We present a sequential fabrication of a three-layer retina-like structure. This innovative approach aims to address the challenges associated with age-related macular degeneration (AMD) and other retinal degenerative diseases by creating a bioengineered retinal implant that mimics the natural structure and function of the human retina.

Unmet Need:
Age-related macular degeneration is the leading cause of blindness in Western countries, affecting millions of individuals and resulting in irreversible vision loss. Current treatment options are limited, primarily focusing on managing symptoms rather than providing a cure. There is a significant unmet need for effective regenerative therapies that can restore retinal function and improve the quality of life for patients suffering from advanced stages of AMD, particularly those with geographic atrophy.

Our Solution:
Our technology offers a novel solution by utilizing advanced 3D bioprinting techniques to fabricate a three-layer retina-like structure. This structure consists of a choroid-like layer, a retinal pigment epithelium (RPE) monolayer, and photoreceptor cells, all embedded in a patient-specific extracellular matrix (ECM) hydrogel. This sequential fabrication process ensures that each layer is optimally designed to support the survival and function of retinal cells, providing a potential therapeutic option for restoring vision in AMD patients.

Unique Advantages:
–  Personalized Approach: The use of patient-specific ECM hydrogels enhances compatibility and integration, improving the likelihood of successful engraftment.
–  Vascularization:The technology incorporates a vascularized structure, which is crucial for nutrient and oxygen supply to the retinal cells, promoting their survival and functionality.
–  Advanced Bioprinting: The precision of 3D bioprinting allows for controlled cell distribution and scaffold fabrication, closely mimicking the natural architecture of the retina.
–  Regenerative Potential: By addressing the critical layers of the retina, this technology has the potential to restore vision and significantly improve the quality of life for individuals affected by     retinal degenerative diseases.

Potential Applications:
–  Retinal Implants: Development of bioengineered retinal implants for patients with AMD and other retinal degenerative diseases, aiming to restore vision.
–  Research Models: Creation of in vitro models for studying retinal diseases, drug testing, and the development of new therapeutic strategies.
–  Tissue Engineering: Application in broader tissue engineering fields, including the fabrication of other complex organ structures that require multi-layered cellular arrangements.
–  Regenerative Medicine:Potential use in regenerative medicine to treat various ocular conditions and injuries, enhancing recovery and functional restoration.

Patent
METHOD FOR REINFORCING CELLULARIZED-RETINAL CONSTRUCTS PCT/IL2024/050152