Prof. Attali Bernard
Normal and Diseased Potassium Channels in Human Brain and Heart
Reaching an understanding in molecular terms of the mechanisms by which changes in membrane potential regulate cellular events is the main concern of our research. We focus our interest on potassium channels because they play crucial roles in many cellular functions such as shaping cardiac and neuronal action potentials, tuning neuronal firing patterns, synaptic integration or modulating neurotransmitter release. Using the powerful combination of molecular biology, biophysics, biochemistry and electrophysiology, our research aims at elucidating the structural, biophysical and physiological attributes of potassium channels in human brain and heart and whose mutations lead to major neurological and cardiovascular disorders like epilepsy, myokymia, atrial or ventricular fibrillation.