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Print/PDF Protection of Oxygen-Sensitive-Enzymes by Peptide Hydrogel
Molecular oxygen (O2) is a highly reactive oxidizing agent harmful to many biological and industrial systems. A simple encapsulation in a protective aqueous environment of O2 -sensitive reactions is of need. Self-assembling peptide-based hydrogels are simple hydrogels that can be combined with a wide variety of reagents and are able to encage O2 and significantly limit its diffusion and penetration.
APPLICATIONS
• A platform for chemical reactions:
o O2-sensitive enzymes
o O2-reactive reagents
o Catalysts or chemical reactions can be encapsulated in a buffered hydrogel to maintain their activity in aerobic conditions
STATUS
• The peptide hydrogels limit the diffusion of O2 significantly better than other hydrogels.
• Binding is specific to O2.
• Also works in liquid suspension with a low peptide concentration.
INTELLECTUAL PROPERTY
US Provisional Patent
REFERENCES
Ben-Zvi, O., Grinberg, I., Orr, A. A., Noy, D., Tamamis, P., Yacoby, I., & Adler-Abramovich, L. (2021). Protection of Oxygen-Sensitive Enzymes by Peptide Hydrogel. ACS Nano, 15(4), 6530–6539. https://doi.org/10.1021/acsnan…
