The Fridman laboratory is engaged in the use of organic chemistry, especially carbohydrate chemistry, to solve key biological and medicinal problems.

Our interdisciplinary studies involve the use of organic chemistry, microbiology, cell biology, molecular biology, and confocal microscopy to study and/or alter the mode of action of biologically active molecules with the focus on novel approaches for the development of antimicrobial and antitumor agents. Our current research covers four major topics: I) rational design of membrane targeting antibiotics, II) development of chemoenzymatic and chemical approaches to circumvent the action of certain resistance mechanisms to aminoglycoside antibiotics, II) structure-function studies and rational design of novel antitumor agents, and IV) exploration of bacterial biofilm matrix assembly and strategies for its formation inhibition.

Education

• B.A. in Molecular Biochemistry, Technion, Israel, 1997-2000
• M.Sc. in Organic Chemistry, Technion, Israel, 2000-2001
• Direct pathway to Ph.D. studies, Department of Chemistry, Technion- Israel Institute of Technology, 2002-2005
• Post-Doctoral Research Fellow, Department of Chemistry and Chemical Biology, Harvard University, 2005-2008