Therapeutics
21 Results were found on Technologies
Sub Category Name
Genetic Engineering of B Cell Receptors for Antigen-Induced, Evolvable Antibody Secretion
We developed a platform for engineering B cells via targeted integration of antibody sequences into the immunoglobulin heavy chain (IgH) locus, enabling physiological expression as a B cell receptor (BCR) and subsequent antigen-induced secretion. Unlike conventional antibody therapies or ectopic expression systems, this approach preserves key adaptive immune functions including antigen-dependent activation, class-switch recombination (CSR), […] Read More >
Magnetic Nanoparticle Theranostic Platform
Many severe diseases are located in deep tissues or behind biological barriers that standard systemic drugs cannot penetrate effectively. This anatomical challenge severely limits therapeutic efficacy for conditions affecting the central nervous system, solid tumors, and other immunologically privileged sites. Systemic therapies (such as chemotherapy) produce severe adverse effects while remaining limited in efficacy due […] Read More >
Targeted Antisense Oligonucleotide Therapy Using Lipid Nanoparticles
Antisense Oligonucleotides (ASOs) are among the fastest-growing classes of therapeutics used to modulate gene expression. Among ASOs, Locked Nucleic Acids (LNAs) are an advanced form of ASO with chemical modifications that enhance their binding affinity and stability (1). As of today, several ASOs have been approved for clinical use, primarily for the treatment of rare […] Read More >
New Anti-Influenza Virus (FLU) Drug Discovery
Influenza A virus infection is one of the most common respiratory tract diseases in humans. It is the cause of typical seasonal flu and major human pandemics worldwide. According to the World Health Organization (WHO), in October 2023, approximately 3 to 5 million severe influenza cases were reported, resulting in 290,000 to 650,000 deaths worldwide. […] Read More >
Cell-Permeable Abiotic Transcription Factor Modulators with Enhanced Stability, Intrinsic Cell Pearmiability, and Specific DNA Binding
Cell-Permeable Miniproteins to target Myc oncoprotein Chemically engineered family of Max-derived transcription factor (TF) analogs (μMax modulators) with intrinsic cell permeability, nanomolar DNA binding, and enhanced stability. These abiotic proteins can directly modulate gene expression driven by Myc TF – offering a therapeutic strategy for drugging the undruggable Myc pathway. Unmet Need TFs, especially Myc, are among the […] Read More >
CRISPR-Cas3 Phage Platform Enabling Precision Gut Delivery of Biotherapeutics
This technology introduces a first-in-class engineered phage platform that delivers proprietary DNA Cargos into targeted E. coli strains of the human gut microbiome. Using CRISPR-Cas3–mediated in-vivo selection, the system converts bacterial populations and drives local production of human biotherapeutics directly inside the gut. The platform achieves durable bacterial trait modification without disrupting microbiome balance and […] Read More >
OGP: Immune-Modulating Cancer Therapy
Osteogenic growth peptide (OGP), a selective CB2 agonist, reduces cancer progression in two models of colon cancer and one model of breast cancer in mice by modulating immune responses. Human genetic data supports the role of CB2 in tumor immunology. UNMET NEED Colon carcinoma and breast cancer are prevalent solid tumors with limited therapies and […] Read More >
Bedside Manufacturing of Personalized mRNA Vaccines
A microfluidic lab-on-a-chip platform enabling on-demand, bedside production of mRNA vaccines encapsulated in lipid nanoparticles (LNPs). Unlike conventional centralized manufacturing, this integrated system performs cell-free transcription and LNP formulation on a single device, delivering ready-to-use mRNA-LNP vaccines rapidly and efficiently. KEY ADVANTAGES • End-to-end automation: From DNA template to formulated mRNA-LNP in one device • […] Read More >
Innovative Drug Delivery: Hydrogel-Forming Microneedles with Programmed Mesophase Transitions
An innovative drug delivery system utilizing hydrogel-forming microneedles that undergo programmed mesophase transitions. This technology allows for the controlled release of drugs, enhancing the efficacy and safety of pharmaceutical treatments. The microneedles transition from solid to swollen hydrogel upon contact with biological fluids, followed by further transformation into hydrogel microparticles, which facilitates a sustained release […] Read More >
Plant-Derived Anti- Herpesvirus Composition
Herpes simplex virus infection is commonly known as herpes. The two types of herpes simplex virus are HSV-1 (known to cause orofacial disease such as cold sores) and HSV-2 (causes genital infections). Over 80% of herpes infections is asymptomatic. Symptomatic infections are presented with blistering sores, pain during urination, swollen lymph nodes, and fever. Acyclovir […] Read More >
