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Print/PDF Bedside Manufacturing of Personalized mRNA Vaccines
A microfluidic lab-on-a-chip platform enabling on-demand, bedside production of mRNA vaccines encapsulated in lipid nanoparticles (LNPs). Unlike conventional centralized manufacturing, this integrated system performs cell-free transcription and LNP formulation on a single device, delivering ready-to-use mRNA-LNP vaccines rapidly and efficiently.
KEY ADVANTAGES
• End-to-end automation: From DNA template to formulated mRNA-LNP in one device
• Portable and scalable: Decentralized, point-of-care vaccine production
• Reduced costs and waste: Precision microfluidic production minimizes reagents and time
• Enhanced stability: Immediate encapsulation protects mRNA integrity
• Rapid response: Critical for emerging diseases and personalized therapeutics
APPLICATIONS
Commercial Applications
Human Health: Personalized cancer vaccines, pandemic preparedness, decentralized production in clinics or hospitals
Veterinary Health: Rapid field-deployable vaccines for livestock, zoonotic diseases, and One Health initiatives.
STATUS
POC completed. Avialable for license.
INTELLECTUAL PROPERTY
Provisional application.
REFERENCES
Reference Publication: Zilberzwige-Tal et al., 2024, PMCID: PMC12366276.
