The Finkelstein Laboratory for Cognitive Neuroscience and Neural Dynamics explores how cognitive abilities emerge from interactions between neurons. The lab is especially interested in understanding how the collective activity of neurons in brain networks gives rise to cognitive phenomena, such as the ability to make decisions and form new memories.

Mesoscale imaging of neural activity at single-neuron resolution during behavior

Key Research Areas

1. Neural Circuit Dynamics
The team investigates how the collective activity of neurons in brain networks generates cognitive phenomena, with particular focus on:
• Attractor dynamics in cortical information flow
• Neural algorithms for motor planning
• Three-dimensional head-direction coding systems

2. Brain-Machine Interface Technology
The lab develops cutting-edge methods that enable both “reading” and “writing” neural information:
• Neural Reading: Recording neural activity during behavior to decode cognitive processes
• Neural Writing: Manipulating cognitive processes by directly influencing brain activity to create artificial memories and influence decisions

3. Neuroplasticity and Recovery
Reorganization of brain networks during neurodegeneration, with special focus on:
• Brain plasticity following stroke
• Recovery mechanisms in neurodegenerative disorders
• Immune-based therapeutic approaches

Technologies & Methods
• Electrophysiological Recording: Multi-electrode arrays and single-cell recordings
• Optical Imaging: Advanced calcium imaging and voltage-sensitive dye imaging
• Optogenetics: Light-controlled manipulation of specific neuronal populations
• Computational Neuroscience: Advanced modeling and analysis of neural dynamics
• Behavioral Paradigms: Naturalistic behavioral tasks in freely-moving animals

The lab’s research has direct implications for:
• Stroke Recovery: Understanding brain plasticity mechanisms for therapeutic development
• Neurodegenerative Diseases: Developing immune-based therapies for ALS and other conditions
• Brain-Computer Interfaces: Advancing neuroprosthetic technologies
• Memory Disorders: Therapeutic approaches for memory-related conditions

Laboratory Website: www.finkelstein.sites.tau.ac.il