Our innovative genetic engineering technology offers a transformative solution for livestock and pet industries by generating offspring with a skewed sex ratio. The technology, proven in mice, is now aimed at practical application in cattle, swine, poultry, and other farm animals, as well as pets.
The Problem: Current breeding practices lead to significant waste due to unwanted offspring of a particular sex. This requires unnecessary culling, consumes valuable resources, and increases labor costs.

The Solution:
Our technology introduces a controllable genetic cassette into male animals that targets and silences a key gene necessary for the maturation of sperm containing the Y chromosome. This results in predominantly female offspring, with up to 94% of the progeny being female, while leaving litter size unchanged. Importantly, these female offspring are not genetically modified, as they do not inherit the engineered Y chromosome.

Business Potential:
By significantly reducing the need for sex-based culling, this technology provides:
• Increased efficiency in breeding operations.
• Cost savings from lower feed, housing, and labor requirements.
• Sustainability benefits by curbing resource waste.
• Scalability for application in a variety of species including cattle, swine, and poultry, with future potential for other markets like pet breeding.

This breakthrough represents a pioneering advance in animal breeding, poised to bring economic and ethical improvements to the industry.

Patent:
PCT/IL2023/050881, GENETICALLY ENGINEERED EUKARYOTIC ORGANISMS, SYSTEMS AND METHODS FOR IN VIVO BIASING SEX-RATIO OF POPULATIONS