Department: Cell Research and Immunology
Faculty: Life Sciences
Tel Aviv University

Prof. EHRLICH Marcelo

I am interested on the dynamic aspects of the cell’s trafficking machinery, with a special focus on endocytic dynamics. More specifically, our study centers on the mechanisms by which the cell modulates vesicular traffic by altering:

  • The rate of formation of vesicular carriers, such as clathrin coated vesicles.
  • The spatio-temporal distribution of the process of vesicular carrier formation.
  • The make-up and structure of transport vesicles.

We will look at the modulatory effects of the following processes:

  • Viral infection. We are currently working with viruses from the Reoviridae family.
  • Cell attachment and spreading.
  • Epithelial to mesenchymal transition (EMT); a process essential for the metastatic progression of epithelial tumors.

In addition to the basic biochemical and cell biological techniques, we employ time-lapse microscopy with living cells as a mean to observe, characterize and quantify the cell’s trafficking events.

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