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258 Results were found on Technologies
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Wearable Sensor Platform for Dynamic Cervical Range of Motion Analysis
Unmet Need Current cervical spine assessment methods suffer from notable limitations in accuracy, reproducibility, and practicality. Universal goniometers (the clinical standard) provide inconsistent measurements of cervical range of motion (CROM) due to operator dependence, trunk stabilization requirements, and restricted testing to mostly upright positions, which prevents reliable assessment during dynamic activities or varied postures. Optical […] Read More >
New Anti-Influenza Virus (FLU) Drug Discovery
Influenza A virus infection is one of the most common respiratory tract diseases in humans. It is the cause of typical seasonal flu and major human pandemics worldwide. According to the World Health Organization (WHO), in October 2023, approximately 3 to 5 million severe influenza cases were reported, resulting in 290,000 to 650,000 deaths worldwide. […] Read More >
Scalable Wet-Etching Technology for High-Resolution MXene Microelectrodes
MXenes are an emerging class of highly conductive, two dimensional materials that combine metallic performance with solution based processing. These properties position MXenes as promising candidates for next generation technologies in microelectronics, sensing, and flexible devices. Despite their potential, widespread adoption has been limited by the lack of a practical and scalable method that can […] Read More >
Cell-Permeable Abiotic Transcription Factor Modulators with Enhanced Stability, Intrinsic Cell Pearmiability, and Specific DNA Binding
Cell-Permeable Miniproteins to target Myc oncoprotein Chemically engineered family of Max-derived transcription factor (TF) analogs (μMax modulators) with intrinsic cell permeability, nanomolar DNA binding, and enhanced stability. These abiotic proteins can directly modulate gene expression driven by Myc TF – offering a therapeutic strategy for drugging the undruggable Myc pathway. Unmet Need TFs, especially Myc, are among the […] Read More >
CRISPR-Cas3 Phage Platform Enabling Precision Gut Delivery of Biotherapeutics
This technology introduces a first-in-class engineered phage platform that delivers proprietary DNA Cargos into targeted E. coli strains of the human gut microbiome. Using CRISPR-Cas3–mediated in-vivo selection, the system converts bacterial populations and drives local production of human biotherapeutics directly inside the gut. The platform achieves durable bacterial trait modification without disrupting microbiome balance and […] Read More >
Agent-Based Modeling of Pedestrian Mobility in the City From Research to Opportunity: Unlocking the Value of Pedestrian Flow Data
Understanding and predicting pedestrian flows across a city is critical for smarter urban planning, infrastructure investment, and business decision-making. Traditional data collection is expensive, fragmented, and limited in scope, making large-scale insights difficult to obtain. Our solution: a city-scale Agent-Based Modeling (ABM) platform that combines high-resolution spatio-temporal and GPS-based walking data with advanced Machine Learning […] Read More >
OGP: Immune-Modulating Cancer Therapy
Osteogenic growth peptide (OGP), a selective CB2 agonist, reduces cancer progression in two models of colon cancer and one model of breast cancer in mice by modulating immune responses. Human genetic data supports the role of CB2 in tumor immunology. UNMET NEED Colon carcinoma and breast cancer are prevalent solid tumors with limited therapies and […] Read More >
Catalytic Depolymerization Technology for Sustainable PLA Recycling
As the world strives toward a circular economy and faces mounting environmental concerns about plastic waste, innovative recycling solutions for bioplastics are urgently required. Polylactic acid (PLA), the most common bioplastic, is widely used in packaging, textiles, disposables, biomedical devices, and more due to its biodegradability and non-toxic degradation. However, current end-of-life solutions for PLA—such […] Read More >
Neural Segmentation of Seeding ROIs for Pre-Surgical Brain Tractography
White matter tractography mapping relies on accurate manual delineation of anatomical seeding regions of interest (sROIs) by neuroanatomy experts, but stringent pre-operative time constraints and limited availability of experts create a critical bottleneck for neuro-surgical planning and navigation. Moreover, the manual segmentation process is labor-intensive and not feasible given the time pressures of pre-surgical planning, […] Read More >
Bedside Manufacturing of Personalized mRNA Vaccines
A microfluidic lab-on-a-chip platform enabling on-demand, bedside production of mRNA vaccines encapsulated in lipid nanoparticles (LNPs). Unlike conventional centralized manufacturing, this integrated system performs cell-free transcription and LNP formulation on a single device, delivering ready-to-use mRNA-LNP vaccines rapidly and efficiently. KEY ADVANTAGES • End-to-end automation: From DNA template to formulated mRNA-LNP in one device • […] Read More >
