Department: Cell and Developmental Biology
Faculty: Faculty of Medical & Health Sciences
Tel Aviv University

Dr. Luxenburg Chen

Senior Lecturer (Assistant Professor), Faculty of Medicine

Dr. Luxenburg completed his Ph.D. studies at the Weizmann Institute of Science under the supervision of Profs. Lia Addadi and Benny Geiger, where he studied molecular and structural mechanisms of osteoclast adhesion. For his post-doctoral training, he moved to the laboratory of Prof. Elaine Fuchs at Rockefeller University in New York, where he studied the roles of the actin cytoskeleton in epidermal development. In October 2013 he returned to Israel and opened his independent research group. Luxenburg is a member of the Israeli Center of Research Excellence (I-CORE) “Gene Regulation in Complex Human Disease.”

Cytoskeletal Regulation of Epidermal Stem Cells

Our laboratory studies how cytoskeleton-derived signals control stem cell’s ability to give rise to a functional tissue during development, to maintain it throughout life and repair it upon wounding.

The actomyosin cytoskeleton is a complex cellular structure that plays a role in many biological processes. Classic studies established its role in cell structural organization. However, new studies demonstrate that the cytoskeleton plays a major role in regulatory processes that control signal transduction, gene expression and stem cell lineage specification.

Our laboratory uses the skin epidermis as its main model system. Projects in the lab explore both skin development and skin common diseases such as cancer and psoriasis. In addition to classic genetic tools and in vivo models we also use state of the art technology to manipulate stem cells in utero. Genome wide analysis of gene expression, quantitative digital microscopy and a variety of molecular and cellular methods are all commonly used in our lab.

Phone: 03-6409272
Another phone: 03-6409508
Fax: 03-6407432
Lab Website:
Office: School of Medicine, 406

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