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Microelecronic scaffold for tissue engineering

Tissue engineering has emerged as a promising treatment for replacing defective tissues and organs. However, current cell therapy options do not allow for online monitoring and reporting of tissue performance and do not interfere with delivering signals for organ reactivation. 

The proposed technology is a stand-alone, electronic system, either embedded within an engineered tissue of any type or directly integrated with defected organ to sense and regulate tissue function and supply on-demand drugs or bio-factors. 

• Once the 3D engineered tissues have been generated, in-vitro assessment of their quality without affecting their performance is limited. 
   - The technology provides online monitoring of the engineered-tissue function in-vitro and in-vivo.
• For example, in engineered heart patches, transplanted after a heart attack, unsynchronized contraction may jeopardize the success of this therapeutic approach 
   - This technology may be equipped with built-in sensing and pacing capabilities.
• Integration of engineered patch to the surrounding tissue may require biological or pharmacological agents to be released locally.
   - The technology can store and release various bio-factors to trigger physiological processes such as blood vessel formation, cell       migration, etc. 

Engineered tissues can serve for drug screening and toxicity tests.

Granted US Patent

Feiner, R., Engel, L., Fleischer, S., Malki, M., Gal, I., Shapira, A., Shacham-Diamand, Y., & Dvir, T. (2016). Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function. Nature Materials, 15(6), 679–685.