We are leveraging the natural S100 proteins as a green, broad-spectrum antimicrobial platform. These can be efficiently recombinantly produced via fermentation and exhibit potent antibacterial and antifungal activity while also modulating inflammation. These proteins can be formulated as coatings or additives to prevent microbial infections and spoilage in medical, dental, and food applications.
This technology offers a safe, sustainable alternative to conventional chemical preservatives and antimicrobials.

UNMET NEED
Medicine

> Biofilm persistence on teeth & implants: Mechanical debridement and antiseptics often fail to eradicate mature, mixed species biofilms on rough implant threads and subgingival niches, driving recurrence of peri implantitis and periodontitis.

> Durable local delivery: There is a shortage of long acting coatings/gels/injectables that provide sustained antimicrobial and anti inflammatory activity on devices, gums, or mucosa.

> Recurrent mucosal infections: Vaginal and cutaneous fungal infections frequently recur due to biofilm reservoirs and azole resistance; Alternatives are limited.

Food

> Clean label food preservation: Consumer and regulatory pressure is shifting away from synthetic preservatives; industry needs natural, “green” antimicrobials that control molds/yeasts/bacteria without altering taste/texture.

> Scalable, consistent manufacturing: Markets require fermentation based, GMP ready biologics with reliable cost and yield.

OUR SOLUTION
We propose using the S100 proteins as natural antimicrobial agents. These proteins efficiently protects from a broad range of pathogens, addressing a key factor in persistent infections.
The proteins are biocompatible and cause minimal inflammatory reaction – in fact, psoriasin is naturally expressed in skin and mucosa as part of our immune defense.
We produce these proteins recombinantly (e.g. in fermentation systems), allowing scalable manufacturing of purified proteins.

APPLICATIONS
Food Preservation: Natural food and beverage preservative for preventing mold and bacterial spoilage without chemical additives.
Oral Healthcare: Coatings for dental implants, dentures, and periodontal devices to prevent infections like peri-implantitis, periodontitis, and denture stomatitis.
Medical Devices & Wound Care: Antimicrobial coatings on catheters, surgical implants, and wound dressings to curb hospital-acquired infections.
Dermatology and Personal Care: Topical creams, gels or wash.

INTELLECTUAL PROPERTY AND REFERENCES
WO 2025/088611: “Treatment and Prevention of Microbial Infections in the Oral Cavity.”
WO 2024/180552: “Eco-friendly, sustainable food preservative.”
Lifshits et al., 2025. Antifungal recombinant psoriasin of human origin effectively inhibits fungal growth on denture base.
bioRxiv preprint 2025. Psoriasin inhibits microbial growth in food by metal sequestering.