform achieves durable bacterial trait modification without disrupting microbiome balance and […] Read More >
OGP: Immune-Modulating Cancer Therapy
Osteogenic growth peptide (OGP), a selective CB2 agonist, reduces cancer progression in two models of colon cancer and one model of breast cancer in mice by modulating immune responses. Human genetic data supports the role of CB2 in tumor immunology. UNMET NEED Colon carcinoma and breast cancer are prevalent solid tumors with limited therapies and […] Read More >
Bedside Manufacturing of Personalized mRNA Vaccines
A microfluidic lab-on-a-chip platform enabling on-demand, bedside production of mRNA vaccines encapsulated in lipid nanoparticles (LNPs). Unlike conventional centralized manufacturing, this integrated system performs cell-free transcription and LNP formulation on a single device, delivering ready-to-use mRNA-LNP vaccines rapidly and efficiently. KEY ADVANTAGES • End-to-end automation: From DNA template to formulated mRNA-LNP in one device • […] Read More >
Innovative Drug Delivery: Hydrogel-Forming Microneedles with Programmed Mesophase Transitions
An innovative drug delivery system utilizing hydrogel-forming microneedles that undergo programmed mesophase transitions. This technology allows for the controlled release of drugs, enhancing the efficacy and safety of pharmaceutical treatments. The microneedles transition from solid to swollen hydrogel upon contact with biological fluids, followed by further transformation into hydrogel microparticles, which facilitates a sustained release […] Read More >
Plant-Derived Anti- Herpesvirus Composition
Herpes simplex virus infection is commonly known as herpes. The two types of herpes simplex virus are HSV-1 (known to cause orofacial disease such as cold sores) and HSV-2 (causes genital infections). Over 80% of herpes infections is asymptomatic. Symptomatic infections are presented with blistering sores, pain during urination, swollen lymph nodes, and fever. Acyclovir […] Read More >
Novel Human Anti-Met Monoclonal Antibodies for Cancer Immunotherapy
MET is clinically validated target in several cancer types. MET operates just downstream to the famous P53. Addiction of cancers like breast and lung to MET as well as its absence from healthy adult tissues makes it a highly desirable target. Existing anti-MET marketed drugs (crizotinib & cabozantinib) are non-specific kinase inhibitors, having high toxicity […] Read More >
Targeting miR126-5p: A Novel RNA-Based Therapeutic Strategy for ALS
Amyotrophic Lateral Sclerosis (ALS) is a devastating and fatal neurodegenerative disease affecting motor neurons, leading to progressive paralysis. With a lifetime risk of 1:400 and no effective treatment available, there is an urgent need for novel therapeutic strategies to slow disease progression and improve patient outcomes. OUR SOLUTION We have identified miR126-5p as a novel […] Read More >
Repurposing of Antibiotics for treating APC (Adenomatous Polyposis Coli) Related Colorectal Cancer
Restoration of Adenomatous Polyposis Coli (APC) gene expression by means of antibiotic erythromycin for the treatment of Familial Adenomatous Polyposis. The Technology: Treatment for APC by conventional antibiotics to regulate adenoma growth and delay the need for preventive surgery in Familial Adenomatous Polyposis (FAP) patients. The Need: FAP is a high penetrance devastating syndrome manifested […] Read More >
Macrolid Induced Correction of Premature Stop Codons: A novel Treatment for Colorectal Cancer
Restoration of premature termination codons (PTCs) caused by nonsense mutations for the treatment of Familial Adenomatous Polyposis. The Need Familial Adenomatous Polyposis (FAP) is a high penetrance devastating syndrome manifested by dozens to thousands of colonic adenomas. FAP patients require tight supervision and eventually undergo surgery, to prevent inevitable development of colorectal cancer (CRC) by […] Read More >
