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196 Results were found on Technologies
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Personalized Human Immune System Platform for Drug Validation
The Challenge Advances in AI, single cell multiomics, and large-scale datasets are transforming drug discovery, enabling rapid identification of targets, biomarkers, and therapeutic opportunities. However, a key bottleneck remains: validating these discoveries in a human-relevant system before clinical development. Current preclinical models often fail to capture human immune complexity, leading to high development risk and limited predictive power. Our Solution […] Read More >
Innovative Micro-Structured Targets for Enhanced Laser-Driven Proton Acceleration
Laser-driven ion acceleration is an emerging promising technology for generating high-energy proton beams in a compact and cost-effective manner. By utilizing intense laser pulses to interact with solid targets, it is possible to produce ion beams with energies suitable for various applications, including medical therapy, materials science, and imaging. Traditional flat-foil targets, while well-understood, face […] Read More >
Bringing Cloud-Costs and Performance Under Control
The use of micro-services architectures over cloud computing has become the industry standard for operating web and mobile applications as well as internal company computer systems. AI services are becoming a dominant factor, affecting cost/performance dramatically. The Problem: Uncontrollable operational cost/performance The micro-service architecture “pretentiously” offers a panacea of performance/cost worry-free environment. In practice, system […] Read More >
Universal Optical Spatial Mode Transformer
Description and Need Designing optical systems for complex matrix transformations is a mathematically slow and challenging process. Existing solutions are often bulky, limited to specific transformations, and require intensive optimization procedures. There is a market need for a compact method to realize any desired linear operator or matrix to manipulate light. This technology addresses these […] Read More >
3D Multi-Sensory Platform for Advanced In Vitro Models
UNMET NEED As biological models continue to evolve from traditional 2D cultures to complex 3D tissues, organoids, and bioprinted constructs, there is a growing need for sensing technologies capable of monitoring functionality within these physiologically relevant systems. Current sensing platforms, including conventional MEA and TEER systems, are largely limited to two-dimensional measurements. OUR SOLUTION Researchers […] Read More >
Write-and-Read: Programmable Epigenomic Sequencing via Synthetic DNA Labeling
DESCRIPTION A chemo-enzymatic platform that actively encodes new biological information into DNA before nanopore sequencing — enabling simultaneous genetic and epigenomic readout from a single molecule, in a single run. By installing synthetic base modifications at targeted sites, the platform converts epigenetic events (5-hydroxymethylcytosine, chromatin accessibility, DNA damage) into distinct, machine-readable electrical signals without bisulfite […] Read More >
OGP: A CB2 Agonist Enhancing CAR-T Therapy
CAR-T therapies show promising clinical responses, yet many patients relapse due to the immunosuppressive tumor microenvironment (TME). Multiple Myeloma remains largely incurable. OUR SOLUTION Osteogenic growth peptide (OGP), a selective CB2 agonist, enhances anti-tumor immunity by reducing immunosuppressive myeloid cells and boosting cytotoxic T-cell activity. In preclinical studies, OGP demonstrated synergistic activity with CAR-T therapy, […] Read More >
Peak-to-Average Power Ratio (PAPR) Reduction for High-Speed Communications
Description and Need Modern data communication demands ever-increasing transmission rates, with current standards targeting 100 Gbps to 400 Gbps. As symbol rates rise, intersymbol interference (ISI) causes the Peak-to-Average Power Ratio (PAPR) at the receiver to increase significantly, sometimes exceeding 10 dB. High PAPR requires receivers with a large dynamic range, leading to higher circuit […] Read More >
Peptide Condensate Platform for High-Capacity Delivery of Hydrophobic Active Ingredients
Hydrophobic active ingredients are widely used across cosmetics, food-tech, and pharmaceuticals, yet their formulation remains a key challenge due to poor solubility, limited loading capacity, and complex delivery systems. We present a proprietary peptide-based condensate platform that enables efficient, high-capacity encapsulation of hydrophobic molecules within biocompatible, liquid-like microcompartments. This tunable and scalable technology enhances solubility […] Read More >
Genetic Engineering of B Cell Receptors for Antigen-Induced, Evolvable Antibody Secretion
We developed a platform for engineering B cells via targeted integration of antibody sequences into the immunoglobulin heavy chain (IgH) locus, enabling physiological expression as a B cell receptor (BCR) and subsequent antigen-induced secretion. Unlike conventional antibody therapies or ectopic expression systems, this approach preserves key adaptive immune functions including antigen-dependent activation, class-switch recombination (CSR), […] Read More >
