Briefcase
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249 Results were found on Technologies
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Bio-Inspired Liquid Compartments for Efficient Encapsulation and Controlled Release of Payloads
Tunable peptide-RNA microcompartments inspired by viral structures that have high encapsulation efficiency of small organic molecules and large macromolecules that their release is triggered by light. UNMET NEED Current drug delivery or microreactor systems are lipid-based nanoparticles (NPs) that has shown a wide range of applications as drug delivery vehicles and are used for various […] Read More >
Diagnostic Tool for Assessing Breast Cancer Aggressiveness via Neutrophil-Tumor Cell Interactions
A novel diagnostic approach based on the discovery that neutrophils physically interact with tumor cells in breast cancer, creating a unique signaling niche that enhances cancer aggressiveness. This interaction can be used to assess the aggressiveness of breast cancer, offering a new way to predict patient outcomes and guide treatment strategies. Unmet Need Current diagnostic […] Read More >
Light-Controlled Nanostructured Device for Biomolecule Separation
In the realms of proteomics, genomics, and biosensing, the analysis of complex biological samples such as blood and urine presents significant challenges. These samples contain a vast array of biomolecules, often exceeding 10,000 proteins with concentration variations spanning over 10 orders of magnitude. Traditional methods like chromatography, electrophoresis, and centrifugation are either time-consuming or lack […] Read More >
Therapeutic Targeting of CD45: A Novel Approach to Overcome Immunotherapy Resistance
Revolutionizing Cancer Immunotherapy While immune checkpoint inhibitors have transformed cancer treatment, only 50% of patients fail to respond, with resistance being a major challenge, particularly in aggressive cancers such as triple-negative breast cancer (TNBC). TNBC accounts for 15–20% of breast cancer cases and is often diagnosed at advanced stages, with current therapies offering limited efficacy. […] Read More >
Peptide Nanostructures for Enhanced Hydrogen Production
As the world pivots toward sustainable energy solutions, hydrogen has emerged as a key player in the quest for clean energy. Unlike conventional “gray” hydrogen produced from fossil fuels, “green” hydrogen offers a carbon-neutral alternative that can be generated through innovative electrochemical processes powered by renewable energy sources. Harnessing the catalytic power of redox enzymes, […] Read More >
P32-Specific Antibodies and CAR T Cells for Glioblastoma and P32-Expressing Tumors
This innovative immunotherapy platform leverages p32-specific antibodies to create Chimeric Antigen Receptor (CAR) T cells, specifically targeting p32—a tumor-associated antigen expressed in glioblastomas and other aggressive cancers. The approach combines tumor elimination with antiangiogenic effects, paving the way for enhanced therapeutic outcomes in solid tumors. Unmet Need Glioblastoma, a highly aggressive brain cancer, has limited […] Read More >
Energy Harvesting Module and Low Power Rectifier Circuit
RADIO frequency (RF) energy harvesting has garnered much interest in recent years as our lives have become more connected. Whether it be smart homes, industry 4.0, wearables or sport-tech; objects which were once inanimate are brought to life with electronics such as sensors, and low-power transceivers. This evolution of ‘things’ is commonly referred to as […] Read More >
Direct Seawater Splitting Technology for Pure Hydrogen Production
The quest for sustainable and renewable energy sources has intensified in recent years, driven by the urgent need to combat climate change and reduce reliance on fossil fuels. Among various approaches, direct seawater splitting presents a promising avenue for producing clean hydrogen and oxygen. This innovative technology leverages the abundant availability of seawater, eliminating the […] Read More >
Ultrafast One-Minute Electronic Detection of SARS-CoV-2
Since its emergence in December 2019, SARS-CoV-2 has led to a global pandemic, resulting in over 6.5 million deaths as of October 2022. The rapid and accurate detection of this virus is crucial for controlling its spread and managing public health responses. Traditional diagnostic methods, such as PCR testing, while effective, often require specialized equipment, […] Read More >
Sensitive Electrochemical Detection of Soybean Rust Fungi Airborne Urediniospores
The agricultural sector faces significant challenges due to plant diseases, which can lead to substantial economic losses. Among these diseases, soybean rust, caused by the fungus Phakopsora pachyrhizi, poses a severe threat to soybean crops worldwide. Early detection of airborne urediniospores is crucial for effective disease management and prevention strategies. Traditional detection methods often lack […] Read More >
Multi-Sample Array Chip for DNA Modification Quantification
Introducing an advanced multi-sample array chip that enables precise quantification of epigenetic DNA modifications, including 5-hydroxymethylcytosine (5-hmC) and DNA damage. This technology bridges the gap between sensitivity and throughput, providing a robust platform for cancer diagnostics and personalized medicine. Unmet Need Current methods for analyzing DNA modifications suffer from limitations such as low sensitivity, high […] Read More >
Simultaneous Analysis of Large Genomic Structural Variations and Their Epigenetic Profile
This innovative technology enables simultaneous quantification of DNA repeat sequences, large deletions, insertion, inversion and translocations, together with CpG methylation and hydromethylation patterns in individual molecules. By leveraging state-of-the-art optical mapping and fluorescence-based methylation detection, this method provides unprecedented precision in diagnosing diseases like facioscapulohumeral muscular dystrophy (FSHD) and cancers. Unmet Need Current technologies for […] Read More >
SLOW RELEASE OF A SYNTHETIC AUXIN INDUCES ADVENTITIOUS ROOT FORMATION
The ability to propagate plants efficiently is crucial for agriculture, horticulture, and forestry. Adventitious root formation, the process by which roots develop from non-root tissues, is a key factor in successful plant propagation. However, many woody plant species exhibit low rooting success, presenting a significant challenge for growers. Traditional rooting hormones, while effective, often have […] Read More >
DifuzCam: Replacing Camera Lens with a Mask and a Diffusion Model
DifuzCam represents a novel approach of flat lensless camera imaging. By eliminating traditional lenses and instead using a diffuser near the sensor, the camera size, weight and cost are drastically reduced. However, reconstructing high-quality images from the raw sensor data of such cameras is an ongoing challenge. Our invention proposes a solution by leveraging a […] Read More >
Next Generation of the mRNA Therapy: Targeting Cancer Cells Via Boolean Circuits Based on mRNA Molecules
Currently most cancer treatment target proteins that are modified or activated in cancer cells; usually this is done by producing a relevant antibody. The process of finding a new therapy that targets a protein is long and tedious and in addition, in many cancer types there is no therapy at all. Specifically, today there are […] Read More >
Pharmacological Activation of the cAMP Signaling Pathway Enhances the Function of Cord Blood – Hematopoietic Stem Cells
Allogeneic Hematopoietic Stem Cell Transplantation is a curative therapy for many blood disorders, including leukemias and inherited blood diseases. It involves depleting a patient’s diseased bone marrow by cytotoxic therapies and then regenerating a healthy hematopoietic system by transplantation of healthy Hematopoietic Stem Cells (HSCs). UNMET NEED Cord blood is an attractive source for stem […] Read More >
Agent-Based Modeling (ABM) of Pedestrian Mobility in the City
Accurate assessment and prediction of pedestrian flows over the urban street network could enable data-driven transportation and city planning for promoting walking and other planning goals related to pedestrian flows. Since the available data collection methods are limited, and too costly to implement on a large urban scale, it is practically unfeasible to measure pedestrian […] Read More >
Enhancing Plasmid Conjugation Efficiency for Transformative Biotechnological Applications
This technology enhances plasmid-based gene transfer by utilizing a leading region enriched with anti-defense genes. It enables more efficient overcoming of bacterial immune systems, improving applications in biotechnology and microbial engineering. ABSTRACT Our groundbreaking technology dramatically improves plasmid-based gene transfer by utilizing a strategically designed leading region enriched with anti-defense genes. We revealed that the […] Read More >
Development Of Improved Immunosuppressant Targeting Calcineurin-NFAT Protein-Protein Interaction Via Novel Peptides
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
Development Of Improved Immunosuppressant Targeting Calcineurin-NFAT Protein-Protein Interaction Via Small Molecule Drugs
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
Anti-Influenza A Virus Drug Discovery
Influenza A virus infection is one of the most common respiratory tract diseases in humans. It is the cause of typical seasonal flu as well as major human pandemics worldwide. According to the World Health Organization (WHO) in October 2023, around 3 to 5 million severe influenza cases were recorded, leading to 290,000 to 650,000 […] Read More >
Advancements in Metrology through Interferometry with Doubled Imaging Area (IDIA)
Metrology, the science of measurement, plays a crucial role in various fields, including manufacturing, healthcare, and materials science. Accurate and efficient imaging techniques are essential for characterizing materials and biological samples. Traditional interferometric methods often face limitations in field of view (FOV) and acquisition speed, hindering their application in dynamic and large-scale measurements. The recent […] Read More >
Evaluation of Single Strand DNA Damage in Sperm Using a novel Damage Detection Technique
The Damage Detection technique is an innovative approach to assessing Single Strand DNA (ssDNA) damage by utilizing DNA repair enzymes to identify DNA adducts and single-strand breaks. Spermatozoa are characterized by high levels of DNA fragmentation, despite their condensed nuclear DNA packaging. Sublethal DNA damage, such as single strand breaks and adducts, can occur and […] Read More >
Hierarchically Structured Core/ Sheath Microfibers for Filtration, Separation, and Catalysis Applications
The development of synthetic fibers that mimic the complex, hierarchical nano-to-microscale structures found in nature, like cellulose and silk, can potentially revolutionize various fields, from smart active textiles to environmental science an sustainability. These fibers, which contain internal features spanning from the nano- to the microscale, can exhibit superior properties compared to conventional fibers, opening […] Read More >
Alkali Metal-Sulfur Rechargeable Battery Technology
The demand for efficient and sustainable energy storage solutions is rapidly increasing, driven by the growth of electric vehicles (EVs) and renewable energy sources. Traditional lithium-ion batteries, while widely used, face limitations in energy density, cost, and environmental impact. This one-pager presents an innovative cathode design for alkali metal-sulfur rechargeable batteries, which offers a promising […] Read More >
3D Printing of 3-Layered Retina and Choroid Tissue
We present a sequential fabrication of a three-layer retina-like structure. This innovative approach aims to address the challenges associated with age-related macular degeneration (AMD) and other retinal degenerative diseases by creating a bioengineered retinal implant that mimics the natural structure and function of the human retina. Unmet Need: Age-related macular degeneration is the leading cause […] Read More >
‘Super-Seaweeds’ Enriched with Nutritional and Health Compounds
The world population is growing and is expected to reach 10 billion by 2050. The increasing awareness of alternative natural products has led to a growing demand for plant-based goods. Currently, there’s an urgent need to enhance Earth’s capacity to support the expanding human population and address the depletion of natural resources. Humanity seeks a […] Read More >
Skewed Sex Ratio Technology for Livestock and Pets: Reducing Resource Wastage and Labor in Animal Breeding
Our innovative genetic engineering technology offers a transformative solution for livestock and pet industries by generating offspring with a skewed sex ratio. The technology, proven in mice, is now aimed at practical application in cattle, swine, poultry, and other farm animals, as well as pets. The Problem: Current breeding practices lead to significant waste due […] Read More >
Touchless Short-Wave Infrared Imaging for Closed Eyes Pupillometry
Pupillometry, the measurement of pupil size and reactivity, is a critical component in neurological examinations and research. Traditional methods of assessing pupil dynamics are often limited to open-eye conditions and require direct contact, which can be impractical in various clinical settings, such as during sleep studies, anesthesia, or intensive care. The advent of touchless imaging […] Read More >
An Improved Fast-Growing Halophilic haloarchaeon Strain
The Challenge: Halophilic archaea (HA) are ideal for biotechnological processes because they thrive in extreme conditions, requiring minimal sterility and no freshwater. However, unlike other microorganisms like fungi, algae, and bacteria, HA are underutilized in large-scale biotechnology. Currently, HA are mostly used for producing carotenoids, like bacterioruberin, and other high-value compounds. The primary species used, […] Read More >
New Formulation for Repurposing of a Drug to Treat Retinitis Pigmentosa
Heterozygous mutations in the gene encoding the RNA splicing factor pre-mRNA processing factor 31 (PRPF31) have been identified as a major cause of autosomal dominant retinitis pigmentosa (RP), a debilitating and currently incurable blinding disease. The severity and progression of RP vary significantly among patients, with some carriers remaining asymptomatic. Intriguingly, asymptomatic mutation carriers exhibit […] Read More >
Pressure-Absorbing Skin Patch for Preventing Medical Device-Related Pressure Injuries
In the realm of medical device usage within clinical settings, a critical challenge faced is the occurrence of medical device-related pressure injuries (MDRPI). These injuries result from prolonged pressure and shear stress applied by medical devices directly on the patient’s skin, leading to significant discomfort and potential complications. Unmet Need MDRPIs pose a significant risk […] Read More >
Protecting the Diabetic Neuropathic Foot Using Optimized Wound Site Foot-Loading Footwear
Diabetic neuropathic foot ulcers are a common and serious complication of diabetes, leading to significant morbidity and healthcare costs. Current offloading solutions often face challenges in effectively redistributing plantar pressure to prevent ulcer formation. In this context, the development of innovative technologies such as graded stiffness offloading insoles presents a promising approach to address this […] Read More >
Text-Guided Real-World Image Restoration
Capturing images in limited conditions (such as low-light, high dynamic range, etc.) is hard and the resulting images are not good. Since the camera is limited in such scenarios, capturing such scenes becomes difficult. Using a novel image processing method with artificial intelligence (AI) technology the user can talk to the camera and describe the […] Read More >
Calibration of Fiber Optic Sensor Underground
The precise geolocation of underground fiber optic telecom cables is crucial for operator maintenance, to avoid construction-related damage, and to minimize costs during network upgrades. Our innovative calibration technology provides non-instrusive high-accuracy localization of subsurface fiber optic cables, using only video inputs and ambient urban under any noise conditions. In addition, the same data are […] Read More >
Traffic Monitoring Using Fiber Optic Sensor
The rapid development of smart cities and their infrastructure requires innovative solutions for traffic monitoring. Fiber optic sensors offer a high-precision, reliable, anonymous, and cost-effective method for real-time traffic data acquisition and analysis. We have developed an AI-based technology, using fiber-optic sensors for comprehensive traffic monitoring systems, enhancing traffic management and safety. UNMET NEED Current […] Read More >
Graphenic Silicon Thin Films for Lithium-Ion Batteries
The rapid growth of portable electronics and electric vehicles demands advancements in battery technology to improve energy storage, extend lifespan, and reduce environmental impact. Current lithium-ion batteries struggle with limited capacity, long charging times, and degradation over time, which are significant hurdles in technology and transportation sectors. OUR SOLUTION Our solution leverages advanced material science […] Read More >
Accelerated Brain MRI
MRI has become an invaluable tool for diagnostic brain imaging, providing unrivalled qualitative and quantitative information to the radiologist. However, due to long scanning times and capital costs, access to MRI lags behind CT. Typical brain protocols, lasting between 20-50 minutes per patient, set a clear limitation to patient experience, scanner throughput and operation profitability, […] Read More >
Caches With Many Ways: 16-way Associativity for the Price of 2-way Associativity
Cache design must meet many conflicting demands: high hit rates, low cost, low power, low latency and high throughput. We propose a novel cache design for 16-way associativity with cost and power consumption like 2-way associativity. UNMET NEED We propose a novel cache design with the following features: • High effective cache capacity • Misses […] Read More >
Grid-To-Belt Automatic Sorter
Sorting involves organizing items according to their common characteristics or destinations. The primary performance metric for a sorting system is the number of items it can process in a given time unit, namely, the system’s throughput. Circular conveyor belts (or similar technologies) segmented into sections are the prevailing technology used for sorting. In such systems, […] Read More >
Restoring Immunity Against GI Cancers
BACKGROUND GI cancers cause over 3.5 million deaths per year globally, accounting for 35% of all cancer-related deaths. Colorectal carcinoma (CRC) is the world’s second leading cause of cancer death. Current immunotherapy treatments for CRC are hamstrung by low response rate, acquired resistance, relapse and severe side effects. ImmuNovation presents a disruptive nanomodular technology utilizing […] Read More >
Discovery of a Virus That Threatens The Rainbow Trout Aquaculture
Rainbow trout (Oncorhynchus mykissis) is a North Pacific salmonid species, which, in the Western hemisphere, is the principal inland-farmed fish. In terms of production, global rainbow trout reached 600,000 tons in 2012; by 2019, it had exceeded 950,000 tons. Recently, we discovered a novel and ongoing disease in farmed rainbow trout, the hallmark of which […] Read More >
New MicroRNAs as Candidates for Depression Therapy
Major depressive disorder (MDD) is a complex, common, and recurrent mental disorder (1). The current first-line treatment for MDD is selective serotonin reuptake inhibitors (SSRIs), which are antidepressant drugs that block serotonin reuptake. Two microRNA (miRNAs) molecules namely miR-30b-5p and miR-101a-3p were found to be downregulated in the raphe nuclei (RN) of mice following chronic […] Read More >
Tailorable Sensors for Enzymatic Activity Based on Single-Walled Carbon Nanotubes with a Responsive Corona of Dendron–Polymer Hybrids
We have developed highly modular amphiphilic polymer-dendron hybrids composed of hydrophobic dendrons and hydrophilic linear polymer (e.g. polyethylene glycol (PEG)) that can be synthesized with a high degree of structural precision for suspending SWCNTs in an aqueous solution. Utilizing the susceptibility of the dendritic block of these amphiphiles toward enzymatic degradation, we demonstrated the ability […] Read More >
Rationally Designed Functionalization of Single-Walled Carbon Nanotubes for Real-Time Monitoring of Cholinesterase Activity and Inhibition in Plasma
We employ a fluorometric approach to monitor the activity and inhibition of cholinesterase (CHE) enzymes in blood plasma. We utilize near-infrared (NIR) fluorescent single-walled carbon nanotubes (SWCNTs) as probes strategically functionalized with myristoylcholine (MC), which is a substrate for CHE. The fluorescence intensity of MC-suspended SWCNTs undergoes a significant decrease upon interaction with CHE, attributed […] Read More >
Novel Immuno-Metabolism Pathways to Combat Obesity and Insulin Resistance
Nutritional unbalance develops the obesity led to diabetes and accompanied by insulin resistance is being the epidemics of the 21st century. Inflammation of adipose tissue serves one notable pathway that is driving the development of dysfunctional metabolic state, leading to hyperglycaemia and other pathophysiology complications. Within the adipose tissue, a pivotal role in modulating interactions […] Read More >
Hardware Accelerators for Data Structures
We present the first parallel architecture for a dynamic data-structure for approximate membership (i.e., a filter). The dynamic filter supports insertions, deletions, and approximate membership queries. Our architecture borrows techniques from PRAM emulation to parallelize filters based on two levels of fingerprints. A key component in the architecture is a special-purpose wide-word processor we designed […] Read More >
Development of Improved Peptide Inhibitors of the HIF/PHD Interaction – Anemia and HIF – Related Diseases
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
A Computational Based Approach For Designing Plasmids’ Copy Number
We used plasmids in any biotechnological objective (both in the academia and in the industry) and in all model organisms. For example, plasmids are used in fields such as FoodTech, pharma, agriculture, etc. Currently, researchers chose between two possibilities: high copy plasmid (e.g. 500 copies) and low copy plasmid (e.g. 10 copies). However, the ability […] Read More >
A Parallel Algorithm and Scalable Architecture for Routing in Beneš Networks
Beneš/CLOS architectures are the common scalable interconnection networks widely used in backbone routers, data centers, on-chip networks, multi-processor systems, and parallel computers. Recent advances in Silicon Photonic technology, especially MZI technology, had made Beneš networks a very attractive scalable architecture for optical circuit switches. UNMET NEED Our solutions enable the outstanding improvement of the ability […] Read More >
Print-N-Grip: A Disposable, Compliant, Scalable and One-Shot 3D-Printed Multi-Fingered Robotic Hand
Robotic hands are an important tool for replacing humans in handling toxic or radioactive materials. However, these are usually highly expensive, and in many cases, once they are contaminated, they cannot be re-used. Some solutions cope with this challenge by 3D printing parts of a tendon-based hand. However, fabrication requires additional assembly steps. Therefore, a […] Read More >
Micropatterning Cells and Spheroids in 3D Hydrogels
Control over cell organization within 3D hydrogels, strategically placing cells in specific locations, holds significant potential for engineering tissues with precise and intricate architectures, as well as for advancing drug testing applications. Although methods for micropatterning cells on 2D substrates are well-established and widely accessible, achieving cell micropatterning within biomimetic 3D hydrogels—mimicking the soft cellular […] Read More >
A Dedicated Hardware for Accelerating Whole Cell Simulations of mRNA Translation for Various Biotechnological Pharma Applications
Gene expression (is a fundamental process defining all type of life where information encoded in the genetic material is used for generating proteins. Gene expression is a multi-steps process mediated by millions of intracellular biological machines (e.g. RNA polymerases, transcription factors, ribosomes, tRNAs, miRNAs), with complex interactions among them. Recently, intracellular biophysical simulations of gene […] Read More >
A Generic Approach Constructing an Evolutionary Stable Genetic Circuit
Any genetic circuit engineered in any organism will cause a huge metabolic load on its host, compiling the organism to manufacture numerous proteins against his own benefit thus greatly decreasing its fitness. Random mutations that arise during normal DNA replication or during DNA damage repair dictate that it’s unavoidable outcome that the genetic circuit will […] Read More >
Deep Cell-Type Deconvolution From Bulk Gene Expression Data
It is becoming clear that bulk gene expression measurements represent an average over very different cells. Elucidating the expression and abundance of each of the encompassed cells is key to disease understanding and precision medicine approaches. A first step in any such deconvolution is the inference of cell type abundances in the given mixture. To […] Read More >
Epitope Based Vaccines for Flaviviruses
Flaviviridae are a family of positive, single-stranded enveloped RNA viruses that are typically transmitted to humans via mosquitoes and ticks. Yellow Fever virus, West Nile virus and Dengue virus are examples of human Flavivirus pathogens. Dengue virus has 4 serotypes, and getting infected by one serotype, does not protect against the other three. Moreover, pre-infection […] Read More >
Dense Speed of Sound Shift Imaging for Ultrasonic Thermometry
During thermal therapeutic applications such as high-intensity focused ultrasound (HIFU), hyperthermia, and cryoablation, it is crucial to monitor internal tissue temperature to provide feedback on the procedure. Non-invasive MRI techniques for thermal monitoring are limited by their availability and cost. Ultrasonic thermometry is an emerging adaptable alternative due to the advantages of ultrasound in accessibility, […] Read More >
Designing Novel Protein-protein Interaction Modulators with Generative Models
UNMET NEED• Protein-protein interactions (PPIs) are essential components of all cell signaling pathways and important therapeutic targets. However, the design of PPI modulators, especially in the form of small molecules, remains a major challenge.• Interfering with PPIs is especially challenging when one of the interactors is a disordered protein (i.e., with no stable structure).• Peptides, […] Read More >
Veye AI-Based Non-Invasive Blood Test for Remote Care
The Clinical Need: Non-invasive blood testing for remote care • Blood count test is the most common clinical test routinely done in billions of patients,• Blood sampling procedure has not significantly changed over a century, requiring an invasive bloodcollection under sterile conditions and laboratory analysis.• Limited accessibility and testing frequency may be life-threatening• Highly invasive […] Read More >
Using Eye-Tracking in VR to Identify Subject Preferences to Optimize Personalization
The implementation of virtual reality (VR) has been spreading in many research fields and healthcare applications. In order to better personalize the presented content, there is a need to identify the subjective experience at each time point. Previous studies with eye-tracking (ET) have demonstrated its links to preferences; therefore, collecting ET data during VR experiences […] Read More >
Spatially Targeted Transfection of Mammalian Cells
Mammalian cell transfection with DNA, RNA, small molecules, and proteins is a widely used molecular biology technique. The primary method of cell transfection is electropermeabilization, which increases the permeability of the cell membrane, allowing chemicals, drugs or DNA to be introduced into the cell. Bulk electroporation has been used for DNA transfection in suspension cells […] Read More >
Jellyfish׳ Collagen-Based Smart Wound Dressing with Antibacterial Properties
Collagen-based dressing in wounds greatly benefits the healing process. Unfortunately, most collagen is extracted from bovine tissues, which bears a significant risk of transmitting various biological contaminations. Moreover, the collagen extraction process from bovine tissue involves time and cost-consuming steps, reducing the total collagen yield and increasing the overall cost of goods. In addition, the […] Read More >
Repurposing FDA-Approved Drugs for the Treatment of Aniridia
Aniridia is a panocular disease causing progressive severe visual impairment and blindness. The disease is characterized by abnormal development of almost all eye structures, caused by dominantly inherited heterozygous mutations in primarily the PAX6 gene. Although aniridia is a developmental disorder, corneal opacification begins late in childhood, leaving a large time window for therapy. Unfortunately, […] Read More >
Anti-Oxidation Agent to be Incorporated Into Cosmetics Leading to More Stable and Longer Shelf-Life Products
Oxidation is the reaction of Oxygen with a wide array of reactants. In cosmetics, product oxidation leads to spoilage of ingredients used in the manufacturing products, the inactivation of oxygen-sensitive enzymes, shortening of product shelf-life, and discolorations of end-product. Self-assembling peptide-based hydrogels are simple hydrogels that can be combined with a wide variety of ingredients […] Read More >
Protection of Oxygen-Sensitive-Enzymes by Peptide Hydrogel
Molecular oxygen (O2) is a highly reactive oxidizing agent harmful to many biological and industrial systems. A simple encapsulation in a protective aqueous environment of O2 -sensitive reactions is of need. Self-assembling peptide-based hydrogels are simple hydrogels that can be combined with a wide variety of reagents and are able to encage O2 and significantly limit its […] Read More >
Culturing a plurality of cell types on a 3D-printed microfluidic chip
Organ-on-a-Chip platforms provide rich opportunities to observe interactions between different cell types under in vivo-like conditions. Co-culturing and the application of flow and other mechanical forces organoids, mimic 3D tissue structure and greatly enrich the data collection from such platforms. ‘Insert-chip’ is a cost-efficient, reusable, modular organ-on-a-chip platform that allows co-culturing and overcome scientific data […] Read More >
Novel Anti-Tumor Response treatment targeting ErbB receptors and Nucleolin interactions
ErbBs subfamily receptors are mediators of cell growth signals. They have long been associated with a wide variety of lung, ovarian, colon, breast, prostate, and other carcinomas. Nucleolin is a major nucleolar protein of growing eukaryotic cells and is present on the cell surface of a range of cancers. Recently, a robust oncogenic interaction between […] Read More >
Fuels and other valuable compounds from biomass and agricultural wastes using Hydrothermal Liquefaction
• The growth of human population increases both the overall energy demand and the environmental footprint in the form of a massive production of waste. • Currently energy production and waste treatment are viewed as two separate issues. To change this perspective, the synergy of organic waste conversion and energy production should be developed.• Various […] Read More >
Data Driven Algorithm For Visualizing Myelin in The Human Brain
Quantification of myelin content in the human brain is the key for early disease detection and for assessing treatment response in patients with neurodegenerative diseases. However, it has remained challenging due to lack of a reliable method for probing sub-voxel features from clinical MRI data. We developed a data-driven algorithm that accurately converts clinical MRI […] Read More >
Heterogeneous structures comprising III-V semiconductors and metal oxide dielectrics,and a method of fabrication thereof.
Electron mobility in bulk III-V semiconductors is about an order of magnitude higher than in silicon, which promises much faster nanometer-scale electronics in GaAs-based devices. However, fabrication of metal oxide – semiconductor field effect transistors (MOSFETs), the central element of modern electronics, with III-V semiconductors is hampered for years by the unresolved problem of the […] Read More >
Solution Monolayer Epitaxy for Semiconductor Surface Passivation
Passivating the surface of various semiconductors, such as the III-V family of materials, has been a long-standing unsolved problem, which limits the performance of many devices. We have recently developed the technique of Solution Monolayer Epitaxy (SoME) which has a potential to solve such problems better than previous methods. UNMET NEEDUnlike silicon, where silicon […] Read More >
MACHINE VISION SYSTEM FOR LARVAL FISH REARING
Most marine fish hatch from mm-size eggs irrespective of adult size, and suffer prodigious mortality (rates of 70-90% of the brood) in the first weeks of their lives. This mortality makes the rearing of larval (very young) fish costly, and an impediment for introducing new species to the growth cycle. We propose an automated system, […] Read More >
Device and methods for voltage regulation in pulsed electric field generators using asymmetric voltage dubler
The Need Global population growth together with enhanced quality of life, in the era of climate change, is expected to cause doubling of the world’s food and energy demand by 2050. Furthermore, there is a strong interest in the replacement of fossil-based industries towards economical, environmentally friendly, and sustainable resource, for food, chemical and energy […] Read More >
Ulva sp. (Chlorophyta) intensive cultivation in a coastal area of the Eastern Mediterranean Sea.
The Need Global population growth together with enhanced quality of life, in the era of climate change, is expected to cause doubling of the world’s food and energy demand by 2050. Furthermore, there is a strong interest in the replacement of fossil-based industries towards economical, environmentally friendly, and sustainable resource, for food, chemical and energy […] Read More >
COPRUDUCTION OF SUSTAINABLE FOOD & MATERIALS FROM SEAWEED
The Need Global population growth together with enhanced quality of life, in the era of climate change, is expected to cause doubling of the world’s food and energy demand by 2050. Furthermore, there is a strong interest in the replacement of fossil-based industries towards economical, environmentally friendly, and sustainable resource, for food, chemical and energy […] Read More >
Novel gas sensors with enhanced selectivity based on integrated magnetic and conductometric measurements
Reliable detection of hazardous gases has become a key issue due to the more stringent environmental and safety regulations worldwide. Solid-state conductometric gas sensors present a high potential for applications where the use of conventional analytical systems such as gas chromatography or optical detection is prohibitively expensive or impossible. The operation of such sensors […] Read More >
A Wheat Leaf and Stipe Rust Resistance Gene
Background Rusts are a group of plant diseases that are caused by certain types of plant pathogenic fungi. Three types of rust diseases, namely leaf, stem and stripe rusts, are the most widespread diseases of wheat, each causing great yield losses globally; Modern wheat cultivars contain many resistance (R) genes that have been used to […] Read More >
Peptide-based water-soluble and transparent adhesive
Most adhesives involve various undesirable solvents or non-environment friendly elements. Other, more pleasant options often offer decreased adhesion between surfaces. Hence, bio-inspired peptide-based water-soluble adhesives could provide a favorable solution. Transparency, non-flammability and thermal stability of the material are additional key features attributed to this material.We have developed simple synthetic peptides, with aromatic and hydrophilic […] Read More >
Improved Diagnosis and Prognosis of Neurological Diseases using Novel Training Tools and Decision Support Systems Based on a New Quantitative MRI Imaging Technique
Recently, we developed a quantitative MRI (qMRI) based technique, which can emulate pathologies on radiologic images at arbitrary levels of severity. This qMRI technique relies on the actual biological changes that occur during disease, thereby producing more faithful representation of how pathologies appear in radiologic images. The technique can also simulate a range of scanning […] Read More >
Virtual Robot Facilitator for Small Group Discussions in an Online Environment
In the post-COVID era, many activities has transferred to a collaborative online environment. Both in the education system as well as the workplace, many classes and meetings are held in videoconferencing of small groups. These have been repeatedly shown to be the most effective mode of operation. The problemOnline meetings of small groups tend to […] Read More >
Early Detection of Ovarian Cancer
We developed a novel proteomic diagnostic assay for detection of epithelial ovarian cancer, offering: • High sensitivity for early stage disease to increase the likelihood of cure. • High specificity for potential delay of risk-reducing surgical procedure. • Early ovarian cancer diagnosis for all age-groups and risk-groups (i.e., BRCA carriers). THE NEED Over 240,000 new […] Read More >
Image Processing – Non-Local Image Dehazing
Prof. Shai Avidan Tel Aviv University, School of Electrical EngineeringHaze limits visibility and reduces image contrast in outdoor images. The degradation is different for every pixel and depends on the distance of the scene point from the camera. This dependency is expressed in the transmission coefficients, that control the scene attenuation and amount of haze […] Read More >
Online Training of Stereo Self-Calibration usingMonocular Depth Estimation
Stereo imaging is the most common passive method for producing reliable depth maps. Calibration is a crucial step for every stereo-based system, and despite all the advancements in the field, most calibrations are still done by the same tedious method using a checkerboard target. Monocular-based depth estimation methods do not require extrinsic calibration but generally […] Read More >
Anomaly Detection in Video
We propose a new method for anomaly detection of human actions. Our method works directly on human pose graphs that can be computed from an input video sequence. This makes the analysis independent of nuisance parameters such as viewpoint or illumination. We map these graphs to a latent space and cluster them. Each action is […] Read More >
New Chemiluminescent Protease Probe for Rapid, Sensitive, and Inexpensive Detection of Live Mycobacterium tuberculosis
Tuberculosis (TB) is a top-ten cause of death worldwide. Successful treatment is often limited by insufficient diagnostic capabilities, especially at the point of care in low-resource settings. The ideal diagnostic must be fast, be cheap, and require minimal clinical resources while providing high sensitivity, selectivity, and the ability to differentiate live from dead bacteria.OUR SOLUTION• We […] Read More >
Bio-Inspired Metal-Organic Crystal Interconnect for Spintronic Logic Operations
Ever since its discovery in the 1920’s, the electron spin has become an integral part of quantum mechanics. Electronic spin relates to and explains many properties, such as magnetism, spin-orbit coupling, and more. One important application of spin is in the field of spintronics – the use of spin as a basis for computation. In […] Read More >
Solar-Powered Water Disinfection Based on UV-LED
Preventing mortality and improving health of billion people through accessible, environmentally friendly water disinfection. The pain people suffer due to contaminated water Over 2 billion people use a drinking water source contaminated with faces (WHO 2019), which contains bacteria, protozoa, and viruses causing a variety of diseases. In India specifically, 128M households live in rural […] Read More >
Point of Care Monitoring of Osteoporosis Treatment Efficacy
A small, simple, affordable, table top scanner to detect cellular changes in fat percentage in bone marrow as an early indicator of treatment efficacy. Accessible, Affordable, Sensitive, Noninvasive, at the Doctor’s clinic UNMET NEEDBone marrow adiposity in postmenopausal women increases with osteoporosis There is a negative association between bone marrow fat and the rate of […] Read More >
MAPPING THE SITES OF INTERACTION OF THE SMALL GTPASE RAB12 WITH ITS RILP FAMILY EFFECTOR PROTEINS
We have recently shown that the small GTPase Rab12, which was previously shown to control housekeepingfunctions, such as autophagy and iron regulation1,2, negatively regulates degranulation of mastcells (MCs), by binding and recruiting the RILP-dynein motor complex to the MC secretory granules(SGs), and driving their retrograde transport, thus restricting degranulation3. These results havemarked the Rab12-RILP complex […] Read More >
A novel method to remotely detect plant sound emission, as a response to induced stress
A novel system developed to remotely detect plant sound emission, as a response to stress. The system consists of hardware and software components: microphones that remotely pick up the plant’s sounds in the ultrasonic range of 20 to 100 kilohertz; a signal processing layer; and a machine-learning algorithm that classifies the recorded sounds and reports […] Read More >
A Fully Integrated Chip Scale Dielectric Resonance Antenna
Due to limited voltage supplies in scaled CMOS and the lower amplitude of harmonic generation at frequencies above transistors’ fmax, the radiated power out of a single element around 300GHz is limited to 0.5mW. Generating more power by combining signals from several locked sources on chip to the same on-chip antenna is not efficient due […] Read More >
Mirna for the Treatment of Metastatic Breast Cancer
Metastasis is the primary cause for mortality in breast cancer. We showed that breast cancer metastasis can be prevented by miR-96 or miR-182 treatment. We found that miR-96/miR-182 downregulates Palladin protein levels, thereby reducing breast cancer cell migration and invasion. A hydrogel-embedded, gold-nanoparticle-based delivery vehicle provides efficient local, selective, and sustained release of miR-96/miR-182, markedly […] Read More >
Mapping Transverse Relaxation in Preclinical MRI Scanners
UNMET NEEDAccurate quantitative magnetic resonance imaging (qMRI) is gradually becoming indispensable in clinical diagnostics and research. It’s application on preclinical MRI scanners, however, is hampered by the use of strong imaging gradients, which act to increase the effects of molecular diffusion, leading to bias of the measured signals. This inherent bias makes qMRI techniques irreproducible […] Read More >
Novel way to produce alcohol from waste. Producing alcohol to fight Covid -19
The increase in the world’s population as well as the development of technology and economics results among others in the increase in generation of waste. Large amounts of trash are the result of products that were consumed and discarded as Municipal Solid Waste (MSW). As biomass materials are rich in cellulose, they can be used […] Read More >
Peptide-based biomimetic hydrogels for bone regeneration
A multi-component biomimetic hydrogel scaffolds that will guide the architecture of tissue formation in bone defects. UNMET NEED Regeneration of bone defects is a major clinical challenge worldwide. The main objective is to restore and improve the function of bone tissue by scaffolds, providing a suitable environment for tissue regeneration and repair. An ideal, predictable, […] Read More >
Development of Innovative Treatment Agents for Phenylketonuria and New Diagnostic Biomarkers
We recently provided a patented mechanistic explanation and a novel therapeutic target for phenylketonuria (PKU), one of the most common among the rare inborn error of metabolism (IEM) disorders with a continuously expending market. Drugs to be developed in this path could be disease-modifying. And have the tremendous potential to help a wide range of […] Read More >
Antibody-Based Biosensor Diagnostic tool for Pathogenic Bacteria Detection
UNMET NEED • Antibiotic resistance crisis is driven by extensive and inappropriate usage of antibiotics and is predicted to result in an annual death toll of 10 million people by 2050. The ability to provide a rapid and accurate surveillance and diagnosis of multiple-drug resistant (MDR) bacteria is pivotal to the efficiency of controlling the growing […] Read More >
Rapid Detection of Drug Resistance in Patients Suffering from Invasive Fungal Infections
Global epidemics of fungal infections caused by drug resistant pathogens has beenrising sharply in recent decades including the most recently discovered Candida auris(an extensive multi-drug resistant fungal pathogen). The Echioncandin class ofantifungal drugs approved as the first-line treatment of candidaemia, invasivecandidiasis and severe infections caused by pathogenic yeast of the genus Candida,the most prevalent fungal […] Read More >
A Cost-Effective On-Site Cell-Free Biomolecules Manufacturing
ABSTRACT On-site biomolecules production is a need for many applications such as drug screening, personalized therapeutics, remote clinics, and more. CONTRALL is a silicone chip that enables cost-effective production and purification of biomolecules (proteins, Abs, etc.). The technology is especially useful for the on-site production of simple and complex biomolecules, thus surpassing the need for a […] Read More >
A New Type of Anemometer
A new type of anemometer enables the measurement of flow rate at a low current speed, for long periods of time. UNMET NEEDMeasuring a low-speed flow in complex environments has always been a challenging task. As a result, applications and studies in which measurements of very low flow speed are difficult to perform, i.e. study […] Read More >
Molecular Harvesting with Electroporation for Tissue Profiling
Detecting tumors in unknown locations and Creating molecular maps of therapeutically relevant targets in heterogeneous tumors by molecular harvesting with electroporation. Our vision is to assist physicians to diagnose cancer more precise and help scientists and drug companies develop personalized, targeted therapies. We achieved this by providing tools for accurate spatial molecular mapping of tumors […] Read More >
Label-Free 3D Quantitative Imaging of Live Cells
A method for a real-time visualization and automatic processing for detection and classification of untouched and unstained cells during stain-free imaging flow cytometry and digital pathology using digital holographic microscopy and machine learning. UNMET NEEDMost approaches dealing with the identification and characterization of specific cell types rely on using unique antigens or contrast agents. The […] Read More >
One-Step Electrophoretic Deposition of Membrane-Electrode Assembly for Flexible-Batteries Application
a unique fabrication method of a three-layer membrane- electrode assembly (MEA) by concurrent electrophoretic deposition of two electrodes directly on each side of an electrically insulating and ion-permeable membrane. The MEAs manufactured by the simultaneous EPD method can be used in various energy devices, including, inter alia, batteries, fuel cells, flow cells, and super capacitors.UNMET […] Read More >
Flexible Multi-Coaxial-Cable 3D-Printed Battery
3-D printing of a battery with any shape, using multi-coaxial, cable-type 3D printable filament UNMET NEEDPrinted batteries are an excellent alternative to conventional batteries for an increasing number of applications such as radio frequency sensing, interactive packaging, medical devices, sensors, and wearable electronics. OUR SOLUTIONMulti-coaxial, cable-type 3D printable battery, in which the inner electrode (anode […] Read More >
Scalable Bio-Hydrogen Production; a Novel Green Energy Technology
Molecular hydrogen (H2) is a promising clean energy carrier and a valuable commodity with over 60 million tons produced globally and used in many industrial technologies. The current industrial method of hydrogen production is consuming methane (a high-value fuel) and polluting the environment. Bio-hydrogen production by photosynthetic microbes represents an alternate green energy strategy that […] Read More >
Antibacterial and Antibiofilm Activity of Self-Assembled Nanostuctures
The self-assembly of peptides and functionalized amino acids into supramolecular nanostructures has yielded a wide variety of nanomaterials with numerous biomedical applications. UNMET NEED Bacterial biofilm formation on wet surfaces represents a significant problem in medicine and environmental sciences. One of the strategies to prevent or eliminate surface adhesion of organisms is surface modification and […] Read More >
Plant-Derived Anti- Herpesvirus Composition
Herpes simplex virus infection is commonly known as herpes. The two types of herpes simplex virus are HSV-1 (known to cause orofacial disease such as cold sores) and HSV-2 (causes genital infections). Over 80% of herpes infections is asymptomatic. Symptomatic infections are presented with blistering sores, pain during urination, swollen lymph nodes, and fever. Acyclovir […] Read More >
Novel Elastic Flapping-wings for Micro Air Vehicles
The technologyFlexible, 3D printed insect-inspired wings that elastically deform during flapping to improve flight performance and efficiency. The deformations are inspired by wings of beetles, adapted for different flight styles 1,2. The passive elastic deformations that the wings undergo during flapping are engineered at the fabrication stage to tailor the wing for specific flight missions […] Read More >
Plants Having Increase Tolerance to Drought and Salt Stress
Loss of function mutant of a specific gene in tomato, using CRISR/Cas9 genome editing, that results in plants with increase water use efficiency (WUE), drought and salt tolerance. Combined results from five different analyses demonstrate that the mutant tomatoes display increased WUE due to lower stomata conductance and transpiration while photosynthesis rates and yield are […] Read More >
Gene Expression for Improved Crop Pproductivity
Enhancing crop productivity by optimizing gene expression in plants, using proprietary and proven computational tools, together with genome base editing capabilities. Tapping into gene expression for improved crop UNMET NEED Crop productivity needs to substantially increase to meet global food and feed demand for a rapidly growing world population. Agricultural technology developers are pursuing a […] Read More >
A Novel Antibacterial Bio-Treatment for USE In Aquaculture
Aquaculture is the globe’s fastest growing food production sector. Diseases are a primary constraint to the culture of many aquatic species and as a result, there is widespread use of anti-microbial veterinary medicines across the globe. The medicines pose a threat to human health because of the possible emergence of resistant strains and the transfer […] Read More >
Six pack off axis holography
A method for multiplexing six off-axis holograms into a single multiplexed hologram, where the multiplexing can be done optically or digitally.BACKGROUNDWe present a novel technology, which is able to yield the thickness profile of metrological samples and stain-free biological samples in six times more information contents compared to the state-of-the art, without loss of data. […] Read More >
Novel Human Anti-Met Monoclonal Antibodies for Cancer Immunotherapy
MET is clinically validated target in several cancer types. MET operates just downstream to the famous P53. Addiction of cancers like breast and lung to MET as well as its absence from healthy adult tissues makes it a highly desirable target. Existing anti-MET marketed drugs (crizotinib & cabozantinib) are non-specific kinase inhibitors, having high toxicity […] Read More >
A Novel Drug Discovery Platform for Inborn Errors of Metabolism
A yeast-based screening system designed for each specific disease that recapitulates the metabolic state of patients and allows fast compound screening. The use of high-throughput screening of small molecules can significantly accelerate both drug discovery and target identification.The formation of amyloid fibrils is the hallmark of aging and various human pathologies, including neurodegenerations such as […] Read More >
An early stage screening tool for distinguishing pregnant women having an increased risk of developing preeclampsia
Preeclampsia is one of the most dangerous pregnancy complications occurs in the second or third trimester, affecting 3–8% of pregnancies; it is the leading cause of maternal and perinatal mortality and morbidity. Preeclampsia cannot reliably be predicted as no tests available in early pregnancy. OUR INNOVATION The invention is based in part on the finding […] Read More >
Early and Accurate Categorization and Identification of the Pathogen Infection
The detection of pathogens is important to the prevention and identification of health problems and for a better lifestyle. The growth of this market is chiefly credited to the high prevalence of infectious diseases, technological advances, growing concern for safety; government initiatives, bioterrorism surveillance and high healthcare expenditure are expected to provide the required impetus […] Read More >
Methos, System and Computer Program Product for Generating a Two Dimensional Fog Map from Cellular Communication Network Information
A computerized method for generating a two-dimensional fog map of a region from a near-ground sensors network of commercial microwave links (CMLs), the region is virtually segmented to a grid of multiple pixels, the method comprises: collecting received signals levels from the CMLs, deriving the links’ attenuation that are spread within multiple pixels of the […] Read More >
Efficient, broadband fiber-integrated frequency conversion based on Adiabatic Four-wave-mixing (AFWM) device
Powerful nonlinear frequency conversion in fiber/silicon devicesWe propose an efficient, broadband frequency translation platform based on χ_3 materials, such as optical fibers and silicon waveguides, that can be readily integrated with existing fiber laser technology and is suited for a wide range of applications, including: Multi-color ultrafast/continuum sources for spectroscopy, imaging, and sensingUpconversion detectionQuantum frequency […] Read More >
A novel RNA treatment for ALS
Amyotrophic Lateral Sclerosis (ALS) is a devastating and fatal neurodegenerative disease affecting motor neurons, leading to progressive paralysis. With a lifetime risk of 1:400 and no effective treatment available, there is an urgent need for novel therapeutic strategies to slow disease progression and improve patient outcomes. OUR SOLUTION We have identified miR126-5p as a novel […] Read More >
Repurposing of Antibiotics for treating APC (Adenomatous Polyposis Coli) Related Colorectal Cancer
Restoration of Adenomatous Polyposis Coli (APC) gene expression by means of antibiotic erythromycin for the treatment of Familial Adenomatous Polyposis. The Technology: Treatment for APC by conventional antibiotics to regulate adenoma growth and delay the need for preventive surgery in Familial Adenomatous Polyposis (FAP) patients. The Need: FAP is a high penetrance devastating syndrome manifested […] Read More >
Nanocomposite of Poly L-lactic acid with inorganic nanotubes
Strong, tough and bio-degradable polymer-based 3D-ink for fused deposition modeling (FDM) using inorganic WS2 nanotubes.WS2-NT are metals dichalcogenides nanotubes (NT) of the shape MX2 (M = transition metal, Mo, W, etc.; X = S, Se, Te). In its tube form, WS2 is a semiconductor, nontoxic, and dispersible in both organic solvents and polymers. With a […] Read More >
Deep Learning-based design of nano-photonics structures
TAU Researchers have developed a unique deep-learning algorithm that can predict the spectral response of nanostructures with high accuracy as well as provide a single nanostructure’s design, geometry and dimension, for a targeted or measured optical response. Nano-optics and Nano-photonics aim to do what is unachievable with standard linear optics, which is to go beyond […] Read More >
Macrolid Induced Correction of Premature Stop Codons: A novel Treatment for Colorectal Cancer
Restoration of premature termination codons (PTCs) caused by nonsense mutations for the treatment of Familial Adenomatous Polyposis. The Need Familial Adenomatous Polyposis (FAP) is a high penetrance devastating syndrome manifested by dozens to thousands of colonic adenomas. FAP patients require tight supervision and eventually undergo surgery, to prevent inevitable development of colorectal cancer (CRC) by […] Read More >
An Effective Sema3A Antibody as a Therapy for Optic Nerve Neurodegenerative Diseases
Glaucoma and ischemic or neuro-degenerative diseases of the optic nerve lead to vision loss and blindness. These pathologies are associated with progressive apoptosis of the retinal ganglion cells (RGC), a process which involves expression of Semaphorin 3A protein in the axonal guidance pathways. The identified Sema3A antibody provides a potentially innovative therapeutic tool for these […] Read More >
Therapeutic Vaccine for the Treatment of Cancer
An active cancer vaccine strategy targeting tumor-associated carbohydrate antigens expressed on tumor cells using biomimetic glyconanoparticles generated from unique red blood cells. The resulting sustained immune response inhibits tumor growth. THE NEED While envisioned already in 1891, only a few cancer vaccines have been approved by the FDA thus far. The key barriers to their […] Read More >
SK4 K+ channel blockers: a new treatment for cardiac atrial fibrillation
We discovered a previously unidentified target in the heart, namely the SK4 calcium-activated K+ channels, which are functionally expressed in pacemaker cells as well as in atrial and ventricular cardiomyocytes. They are crucial for proper cardiac function and represent a completely new therapeutic target for the treatment of cardiac arrhythmias. SK4 channel blockers successfully prevented […] Read More >
Ultra-low doses of tetrahydrocannabinol (THC) for cognitive deficits
Ultra-low doses of THC for the treatment of cognitive deficits Prof. Sarne has published several studies on neuroprotection induced by ultra-low doses of THC against cognitive damage that results from various insults, including hypoxia, epileptic seizures, neurotoxicity and brain inflammation (see attached two articles). The advantage of using ultra low doses is […] Read More >
3D Bioprinting of Tumor Models for Personalized Drug Screening and Disease Modeling
This technology aims to provide a three-dimensional (3D) bioprinted tumor model based on natural and synthetic polymers containing several types of cells, which resembles cancer tissue. Our 3D-bioprinted tumor model has potential to predict the clinical outcome of a treatment compared to the other existing solutions, which either rely solely on genetic profiling or do […] Read More >
Novel Ionizable Lipids for Delivery of Nucleic Acids (mRNA, DNA, siRNA)
BackgroundChemotherapy treatment is generally accompanied by adverse effects, which can be significantly reduced using site specific, targeted delivery systems, such as antibody-coated LNPs (immuno-LNPs). However due to inter-and intra-tumor heterogeneity targeting with a single targeting moiety is not sufficient in many cases and in others may induce cancer relapse due to the survival of side […] Read More >
Partially coherent radar for car applications
Many different approaches for mapping nearby moving objects are under fast development nowadays due to a number of highly important emerging applications, including autonomous cars and many others. The majority of existent proposals for solving the problem are based on optical imaging with subsequent post processing. While this concept already delivered impressive working prototypes (e.g. […] Read More >
A Novel Nanoparticle that Selectively Delivers RNAi Oligonucelotides to Tumors, Preventing Side Effects to Tissues
UNMET NEEDPancreatic cancer numbers among the most aggressive cancers known today. The overwhelming majority of pancreatic cancer patients pass away within just a year of diagnosis. However, a small minority of patients may live several years with the disease. Our findings pinpoint the inverse correlation between a known oncogene (PLK1) and the expression of an […] Read More >
Narrow nanometer-thin optical filters based on double Fano resonance in metallic films
Realize a spatially varying, nanometer-thick optical filter, with high spectral resolution (a few nanometer) at an arbitrary spectral band. Such filters could be integrated with light array detectors (CCD) to realize truly, high-performance, miniature spectrometers. Scientific background of the technology Category: Nano-photonics, meta-surfaces – sub wavelength variations of materials for desired optical response. Main idea: generalization of […] Read More >
Dynamic structured light projector based on resonance domain diffractive optical elements
The field is the 3D scanning for sensing, imaging, 3D printing and computer-integrated manufacturing. We develop a critical device for dynamic creation of the structured light (SL) patterns that was a bottleneck in triangulation-based 3D sensing with active illumination. Resorting to matured technology of lasers arrays as well as to emerging academically proven technology of […] Read More >
Block polyester copolymers by ring opening polymerization employing new catalysts
Poly(lactic acid) (PLA) is a plastic material derived from annually-renewable resources, which decomposes post-consumption to non-toxic materials. PLA is produced by the catalyzed ring opening polymerization (ROP) of lactide. PLA is attracting considerable current interest and has found various commodity (packaging, fibres, etc.) and biomedical (sutures, stents, tissue engineering, drug release) applications. Substantial worldwide effort […] Read More >
Water-Tech Laboratory
Our group focuses on developing water-treatment processes and technologies by introducing natural and induced photons, radicals, reactive species and nanoparticles into the water, using UV photocatalysis- and ozone-based advanced oxidation processes (AOPs), as well as Reuse technologies via hybrid biofiltration, ozonation and short soil aquifer treatment (SAT) of secondary effluent. We’ve assembled an AOP pilot […] Read More >
An Oncolytic Virus That Exploits Immune Defects of Cancer Cells
An oncolytic virus for tumors of different etiology presenting defects in interferon signaling, designed as a potent, specific and safe therapy. Promising in-vivo murine melanoma model shows potential for development as a mono or an add-on to chemotherapy or check-point inhibitors. UNMET NEED On Nov. 2015 the FDA approved the first oncolytic virus based treatment. […] Read More >
Passive communications with time-varying metamaterials
The coming years will see a revolution by connecting everything to anyone, and RFID and similar technologies, will lead this 300B$ USD industry and 50B connected devices. Examining existing RFID standards suggests that the leading standard, called EPC Gen 2, is a standard in the 900MHz frequency which allows hundreds of tags to be read […] Read More >
HYDEN (HighlY DEgeNerate primers) – A Software for designing pairs of degenerate primers for a given set of DNA sequences
Overview HYDEN (HighlY DEgeNerate primers) is a program for designing pairs of degenerate primers for a given set of DNA sequences. HYDEN works well for large input sets of genomic sequences (e.g., hundreds of sequences of length 1Kbp). HYDEN is a batch (i.e., command-line, as opposed to graphical interface) program, available for Windows XP (downloadable […] Read More >
Synthetic 9-cis beta Carotene for treatment of retinal degeneration
9-cis β-carotene-rich is an effective treatment for retinal diseases. Its production in algae was a bottleneck of clinical trials. Now there is a new a synthetic method for its production. BACKGROUNDAge related macular degeneration (AMD) and Retinitis pigmentosa (RP) are a leading cause of vision incapacitation and blindness worldwide (>30 million people). In recent clinical […] Read More >
Inhibition of the Pax8 Transcription Factor as a Novel Therapeutic Approach for Ovarian and Endometrial Cancer
OUTLINEThe PAX8 transcription factor is essential for ovarian cancer proliferation, and its silencing in ovarian and endometrial cancer cells leads to apoptosis 1,2. PAX8 expression in other tissues is restricted to non-essential organs, suggesting that it is a good target for therapy with minimal side effects 3,4. We propose a novel anti-ovarian and -endometrial cancer […] Read More >
A Software Only Anti-Spoofing Defense System for In-Car CAN Bus Networks
Modern cars have multiple dedicated computers under the hood called “electronic control units” (ECUs). These ECUs control many aspects of the car’s operation and are connected to each other in a network that typically uses the CAN bus protocol, which bus is a serial protocol with no security components. Replacing CAN bus with another technology […] Read More >
Novel Specific Disease-Modifying PERK Activator for Huntington’s Disease
The need: There is no efficient therapy at present for Huntington’s disease (HD) nor for any other neurodegenerative disease, including Alzheimer’s and Parkinson’s diseases. No disease-modifying approaches exist. • Gene therapy-based clinical trials have failed so far, highlighting the need for other approaches. These include the recent interruption of antisense oligonucleotide clinical trials for HD. Background […] Read More >
Compilation Integrity Assurance through Deep Code Alignment
TECHNOLOGY & POTENTIAL APPLICATIONWe propose a completely novel approach for detecting hardware Trojans. We obtain, from the foundry or by other means the binaries. These binaries are expected to largely match the programming code provided by the hardware designer with some unavoidable additions inserted in order to support debugging, QA, and to comply with manufacturing […] Read More >
High resolution deep tissue imaging of turbid media
TechnologyImaging through turbid media such as occluding body fluids (e.g. blood, urine, CSF) is restricted due to strong scattering. In applications such as intravascular optical imaging applications clearing of the imaging path (the lumen) are done by, e.g., locally stopping blood flow. The technology utilizes guided shaped light for minimally-invasive Angioscopy without the necessity to […] Read More >
Subharmonic Wireless Locking of THz transmitter
A novel method for wireless sub-harmonic locking a radiating free-running VCO single source or phased-array at THz frequenciesNeed and AdvantagesAlthough many significant challenges remain, results suggest that CMOS THz ICs are inevitability. Still, the lack of efficient, high-power (watt-level) sources remains the most conspicuous impediment to further progress. Promising applications for terahertz technology include non-ionizing […] Read More >
Interferometric phase microscopy for label-free morphological evaluation of sperm cells
Portable, compact, add-on Interferometric Phase Microscope module An optical module and software package which optically compresses several interferometric images into a single camera image and thus provides extended interferometric the field of view (FOV). Records more interferometric information on the same amount of camera pixels. ApplicationsMedical industry In-vitro diagnostics -Measuring quantitative thickness profiles of biological […] Read More >
LACTIC ACID BACTERIA FOR THE PRODUCTION OF ETHANOL FROM BIOMASS MATERIAL
The present invention, in some embodiments thereof, relates to methods and recombinant lactic acid bacteria for the production of ethanol from biomass material by a consolidated bioprocessing approach. Additional information can be provided upon request. Read More >
Multi Focus Imaging using Optical Phase Mask
Abstract A method for extended depth of field imaging based on image acquisition through a thin binary phase plate followed by fast automatic computational post-processing is presented. By placing a wavelength dependent optical mask inside the pupil of a conventional camera lens, one acquires a unique response for each of the three main color channels, […] Read More >
Logic element based on Electrically Formed Nanowire (EFN) device
An electrostatically formed nanowire transistor, includes a source, a drain, and multiple gates surrounding a doped silicon region. The gates include a top gate, a bottom gate, and side gates. The gates induce a channel in said doped silicon region. The channel has a width which is decreased by negative biasing of the side gates, […] Read More >
Video stabilizer for Cardiac-MRI (CMRI) perfusion
TechnologySeveral Cardiac-MRI (CMRI) sequences are influenced by diaphragm body motion throughout the respiratory and cardiac cycles. Stabilizing these videos might allow a better medical diagnosis by radiologists. Video-stabilization and ROI-tracking are well-known problems in computer-vision, with many practical applications. However these two problems become even more challenging for medical gray videos, in which separating ROI […] Read More >
method developed for the extraction of Azithromycin from environmental samples
Hospital wastewaters (HWW) provide a significant point-source of pharmaceuticals into the environment, especially for substances that occur at much higher concentrations in HWW than in urban wastewater. Cytotoxic or cytostatic anti-cancer drugs, derived from oncology wards, are known to be carcinogenic, mutagenic and fetotoxic. Anti-cancer pharmaceuticals are usually found in HWW. Due to their genetically […] Read More >
A smartphone based psychiatrist-aid system to monitor and prevent recurring illnesses
Lifegraph enables early detection of disease deterioration in mental health patients,using proprietary machine-learning algorithms applied to data collected from thesmartphone sensors.VISIONImproving lives of patients with mental disorders and decreasing the burden of disease on patients,their families and society as a whole.NEED AND MARKET POTENTIALMental disorders are a leading cause for loss of productivity and hospital […] Read More >
Disk-like hybrid nanostructures
A process of preparing a plurality of nanostructures, each being composed of at least one target material is disclosed. The process comprises sequentially electrodepositing a first material and the at least one target material into pores of a porous membrane having a nanometric pore diameter, to thereby obtain within the pores nanometric rods, each of […] Read More >
Briloullin simultaneous interrogation
Methods and systems used to perform sweep-free stimulated Brillouin scattering-based fiber optical sensing are described. In one aspect, a method includes interrogating different parts of a Brillouin gain spectrum using multiple optical tones in an optical fiber. The interrogating includes sending at least two pump tones into the optical fiber from one end of the […] Read More >
PNA – Self Assembled peptide nanostructures for OLED / Security applications
TechnologyWe developed nanostructures based on Peptide-Nucleic Acid (PNA) derivatives which show highly promising performance characteristics. The unique electroluminescence/photoluminescence materials can be used as emissive materials in manufacturing Organic Light-Emitting Diodes (OLED) with high emission efficiencies, tunable colors, and improved charge-transport and film-forming properties. The NeedSignificant progress has been made over the past decade in producing […] Read More >
Improvements in BOTDA for fiber optic sensors
TechnologyThis method is based on the Brillouin effect in optical fibers. By using a simple single mode optical fiber, strain is measured in a distributed manner along the entire fiber length, simultaneously, in high repetition rate. By attaching/planting the optical fiber to/in a mechanical structure, its mechanical behavior can be dynamically measured. The Need While […] Read More >
DYNAMIC MAPS FOR EXPLORING AND BROWSING OF IMAGES
Technology Our technology enables navigating over a collection of high dimensional entities (such as images, videos, text documents and more) in an interface similar to online map navigation interfaces. The map is ordered such that similar entities are put next to each other, so the browsing experience is continuous. It is dynamic in the sense […] Read More >
THREE-DIMENSIONAL MODELING FROM SINGLE PHOTOGRAPHS
Technology An interactive technique for modeling 3D man-made objects by extracting them from a single photograph is presented. The technique combines the cognitive ability of humans with the computational accuracy of the machine. To extract an object from a given photo, the user draws its part’s profile and sweeps it using simple gestures, to progressively […] Read More >
INFERRING THE PERIODICITY OF DISCRETE SIGNALS
A method for testing a signal comprises obtaining a signal, determining whether the signal has at least one period, measuring that period and providing the measurement as output. A power spectral density estimation can be used for signals having a single period, and an autocorrelation function with slicing can be used in an iterative procedure […] Read More >
High Temperature superconducting wires on Sapphire
Next generation of superconducting wires – double-sided coated superconductor tapes on sapphire that will be much simpler to fabricate, will have a lower cost, and much lower AC losses compared with current technologies. We are targeting the electricity market addressing a growing problem of blackouts due to power surges. Using our innovation to introduce revolutionary […] Read More >
Diffractive Optics based on metamaterials
A new technology for producing flat optical components based on optical metasurfaces. These components can potentially serve high resolution imaging, spectrometry, light processing and beam shaping devices. The optical metasurfaces that we develop are composed of closely spaced optical nanoantennas which can be deposited on a wide variety of rigid and flexible surfaces. The engineered nanoantennas […] Read More >
Whole Brain Visualization of Distinct Cortical Layers by MRI
The TechnologyAn MRI platform including an imaging protocol and analysis software enabling in-vivo visualization, characterization and measurement of the distinct layers of the human cortex including width in 3D. The imaging protocol utilizes inversion recovery (IR-MRI) pulse sequencing. A set of inversion times, identified and correlated to the different cortical layers provides the sought distinction […] Read More >
Microelectromechanical Systems (Mems) Sensors and Actuators
TechnologyMy research activity in the area of design and modeling of micro- and nanoelectromechanical systems (MEMS/NEMS) combines both theoretical and applied aspects and falls in several directions. The overall scope of the research is in the development of new approaches to actuation and sensing and their implementation in micro devices. In the realm of micro […] Read More >
Super Organic Tunable and White-Light Emitting Diode (OLED) by a Natural Chromophore Separation Matrix
The Technology A bio-organic framework of mucin, controlling electronic interactions between two or more energetically interacting materials, is presented. The hydrophilic mucins act as a host material for introduced nano-sized hydrophobic dyes. These can be combined in any proportion to generate photo-luminescent emitters fully tunable to any visible wavelength. The technology can provide a process […] Read More >
An Add-On Optical Interferometer Chamber to Phase Microscopes for Sub-Nanometer 3D and Dynamic Information
TechnologyAn add-on optical module for microscopes allowing for single frame and dynamic capture of amplitude and phase profiles of transparent or semi-transparent biological and non-biological samples. This easyto-use interferometric device is simply positioned in the camera port of a conventional inverted microscope, enabling quantitative structural, thickness and refractive index measurements in a noncontact, label-free manner. […] Read More >
Metal Nanowire based Transparent Electrodes
Metal nanowire films are increasingly used as transparent electrodes in many applications, including touch screens, displays, smart windows, EMI shielding and others.The group of Prof. Gil Markovich from Tel Aviv University developed a unique process for growing patterned conductive transparent silver nanowires thin film electrodes. In this unique process the nanowires grow in-situ, directly on […] Read More >
localization using TOA from Multipath
The Technology Our expert team has succeeded to develop a unique algorithm for location estimation that attains optimal performance in multipath conditions. The novel estimator advantage is that it attains accuracy which is significantly better than other leading methods and that its computational complexity is low. Meaning the algorithm is well suited for implementation in […] Read More >
Silicon transistors with virtual buried nanochannels for ultrasensitive gas detection
Technology A new device where the active nanowire is not hard coded into the silicon but electrostatically engineered post fabrication. Schematically, the buried nanowire (BN) is a field effect device composed of a silicon region surrounded by gates. Correct voltage application at the gates enables the creation of depletion zones at the gate/silicon interfaces and […] Read More >
METHODS AND KITS FOR DETERMINING PREDISPOSITION TO DEVELOP KIDNEY DISEASES
Many rare kidney disorders exhibit a monogenic, Mendelian pattern of inheritance. Population-based genetic studies have identified many genetic variants associated with an increased risk of developing common kidney diseases. Strongly associated variants have potential clinical uses as predictive markers and may advance our understanding of disease pathogenesis. These principles are elegantly illustrated by a region […] Read More >
Compressive Sensing in Radar Detection
Technology The signal processing in a pulse-Doppler radar is typically based on pulse compression filter and discrete Fourier transform (DFT). Detection, measurement accuracy and good resolution require the transmission of train of pulses, where each pulse is frequency modulated. In some cases, for ambiguity resolution, a few trains of pulses are required. A reasonable assumption […] Read More >
Self-Assembling Aromatic di-Peptide Materials for Cosmetic Applications
TechnologyOrganic, aromatic di-peptide self-assemble into close-caged structures of tubes, spheres and hydrogels. These exhibit excellent properties such as stability, solubility, transparency and rigidness alongside the basic peptide features utilized in cosmetics. The materials can be prepared as powder or hydrogel and be easily mixed with common cosmetic foundations. In addition to these native characteristics, methods […] Read More >
Enhancement of Durability, Sensitivity and Selectivity of Environmental Sensors & BioSensors by Peptide Nanotubes
The Technology A Peptide NanoForest, is a dense array of self assembling organic nanotubes, capable of enhancing sensitivity and selectivity parameters of amperometric electrode high-performance sensors. The patented Diphenylalanine (FF) aromatic dipeptide nanotubes are formed under mild conditions from inexpensive building blocks. These bioinspired materials have a unique mechanical strength. They have a high Young’s […] Read More >
Nano-Reinforcement of Adhesives, Plastics, Paints and Coatings
Technology Reinforcement of common and proprietary polymers (plastics) and composite materials for coatings and casts with nano-additives in small percentages leads to improvement of anti crack, anti-scratch, anti-rust and anti-moisture properties. Novel, patented, self-assembled organic aromatic peptide nanotubes and nanospheres exhibit exceptional thermal and chemical durability and outstanding mechanical properties. These nanostructures have demonstrated increase […] Read More >
Cobalt tungsten phosphorous electroless deposition process and materials
The Technology The new technology of electroless cobalt has lower resistance and enhanced electromigration resistance compared to alternative barriers that are used today. Therefore, for submicron technology, the new technology yields better global interconnect delay, improved reliability and increased resistance to corrosion. Furthermore, it is well conformed to the use since the deposition is a […] Read More >
Magnetic Devices based on Extraordinary Hall Effect
The Invention Magnetic based sensors and memory elements based on the Extraordinary Hall Effect (EHE). Non-volatile memories can be constructed by utilizing anisotropic thin films resulting in stable hysteresis which can represent binary states. Extremely sensitive sensors can be constructed which generate voltage as a function of magnetic disturbances. Potential Applications Memory devices complementing or […] Read More >
Improved Calcitonin-based Therapeutics
TechnologyThe aggregation site on human calcitonin has been identified, paving the way for development of specific inhibitors of calcitonin amyloid fibril formation. Such inhibitors will enable development of improved calcitonin therapeutics as well as greatly facilitate in vitro calcitonin manipulations. The NeedThe therapeutic use of human calcitonin is severely limited by its tendency to associate […] Read More >
High Speed Photonic Digital-To-Analog Conversion
The Technology A novel integrated optical modulator based on a multi-electrode Mach-Zehnder modulator has been developed at Tel-Aviv University. The device has superior performance in terms of linearity, dynamic range and implementation simplicity. These improvements are achieved by utilizing a unique mapping method between the analog input and the digital sequence applied to the device, […] Read More >
Electrochemically Identifying and Measuring Genotoxins in Water
The Invention A field deployable device for near real-time identification and quantitiatve measurement of genotoxins in water. The device contains a low cost disposable probe head which quickly and accurately alerts if genotoxins are present at dangerous levels. The probe consists of genetically modified bacteria which are sensitive to various genotoxins and produce an electrical […] Read More >
Display of High Dynamic Range Images on Conventional Displays
The Invention Current image acquisition and processing allow construction of images with a very wide range of luminous levels. The invention is a method for intelligently manipulating the luminous levels into a displayed image where a maximum amount of significant viewable detail can be simultaneously displayed. The algorithm is based on a visual model which […] Read More >
Eye Gaze Correction for Video Conference
The Invention An algorithm has been developed that can detect the eyes of a video photographed subject. The eyes can then be artificially placed so that they are looking at the camera irrespective of the actual direction the eyes may be directed. The Need Video conferencing is a popular method of communication, whether through IP […] Read More >
”Smart” Textiles integrating Peptide Nanostructures
The TechnologyTextiles that have been modified by integrating peptide nanostructures show remarkable properties. These include the physical and chemical properties of the fabric, such as strength and fire-resistance, as well as much more advanced properties including enzymatic activities such as self-cleaning and hazardous materials-decontamination. Potential applicationsSmart textiles have many applications. Among them are self-cleaning […] Read More >
Product Authentication using Nanoimprinting Lithography (NIL)
A unique Nano Imprinting Lithography (NIL) technology, based on a polymeric replication method, to battle counterfeiting• Extremely difficult to copy or forge• Inexpensive implementation (tag printing)Tag printing: Imprint on the brand product a set of nanometer scale patterns that are invisible to the naked eye (and most microscopes)Authentication: “Read” and analyze the tag using an appropriate device. […] Read More >
Self Assembled Peptide Hydrogel
The Technology A breakthrough Self Assembled Peptide Hydrogel (SAPH) has been developed. SAPH is a safe, self-assembled, biocompatible, remarkably strong hydrogel with modulated stability that is suitable for various medicinal and cosmetic applications. SAPH is based on the highly efficient self-assembly of the short aromatic peptides diphenylalanine. The discovery and development of SAPH is the […] Read More >
Harnessing Inhibitory RNA Based- Nanoparticles for Therapeutic Intervention in Blood Cancers
The current treatment of multiple myeloma (MM) included standard chemotherapy and small molecules such as the proteasome inhibitor and the immunomodulatory drugs. Although these drugs have improved the response and survival of MM patients, MM is still an incurable disease. Drug resistance and disease refractoriness are the common terminal pathways leading to patients’ mortality. Therefore, […] Read More >
An agricultural mobile robot guided by sonar and vision for crops and yield estimation
Using bio-inspired sensing methods (from bats) for crop estimation, plant examination and plant classification. The system is based on a mobile robotic platform with vision and sonar sensing that is doing the agricultural tests.The NeedAn agricultural manager‘s success depends on his ability to estimate accurately the status of the crops. Although it is assumed that […] Read More >
Multiple Stated Electrostatically Formed Nanowire Transistors (MSET)
TECHNOLOGYElectrostatically Formed Nanowires (EFN) based transistors have been recently suggested as robust sensing (Shalev et al. 2013) and memory devices (Shalev et al. 2012). The EFN device resembles the silicon-on-insulator (SOI) four gate field-effect transistor (G4-FET) developed in 2002 (Blalock et al. 2002) which emerged from the volume inversion SOI MOSFET. The G4-FET combines MOSFET […] Read More >
Active Flow Technology for Motor Vehicles up to 4,500 kilograms
The InventionMiniature Air Vehicles (MAV’s) with Active Flow Control (AFC) is an aviation invention in which the means for thrust generation, flight control and lift augmentation are created by the same fluidic actuators, located within the MAV. This can solve many of the problems that inhibit further development of the field. The most compelling reason […] Read More >
Computational Platform for Enhancing Gene Expression for Increased Protein Yield and Viral Titer
Technology Deciphering Gene Expression Code – We perform large-scale analyses of genomic data to discern the rules behind the various aspects of gene expression encoded in the transcript. Computational Modeling of Gene Expression – We develop predictive computational models to mathematically analyze and simulate the different stages of gene expression, focusing on gene translation. Engineering […] Read More >
Big Data Analytics
Data Mining and Machine Learning; User-Oriented Security: A Multi-Disciplinary Approach The proposed research is an interdisciplinary project, aiming to develop an adaptive cyber-security system that is personally-adjusted to characteristics of a human user. The project is based on the rapidly developing literature on “usable security” which emerged from the realization that system security often depends […] Read More >
Biodegradable, Multifunctional, Jellyfish Based Bioplastics
Plastic pollution has become the most pressing environmental issue, and biodegradable solutions are a promising alternative. Unfortunately, most plastic alternatives are difficult to upscale and require the cultivation of the process substrate. Due to climate change, overfishing, and habitat modifications Jellyfish (JF) blooms are prevalent, resulting in the harm of electrical powerhouse, industrial cooling systems, […] Read More >
Capacitive Matrix for Continuous Voltage Output
A direct current (DC) to DC converter, including: input ports for receiving an input DC voltage; output ports for outputting an output DC voltage; a first matrix of capacitors and switches; a second matrix of capacitors and switches; and a control circuit, coupled to the switches of the first and second matrices, configure d to […] Read More >
Novel Class of Turn-ON Near-Infrared Probes for Diagnosis and Imaging of Inflammation and Cancer
Complete tumor removal during surgery has a great impact on patient survival. To that end, the surgeon should detect the tumor, remove it and validate that there are no residual cancer cells left behind. Residual cells at the incision margin of the tissue removed during surgery are associated with tumor recurrence and poor prognosis for […] Read More >
Flexible Blade Rheometer
The innovation is a low-cost flexible extension to the standard off-the-shelf rotational blade rheometer. State of the art rotational rheometers use fixed and rigid blades, which rotate against a fluid and have limited accuracy at extremely high or low viscosities. Our inventions replaces the rigid blades with flexible blades work by utilizing fluid mechanics and […] Read More >
Miniature Air Vehicle Controlled and Propelled by Active Flow Control
Miniature Air Vehicles (MAV’s) with Active Flow Control (AFC) is an aviation invention in which the means for thrust generation, flight control and lift augmentation are created by the same fluidic actuators, located within the MAV. This can solve many of the problems that inhibit further development of the field. The most compelling reason for […] Read More >
Direction of Arrival Deception Using Metasurfaces
The invention of radars was soon followed by extensive research and development of counter measures, the most well-known being the invention of stealth technology. By employing special geometric designs and carefully selected materials, a reduction of the target’s radar cross section and the resulting backscattered energy was successfully achieved, substantially reducing distances between the radar […] Read More >
Molecular Classification of Inflammation and Uses for Personalized Therapy
Our work is focused on decoupling between four inflammatory molecular states: i. Disease tolerance activity. Maintenance of health in the presence of stress, injury, infection. Healing through tissue repair and renewal mechanisms. ii. Antimicrobial activity. Detects, neutralizes, and eliminates the invading pathogen (“resistance”). iii. Metabolic status. Reflects the abnormal cardiometabolic status related to hypertension, diabetes […] Read More >
Hardware Accelerators for Data Structures
We developed the first parallel architecture for a dynamic data-structure for approximate membership (i.e., a Bloom filter that also supports deletions). UNMET NEEDThe filter architecture supports multiple operations per cycle while preserving sequential order with a fixed and stable throughput that does not depend on the type of operations, the workload, or how populated the […] Read More >
Using Eye-Tracking During Sentence Reading to Identify Subject Tendency to Depression
Depression is a common and disabling mental health disorder, which impacts hundreds of millions of people worldwide. Current diagnosis methods rely almost solely on self-report and are prone to subjectivity and biases. In recent years, computational psychiatry has employed advanced sensing technology, utilizing rich data, in order to train accurate algorithms to detect depression from […] Read More >
Methods of Treating Diseases Associated with Polyalanine Expansion Mutations
The invention describes the inhibition of ubiquitin like modifier activating enzyme 6 (UBA6) by disease-causing polyalanine expanded mutant proteins in a variety of cell types. Polyalanine-expanded proteins can interact with UBA6 and inhibit UBA6-mediated protein degradation of downstream targets, such as the neurodevelopmental E3-ubiquitin ligase E6-AP. Ectopic administration of vectors expressing UBA6 in patient cells […] Read More >
Tomato Plants with Broad-Spectrum Pathogen Resistance
Plants rely on innate immunity to perceive and ward off microbes and pests, and are able to overcome many invading microorganisms. Even so, pathogens overcome plant defenses, posing a persistent threat to crop and food security worldwide, raising the need for agricultural products with broad, efficient resistance. The combined goal of several projects in our […] Read More >
MiRacle: Revolutionizing Disease Diagnostics with MicroRNA
MiRacle is a groundbreaking startup focused on transforming disease diagnostics using microRNA analysis. Our innovative method offers a non-invasive, cost-effective, and highly accurate solution for early-stage disease detection. By leveraging our proprietary technology, we aim to revolutionize the field of diagnostics and save countless lives. Problem: Accurate diagnosis is a prerequisite for efficient health care. […] Read More >
Incidental Detection of Colon Cancer Using AI Analysis of Abdominal CT Scans
Detecting colon cancer in general abdominal CT scans, i.e. without bowel emptying performed before colonoscopy, is extremely challenging. With nowadays technology, it is not possible to automatically detect cancer in the large intestine without prior preparation of the intestine as required in colonoscopy. A study has revealed that more than 20% of malignant findings in […] Read More >
Development of a Biological Safe Anti-Candida Agent for the Treatment of Denture Stomatitis
UNMET NEED● Denture stomatitis is a common form of oral candidiasis afflicting according to some reports up to 65% of dentures wearers.● Current treatments are based on toxic chemical agents and are non-effective.● Ani candida solution can be extended towards a broad range of other indications. Treating denture stomatitis holds clinical and patient-related significance. Firstly, […] Read More >
Cost-Effective Distributed Acoustic Sensing
Optical fibers are widely known in their ability to transfer huge amounts of data efficiently and cost-effectively. As the backbone of our communications networks, optical fibers are everywhere: underground or aerial in our streets, underwater in the oceans, along highways, railways, pipelines, power lines and fences, in campuses and in data centers. Optical fibers are […] Read More >
Hyperspectral Imaging Method and System using a Flock of Small Satellites
Remote sensing by satellites is the most major tool in earth observation. In recent decades, governments and the private sector have invested billions in earth surveillance satellite missions. Environmental and agricultural surveillance requires multi-spectral visible, NIR, SWIR, and thermal imagery. Traditionally imagery satellites equipped with a bulky high-resolution camera resulted in heavy and expensive satellite […] Read More >
A Cytoskeletal Protein Predicts Disease Incidence, Progression, and Prognosis
Brain tumors comprise over one hundred types of masses, differing in location; patient age; molecular, histological, and immunohistochemical characteristics; prognosis and treatment. Glioma tumors originate from neuroglia, cells supporting the brain. Palladin, a structural protein widely expressed in mammalian tissues, has a pivotal role in cytoskeletal dynamics and motility in health and disease. Palladin is […] Read More >
Low Frequency Nanobubbles-Enhanced Ultrasound Mechanotherapy for Noninvasive Cancer Surgery
A unique theranostic ultrasound-based technology for low-energy mechanical ablation of tissues. Noninvasive ultrasound surgery can be achieved using focused ultrasound to locally affect the targeted site without damaging intervening tissues. Mechanical ablation and histotripsy use short and intense acoustic pulses to destroy the tissue via a purely mechanical effect. Here we show that coupled with […] Read More >
Error Correction Code Transformer
Error correction code is a major part of the communication physical layer, ensuring the reliable transfer of data over noisy channels. Recently, neural decoders were shown to outperform classical decoding techniques. However, the existing neural approaches present strong overfitting due to the exponential training complexity, or a restrictive inductive bias due to reliance on Belief […] Read More >
Apparently Silent Mutations That Affect Splicing in Cancer and Other Diseases
Many mutations that cause cancer and other diseases may not be detected since they look like silent mutations that do not change the encoded proteins. One fundamental mechanism that apparently silent mutations can severely disrupt is alternative splicing. We introduce a tool that scores mutations based on models of proteomes generated using aberrant splicing predictions. […] Read More >
Deep Quantum Error Correction
Quantum error correction codes are essential for building reliable quantum computing devices and a key component for realizing the potential of quantum computing. QECC, as its classical counterpart (ECC), allows the reduction of the error rates by distributing quantum logical information across redundant physical qubits such that errors can be detected and corrected. UNMET NEEDAs […] Read More >
Tuning Stylegan Locally to Faithfully Encode Any Input Image
The ability to distinguish between synthetic images and real ones has become increasingly challenging since the introduction of Generative Adversarial Networks (GAN). Although the images produced by this framework are often indistinguishable from real ones, one lacks the ability to control the specific outcome. Most relevant to our work is the StyleGAN family of generators, […] Read More >
A Lensless Polarization Camera
Polarization imaging is a technique that creates a pixel-map of the polarization state in a scene. Although invisible to the human eye (and for most conventional cameras), polarization can assist various sensing and computer vision tasks. Existing polarization cameras acquire the additional modality using either spatial or temporal multiplexing, which increases the camera volume, weight, […] Read More >
Models for Protein Levels Optimization in Chloroplasts Based on mRNA-rRNA Folding and Interactions
Chloroplasts which have evolved from an ancestral bacterium can be the target very efficient expression of heterologous protein with huge economical potential. However, translation in chloroplasts, which have evolved from an ancestral bacterium is not well understood and currently there is no generic quantitative model related to these aspects in the chloroplast. The patent includes […] Read More >
Targeting Mitochondrial IGF-1 Receptors as Therapy for Neurodevelopmental Disorders
Neurodevelopmental brain disorders (NDDs) pose an immense burden on both the families of patients and the health and educational systems, without any effective therapies. We propose, based on our novel findings that are supported by recent clinical data, a potential gene therapy strategy that might restore the brain activity of patients to a healthy regime. […] Read More >
Deep Brain Stimulation of Thalamic Nucleus Reuniens as a New Therapeutic Tool to Prevent Neuronal and Cognitive Dysfunctions in Alzheimer’s Disease
We utilize the basic concepts of control theory and an integrative approach which spans brain-state, neural circuit, synaptic and molecular levels to boost cognitive resilience to AD pathology1,2. UNMET NEED There is no efficient, disease-modifying therapy at present for Alzheimer’s disease (AD). Even the most successful, recently FDA approved anti-amyloid drug lecanemab shows a great […] Read More >
Agrivoltaics with Spectral Beam Splitting
Agri-Photovoltaics (Agrivoltaics, APV) is an emerging field with rapidly growing interest. However, the typical APV layout is no different than standard PV farms. Because standard PV panels essentially block all sunlight, the field density is highly compromised to allow sufficient visible light to reach the crops, thus significantly reducing the potential electrical output from the […] Read More >
Stabilizing Gelatin-Based Bioinks under Physiological Conditions by Incorporation of Ethylene-Glycol-Conjugated Fmoc-Ff Peptides
Peptide-based bioinks that stabilize gelatin-based 3D printed scaffolds under physiological conditions. UNMET NEED Gelatin is one of the most widely-used materials for the fabrication of 3D scaffolds. In order to fabricate stable scaffolds under physiological conditions, gelatin need to be methacrylated, allowing the crosslinking and therefore the stabilization of the hydrogel through UV treatment. However, […] Read More >
System and Method for Determining Design Parameters for Marine Infrastructure
In the 60s-70s, a remarkable advancement was reached: instruments for directional wave measurements were developed. Data processing techniques based on potential wave theory enabled for the first time the evaluation of wave directional spectra. However, the irrotational potential theory lacks essential terms of waves and ambient shearing current interactions. By constructing suitable simulations, we proved […] Read More >
LWIR / FIR / THz Detectors and Sources For High Sensitivity Remote Sensing
The discoveries of novel materials and physical phenomena continuously drive technological advancements and their applications. So is the case for Terahertz (THz) optoelectronics, operating roughly in the frequency range of f≈0.5-35THz. In this spectral range radiation penetrates through opaque materials without the risk of ionization, making THz radiation highly attractive for technological applications, such as […] Read More >
Highly Active and Stable Multifunctional Low-Pressure Ammonia Synthesis Catalyst
The Haber process for synthesis of ammonia is one of the most studied and important reaction of the last century. Ammonia is used mostly as a feedstock for fertilizer, but has gained considerable interest as a hydrogen carrier in a future hydrogen economy owing toits specific energy content and ease of transportation. The Haber process, […] Read More >
Visual Data Transfer Between the End and Side of a Multimode Fiber
It is well known that light propagation in optical fibers is accompanied by random omnidirectional scattering. This type of scattering is called ‘Rayleigh scattering’ and is due to small inhomogeneities in the fiber core. The small fraction of coherent guided light that escapes outside the cladding of the fiber forms a speckle pattern. While works […] Read More >
Shape Sensing of Multimode Optical Fibers
Fiber optic shape sensing (FOSS) is an emerging technology which uses optical fibers for real-time 3-dimensional (3D) sensing of the shape of objects in space. It has many advantages with respect to competing technologies. These include ease of installation, flexibility and compactness, immunity to electromagnetic interference, low weight, compatibility with harsh environments, compatibility with in-vivo […] Read More >
An On-Chip Sub-THz Scalable Beam Steering Antenna Array
We present a novel way of distributing signal to an antenna array without the use of power dividers. In our proposed method, we use the leaked fundamental from a non-linear harmonic generator circuit as an input to drive the next element in the chain. As a proof of concept, we show this distribution method at […] Read More >
Extending the Life of Lithium-Based Batteries Via Metal-Oxide Nanoparticles Addition
Due to the need to reduce environmental pollution and reduce the use of fossil fuels, the whole world is moving towards increasing the use of electric vehicles that will be charged from renewable energies – sun and wind. Lithium batteries are currently used as the main source of energy for electric vehicles. The challenges that […] Read More >
Broad-Bandwidth, Long-Haul, Underwater Fiber-Optic Sensing System
An optical fiber can be described as a glass pipeline which can guide light over great distances with very little loss. In addition to being the central communication channel of the information era, it has another very interesting application. This application is called distributed sensing. By launching into the fiber specially designed pulse sequences of […] Read More >
iPONT- Israeli Platform for Online Neuropsychological Testing
ObstaclesTwo main obstacles in testing the cognitive status of patients with neurological disorders are: 1. Small and Unrepresentative Samples: The sample size of studies is small and not diverse, frequently with 50 or fewer participants from the same geographic area. 2. Time Required: It can take significant time to undertake a single study, let alone […] Read More >
Explainable AI (XAI)
One important challenge in machine learning is the “black box” problem, in which an artificial intelligence reaches a result without any humans being able to explain why. This problem is typically present in deep artificial neural networks, in which the hidden layers are impenetrable. To tackle this problem, our researchers have introduced the notion of explainable […] Read More >
Glioblastoma Regression by Regulating Astrocytes’ Immunometabolic Signaling
Malignant brain tumors are the cause of a disproportionate level of morbidity and mortality among cancer patients, an unfortunate statistic that has remained constant for decades. Despite considerable advances in the molecular characterization of these tumors, targeting the cancer cells has yet to produce significant advances in treatment OUR SOLUTIONAn alternative strategy is to target […] Read More >
Method for Isolating Oral Mucosa-Derived Mesenchymal Stem Cells for Tissue and Organ Regeneration
Identification and isolation of the mesenchymal stem cells from the general population of oral mucosa-derived cells may further improve regenerative therapies. Using cutting edge technology, we’ve been able to identify the subpopulation of mesenchymal stem cells with superior osteogenic capacity and furthermore, to unveil a list of unique markers to isolate these cells. Our findings […] Read More >
Therapeutic Monoclonal Antibodies to Combat Multidrug-Resistant Pathogenic Bacteria
It is predicted that a failure to address the problem of antibiotic-resistant pathogens will result in the death of 10 million people annually, costing the economy more than 100 trillion dollars by the year 2050. In high-income countries where antibiotics are heavily used in the community and agriculture, the strong selection pressure and non-completed antibiotic […] Read More >
A METHOD FOR ENGINEERING OF PLASMID FOR ORGANISM SPECIFIC EXPRESSION
Automatic designing a plasmid such that it will be expressed only in sub-set of organisms in a microbiomes/community. Current microbiome engineering techniques are usually manually tailored for a specific system and neglect the different interactions between the new genetic information and the bacterial population, turning a blind eye to processes such as horizontal gene transfer, […] Read More >
A-Traumatic Teeth Extraction and Immediate Implant Placement
The global dental services market is expected to reach 554.5 billion USD by 2028, with dental implants dominating the market as R&D in this field continues to excel with better biomaterials, improved designs, and surface modifications. Tooth extraction is a crucial step in dental implants procedure. The standard extraction method is based on mechanical rocking […] Read More >
Stable enzyme-responsive nanocarriers with a-two step activation mechanism
The Challenge: Polymeric nanocarriers that can release their covalently attached or encapsulated cargo in response to specific stimuli can offer many advantages such as greater selectivity and consequently reduced side-effects. Among the different types of stimuli-responsive nanocarriers, enzyme-responsive delivery systems can act as a Trojan horse and release their active payload in response to specific […] Read More >
Dynamic Budget Allocation for Web Media Advertising Campaigns
Companies are required to define an advertising strategy determining how to allocate advertising funds over time, to maximize exposure to as many potential consumers as possible to the brand. Several models of advertising budget allocation have been developed over the years, however, these mjavascript:void(null);odels fall short in their capacity to inform budget allocation problems that […] Read More >
Increased Enzyme Shelf-Life by Encapsulation in Peptide-Based Materials
Peptide-based nanomaterials that protect enzymes over time leading to increased shelf-life. UNMET NEED Enzymes are naturally susceptible to environmental changes resulting in their denaturation and loss of activity, thus rendering them less practical for everyday applications. The main objective is the improvement and increase in enzyme shelf-life thereby allowing their practical use in various daily […] Read More >
Therapeutic Targeting of PD-1/PD-L1 blockade by Novel Small-molecule Inhibitors
Interactions between programmed cell death ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1) lead to the evasion of cancer cells from an efficient immune response. The inhibition of PD-L1/PD-1 has prevented or reversed exhausted T cells, thus enhancing antitumor T-cell responses. In fact, immune checkpoint blockade targeting the PD-1 axis has become one […] Read More >
STEREOGRADIENT POLY-(LACTIC ACID) PRODUCTION BY RING OPENING POLYMERIZATION, EMPLOYING HIGHLY ACTIVE NOVEL CATALYSTS
The Kol group at the School of Chemistry of Tel Aviv University has been developing catalysts and technologies for the ring opening polymerization of lactones, and in-particular lactide to produce PLLA-based polymers, block-copolymers and tailor-made copolymers. Recently, a new family of catalysts was developed by the Kol group. These catalysts combine several attractive properties: 1. […] Read More >
Leveraging Gene Panel Sequencing Data for Mutational Signature Analysis with Applications to Personalized Treatment
UNMET NEED Mutational signatures and their exposures are key to understanding the processes that shape cancer genomes with applications to diagnosis and treatment. Yet current signature analysis approaches are limited to relatively rich mutation data that comes from whole-genome or whole-exome sequencing. Recently, orders of magnitude sparser data sets from gene panel sequencing have become […] Read More >
High Resolution Robotic Fingers
Traditional robotic hands have a complex structure with many degrees-of-freedom, while they can be large, fragile and with high cost. In addition, they usually cannot perform gentle and precise in-hand manipulation that is required in, for example, medical procedures and assembly of small components. We propose a sophisticated mechanism that enables to augment the capabilities […] Read More >
Optimal retrieval in puzzle-based storage (PBS) systems using automated mobile robots (AMR)
Puzzle-based systems (PBS), store unit loads in very high density, without consuming space for transport aisles. In such systems, each load is stored on a moving device (conveyor module or transport vehicle), making these systems very expensive to build and maintain. We propose a new type of PBS system where loads are moved by a […] Read More >
Advanced Sensitivity in Point-of-Care Diagnostics: Electrokinetic Preconcentration Technology
As is evident from the lateral-flow-assay (LFA) that became so popular with detection of Corona virus, there is an urgent need to increase the sensitivity of detection of both point-of-care (POC) and self-testing (for example, used by individuals at home) devices. Lateral flow kits result in relatively low detection limit as only a small fraction […] Read More >
Microfluidic Flow-meter and Sensor for Drug Delivery Applications
The current structure of medical pumps does not allow real-time measurement of different parameters of drug delivery in general and low flow rates (μL/min) in particular. The current structure wherein only indirect measurements are performed (commonly pressure) makes it difficult to detect failures (e.g. air bubbles, occlusion, infiltration) in real-time on the one hand and […] Read More >
FABRICATION OF ELECTRODES WITH ULTRA-SHORT CHANNEL LENGTH
Nanofabrication represents one of the most important features of modern electronics, optoelectronics, photonics and information technologies. However, the ability to fabricate nanoscale (sub-20 nm) devices, requires the introduction of unconventional techniques for material patterning, which is cumbersome, expensive, time consuming, typically available mainly to big industrial companies or to specific research centers, hence, not reachable […] Read More >
Bio-inspired flexible piezoelectric layer showing powerful performance
The piezoelectric effect, the conversion of mechanical energy to electrical energy can serve as the basictechnology for many applications such as energy harvesting sensing and actuating. Currently, the fieldof piezoelectric materials is dominate by lead-based ceramic materials such as lead zirconate titanate(PZT). However, lead is toxic and brittle, emerging the need for alternative lead free, […] Read More >
METHOD FOR GENERATION OF CONTROLLED THz WAVES
We present a method for the generation of THz pulses with tailored temporal shape from nonlinear metasurfaces. The method is based on single-cycle THz emission by the metasurface inclusions. We show that the spatial amplitude and phase structure of the nonlinear response is mapped to the temporal shape of pulses emitted at certain angles. We […] Read More >
Automatic Music Transcription in The Wild using Unaligned Supervision
We have developed a novel system that enables automatic transcription of real musical performances. The system detects in unmatched high accuracy which notes were played, at what time, and by which instrument. In other words, the system can parse the musical content from a recording with high precision in timing and instrumentation. The prediction of […] Read More >
Efficient information coding in living organisms
It is clear that DNA can be used as a storage medium, each nucleotide carrying two information bits, which can store vast amounts of data for very long periods of time and with high reliability; as overtime, humans remain human just as cats remain cats. However, it is also clear that it is a very […] Read More >
Development of Alzheimer Disease therapy based on counteracting the pathological effects of ApoE4
Alzheimer’s disease (AD) is the most common cause of dementia and is the outcome of progressive brain cells death. Due to the disorder’s heterogeneity and in view of the variety of pathological mechanisms inducing the disease we have undertaken an innovative – science based (Animal model) approach, which is presented here. Our unique approach […] Read More >
Homocysteine fibrillar assemblies display crosstalk with Alzheimer’s disease amyloid polypeptide
High levels of homocysteine (Hcy) are reported as a risk factor for Alzheimer’s disease (AD). Correspondingly, inborn hyperhomocysteinemia is associated with an increased predisposition to the development of dementia in later stages of life. Furthermore, despite the apparent association between protein aggregation and AD, attempts to develop a therapy that targets explicitly this process have […] Read More >
