Genetics: Our laboratory focuses on the genetic and hormonal regulation of bone remodeling, microarchitecture and strength. These traits have a high degree of heritability, and one aspect of our research is to characterize new genetic determinants of bone remodeling as well as elucidate the mechanism of action of selected genes. Our GWAS confirmed the role of AVP (vasopressin) and OXT (precursor of oxytocin) in bone and identified for the first time Rhbdf2 as a significant determinant of bone structure.

Sex hormones: We investigate the actions of sex hormones with an emphasis on the skeletal dimorphism between males and females, and their interaction with other genes and transcription factors.

Erythropoietin: Epo is the main hormone that regulates blood cells production. We are investigating the role of Epo in bone remodeling in general and on the bone cells in particular.

Inflammation-induced osteolysis: Today, most dental implants undergo surface roughening to enhance osseointegration. However, ultrasonic scaling performed routinely for oral hygiene releases particles from titanium implants. We found that these particles stimulate the secretion of inflammatory cytokines and induce osteoclastogenesis in vitro and in vivo.

Cannabinoids: Cannabis-derived and endogenous cannabinoids are important regulators of bone cells. We investigate the beneficial actions of cannabinoids in bone fracture healing, osteoporosis, Osteogenesis Imperfecta, and inflammation-induced bone destruction.