A modular organ-on-a-chip platform, configured for cultivating cells, tissues, organoids, and organelles and capable of performing high throughput analyses, including pharmacokinetic evaluations.

UNMET NEED
There is an unmet need for modular organ-on-a-chip, cost-effective, platforms and devices to approach the real complexity of human physiology and provide reliable extrapolations for clinical investigations and personalized medicine.

OUR SOLUTION
A system in the form of a cartridge configured to include one or more (a plurality) of organ-on-a-chip units, which are fluidly connected under a single pool of blood (or blood equivalent medium). Optionally, the cartridge may comprise three main components: one or more organ chips configured for culturing cells, organelles, and/or organoids on a membrane included therein, a receptacle configured to contain blood (or blood equivalent medium), and a cover layer which may be configured to hold the one or more organ chips such that their bottom part which may include a membrane with cells (including such cells as, but not limited to vascular endothelial cells, cancerous cells, epithelial cells, alveolar epithelial cells, immune cells, enterocytes, and goblet cells, cardiac cells, muscle cells, adipose cells, skin cells, hepatic cells, spheroids.

APPLICATIONS
The Organizer enables high throughput human relevant physiological assessment in fluidically linked Organ-on-a-Chip platform. This platform tackles fundamental problems and weaknesses other systems have, such as Organoid compatibility, Modular design, Scalable production, Low drug absorption, High throughput, Availability to small-scale users. These issues will be overcome by 1. Using biocompatible, non-absorbent materials. 2. Implementing commercially available components. 3. The system design will allow modularity and flexibility, regarding the linkage order, and the organs that will be linked. 4. The system will not have integrated pumps, which will lower the cost significantly.         

INTELLECTUAL PROPERTY
PCT/IL2022/050698