Low-Level Light therapy: a new therapeutic approach in cell therapy and regenerative medicine

Regenerative medicine is currently a very active field of research and clinical trials due to the extensive research and new approaches of cell-based therapies for the reconstruction of impaired organs. Low-level laser therapy (LLLT) has been found to modulate various biological processes such as increasing mitochondrial respiration and ATP synthesis, facilitating wound healing, and promoting the process of skeletal muscle regeneration and angiogenesis  This phenomenon was partially attributed to a significant elevation in ATP content, heat shock proteins, vascular endothelial growth factor (VEGF), and angiogenesis in the ischemic zone of the laser-irradiated organs, as compared to non-irradiated ones. The mechanism associated with the photobiostimulation by LLLT is not yet clearly understood. There is evidence that cytochrome c oxidase and perhaps also plasma membrane in cells function as photo acceptor of the photons, and thereafter a cascade of events occurs in the mitochondria, leading to effects on various processes like ATP production, up-regulation of growth factors, etc.

LLLT to the bone marrow, had been shown to be beneficial in
• Formation of significantly less scar tissue and better heart function after acute myocardial infarction (AMI) AMI in animal models.
• Improving neurological performance and cognition of Alzheimer’s disease mice

Applying LLLT to autologous bone marrow induce stem cells that are consequently recruited to the injured/ischemic organ leading to a marked beneficial effect post-ischemic or traumatic event. The LLLT application appears to be safe in humans. 

US and European Patents (Granted)

Sign up for
our events

    Life Science