Email 
Linkedin 
WhatsApp 
Print/PDF Molecular Signatures of Inflammation and Uses for Personalized Therapy
OUR SOLUTION
Our work is focused on four molecular states that impact the inflammatory status:
i. Disease tolerance activity. Maintenance of health in the presence of stress, injury, infection. Healing through tissue repair and renewal mechanisms.
ii. Antimicrobial activity. Detects, neutralizes, and eliminates the invading pathogen (“resistance”).
iii. Metabolic status. Reflects the abnormal cardiometabolic status related to hypertension, diabetes and atherosclerosis (“metabolic syndrome”, MetS)
iv. Systemic inflammation. The systemic inflammatory reaction due to infection, injury, autoimmunity, an irritant or an unknown cause.
Insights/abilities we already have:
• We defined a readout as indication for each of these immune states (both in vivo & in vitro).
• Each readout captures one global aspect of the inflammatory status (rather than a specific pathway).
What makes these 4D inflammatory-states different?
1) The four states co-exist in the same cells (PBMCs, monocytes, astrocytes)
2) Each of the four states explains variation in many cohorts, in both health and disease
3) Provide successful diagnostic/prognostics of multiple types of disease
APPLICATIONS
1) Consider the inflammatory state in precision medicine AI: e.g., predictors, disease subtypes, selection of individuals to clinical trials
2) Drug classification that specifically indicates the effect on the four-arms inflammatory status
3) Identify drugs to reverse disease state or drugs that may have side effects on the inflammatory state
